{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,25]],"date-time":"2026-01-25T22:13:09Z","timestamp":1769379189396,"version":"3.49.0"},"reference-count":50,"publisher":"Impact Journals, LLC","issue":"55","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncotarget"],"published-print":{"date-parts":[[2017,11,7]]},"DOI":"10.18632\/oncotarget.21333","type":"journal-article","created":{"date-parts":[[2017,9,29]],"date-time":"2017-09-29T00:03:36Z","timestamp":1506643416000},"page":"93899-93911","source":"Crossref","is-referenced-by-count":16,"title":["Paeoniflorin prevents postoperative peritoneal adhesion formation in an experimental rat model"],"prefix":"10.18632","volume":"8","author":[{"given":"Qi","family":"Gao","sequence":"first","affiliation":[{"name":"Department of General Surgery, The First Affiliated Hospital of Xi\u2019an Jiaotong University, Xi\u2019an 710061, Shaanxi, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guangbing","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of General Surgery, The First Affiliated Hospital of Xi\u2019an Jiaotong University, Xi\u2019an 710061, Shaanxi, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunhua","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of General Surgery, The First Affiliated Hospital of Xi\u2019an Jiaotong University, Xi\u2019an 710061, Shaanxi, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Na","family":"Yao","sequence":"additional","affiliation":[{"name":"College of Nursing, Shaanxi University of Chinese Medicine, Xianyang 712046, Shaanxi, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cancan","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi\u2019an Jiaotong University, Xi\u2019an 710061, Shaanxi, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of General Surgery, The First Affiliated Hospital of Xi\u2019an Jiaotong University, Xi\u2019an 710061, Shaanxi, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of General Surgery, The First Affiliated Hospital of Xi\u2019an Jiaotong University, Xi\u2019an 710061, Shaanxi, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuejun","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of General Surgery, The First Affiliated Hospital of Xi\u2019an Jiaotong University, Xi\u2019an 710061, Shaanxi, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuqi","family":"Li","sequence":"additional","affiliation":[{"name":"Department of General Surgery, The First Affiliated Hospital of Xi\u2019an Jiaotong University, Xi\u2019an 710061, Shaanxi, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7892","published-online":{"date-parts":[[2017,9,28]]},"reference":[{"key":"1","doi-asserted-by":"crossref","first-page":"1476","DOI":"10.1016\/S0140-6736(98)09337-4","article-title":"Adhesion-related hospital readmissions after abdominal and pelvic surgery: a retrospective cohort study","volume":"353","author":"Crowe","year":"1999","journal-title":"Lancet"},{"key":"2","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.1093\/humrep\/deh321","article-title":"Adhesion-related readmissions following gynaecological laparoscopy or laparotomy in Scotland: an epidemiological study of 24 046 patients","volume":"19","author":"Crowe","year":"2004","journal-title":"Hum Reprod"},{"key":"3","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.ijsu.2009.04.004","article-title":"Medico-legal consequences of post-operative intra-abdominal adhesions","volume":"7","author":"Crowe","year":"2009","journal-title":"Int J Surg"},{"key":"4","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1007\/s00268-008-9917-x","article-title":"Adhesion-related complications are common, but rarely discussed in preoperative consent: a multicenter study","volume":"33","author":"Kraemer","year":"2009","journal-title":"World J Surg"},{"key":"5","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1111\/j.1471-0528.2000.tb11083.x","article-title":"The impact of adhesions on hospital readmissions over ten years after 8849 open gynaecological operations: an assessment from the Surgical and Clinical Adhesions Research Study","volume":"107","author":"Crowe","year":"2000","journal-title":"BJOG"},{"key":"6","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1111\/j.1463-1318.2007.01360.x","article-title":"Practicalities and costs of adhesions","volume":"9","author":"Wilson","year":"2007","journal-title":"Colorectal Dis"},{"key":"7","first-page":"167","article-title":"The effect of ethanol extract of rose (Rosa damascena) on intra-abdominal adhesions after laparotomy in rats","volume":"28","author":"Ezzati","year":"2016","journal-title":"Wounds"},{"key":"8","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1159\/000445603","article-title":"Effect of resveratrol on the prevention of intra-abdominal adhesion formation in a rat model","volume":"39","author":"Li","year":"2016","journal-title":"Cell Physiol Biochem"},{"key":"9","doi-asserted-by":"crossref","first-page":"1621894","DOI":"10.1155\/2016\/1621894","article-title":"Preventive effects of the intestine function recovery decoction, a traditional Chinese medicine, on postoperative intra-abdominal adhesion formation in a rat model","volume":"2016","author":"Li","year":"2016","journal-title":"Evid Based Complement Alternat Med"},{"key":"10","doi-asserted-by":"crossref","first-page":"E1611","DOI":"10.3390\/ijms17101611","article-title":"Keratinocyte growth factor combined with a sodium hyaluronate gel inhibits postoperative intra-abdominal adhesions","volume":"17","author":"Li","year":"2016","journal-title":"Int J Mol Sci"},{"key":"11","first-page":"CD005080","article-title":"Intra-peritoneal prophylactic agents for preventing adhesions and adhesive intestinal obstruction after non-gynaecological abdominal surgery","volume":"1","author":"Leaper","year":"2009","journal-title":"Cochrane Database Syst Rev"},{"key":"12","doi-asserted-by":"crossref","first-page":"2415","DOI":"10.1007\/s00464-015-4492-3","article-title":"Causes, predictors and consequences of conversion from VATS to open lung lobectomy","volume":"30","author":"Schmid","year":"2016","journal-title":"Surg Endosc"},{"key":"13","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1016\/j.fertnstert.2016.08.029","article-title":"Reduction of postoperative adhesion development","volume":"106","author":"Diamond","year":"2016","journal-title":"Fertil Steril"},{"key":"14","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1016\/j.fertnstert.2016.07.1075","article-title":"Oxidative stress in the pelvic cavity and its role in the pathogenesis of endometriosis","volume":"106","author":"Dolmans","year":"2016","journal-title":"Fertil Steril"},{"key":"15","doi-asserted-by":"crossref","first-page":"3083","DOI":"10.2147\/DDDT.S80221","article-title":"Inhibition of cyclooxygenase-2 prevents intra-abdominal adhesions by decreasing activity of peritoneal fibroblasts","volume":"9","author":"Li","year":"2015","journal-title":"Drug Des Devel Ther"},{"key":"16","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1016\/j.fertnstert.2016.08.012","article-title":"Role of the peritoneal cavity in the prevention of postoperative adhesions, pain, and fatigue","volume":"106","author":"Adamyan","year":"2016","journal-title":"Fertil Steril"},{"key":"17","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1007\/s00268-007-9330-x","article-title":"Macrophage and T-lymphocyte infiltrates in human peritoneal adhesions indicate a chronic inflammatory disease","volume":"32","author":"Klinge","year":"2008","journal-title":"World J Surg"},{"key":"18","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1002\/bjs.9405","article-title":"Interferon \u03b3 and plasminogen activator inhibitor 1 regulate adhesion formation after partial hepatectomy","volume":"101","author":"Fujimoto","year":"2014","journal-title":"Br J Surg"},{"key":"19","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.jep.2017.03.054","article-title":"Paeoniflorin and liquiritin, two major constituents in Chinese herbal formulas used to treat hyperprolactinemia-associated disorders, inhibits prolactin secretion in prolactinoma cells by different mechanisms","volume":"204","author":"Li","year":"2017","journal-title":"J Ethnopharmacol"},{"key":"20","doi-asserted-by":"crossref","first-page":"655","DOI":"10.3892\/etm.2015.2908","article-title":"Paeoniflorin ameliorates rheumatoid arthritis in rat models through oxidative stress, inflammation and cyclooxygenase 2","volume":"11","author":"He","year":"2016","journal-title":"Exp Ther Med"},{"key":"21","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1111\/jre.12305","article-title":"Protective effects of paeoniflorin on alveolar bone resorption and soft-tissue breakdown in experimental periodontitis","volume":"51","author":"Li","year":"2016","journal-title":"J Periodontal Res"},{"key":"22","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.toxlet.2013.01.028","article-title":"Paeoniflorin protects human EA. hy926 endothelial cells against gamma-radiation induced oxidative injury by activating the NF-E2-related factor 2\/heme oxygenase-1 pathway","volume":"218","author":"Cao","year":"2013","journal-title":"Toxicol Lett"},{"key":"23","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1007\/s00011-006-6002-5","article-title":"Effects and mechanisms of Paeoniflorin, a bioactive glucoside from paeony root, on adjuvant arthritis in rats","volume":"56","author":"Liu","year":"2007","journal-title":"Inflamm Res"},{"key":"24","doi-asserted-by":"crossref","first-page":"263","DOI":"10.3892\/etm.2015.2902","article-title":"Paeoniflorin attenuates hepatic ischemia\/reperfusion injury via anti-oxidative, anti-inflammatory and anti-apoptotic pathways","volume":"11","author":"Wang","year":"2016","journal-title":"Exp Ther Med"},{"key":"25","doi-asserted-by":"crossref","first-page":"e2354","DOI":"10.1097\/MD.0000000000002354","article-title":"Safety and efficacy of sodium hyaluronate gel and chitosan in preventing postoperative peristomal adhesions after defunctioning enterostomy: a prospective randomized controlled trials","volume":"94","author":"Lan","year":"2015","journal-title":"Medicine (Baltimore)"},{"key":"26","doi-asserted-by":"crossref","first-page":"547","DOI":"10.2147\/IJN.S26141","article-title":"Preventing postoperative abdominal adhesions in a rat model with PEG-PCL-PEG hydrogel","volume":"7","author":"Qian","year":"2012","journal-title":"Int J Nanomedicine"},{"key":"27","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1002\/jbm.a.35653","article-title":"Effect of carbodiimide-derivatized hyaluronic acid gelatin on preventing postsurgical intra-abdominal adhesion formation and promoting healing in a rat model","volume":"104","author":"Sun","year":"2016","journal-title":"J Biomed Mater Res A"},{"key":"28","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1097\/01.sla.0000207837.71831.a2","article-title":"A randomized controlled trial of 0.5% ferric hyaluronate gel (Intergel) in the prevention of adhesions following abdominal surgery","volume":"243","author":"Mustapha","year":"2006","journal-title":"Ann Surg"},{"key":"29","doi-asserted-by":"crossref","first-page":"136","DOI":"10.7326\/0003-4819-134-2-200101160-00015","article-title":"Idiopathic pulmonary fibrosis: prevailing and evolving hypotheses about its pathogenesis and implications for therapy","volume":"134","author":"Pardo","year":"2001","journal-title":"Ann Intern Med"},{"key":"30","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1146\/annurev-pathol-020712-163942","article-title":"Molecular basis of asbestos-induced lung disease","volume":"8","author":"Kamp","year":"2013","journal-title":"Annu Rev Pathol"},{"key":"31","doi-asserted-by":"crossref","first-page":"117","DOI":"10.3233\/JAD-2008-15110","article-title":"Peripheral oxidative damage in mild cognitive impairment and mild Alzheimer\u2019s disease","volume":"15","author":"Oliveira","year":"2008","journal-title":"J Alzheimers Dis"},{"key":"32","doi-asserted-by":"crossref","first-page":"8803","DOI":"10.1073\/pnas.1010042108","article-title":"Enteric commensal bacteria potentiate epithelial restitution via reactive oxygen species-mediated inactivation of focal adhesion kinase phosphatases","volume":"108","author":"Neish","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"33","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1002\/iub.61","article-title":"Molecular mechanisms of oxidative stress-induced carcinogenesis: from epidemiology to oxygenomics","volume":"60","author":"Toyokuni","year":"2008","journal-title":"IUBMB Life"},{"key":"34","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1002\/bjs.4141","article-title":"Pathophysiology of intra-abdominal adhesion and abscess formation, and the effect of hyaluronan","volume":"90","author":"van Goor","year":"2003","journal-title":"Br J Surg"},{"key":"35","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1006\/jsre.2002.6533","article-title":"Neurokinin-1 receptor and substance P messenger RNA levels increase during intraabdominal adhesion formation","volume":"108","author":"Becker","year":"2002","journal-title":"J Surg Res"},{"key":"36","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1093\/humrep\/17.1.69","article-title":"IL-1, IL-6 and TNF-alpha concentrations in the peritoneal fluid of women with pelvic adhesions","volume":"17","author":"Ledger","year":"2002","journal-title":"Hum Reprod"},{"key":"37","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.ijsu.2012.11.015","article-title":"Effects of tamoxifen citrate on postoperative intra-abdominal adhesion in a rat model","volume":"11","author":"Tezer","year":"2013","journal-title":"Int J Surg"},{"key":"38","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1007\/s00011-013-0662-8","article-title":"Paeoniflorin inhibits inflammatory responses in mice with allergic contact dermatitis by regulating the balance between inflammatory and anti-inflammatory cytokines","volume":"62","author":"Wei","year":"2013","journal-title":"Inflamm Res"},{"key":"39","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1001\/archsurg.138.11.1249","article-title":"Expression of transforming growth factor beta1 in patients with and without previous abdominal surgery","volume":"138","author":"Greenhalgh","year":"2003","journal-title":"Arch Surg"},{"key":"40","first-page":"435463","article-title":"Concentration kinetics of serum MMP-9 and TIMP-1 after blunt multiple injuries in the early posttraumatic period","volume":"2012","author":"Bogner","year":"2012","journal-title":"Mediators Inflamm"},{"key":"41","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1002\/art.1780310614","article-title":"Interleukin-6 in synovial fluid and serum of patients with rheumatoid arthritis and other inflammatory arthritides","volume":"31","author":"Van Snick","year":"1988","journal-title":"Arthritis Rheum"},{"key":"42","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/0192-0561(92)90117-4","article-title":"Interleukin-6 (IL-6) in adjuvant arthritis of rats and its pharmacological modulation","volume":"14","author":"M\u00fcller-Peddinghaus","year":"1992","journal-title":"Int J Immunopharmacol"},{"key":"43","doi-asserted-by":"crossref","first-page":"2672","DOI":"10.1172\/JCI118717","article-title":"Selective inhibition of cyclooxygenase (COX)-2 reverses inflammation and expression of COX-2 and interleukin 6 in rat adjuvant arthritis","volume":"97","author":"Gregory","year":"1996","journal-title":"J Clin Invest"},{"key":"44","doi-asserted-by":"crossref","first-page":"599","DOI":"10.12669\/pjms.323.9717","article-title":"Effects of early enteral nutrition on the gastrointestinal motility and intestinal mucosal barrier of patients with burn-induced invasive fungal infection","volume":"32","author":"Zhang","year":"2016","journal-title":"Pak J Med Sci"},{"key":"45","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/j.clnu.2012.08.013","article-title":"Guidelines for perioperative care in elective colonic surgery: Enhanced Recovery After Surgery (ERAS\u00ae) Society recommendations","volume":"31","author":"Lobo","year":"2012","journal-title":"Clin Nutr"},{"key":"46","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1007\/BF02234701","article-title":"Postoperative adhesions: ten-year follow-up of 12,584 patients undergoing lower abdominal surgery","volume":"44","author":"Crowe","year":"2001","journal-title":"Dis Colon Rectum"},{"key":"47","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1007\/BF02234744","article-title":"Microscopic analysis of anastomotic healing in the intestine of normal and diabetic rats","volume":"44","author":"Hendriks","year":"2001","journal-title":"Dis Colon Rectum"},{"key":"48","doi-asserted-by":"crossref","first-page":"1982","DOI":"10.1093\/humrep\/16.9.1982","article-title":"Reduction of post-surgical adhesions with ferric hyaluronate gel: a European study","volume":"16","author":"diZerega","year":"2001","journal-title":"Hum Reprod"},{"key":"49","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.ijsu.2009.11.010","article-title":"Effect of honey versus intergel in intraperitoneal adhesion prevention and colonic anastomotic healing: a randomized controlled study in rats","volume":"8","author":"Saber","year":"2010","journal-title":"Int J Surg"},{"key":"50","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1006\/jsre.1996.4973","article-title":"Influence of polyethylene glycol 4000 and dextran 70 on adhesion formation in rats","volume":"67","author":"Saad","year":"1997","journal-title":"J Surg Res"}],"container-title":["Oncotarget"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.21333","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T22:55:39Z","timestamp":1750892139000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.21333"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9,28]]},"references-count":50,"journal-issue":{"issue":"55","published-print":{"date-parts":[[2017,11,7]]}},"alternative-id":["21333","29212197"],"URL":"https:\/\/doi.org\/10.18632\/oncotarget.21333","relation":{},"ISSN":["1949-2553"],"issn-type":[{"value":"1949-2553","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,9,28]]}}}