{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T20:36:47Z","timestamp":1789936607325,"version":"4.0.1"},"reference-count":139,"publisher":"Impact Journals, LLC","issue":"60","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncotarget"],"published-print":{"date-parts":[[2017,11,24]]},"DOI":"10.18632\/oncotarget.22170","type":"journal-article","created":{"date-parts":[[2017,10,30]],"date-time":"2017-10-30T18:40:31Z","timestamp":1509388831000},"page":"102705-102720","source":"Crossref","is-referenced-by-count":55,"title":["Role of tandospirone, a 5-HT1A receptor partial agonist, in the treatment of central nervous system disorders and the underlying mechanisms"],"prefix":"10.18632","volume":"8","author":[{"given":"Xuefei","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacy, School of Pharmacy, Southwest Medical University, Luzhou, Sichuan, 646000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Yang","sequence":"additional","affiliation":[{"name":"Laboratory of Chinese Materia Medica, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, Sichuan, 646000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sijin","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Neurology, Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, Sichuan, 646000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shousong","family":"Cao","sequence":"additional","affiliation":[{"name":"Laboratory of Cancer Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, Sichuan, 646000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dalian","family":"Qin","sequence":"additional","affiliation":[{"name":"Laboratory of Chinese Materia Medica, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, Sichuan, 646000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy, School of Pharmacy, Southwest Medical University, Luzhou, Sichuan, 646000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoli","family":"Li","sequence":"additional","affiliation":[{"name":"Department of R&D, Sichuan CREDIT Pharmaceutical Ltd., Luzhou, Sichuan, 646000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy, School of Pharmacy, Southwest Medical University, Luzhou, Sichuan, 646000, China"},{"name":"Department of Pharmacy, Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, 646000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianming","family":"Wu","sequence":"additional","affiliation":[{"name":"Laboratory of Chinese Materia Medica, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, Sichuan, 646000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7892","published-online":{"date-parts":[[2017,10,27]]},"reference":[{"key":"1","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1152\/physrev.1992.72.1.165","article-title":"Structure and function of the brain serotonin system","volume":"72","author":"Azmitia","year":"1992","journal-title":"Physiol Rev"},{"key":"2","doi-asserted-by":"crossref","first-page":"4986","DOI":"10.1172\/JCI70678","article-title":"Lorcaserin and pimavanserin: emerging selectivity of serotonin receptor subtype-targeted drugs","volume":"123","author":"Roth","year":"2013","journal-title":"J Clin Invest"},{"key":"3","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1146\/annurev.med.60.042307.110802","article-title":"The expanded biology of serotonin","volume":"60","author":"Roth","year":"2009","journal-title":"Annu Rev Med"},{"key":"4","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1016\/S0028-3908(99)00010-6","article-title":"A review of central 5-HT receptors and their function","volume":"38","author":"Sharp","year":"1999","journal-title":"Neuropharmacology"},{"key":"5","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/S0091-3057(01)00746-8","article-title":"Molecular, pharmacological and functional diversity of 5-HT receptors","volume":"71","author":"Martin","year":"2002","journal-title":"Pharmacol Biochem Behav"},{"key":"6","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1038\/nrm908","article-title":"Seven-transmembrane receptors","volume":"3","author":"Lefkowitz","year":"2002","journal-title":"Nat Rev Mol Cell Bio"},{"key":"7","doi-asserted-by":"crossref","first-page":"5825","DOI":"10.1016\/S0021-9258(19)39437-2","article-title":"Cloning, functional expression, and mRNA tissue distribution of the rat 5-hydroxytryptamine1A receptor gene","volume":"265","author":"Civelli","year":"1990","journal-title":"J Biol Chem"},{"key":"8","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1038\/329075a0","article-title":"An intronless gene encoding a potential member of the family of receptors coupled to guanine nucleotide regulatory proteins","volume":"329","author":"Caron","year":"1987","journal-title":"Nature"},{"key":"9","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/0028-3908(94)90059-0","article-title":"Molecular biology of 5-HT receptors","volume":"33","author":"Martin","year":"1994","journal-title":"Neuropharmacology"},{"key":"10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2174\/1568007043482570","article-title":"5-HT1 receptors","volume":"3","author":"Hamon","year":"2004","journal-title":"Curr Drug Targets CNS Neurol Disord"},{"key":"11","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1097\/00001756-199306000-00042","article-title":"Immunocytochemical localization of serotonin1A receptors in the rat immature cerebellum","volume":"4","author":"Verg\u00e9","year":"1993","journal-title":"Neuroreport"},{"key":"12","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1002\/syn.890180412","article-title":"binding of [123I]4-(2\u2032-methoxyphenyl)-1-[2\u2032-(N-2\u2033-pyridinyl)-P-iodobenzamido-]ethyl-piperazine, p-MPPI, to 5-HT1A receptors in rat brain","volume":"18","author":"Kung","year":"1994","journal-title":"Synapse"},{"key":"13","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/S0006-3223(02)01643-8","article-title":"Is there a role for 5-HT1A agonists in the treatment of depression?","volume":"53","author":"Ward","year":"2003","journal-title":"Biol Psychiat"},{"key":"14","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.pharmthera.2015.01.009","article-title":"Structure and function of serotonin G protein-coupled receptors","volume":"150","author":"Roth","year":"2015","journal-title":"Pharmacol Ther"},{"key":"15","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1126\/science.1232807","article-title":"Structural basis for molecular recognition at serotonin receptors","volume":"340","author":"Zhou","year":"2013","journal-title":"Science"},{"key":"16","doi-asserted-by":"crossref","first-page":"8661","DOI":"10.1002\/anie.201603766","article-title":"Mechanistic studies on the stereoselectivity of the serotonin 5-HT1A receptor","volume":"55","author":"Filipek","year":"2016","journal-title":"Angew Chem Int Ed"},{"key":"17","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1111\/j.1476-5381.1992.tb14431.x","article-title":"Actions of 5-hydroxytryptamine and 5-HT1A receptor ligands on rat dorso-lateral septal neurons","volume":"106","author":"Galvan","year":"1992","journal-title":"Br J Pharmacol"},{"key":"18","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1111\/j.1476-5381.1988.tb11728.x","article-title":"Centrally acting hypotensive agents with affinity for 5-HT1A binding sites inhibit forskolin-stimulated adenylate cyclase activity in calf hippocampus","volume":"95","author":"Hoyer","year":"1988","journal-title":"Br J Pharmacol"},{"key":"19","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1016\/0306-3623(95)00077-1","article-title":"Effects of tandospirone on second messenger systems and neurotransmitter release in the rat brain","volume":"26","author":"Nakamura","year":"1995","journal-title":"Gen Pharmacol"},{"key":"20","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/S0022-3565(24)37788-2","article-title":"F 11440, a potent, selective, high efficacy 5-HT1A receptor agonist with marked anxiolytic and antidepressant potential","volume":"287","author":"Colpaert","year":"1998","journal-title":"J Pharmacol Exp Ther"},{"key":"21","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/0006-3223(90)90627-E","article-title":"Analysis of tandospirone (SM-3997) interactions with neurotransmitter receptor binding sites","volume":"28","author":"Peroutka","year":"1990","journal-title":"Biol Psychiatry"},{"key":"22","doi-asserted-by":"crossref","first-page":"2495","DOI":"10.1016\/S0960-894X(98)00451-X","article-title":"Selective \u03b1-1A adrenergic receptor antagonists. Effects of pharmacophore regio- and stereochemistry on potency and selectivity","volume":"8","author":"Bock","year":"1998","journal-title":"Bioorg Med Chem Lett"},{"key":"23","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1111\/j.1600-0773.1991.tb01289.x","article-title":"Molecular basis of buspirone's anxiolytic action","volume":"69","author":"Tunnicliff","year":"1991","journal-title":"Pharmacol Toxicol"},{"key":"24","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/0006-8993(91)91564-H","article-title":"Autoradiographic localization and pharmacological characterization of [3H]tandospirone binding sites in the rat brain","volume":"546","author":"Nakamura","year":"1991","journal-title":"Brain Res"},{"key":"25","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1254\/jjp.59.105","article-title":"Serotonergic mechanisms in anxiolytic effect of tandospirone in the Vogel conflict test","volume":"59","author":"Nakamura","year":"1992","journal-title":"Jpn J Pharmacol"},{"key":"26","first-page":"10","article-title":"The global burden of anxiety and mood disorders: putting the European Study of the Epidemiology of Mental Disorders (ESEMeD) findings into perspective","volume":"68","author":"Kessler","year":"2007","journal-title":"J Clin Psychiatry"},{"key":"27","first-page":"941","article-title":"Neurobiology of anxiety disorders and implications treatment","volume":"73","author":"Charney","year":"2006","journal-title":"Mt Sinai J Med"},{"key":"28","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/j.euroneuro.2011.07.018","article-title":"The size and burden of mental disorders and other disorders of the brain in Europe 2010","volume":"21","author":"Lieb","year":"2011","journal-title":"Eur Neuropsychopharmacol"},{"key":"29","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1001\/archgenpsychiatry.2010.180","article-title":"Development of lifetime comorbidity in the World Health Organization world mental health surveys","volume":"68","author":"Girolamo","year":"2011","journal-title":"Arch Gen Psychiatry"},{"key":"30","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1192\/bjp.bp.107.039107","article-title":"Disability and treatment of specific mental and physical disorders across the world","volume":"192","author":"Karam","year":"2008","journal-title":"Br J Psychiatry"},{"key":"31","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.euroneuro.2005.11.009","article-title":"The pharmacokinetics and pharmacodynamics of tandospirone in rats exposed to conditioned fear stress","volume":"16","author":"Higuchi","year":"2006","journal-title":"Eur Neuropsychopharm"},{"key":"32","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/S0022-3565(25)23815-0","article-title":"Tandospirone and alprazolam: comparison of behavioral effects and abuse liability in humans","volume":"271","author":"Griffiths","year":"1994","journal-title":"J Pharmacol Exp Ther"},{"key":"33","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S0278-5846(02)00338-X","article-title":"Role of selective serotonin reuptake inhibitors in psychiatric disorders: a comprehensive review","volume":"27","author":"Ramesh","year":"2003","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"34","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/0014-2999(92)90716-H","article-title":"Effects of tandospirone in three behavioral tests for anxiolytics","volume":"221","author":"Howard","year":"1992","journal-title":"Eur J Pharmacol"},{"key":"35","first-page":"CD006115","article-title":"Azapirones for generalized anxiety disorder","volume":"3","author":"dos Santos Souza","year":"2006","journal-title":"Cochrane Database Syst Rev"},{"key":"36","doi-asserted-by":"crossref","first-page":"121","DOI":"10.2165\/00044011-200424020-00007","article-title":"Tandospirone in the treatment of generalised anxiety disorder and mixed anxiety-depression: results of a comparatively high dosage trial","volume":"24","author":"Mine","year":"2004","journal-title":"Clin Drug Investig"},{"key":"37","doi-asserted-by":"crossref","first-page":"1751","DOI":"10.1038\/sj.bjp.0702723","article-title":"The recombinant 5-HT1A receptor: G protein coupling and signalling pathways","volume":"127","author":"Garnovskaya","year":"1999","journal-title":"Br J Pharmacol"},{"key":"38","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1163\/1569391041501933","article-title":"Effects of tandospirone, a novel anxiolytic agent, on human 5-HT1A receptors expressed in Chinese hamster ovary cells (CHO cells)","volume":"18","author":"Ohno","year":"2004","journal-title":"Biogenic Amines"},{"key":"39","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.1016\/j.cellsig.2010.03.019","article-title":"5-HT1A receptor-regulated signal transduction pathways in brain","volume":"22","author":"Li","year":"2010","journal-title":"Cell Signal"},{"key":"40","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/0028-3908(91)90175-B","article-title":"Tandospirone and its metabolite, 1-(2-pyrimidinyl)-piperazine\u2014I. Effects of acute and long-term administration of tandospirone on serotonin neurotransmission","volume":"30","author":"de Montigny","year":"1991","journal-title":"Neuropharmacology"},{"key":"41","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/S0022-3565(24)38029-2","article-title":"Anxiolytic 5-hydroxytryptamine1A agonists suppress firing activity of dorsal hippocampus CA1 pyramidal neurons through a postsynaptic mechanism: single-unit study in unanesthetized, unrestrained rats","volume":"288","author":"Ishikawa","year":"1999","journal-title":"J Pharmacol Exp Ther"},{"key":"42","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1097\/00000539-200111000-00034","article-title":"The anxiolytic effects of the 5-hydroxytryptamine-1A agonist tandospirone before otolaryngologic surgery","volume":"93","author":"Dohi","year":"2001","journal-title":"Anesth Analg"},{"key":"43","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1007\/BF03018423","article-title":"Oral tandospirone and clonidine provide similar relief of preoperative anxiety","volume":"51","author":"Dohi","year":"2004","journal-title":"Can J Anesth"},{"key":"44","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/j.euroneuro.2007.02.010","article-title":"Synergistic effects of tandospirone and selective serotonin reuptake inhibitors on the contextual conditioned fear stress response in rats","volume":"17","author":"Koyama","year":"2007","journal-title":"Eur Neuropsychopharmacol"},{"key":"45","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1111\/j.1440-1819.2008.01853.x","article-title":"Pharmacokinetic interaction between tandospirone and fluvoxamine in the rat contextual conditioned fear stress model and its functional consequence: Involvement of cytochrome P450 3A4","volume":"62","author":"Koyama","year":"2008","journal-title":"Psychiatry Clin Neurosci"},{"key":"46","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1016\/j.pnpbp.2007.02.010","article-title":"Effects of cytochrome P450 (CYP) 3A4 inhibitors on the anxiolytic action of tandospirone in rat contextual conditioned fear","volume":"31","author":"Koyama","year":"2007","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"47","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1002\/syn.21621","article-title":"Facilitation of fear extinction by the 5-HT1A receptor agonist tandospirone: Possible involvement of dopaminergic modulation","volume":"67","author":"Togashi","year":"2013","journal-title":"Synapse"},{"key":"48","first-page":"241","article-title":"Using the conditioned fear stress (CFS) animal model to understand the neurobiological mechanisms and pharmacological treatment of anxiety","volume":"24","author":"Li","year":"2012","journal-title":"Shanghai Arch Psychiatry"},{"key":"49","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1002\/hup.2361","article-title":"Clinical evaluation of the efficacy and safety of tandospirone versus sertraline monotherapy for social anxiety disorder: a randomized open-label trial","volume":"28","author":"Ji","year":"2013","journal-title":"Hum Psychopharmacol"},{"key":"50","doi-asserted-by":"crossref","first-page":"3095","DOI":"10.1001\/jama.289.23.3095","article-title":"The epidemiology of major depressive disorder: results from the National Comorbidity Survey Replication (NCS-R)","volume":"289","author":"Wang","year":"2003","journal-title":"JAMA"},{"key":"51","unstructured":"Alison, Fadela. \u201cDepression: let's talk\u201d says WHO, as depression tops list of causes of ill health. World Health Organization, media center. 2017."},{"key":"52","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.euroneuro.2008.08.009","article-title":"Does the probability of receiving placebo influence clinical trial outcome? A meta-regression of double-blind, randomized clinical trials in MDD","volume":"19","author":"Fava","year":"2009","journal-title":"Eur Neuropsychopharmacol"},{"key":"53","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.neubiorev.2013.11.009","article-title":"Stress, serotonin, and hippocampal neurogenesis in relation to depression and antidepressant effects","volume":"38","author":"Nobrega","year":"2014","journal-title":"Neurosci Biobehav Rev"},{"key":"54","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1007\/BF02244228","article-title":"Antidepressant-like activity of 5-HT1A agonists measured with the forced swimming test","volume":"101","author":"Lucki","year":"1990","journal-title":"Psychopharmacology"},{"key":"55","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1358\/mf.2001.23.1.619175","article-title":"Alpha 2-adrenoceptor activity induces the antidepressant-like glycolipid in mouse forced swimming","volume":"23","author":"Sugiyama","year":"2001","journal-title":"Methods Find Exp Clin Pharmacol"},{"key":"56","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1620\/tjem.191.47","article-title":"The effect of globopentaosylceramide on a depression model, mouse forced swimming","volume":"191","author":"Sugiyama","year":"2000","journal-title":"Tohoku J Exp Med"},{"key":"57","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jad.2015.03.054","article-title":"Chronic treatment with tandospirone, a serotonin 1A receptor partial agonist, inhibits psychosocial stress-induced changes in hippocampal neurogenesis and behavior","volume":"180","author":"Enjoji","year":"2015","journal-title":"J Affect Disord"},{"key":"58","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1056\/NEJMoa052964","article-title":"Medication augmentation after the failure of SSRIs for depression","volume":"354","author":"Rush","year":"2006","journal-title":"N Engl J Med"},{"key":"59","doi-asserted-by":"crossref","first-page":"A14","DOI":"10.1097\/00004850-200607000-00046","article-title":"The efficacy of combination therapy with paroxetine and tandospirone for depressive and anxiety disorders","volume":"21","author":"Kazunori","year":"2006","journal-title":"Int Clin Psychopharm"},{"key":"60","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/S0197-0186(01)00079-1","article-title":"Tandospirone potentiates the fluoxetine-induced increases in extracellular dopamine via 5-HT1A receptors in the rat medial frontal cortex","volume":"40","author":"Nakamura","year":"2002","journal-title":"Neurochem Int"},{"key":"61","doi-asserted-by":"crossref","first-page":"9104","DOI":"10.1523\/JNEUROSCI.20-24-09104.2000","article-title":"Chronic antidepressant treatment increases neurogenesis in adult rat hippocampus","volume":"20","author":"Duman","year":"2000","journal-title":"J Neurosci"},{"key":"62","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1007\/s40120-013-0015-0","article-title":"Chronic treatment with the 5-HT1A receptor partial agonist tandospirone increases hippocampal neurogenesis","volume":"3","author":"Mine","year":"2014","journal-title":"Neurol Ther"},{"key":"63","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.pbb.2013.10.006","article-title":"Chronic treatment with tandospirone, a 5-HT(1A) receptor partial agonist, suppresses footshock stress-induced lactate production in the prefrontal cortex of rats","volume":"113","author":"Sumiyoshi","year":"2013","journal-title":"Pharmacol Biochem Behav"},{"key":"64","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1046\/j.1440-1819.2003.01099.x","article-title":"Clinical efficacy of tandospirone augmentation in patients with major depressive disorder: a randomized controlled trial","volume":"57","author":"Kanba","year":"2003","journal-title":"Psychiatry Clin Neuroscie"},{"key":"65","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1002\/hup.393","article-title":"Effect of serotonin 1A agonist tandospirone on depression symptoms in senile patients with dementia","volume":"17","author":"Hishikawa","year":"2002","journal-title":"Hum Psychopharmacol"},{"key":"66","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1111\/j.1744-6163.2009.00221.x","article-title":"Antidepressants and sleep: a review","volume":"45","author":"Holshoe","year":"2009","journal-title":"Perspect Psychiatr Care"},{"key":"67","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/0006-3223(95)00188-3","article-title":"Sleep disturbance and psychiatric disorders: a longitudinal epidemiological study of young adults","volume":"39","author":"Andreski","year":"1996","journal-title":"Biol Psychiatry"},{"key":"68","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1176\/appi.ajp.2008.08010129","article-title":"Chronic insomnia","volume":"165","author":"Buysse","year":"2008","journal-title":"Am J Psychiat"},{"key":"69","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0022-3956(02)00052-3","article-title":"Place of chronic insomnia in the course of depressive and anxiety disorders","volume":"37","author":"Roth","year":"2003","journal-title":"J Psychiatr Res"},{"key":"70","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1248\/bpb.b14-00887","article-title":"Effects of the 5-HT1A receptor agonist tandospirone on ACTH-Induced sleep disturbance in rats","volume":"38","author":"Kamei","year":"2015","journal-title":"Biol Pharm Bull"},{"key":"71","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1176\/jnp.2007.19.1.90","article-title":"Paroxetine-induced bruxism effectively treated with tandospirone","volume":"19","author":"Kishi","year":"2007","journal-title":"J Neuropsychiatry Clin Neurosci"},{"key":"72","first-page":"5","article-title":"Behavioral and psychological symptoms in dementia: the role of atypical antipsychotics","volume":"65","author":"Lawlor","year":"2004","journal-title":"J Clinical Psychiatry"},{"key":"73","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/S0006-8993(03)02554-X","article-title":"Reduced serotonin 5-HT1A receptor binding in the temporal cortex correlates with aggressive behavior in Alzheimer disease","volume":"974","author":"Chen","year":"2003","journal-title":"Brain Res"},{"key":"74","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1212\/01.wnl.0000271377.52421.4a","article-title":"Up-regulation of hippocampal serotonin metabolism in mild cognitive impairment","volume":"69","author":"Krolaksalmon","year":"2007","journal-title":"Neurology"},{"key":"75","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1017\/S1461145706007000","article-title":"A preliminary open-label study of 5-HT1A partial agonist tandospirone for behavioural and psychological symptoms associated with dementia","volume":"10","author":"Asada","year":"2007","journal-title":"Int J Neuropsychopharmacol"},{"key":"76","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1056\/NEJM199810083391506","article-title":"Parkinson's disease. First of two parts","volume":"339","author":"Lozano","year":"1998","journal-title":"N Engl J Med"},{"key":"77","first-page":"65","article-title":"A 5-HT1A receptor agonist, tandospirone improves gait disturbance of patients with Parkinson's disease","volume":"7","author":"Kaseda","year":"1997","journal-title":"J Mov Disord Disability"},{"key":"78","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/S0924-9338(99)80690-7","article-title":"Effect of tandospirone on tardive dyskinesia and parkinsonian symptoms","volume":"13","author":"Hishikawa","year":"1998","journal-title":"Eur Psychiatry"},{"key":"79","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1097\/00002826-200107000-00007","article-title":"Amelioration of frozen gait by tandospirone, a serotonin 1A agonist, in a patient with pure akinesia developing resistance to L-threo-3,4-dihydroxyphenylserine","volume":"24","author":"Kuroda","year":"2001","journal-title":"Clin Neuropharmacol"},{"key":"80","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1163\/1569391041501924","article-title":"Antiparkinsonian actions of a selective 5-HT1A agonist, tandospirone, in rats","volume":"18","author":"Ohno","year":"2004","journal-title":"Biogenic Amines"},{"key":"81","first-page":"126","article-title":"Tandospirone, a 5-HT1A agonist, ameliorates movement disorder via non-dopaminergic systems in rats with unilateral 6-hydroxydopamine-generated lesions","author":"Shiono","year":"2006","journal-title":"Brain Res"},{"key":"82","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1254\/jphs.08313FP","article-title":"Effects of tandospirone, a 5-HT1A agonistic anxiolytic agent, on haloperidol-induced catalepsy and forebrain Fos expression in mice","volume":"109","author":"Imaki","year":"2009","journal-title":"J Pharmacol Sci"},{"key":"83","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1016\/j.pnpbp.2008.04.005","article-title":"Evaluation of the antibradykinetic actions of 5-HT1A agonists using the mouse pole test","volume":"32","author":"Kawai","year":"2008","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"84","first-page":"276","article-title":"Non-specific supersensitivity of striatal dopamine receptors after 6-hydroxydopamine lesion of the nigrostriatal pathway","volume":"35","author":"Pycock","year":"1976","journal-title":"Eur J Pharmacol"},{"key":"85","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1046\/j.1460-9568.2003.02795.x","article-title":"The effect of 6-hydroxydopamine lesions on the release of amino acids in the direct and indirect pathways of the basal ganglia: a dual microdialysis probe analysis","volume":"18","author":"Della","year":"2003","journal-title":"Eur J Neurosci"},{"key":"86","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1097\/00001756-200505120-00009","article-title":"8-hydroxy-2-(di-n-propylamino) tetralin reduces striatal glutamate in an animal model of Parkinson's disease","volume":"16","author":"Wolf","year":"2005","journal-title":"Neuroreport"},{"key":"87","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1002\/syn.20195","article-title":"Effects of sarizotan on the corticostriatal glutamate pathways","volume":"58","author":"Ferraro","year":"2005","journal-title":"Synapse"},{"key":"88","first-page":"133","article-title":"Tandospirone citrate, a selective 5-HT1A agonist, alleviates L-DOPA-induced dyskinesia in patients with Parkinson's disease. [Article in Japanese]","volume":"54","author":"Matsunaga","year":"2002","journal-title":"No To Shinkei"},{"key":"89","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.neuropharm.2015.01.012","article-title":"Activity of serotonin 5-HT1A receptor \u2018biased agonists\u2019 in rat models of Parkinson's disease and L-DOPA-induced dyskinesia","volume":"93","author":"Newman-Tancredi","year":"2015","journal-title":"Neuropharmacology"},{"key":"90","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1007\/978-0-306-47593-1_71","article-title":"Management of anxiety and depression in Parkinson's diseaseMapping the progress of Alzheimer's and Parkinson's disease","volume":"51","author":"Hanin","year":"2002","journal-title":"Adv Behav Biol"},{"key":"91","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1007\/978-0-306-47593-1_72","article-title":"Tandospirone citrate, a new serotonergic anxiolytic agent: a potential use in Parkinson's diseaseMapping the progress of Alzheimer's and Parkinson's disease","volume":"51","author":"Hanin","year":"2002","journal-title":"Adv Behav Biol"},{"key":"92","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1093\/schbul\/17.2.263","article-title":"The mechanism of action of novel antipsychotic drugs","volume":"17","author":"Meltzer","year":"1991","journal-title":"Schizophrenia Bull"},{"key":"93","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1146\/annurev.med.52.1.503","article-title":"Atypical antipsychotics: new directions and new challenges in the treatment of schizophrenia","volume":"52","author":"Remington","year":"2001","journal-title":"Annu Rev Med"},{"key":"94","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1001\/archpsyc.56.8.749","article-title":"Generalized cognitive deficits in schizophrenia: a study of first-episode patients","volume":"56","author":"Andreasen","year":"1999","journal-title":"Arch Gen Psychiatry"},{"key":"95","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/S0920-9964(99)00198-X","article-title":"The role of cognition in vocational functioning in schizophrenia","volume":"45","author":"Meltzer","year":"2000","journal-title":"Schizophr Res"},{"key":"96","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/S0014-2999(98)00483-X","article-title":"Agonist and antagonist actions of antipsychotic agents at 5-HT1A receptors: a [35S]GTPgammaS binding study","volume":"355","author":"Millan","year":"1998","journal-title":"Eur J Pharmacol"},{"key":"97","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1038\/sj.npp.1300203","article-title":"Aripiprazole, a novel atypical antipsychotic drug with a unique and robust pharmacology","volume":"28","author":"Mailman","year":"2003","journal-title":"Neuropsychopharmacology"},{"key":"98","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1097\/00004714-200006000-00019","article-title":"Effect of adjunctive treatment with serotonin-1A agonist tandospirone on memory functions in schizophrenia","volume":"20","author":"Meltzer","year":"2000","journal-title":"J Clin Psychopharmacol"},{"key":"99","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/S0006-3223(00)01025-8","article-title":"The Effect of tandospirone, a serotonin1A agonist, on memory function in schizophrenia","volume":"49","author":"Meltzer","year":"2001","journal-title":"Biological Psychiatry"},{"key":"100","doi-asserted-by":"crossref","first-page":"1722","DOI":"10.1176\/appi.ajp.158.10.1722","article-title":"Enhancement of cognitive performance in schizophrenia by addition of tandospirone to neuroleptic treatment","volume":"158","author":"Meltzer","year":"2001","journal-title":"Am J Psychiatry"},{"key":"101","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1097\/JCP.0b013e3181faa57d","article-title":"Effect of tandospirone on mismatch negativity and cognitive performance in schizophrenia: a case report","volume":"30","author":"Suzuki","year":"2010","journal-title":"J Clin Psychopharmacol"},{"key":"102","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1016\/j.pnpbp.2007.02.017","article-title":"Effective adjunctive use of tandospirone with perospirone for enhancing verbal memory and quality of life in schizophrenia","volume":"31","author":"Kurachi","year":"2007","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"103","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1176\/appi.ajp.160.2.334","article-title":"Inhibitory effect of hippocampal 5-HT1A receptors on human explicit memory","volume":"160","author":"Suzuki","year":"2003","journal-title":"Am J Psychiatry"},{"key":"104","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.brainresrev.2008.07.006","article-title":"The acute effects of NMDA antagonism: from the rodent to the human brain","volume":"60","author":"Gunduz-Bruce","year":"2009","journal-title":"Brain Res Rev"},{"key":"105","doi-asserted-by":"crossref","first-page":"2175","DOI":"10.1038\/npp.2012.64","article-title":"Prevention of the phencyclidine-induced impairment in novel object recognition in female rats by co-administration of lurasidone or tandospirone, a 5-HT1A partial agonist","volume":"37","author":"Meltzer","year":"2012","journal-title":"Neuropsychopharmacology"},{"key":"106","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1007\/s12031-009-9204-9","article-title":"Subchronic effects of phencyclidine on dopamine and serotonin receptors: implications for schizophrenia","volume":"38","author":"Tarazi","year":"2009","journal-title":"J Mol Neurosci"},{"key":"107","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1017\/S1461145705005900","article-title":"Clozapine and olanzapine, but not haloperidol, suppress serotonin efflux in the medial prefrontal cortex elicited by phencyclidine and ketamine","volume":"9","author":"Adell","year":"2006","journal-title":"Int J Neuropsychopharmacol"},{"key":"108","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/S0197-0186(96)00124-6","article-title":"[3H]WAY-100635 for 5-HT1A receptor autoradiography in human brain: a comparison with [3H]8-OH-DPAT and demonstration of increased binding in the frontal cortex in schizophrenia","volume":"30","author":"Harrison","year":"1997","journal-title":"Neurochem Int"},{"key":"109","doi-asserted-by":"crossref","first-page":"133","DOI":"10.3109\/15622970209150614","article-title":"Receptor and transporter imaging studies in schizophrenia, depression, bulimia and Tourette's disorder--implications for psychopharmacology","volume":"3","author":"Pirker","year":"2002","journal-title":"World J Biol Psychiatry"},{"key":"110","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.bbr.2015.03.025","article-title":"The serotonin 5-HT1A receptor agonist tandospirone improves executive function in common marmosets","volume":"287","author":"Ikeda","year":"2015","journal-title":"Behav Brain Res"},{"key":"111","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1002\/syn.21529","article-title":"Effect of transient blockade of n-methyl-D-aspartate receptors at neonatal stage on stress-induced lactate metabolism in the medial prefrontal cortex of adult rats: role of 5-HT1A receptor agonism","volume":"66","author":"Sumiyoshi","year":"2012","journal-title":"Synapse"},{"key":"112","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1007\/s00213-010-1951-3","article-title":"Effect of tandospirone, a serotonin-1A receptor partial agonist, on information processing and locomotion in dizocilpine-treated rats","volume":"212","author":"Sumiyoshi","year":"2010","journal-title":"Psychopharmacology"},{"key":"113","first-page":"341","article-title":"Kinetics, brain uptake, and receptor binding of tandospirone and its metabolite 1-(2-pyrimidinyl)-piperazine","volume":"12","author":"Shemer","year":"1992","journal-title":"J Clin Psychopharmacol"},{"key":"114","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1007\/PL00005243","article-title":"Actions of alpha2 adrenoceptor ligands at alpha2A and 5-HT1A receptors: the antagonist, atipamezole, and the agonist, dexmedetomidine, are highly selective for alpha2A adrenoceptors","volume":"358","author":"Millan","year":"1998","journal-title":"Naunyn Schmiedebergs Arch pharmacol"},{"key":"115","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1254\/jphs.12264FP","article-title":"Tandospirone suppresses impulsive action by possible blockade of the 5-HT1A receptor","volume":"122","author":"Yoshioka","year":"2013","journal-title":"J Pharmacol Sci"},{"key":"116","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1038\/sj.bjp.0701922","article-title":"K+ current in acutely dissociated rat dorsal raphe neurones","volume":"124","author":"Tandospirone-induced","year":"1998","journal-title":"Br J pharmacol"},{"key":"117","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1007\/s00210-004-1005-7","article-title":"Tandospirone activates neuroendocrine and ERK (MAP kinase) signaling pathways specifically through 5-HT1A receptor mechanisms","volume":"371","author":"Van de Kar","year":"2005","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"118","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.1016\/S0024-3205(02)02482-7","article-title":"Regulation of 5-HT1A receptor function in brain following agonist or antidepressant administration","volume":"72","author":"Hensler","year":"2003","journal-title":"Life Sci"},{"key":"119","first-page":"357","article-title":"Facilitative effect of serotonin(1A) receptor agonists on cognition in patients with schizophrenia","volume":"20","author":"Higuchi","year":"2013","journal-title":"Curr Med Chem"},{"key":"120","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1111\/jnc.12512","article-title":"Comparative effect of lurasidone and blonanserin on cortical glutamate, dopamine, and acetylcholine efflux: role of relative serotonin (5-HT) 2A and DA D2 antagonism and 5-HT1A partial agonism","volume":"128","author":"Meltzer","year":"2014","journal-title":"J Neurochem"},{"key":"121","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/s00213-011-2561-4","article-title":"The role of 5-HT receptors in phencyclidine (PCP)-induced novel object recognition (NOR) deficit in rats","volume":"221","author":"Meltzer","year":"2012","journal-title":"Psychopharmacology"},{"key":"122","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.biopsych.2004.02.033","article-title":"Depression: a case of neuronal life and death?","volume":"56","author":"Duman","year":"2004","journal-title":"Biol Psychiatry"},{"key":"123","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1111\/j.1460-9568.2011.07614.x","article-title":"Neurogenesis and affective disorders","volume":"33","author":"Hen","year":"2011","journal-title":"Eur J Neurosci"},{"key":"124","first-page":"1","article-title":"Hippocampal neurogenesis: learning to remember","author":"Hollands","year":"2016","journal-title":"Prog Neurobiol"},{"key":"125","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/S0091-3057(01)00546-9","article-title":"Different effects of anxiolytic agents, diazepam and 5-HT(1A) agonist tandospirone, on hippocampal long-term potentiation","volume":"69","author":"Yoshioka","year":"2001","journal-title":"Pharmacol Biochem Behav"},{"key":"126","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/361031a0","article-title":"Asynaptic model of memory: long-term potentiation in the hippocampus","volume":"361","author":"Collingridge","year":"1993","journal-title":"Nature"},{"key":"127","doi-asserted-by":"crossref","first-page":"16448","DOI":"10.1073\/pnas.0505427102","article-title":"Brain lactate kinetics: Modeling evidence for neuronal lactate uptake upon activation","volume":"102","author":"Pellerin","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"128","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1007\/s11064-006-9132-9","article-title":"Kinetic parameters and lactate dehydrogenase isozyme activities support possible lactate utilization by neurons","volume":"32","author":"McKenna","year":"2007","journal-title":"Neurochem Res"},{"key":"129","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/1471-2202-8-35","article-title":"Metabolic compartmentalization in the human cortex and hippocampus: evidence for a cell- and region-specific localization of lactate dehydrogenase 5 and pyruvate dehydrogenase","volume":"8","author":"Bouras","year":"2007","journal-title":"BMC Neurosci"},{"key":"130","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1002\/glia.20528","article-title":"Activity-dependent regulation of energy metabolism by astrocytes: an update","volume":"55","author":"Magistretti","year":"2007","journal-title":"Glia"},{"key":"131","doi-asserted-by":"crossref","first-page":"7477","DOI":"10.1523\/JNEUROSCI.0415-11.2011","article-title":"evidence for lactate as a neuronal energy source","volume":"31","author":"Weber","year":"2011","journal-title":"J Neurosci"},{"key":"132","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1007\/s00213-006-0370-y","article-title":"Role of 5-HT(1A) receptors in the modulation of stress-induced lactate metabolism in the medial prefrontal cortex and basolateral amygdala","volume":"186","author":"Kurachi","year":"2006","journal-title":"Psychopharmacology"},{"key":"133","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1111\/j.1471-4159.2005.03600.x","article-title":"The 5-HT(1A) receptor agonist 8-OH-DPAT prevents prefrontocortical glutamate and serotonin release in response to blockade of cortical NMDA receptors","volume":"96","author":"Invernizzi","year":"2006","journal-title":"J Neurochem"},{"key":"134","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/S0306-4522(01)00384-0","article-title":"Long-term behavioral and neurodegenerative effects of perinatal phencyclidine administration: implications for schizophrenia","volume":"107","author":"Johnson","year":"2001","journal-title":"Neuroscience"},{"key":"135","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.biopsych.2004.11.031","article-title":"Transient N-methyl-D-aspartate receptor blockade in early development causes lasting cognitive deficits relevant to schizophrenia","volume":"57","author":"Moghaddam","year":"2005","journal-title":"Biol Psychiatry"},{"key":"136","doi-asserted-by":"crossref","first-page":"1706","DOI":"10.1046\/j.1460-9568.2003.02902.x","article-title":"Long-term behavioural, molecular and morphological effects of neonatal NMDA receptor antagonism","volume":"18","author":"Harrison","year":"2003","journal-title":"Eur J Neurosci"},{"key":"137","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1124\/jpet.102.041798","article-title":"Blockade of phencyclidine-induced cortical apoptosis and deficits in prepulse inhibition by M40403, a superoxide dismutase mimetic","volume":"304","author":"Johnson","year":"2003","journal-title":"J Pharmacol Exp Ther"},{"key":"138","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1093\/cercor\/bhr220","article-title":"5-HT1A receptor agonists enhance pyramidal cell firing in prefrontal cortex through a preferential action on GABA interneurons","volume":"22","author":"Celada","year":"2012","journal-title":"Cereb Cortex"},{"key":"139","first-page":"291","article-title":"Tandospirone, a 5-HT1A partial agonist, ameliorates aberrant lactate production in the prefrontal cortex of rats exposed to blockade of N-methy-D-aspartate receptors; Toward the therapeutics of cognitive impairment of schizophrenia","volume":"8","author":"Sumiyoshi","year":"2014","journal-title":"Front Behav Neurosci"}],"container-title":["Oncotarget"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.22170","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,26]],"date-time":"2025-06-26T16:10:02Z","timestamp":1750954202000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.22170"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10,27]]},"references-count":139,"journal-issue":{"issue":"60","published-print":{"date-parts":[[2017,11,24]]}},"alternative-id":["22170","29254282"],"URL":"https:\/\/doi.org\/10.18632\/oncotarget.22170","relation":{},"ISSN":["1949-2553"],"issn-type":[{"value":"1949-2553","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,10,27]]}}}