{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T20:27:57Z","timestamp":1792182477239,"version":"4.4.0"},"reference-count":47,"publisher":"Impact Journals, LLC","issue":"64","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncotarget"],"published-print":{"date-parts":[[2017,12,8]]},"DOI":"10.18632\/oncotarget.22444","type":"journal-article","created":{"date-parts":[[2017,11,15]],"date-time":"2017-11-15T17:51:58Z","timestamp":1510768318000},"page":"108006-108019","source":"Crossref","is-referenced-by-count":29,"title":["Coronarin D induces reactive oxygen species-mediated cell death in human nasopharyngeal cancer cells through inhibition of p38 MAPK and activation of JNK"],"prefix":"10.18632","volume":"8","author":[{"given":"Jui-Chieh","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Biochemical Science and Technology, National Chiayi University, Chiayi, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming-Chang","family":"Hsieh","sequence":"additional","affiliation":[{"name":"School of Medical Laboratory and Biotechnology, Chung Shan Medical University, Taichung, Taiwan"},{"name":"Department of Clinical Laboratory, Chung Shan Medical University Hospital, Taichung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu-Hui","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Surgical Pathology, Changhua Christian Hospital, Changhua, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia-Chieh","family":"Lin","sequence":"additional","affiliation":[{"name":"Cancer Research Center, Changhua Christian Hospital, Changhua, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Ting","family":"Hsi","sequence":"additional","affiliation":[{"name":"Cancer Research Center, Changhua Christian Hospital, Changhua, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Sheng","family":"Lo","sequence":"additional","affiliation":[{"name":"Cancer Research Center, Changhua Christian Hospital, Changhua, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Ching","family":"Chuang","sequence":"additional","affiliation":[{"name":"Cancer Research Center, Changhua Christian Hospital, Changhua, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming-Ju","family":"Hsieh","sequence":"additional","affiliation":[{"name":"Cancer Research Center, Changhua Christian Hospital, Changhua, Taiwan"},{"name":"Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mu-Kuan","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology-Head and Neck Surgery, Changhua Christian Hospital, Changhua, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7892","published-online":{"date-parts":[[2017,11,14]]},"reference":[{"key":"1","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.semcancer.2012.01.009","article-title":"Non-viral environmental risk factors for nasopharyngeal carcinoma: a systematic review","volume":"22","author":"Qin","year":"2012","journal-title":"Semin Cancer Biol"},{"key":"2","doi-asserted-by":"crossref","unstructured":"Tu, Zeng, Qi, Li, Yu, Guo, Xiong, Xiang, Zhou, Gong, Liao, Yu, He, et al. Genome-wide analysis of eighteen Epstein-Barr viruses isolated from primary nasopharyngeal carcinoma biopsies. J Virol. 2017.","DOI":"10.1128\/JVI.00301-17"},{"key":"3","doi-asserted-by":"crossref","first-page":"87","DOI":"10.3322\/caac.21262","article-title":"Global cancer statistics, 2012","volume":"65","author":"Jemal","year":"2015","journal-title":"CA Cancer J Clin"},{"key":"4","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/S1470-2045(15)70126-9","article-title":"Chemotherapy and radiotherapy in nasopharyngeal carcinoma: an update of the MAC-NPC meta-analysis","volume":"16","author":"Mai","year":"2015","journal-title":"Lancet Oncol"},{"key":"5","first-page":"401261","article-title":"The treatment outcome and radiation-induced toxicity for patients with head and neck carcinoma in the IMRT era: a systematic review with dosimetric and clinical parameters","volume":"2013","author":"Nikolaos","year":"2013","journal-title":"Biomed Res Int"},{"key":"6","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1093\/jjco\/hyu212","article-title":"Progress and controversy for the role of chemotherapy in nasopharyngeal carcinoma","volume":"45","author":"Wakisaka","year":"2015","journal-title":"Jpn J Clin Oncol"},{"key":"7","doi-asserted-by":"publisher","first-page":"50284","DOI":"10.18632\/oncotarget.17466","article-title":"Integration of phytochemicals and phytotherapy into cancer precision medicine","volume":"8","author":"Daak","year":"2017","journal-title":"Oncotarget"},{"key":"8","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1080\/14786410701726434","article-title":"Labdane diterpenes from the rhizomes of Hedychium coronarium","volume":"22","author":"Techasakul","year":"2008","journal-title":"Nat Prod Res"},{"key":"9","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1248\/cpb.50.1045","article-title":"New farnesane-type sesquiterpenes, hedychiols A and B 8, 9-diacetate, and inhibitors of degranulation in RBL-2H3 cells from the rhizome of Hedychium coronarium","volume":"50","author":"Yoshikawa","year":"2002","journal-title":"Chem Pharm Bull (Tokyo)"},{"key":"10","doi-asserted-by":"crossref","first-page":"7460","DOI":"10.1016\/j.bmcl.2011.09.129","article-title":"Chemical constituents of the rhizomes of Hedychium coronarium and their inhibitory effect on the pro-inflammatory cytokines production LPS-stimulated in bone marrow-derived dendritic cells","volume":"21","author":"Kim","year":"2011","journal-title":"Bioorg Med Chem Lett"},{"key":"11","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.oooo.2012.01.010","article-title":"Antifungal activity of coronarin D against Candida albicans","volume":"114","author":"Techasakul","year":"2012","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol"},{"key":"12","first-page":"581985","article-title":"Antimicrobial activity of coronarin D and its synergistic potential with antibiotics","volume":"2014","author":"Techasakul","year":"2014","journal-title":"Biomed Res Int"},{"key":"13","doi-asserted-by":"crossref","first-page":"3306","DOI":"10.1158\/1535-7163.MCT-08-0432","article-title":"a labdane diterpene, inhibits both constitutive and inducible nuclear factor-kappa B pathway activation, leading to potentiation of apoptosis, inhibition of invasion, and suppression of osteoclastogenesis","volume":"7","author":"Coronarin","year":"2008","journal-title":"Mol Cancer Ther"},{"key":"14","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1038\/nrc1189","article-title":"Cancer chemoprevention with dietary phytochemicals","volume":"3","author":"Surh","year":"2003","journal-title":"Nat Rev Cancer"},{"key":"15","doi-asserted-by":"crossref","first-page":"125","DOI":"10.2174\/138920112798868610","article-title":"Cancer chemoprevention by dietary phytochemicals: promises and pitfalls","volume":"13","author":"Nagini","year":"2012","journal-title":"Curr Pharm Biotechnol"},{"key":"16","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1038\/nrm2245","article-title":"Autophagy: from phenomenology to molecular understanding in less than a decade","volume":"8","author":"Klionsky","year":"2007","journal-title":"Nat Rev Mol Cell Biol"},{"key":"17","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1038\/nrd.2017.22","article-title":"Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles","volume":"16","author":"Kroemer","year":"2017","journal-title":"Nat Rev Drug Discov"},{"key":"18","doi-asserted-by":"publisher","first-page":"58075","DOI":"10.18632\/oncotarget.10873","article-title":"Simultaneous activation and inhibition of autophagy sensitizes cancer cells to chemotherapy","volume":"7","author":"Kao","year":"2016","journal-title":"Oncotarget"},{"key":"19","doi-asserted-by":"publisher","first-page":"62759","DOI":"10.18632\/oncotarget.18663","article-title":"Interplay between apoptosis and autophagy in colorectal cancer","volume":"8","author":"Yang","year":"2017","journal-title":"Oncotarget"},{"key":"20","doi-asserted-by":"crossref","first-page":"19819","DOI":"10.1038\/srep19819","article-title":"Nimbolide inhibits pancreatic cancer growth and metastasis through ROS-mediated apoptosis and inhibition of epithelial-to-mesenchymal transition","volume":"6","author":"Lakshmanaswamy","year":"2016","journal-title":"Sci Rep"},{"key":"21","first-page":"58","article-title":"Polyphyllin VII induces apoptosis in HepG2 cells through ROS-mediated mitochondrial dysfunction and MAPK pathways","volume":"16","author":"He","year":"2016","journal-title":"BMC Complement Altern Med"},{"key":"22","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.tcb.2007.07.009","article-title":"ROS, mitochondria and the regulation of autophagy","volume":"17","author":"Elazar","year":"2007","journal-title":"Trends Cell Biol"},{"key":"23","doi-asserted-by":"crossref","first-page":"838","DOI":"10.4161\/auto.6.7.12113","article-title":"ROS-mediated mechanisms of autophagy stimulation and their relevance in cancer therapy","volume":"6","author":"Agostinis","year":"2010","journal-title":"Autophagy"},{"key":"24","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1172\/JCI28833","article-title":"Autophagy inhibition enhances therapy-induced apoptosis in a Myc-induced model of lymphoma","volume":"117","author":"Thompson","year":"2007","journal-title":"J Clin Invest"},{"key":"25","doi-asserted-by":"crossref","first-page":"4559","DOI":"10.1038\/s41598-017-04258-8","article-title":"Blocking autophagy improves the anti-tumor activity of afatinib in lung adenocarcinoma with activating EGFR mutationsand","volume":"7","author":"Feng","year":"2017","journal-title":"Sci Rep"},{"key":"26","doi-asserted-by":"crossref","first-page":"2502","DOI":"10.1158\/1535-7163.MCT-17-0136","article-title":"Autophagy inhibition improves sunitinib efficacy in pancreatic neuroendocrine tumors via a lysosome-dependent mechanism","volume":"16","author":"Perren","year":"2017","journal-title":"Mol Cancer Ther"},{"key":"27","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.drup.2004.01.004","article-title":"ROS stress in cancer cells and therapeutic implications","volume":"7","author":"Huang","year":"2004","journal-title":"Drug Resist Update"},{"key":"28","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1042\/CS20140542","article-title":"NADPH oxidases and cancer","volume":"128","author":"Doroshow","year":"2015","journal-title":"Clin Sci (Lond)"},{"key":"29","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1007\/s00281-008-0123-6","article-title":"NOX enzymes as novel targets for drug development","volume":"30","author":"Clark","year":"2008","journal-title":"Semin Immunopathol"},{"key":"30","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1038\/ncb2822","article-title":"A tuberous sclerosis complex signalling node at the peroxisome regulates mTORC1 and autophagy in response to ROS","volume":"15","author":"Dodd","year":"2013","journal-title":"Nat Cell Biol"},{"key":"31","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1016\/j.freeradbiomed.2015.10.404","article-title":"ROS-dependent activation of autophagy is a critical mechanism for the induction of anti-glioma effect of sanguinarine","volume":"89","author":"Galadari","year":"2015","journal-title":"Free Radic Biol Med"},{"key":"32","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1007\/s10059-011-0276-3","article-title":"Regulation of reactive oxygen species generation in cell signaling","volume":"32","author":"Yoo","year":"2011","journal-title":"Mol Cells"},{"key":"33","doi-asserted-by":"crossref","first-page":"7866","DOI":"10.1074\/jbc.M116.768283","article-title":"NADPH oxidase 1 supports proliferation of colon cancer cells by modulating reactive oxygen species-dependent signal transduction","volume":"292","author":"Butcher","year":"2017","journal-title":"J Biol Chem"},{"key":"34","doi-asserted-by":"publisher","first-page":"33586","DOI":"10.18632\/oncotarget.16829","article-title":"Overexpression of NOX4 predicts poor prognosis and promotes tumor progression in human colorectal cancer","volume":"8","author":"Ge","year":"2017","journal-title":"Oncotarget"},{"key":"35","doi-asserted-by":"crossref","first-page":"1738","DOI":"10.1158\/1535-7163.MCT-14-1048","article-title":"Cambogin induces caspase-independent apoptosis through the ROS\/JNK pathway and epigenetic regulation in breast cancer cells","volume":"14","author":"Xu","year":"2015","journal-title":"Mol Cancer Ther"},{"key":"36","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.3892\/mmr.2017.6144","article-title":"Moscatilin induces apoptosis of pancreatic cancer cells via reactive oxygen species and the JNK\/SAPK pathway","volume":"15","author":"Jin","year":"2017","journal-title":"Mol Med Rep"},{"key":"37","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1080\/10715760902918683","article-title":"Expression of NADPH oxidase homologues and accessory genes in human cancer cell lines, tumours and adjacent normal tissues","volume":"43","author":"Doroshow","year":"2009","journal-title":"Free Radic Res"},{"key":"38","doi-asserted-by":"crossref","first-page":"9420539","DOI":"10.1155\/2017\/9420539","article-title":"NADPH oxidases: insights into selected functions and mechanisms of action in cancer and stem cells","volume":"2017","author":"Buldak","year":"2017","journal-title":"Oxid Med Cell Longev"},{"key":"39","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1016\/j.freeradbiomed.2011.06.033","article-title":"Cross talk between mitochondria and NADPH oxidases","volume":"51","author":"Dikalov","year":"2011","journal-title":"Free Radic Biol Med"},{"key":"40","doi-asserted-by":"crossref","first-page":"H647","DOI":"10.1152\/ajpheart.01271.2010","article-title":"ROS-induced ROS release in vascular biology: redox-redox signaling","volume":"301","author":"Gutterman","year":"2011","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"41","doi-asserted-by":"crossref","first-page":"C749","DOI":"10.1152\/ajpcell.00346.2016","article-title":"ROS-induced ROS release orchestrated by Nox4, Nox2, and mitochondria in VEGF signaling and angiogenesis","volume":"312","author":"Ushio-Fukai","year":"2017","journal-title":"Am J Physiol Cell Physiol"},{"key":"42","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1042\/BJ20111451","article-title":"Autophagy, mitochondria and oxidative stress: cross-talk and redox signalling","volume":"441","author":"Zhang","year":"2012","journal-title":"Biochem J"},{"key":"43","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.redox.2014.12.003","article-title":"Interplay between ROS and autophagy in cancer cells, from tumor initiation to cancer therapy","volume":"4","author":"Boyer-Guittaut","year":"2015","journal-title":"Redox Biol"},{"key":"44","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1101\/gad.1110003","article-title":"Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling","volume":"17","author":"Guan","year":"2003","journal-title":"Genes Dev"},{"key":"45","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1016\/j.trecan.2016.10.006","article-title":"mTOR signaling confers resistance to targeted cancer drugs","volume":"2","author":"Hall","year":"2016","journal-title":"Trends Cancer"},{"key":"46","doi-asserted-by":"crossref","first-page":"2191","DOI":"10.1038\/onc.2016.363","article-title":"mTORC1 and mTORC2 in cancer and the tumor microenvironment","volume":"36","author":"Chen","year":"2017","journal-title":"Oncogene"},{"key":"47","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.bcp.2017.01.011","article-title":"Dehydroandrographolide inhibits oral cancer cell migration and invasion through NF-kappaB-, AP-1-, and SP-1-modulated matrix metalloproteinase-2 inhibition","volume":"130","author":"Yang","year":"2017","journal-title":"Biochem Pharmacol"}],"container-title":["Oncotarget"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.22444","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,27]],"date-time":"2025-06-27T01:07:00Z","timestamp":1750986420000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.22444"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11,14]]},"references-count":47,"journal-issue":{"issue":"64","published-print":{"date-parts":[[2017,12,8]]}},"alternative-id":["22444","29296219"],"URL":"https:\/\/doi.org\/10.18632\/oncotarget.22444","relation":{},"ISSN":["1949-2553"],"issn-type":[{"value":"1949-2553","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,11,14]]}}}