{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T22:01:55Z","timestamp":1780524115040,"version":"3.54.1"},"reference-count":64,"publisher":"Impact Journals, LLC","issue":"59","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncotarget"],"published-print":{"date-parts":[[2017,11,21]]},"DOI":"10.18632\/oncotarget.21725","type":"journal-article","created":{"date-parts":[[2017,10,11]],"date-time":"2017-10-11T01:39:42Z","timestamp":1507685982000},"page":"99990-100001","source":"Crossref","is-referenced-by-count":56,"title":["Salivary miRNA panel to detect HPV-positive and HPV-negative head and neck cancer patients"],"prefix":"10.18632","volume":"8","author":[{"given":"Yunxia","family":"Wan","sequence":"first","affiliation":[{"name":"School of Biomedical Sciences, Institute of Health and Biomedical Innovation, Queensland University of Technology (QUT), Kelvin Grove, Brisbane, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitrios","family":"Vagenas","sequence":"additional","affiliation":[{"name":"Institute of Health and Biomedical Innovation, Queensland University of Technology (QUT), Kelvin Grove, Brisbane, Woolloongabba, Queensland, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina","family":"Salazar","sequence":"additional","affiliation":[{"name":"The School of Chemistry and Molecular Biosciences, The University of Queensland, Queensland, Australia"},{"name":"The University of Queensland Diamantina Institute, The University of Queensland, The Translational Research Institute, Woolloongabba, Queensland, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liz","family":"Kenny","sequence":"additional","affiliation":[{"name":"The School of Medicine, University of Queensland, Queensland, Australia"},{"name":"Royal Brisbane and Women\u2019s Hospital, Brisbane, Central Integrated Regional Cancer Service, Queensland Health, Woolloongabba, Queensland, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris","family":"Perry","sequence":"additional","affiliation":[{"name":"Princess Alexandra Hospital, Woolloongabba, Brisbane, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diego","family":"Calvopi\u00f1a","sequence":"additional","affiliation":[{"name":"The School of Chemistry and Molecular Biosciences, The University of Queensland, Queensland, Australia"},{"name":"The University of Queensland Diamantina Institute, The University of Queensland, The Translational Research Institute, Woolloongabba, Queensland, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chamindie","family":"Punyadeera","sequence":"additional","affiliation":[{"name":"School of Biomedical Sciences, Institute of Health and Biomedical Innovation, Queensland University of Technology (QUT), Kelvin Grove, Brisbane, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7892","published-online":{"date-parts":[[2017,10,10]]},"reference":[{"key":"1","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1016\/j.oraloncology.2013.09.001","article-title":"Head and neck squamous cell carcinoma in young patients","volume":"49","author":"Balm","year":"2013","journal-title":"Oral Oncol"},{"key":"2","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1053\/j.ro.2012.09.002","article-title":"Head and neck cancer","volume":"48","author":"Aygun","year":"2013","journal-title":"Semin Roentgenol"},{"key":"3","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.oraloncology.2016.07.014","article-title":"The development of a liquid biopsy for head and neck cancers","volume":"61","author":"Punyadeera","year":"2016","journal-title":"Oral Oncol"},{"key":"4","doi-asserted-by":"publisher","first-page":"60101","DOI":"10.18632\/oncotarget.11159","article-title":"Short term ex-vivo expansion of circulating head and neck tumour cells","volume":"7","author":"Punyadeera","year":"2016","journal-title":"Oncotarget"},{"key":"5","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.oraloncology.2014.02.015","article-title":"Methylation as a biomarker for head and neck cancer","volume":"50","author":"Goloni-Bertollo","year":"2014","journal-title":"Oral Oncol"},{"key":"6","first-page":"1723","article-title":"DNA methylation biomarkers in biological fluids for early detection of respiratory tract cancer","volume":"50","author":"Liloglou","year":"2012","journal-title":"Clin Chem Lab Med"},{"key":"7","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1093\/aje\/kwt029","article-title":"Cigarette, cigar, and pipe smoking and the risk of head and neck cancers: pooled analysis in the International Head and Neck Cancer Epidemiology Consortium","volume":"178","author":"Shangina","year":"2013","journal-title":"Am J Epidemiol"},{"key":"8","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1200\/JCO.2007.14.1713","article-title":"Incidence trends for human papillomavirus-related and -unrelated oral squamous cell carcinomas in the United States","volume":"26","author":"Gillison","year":"2008","journal-title":"J Clin Oncol"},{"key":"9","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1186\/s12885-016-2217-1","article-title":"A pilot study to compare the detection of HPV-16 biomarkers in salivary oral rinses with tumour p16(INK4a) expression in head and neck squamous cell carcinoma patients","volume":"16","author":"Punyadeera","year":"2016","journal-title":"BMC Cancer"},{"key":"10","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1002\/cam4.424","article-title":"Current trends in the etiology and diagnosis of HPV-related head and neck cancers","volume":"4","author":"Punyadeera","year":"2015","journal-title":"Cancer Med"},{"key":"11","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1001\/jamaoto.2015.136","article-title":"Effect of human papillomavirus on patterns of distant metastatic failure in oropharyngeal squamous cell carcinoma treated with chemoradiotherapy","volume":"141","author":"Greskovich","year":"2015","journal-title":"JAMA Otolaryngol Head Neck Surg"},{"key":"12","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/S1470-2045(15)00560-4","article-title":"Development and validation of a staging system for HPV-related oropharyngeal cancer by the International Collaboration on Oropharyngeal cancer Network for Staging (ICON-S): a multicentre cohort study","volume":"17","author":"Friborg","year":"2016","journal-title":"The Lancet Oncology"},{"key":"13","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1097\/MOO.0b013e328017f669","article-title":"The economics of squamous cell carcinoma of the head and neck","volume":"15","author":"Manning","year":"2007","journal-title":"Current Opinion in Otolaryngology & Head and Neck Surgery"},{"key":"14","first-page":"1","article-title":"Treatment of recurrent metastatic head and neck cancer: focus on cetuximab","volume":"5","author":"Kim","year":"2012","journal-title":"Clin Med Insights Ear Nose Throat"},{"key":"15","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.oraloncology.2008.06.002","article-title":"Global epidemiology of oral and oropharyngeal cancer","volume":"45","author":"Warnakulasuriya","year":"2009","journal-title":"Oral Oncol"},{"key":"16","doi-asserted-by":"crossref","first-page":"6758","DOI":"10.1158\/1078-0432.CCR-09-0784","article-title":"Human papillomavirus in head and neck cancer: its role in pathogenesis and clinical implications","volume":"15","author":"Gillison","year":"2009","journal-title":"Clin Cancer Res"},{"key":"17","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.radonc.2009.04.014","article-title":"Meta-analysis of chemotherapy in head and neck cancer (MACH-NC): an update on 93 randomised trials and 17,346 patients","volume":"92","author":"Bourhis","year":"2009","journal-title":"Radiother Oncol"},{"key":"18","doi-asserted-by":"crossref","first-page":"6802","DOI":"10.1038\/srep06802","article-title":"The early diagnosis and monitoring of squamous cell carcinoma via saliva metabolomics","volume":"4","author":"Duan","year":"2014","journal-title":"Sci Rep"},{"key":"19","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1038\/nrd4140","article-title":"MicroRNAs and other non-coding RNAs as targets for anticancer drug development","volume":"12","author":"Calin","year":"2013","journal-title":"Nat Rev Drug Discov"},{"key":"20","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1056\/NEJMoa1209026","article-title":"Treatment of HCV infection by targeting microRNA","volume":"368","author":"Kauppinen","year":"2013","journal-title":"N Engl J Med"},{"key":"21","doi-asserted-by":"crossref","first-page":"R17","DOI":"10.1093\/hmg\/ddl046","article-title":"Non-coding RNA","volume":"15","author":"Makunin","year":"2006","journal-title":"Hum Mol Genet"},{"key":"22","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1002\/cbdv.201100386","article-title":"microRNA dysregulation in prostate cancer: network analysis reveals preferential regulation of highly connected nodes","volume":"9","author":"Zehner","year":"2012","journal-title":"Chem Biodivers"},{"key":"23","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1002\/gcc.22032","article-title":"Cell-free microRNAs as diagnostic, prognostic, and predictive biomarkers for lung cancer","volume":"52","author":"Lin\u0113","year":"2013","journal-title":"Genes Chromosomes Cancer"},{"key":"24","first-page":"1","article-title":"Serum microRNAs as non-invasive biomarkers for cancer","volume":"9","author":"S\u00fcltmann","year":"2010","journal-title":"Mol Cancer"},{"key":"25","first-page":"35","article-title":"An In Vitro Diagnostic Multivariate Index Assay (IVDMIA) for Ovarian Cancer: Harvesting the Power of Multiple Biomarkers","volume":"5","author":"Zhang","year":"2012","journal-title":"Rev Obstet Gynecol"},{"key":"26","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1056\/NEJMoa1602253","article-title":"70-Gene Signature as an Aid to Treatment Decisions in Early-Stage Breast Cancer","volume":"375","author":"Goulioti","year":"2016","journal-title":"N Engl J Med"},{"key":"27","first-page":"331","article-title":"A novel saliva-based microRNA biomarker panel to detect head and neck cancers","volume":"37","author":"Punyadeera","year":"2014","journal-title":"Cell Oncol (Dordr)"},{"key":"28","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1038\/nature14129","article-title":"Comprehensive genomic characterization of head and neck squamous cell carcinomas","volume":"517","author":"Cancer Genome Atlas Network","year":"2015","journal-title":"Nature"},{"key":"29","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1056\/NEJMoa0912217","article-title":"Human Papillomavirus and Survival of Patients with Oropharyngeal Cancer","volume":"363","author":"Silverman","year":"2010","journal-title":"N Engl J Med"},{"key":"30","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.oraloncology.2005.12.030","article-title":"Retrospective study of survival and treatment pattern in a cohort of patients with oral and oropharyngeal tongue cancers from 1987 to 2004","volume":"43","author":"Rees","year":"2007","journal-title":"Oral Oncol"},{"key":"31","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1038\/nrclinonc.2014.211","article-title":"Interventional oncology in multidisciplinary cancer treatment in the 21(st) century","volume":"12","author":"Kenny","year":"2015","journal-title":"Nat Rev Clin Oncol"},{"key":"32","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1186\/1745-6215-15-191","article-title":"The ENHANCES study--Enhancing Head and Neck Cancer patients' Experiences of Survivorship: study protocol for a randomized controlled trial","volume":"15","author":"Batstone","year":"2014","journal-title":"Trials"},{"key":"33","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.ctrv.2016.12.005","article-title":"Strategies to design clinical studies to identify predictive biomarkers in cancer research","volume":"53","author":"Rodriguez-Ruiz","year":"2017","journal-title":"Cancer Treat Rev"},{"key":"34","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1586\/14737159.2014.960519","article-title":"miRNAs in human papilloma virus associated oral and oropharyngeal squamous cell carcinomas","volume":"14","author":"Punyadeera","year":"2014","journal-title":"Expert Rev Mol Diagn"},{"key":"35","doi-asserted-by":"crossref","first-page":"5704","DOI":"10.3390\/molecules19055704","article-title":"The role of microRNA in head and neck cancer: current knowledge and perspectives","volume":"19","author":"Numico","year":"2014","journal-title":"Molecules"},{"key":"36","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1038\/nrc1997","article-title":"MicroRNA signatures in human cancers","volume":"6","author":"Croce","year":"2006","journal-title":"Nat Rev Cancer"},{"key":"37","doi-asserted-by":"crossref","first-page":"7390","DOI":"10.1158\/0008-5472.CAN-06-0800","article-title":"MicroRNA-cancer connection: the beginning of a new tale","volume":"66","author":"Croce","year":"2006","journal-title":"Cancer Res"},{"key":"38","doi-asserted-by":"crossref","first-page":"2619","DOI":"10.1016\/j.ejca.2014.07.012","article-title":"MicroRNAs and head and neck cancer: reviewing the first decade of research","volume":"50","author":"Rabbitts","year":"2014","journal-title":"Eur J Cancer"},{"key":"39","doi-asserted-by":"crossref","first-page":"2850","DOI":"10.1158\/1078-0432.CCR-08-3131","article-title":"MicroRNA expression ratio is predictive of head and neck squamous cell carcinoma","volume":"15","author":"Marsit","year":"2009","journal-title":"Clin Cancer Res"},{"key":"40","doi-asserted-by":"crossref","first-page":"2154","DOI":"10.1158\/1078-0432.CCR-12-3572","article-title":"Potentially prognostic miRNAs in HPV-associated oropharyngeal carcinoma","volume":"19","author":"Irish","year":"2013","journal-title":"Clin Cancer Res"},{"key":"41","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1186\/s12885-016-2430-y","article-title":"Comparison of the miRNA profiles in HPV-positive and HPV-negative tonsillar tumors and a model system of human keratinocyte clones","volume":"16","author":"Tachezy","year":"2016","journal-title":"BMC Cancer"},{"key":"42","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1002\/cncr.27696","article-title":"A microRNA expression signature for the prognosis of oropharyngeal squamous cell carcinoma","volume":"119","author":"Wang","year":"2013","journal-title":"Cancer"},{"key":"43","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1186\/1477-7819-12-195","article-title":"MicroRNA-9 expression is a prognostic biomarker in patients with osteosarcoma","volume":"12","author":"Wu","year":"2014","journal-title":"World J Surg Oncol"},{"key":"44","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1002\/ijc.28358","article-title":"miR-134 induces oncogenicity and metastasis in head and neck carcinoma through targeting WWOX gene","volume":"134","author":"Chang","year":"2014","journal-title":"Int J Cancer"},{"key":"45","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1158\/1940-6207.CAPR-11-0358","article-title":"Oncogenic function and early detection potential of miRNA-10b in oral cancer as identified by microRNA profiling","volume":"5","author":"Cheng","year":"2012","journal-title":"Cancer Prev Res (Phila)"},{"key":"46","doi-asserted-by":"crossref","first-page":"S406","DOI":"10.1245\/s10434-012-2618-6","article-title":"miR-196a overexpression and miR-196a2 gene polymorphism are prognostic predictors of oral carcinomas","volume":"20","author":"Lin","year":"2013","journal-title":"Ann Surg Oncol"},{"key":"47","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1186\/1471-2407-13-533","article-title":"MicroRNA expression profile in head and neck cancer: HOX-cluster embedded microRNA-196a and microRNA-10b dysregulation implicated in cell proliferation","volume":"13","author":"Tajara","year":"2013","journal-title":"BMC Cancer"},{"key":"48","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.canlet.2012.11.048","article-title":"Pre-microRNA variants predict HPV16-positive tumors and survival in patients with squamous cell carcinoma of the oropharynx","volume":"330","author":"Li","year":"2013","journal-title":"Cancer Lett"},{"key":"49","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1002\/hed.23011","article-title":"Comprehensive expression profiling of microRNAs in laryngeal squamous cell carcinoma","volume":"35","author":"Tian","year":"2013","journal-title":"Head Neck"},{"key":"50","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1002\/hed.21356","article-title":"Potential role of micro-RNAs in head and neck tumorigenesis","volume":"32","author":"Rose","year":"2010","journal-title":"Head Neck"},{"key":"51","doi-asserted-by":"crossref","first-page":"4262","DOI":"10.1073\/pnas.1401430111","article-title":"microRNAs are biomarkers of oncogenic human papillomavirus infections","volume":"111","author":"Zheng","year":"2014","journal-title":"Proc Natl Acad Sci U S A"},{"key":"52","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1038\/bjc.2011.29","article-title":"Different miRNA signatures of oral and pharyngeal squamous cell carcinomas: a prospective translational study","volume":"104","author":"von Buchwald","year":"2011","journal-title":"Br J Cancer"},{"key":"53","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1002\/cam4.718","article-title":"Prognostic microRNA signatures derived from The Cancer Genome Atlas for head and neck squamous cell carcinomas","volume":"5","author":"Wang","year":"2016","journal-title":"Cancer Med"},{"key":"54","volume-title":"Practical Statistics for Medical Research","author":"Altman","year":"2015"},{"key":"55","doi-asserted-by":"crossref","first-page":"21294","DOI":"10.3390\/ijms160921294","article-title":"MicroRNAs in Salivary Exosome as Potential Biomarkers of Aging","volume":"16","author":"Morita","year":"2015","journal-title":"Int J Mol Sci"},{"key":"56","volume-title":"NCCN Clinical Practice Guidelines in Oncology: Head and Neck Cancers","author":"National Comprehensive Cancer Network","year":"2015"},{"key":"57","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1373\/clinchem.2012.197863","article-title":"High-yield RNA-extraction method for saliva","volume":"59","author":"Punyadeera","year":"2013","journal-title":"Clin Chem"},{"key":"58","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/2001-1326-1-19","article-title":"The impact of saliva collection and processing methods on CRP, IgE, and Myoglobin immunoassays","volume":"1","author":"Punyadeera","year":"2012","journal-title":"Clin Transl Med"},{"key":"59","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1373\/clinchem.2008.112797","article-title":"The MIQE Guidelines: Minimum Information for Publication of Quantitative Real-Time PCR Experiments","volume":"55","author":"Pfaffl","year":"2009","journal-title":"Clin Chem"},{"key":"60","volume-title":"R: A language and environment for statistical computing","author":"R Core Team.","year":"2013"},{"key":"61","first-page":"225","article-title":"Open-source machine learning: R meets Weka","volume":"24","author":"Zeileis","year":"2008","journal-title":"Computational Statistics"},{"key":"62","article-title":"caret: classification and regression training","author":"Benesty","year":"2014","journal-title":"R package version 6.0-24"},{"key":"63","volume-title":"Data Mining: Practical machine learning tools and techniques","author":"Frank","year":"2005"},{"key":"64","doi-asserted-by":"crossref","first-page":"3940","DOI":"10.1093\/bioinformatics\/bti623","article-title":"ROCR: visualizing classifier performance in R","volume":"21","author":"Lengauer","year":"2005","journal-title":"Bioinformatics"}],"container-title":["Oncotarget"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.21725","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,26]],"date-time":"2023-08-26T23:15:38Z","timestamp":1693091738000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.21725"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10,10]]},"references-count":64,"journal-issue":{"issue":"59","published-print":{"date-parts":[[2017,11,21]]}},"alternative-id":["21725","29245955"],"URL":"https:\/\/doi.org\/10.18632\/oncotarget.21725","relation":{},"ISSN":["1949-2553"],"issn-type":[{"value":"1949-2553","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,10,10]]}}}