{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T06:36:07Z","timestamp":1790922967384,"version":"4.1.0"},"reference-count":38,"publisher":"Impact Journals, LLC","issue":"65","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncotarget"],"published-print":{"date-parts":[[2017,12,12]]},"DOI":"10.18632\/oncotarget.22658","type":"journal-article","created":{"date-parts":[[2017,11,27]],"date-time":"2017-11-27T04:16:17Z","timestamp":1511756177000},"page":"108406-108417","source":"Crossref","is-referenced-by-count":9,"title":["Regulatory T cells with a defect in inhibition on co-stimulation deteriorated primary biliary cholangitis"],"prefix":"10.18632","volume":"8","author":[{"given":"Jianing","family":"Chen","sequence":"first","affiliation":[{"name":"State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianliang","family":"Hou","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyu","family":"Jia","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangying","family":"Cui","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongwen","family":"Wu","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chong","family":"Lu","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wu","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingfeng","family":"Wei","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshimitsu","family":"Uede","sequence":"additional","affiliation":[{"name":"Molecular Immunology, Institute for Genetic Medicine, Hokkaido University, Sapporo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lanjuan","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhexiong","family":"Lian","sequence":"additional","affiliation":[{"name":"Liver Immunology Laboratory, Institute of Immunology and The CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences, University of Science and Technology of China, Hefei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyan","family":"Diao","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7892","published-online":{"date-parts":[[2017,11,26]]},"reference":[{"key":"1","doi-asserted-by":"crossref","first-page":"1600","DOI":"10.1016\/S0140-6736(10)61965-4","article-title":"Primary biliary cirrhosis","volume":"377","author":"Coppel","year":"2011","journal-title":"Lancet"},{"key":"2","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1056\/NEJMra043898","article-title":"Primary biliary cirrhosis","volume":"353","author":"Gershwin","year":"2005","journal-title":"N Engl J Med"},{"key":"3","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1016\/j.jhep.2015.07.038","article-title":"Preventive administration of UDCA after liver transplantation for primary biliary cirrhosis is associated with a lower risk of disease recurrence","volume":"63","author":"Chazouilleres","year":"2015","journal-title":"J Hepatol"},{"key":"4","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1182\/blood-2007-07-103895","article-title":"The impact of regulatory T cells on T-cell immunity following hematopoietic cell transplantation","volume":"111","author":"Negrin","year":"2008","journal-title":"Blood"},{"key":"5","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1002\/hep.22591","article-title":"Differential mechanisms in the pathogenesis of autoimmune cholangitis versus inflammatory bowel disease in interleukin-2Ralpha(-\/-) mice","volume":"49","author":"Gershwin","year":"2009","journal-title":"Hepatology"},{"key":"6","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/j.autrev.2011.09.008","article-title":"Regulatory T cells in systemic lupus erythematosus (SLE); role of peptide tolerance","volume":"11","author":"Singh","year":"2012","journal-title":"Autoimmun Rev"},{"key":"7","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.cellimm.2015.04.001","article-title":"Abnormal quantity and function of regulatory T cells in peripheral blood of patients with severe aplastic anemia","volume":"296","author":"Shao","year":"2015","journal-title":"Cell Immunol"},{"key":"8","first-page":"300","article-title":"Novel Senescent Regulatory T-Cell Subset with Impaired Suppressive Function in Rheumatoid Arthritis","volume":"8","author":"Dejaco","year":"2017","journal-title":"Front Immunol"},{"key":"9","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1002\/(SICI)1096-9896(1998100)186:2<126::AID-PATH167>3.0.CO;2-1","article-title":"Expression of co-stimulatory factor B7-2 on the intrahepatic bile ducts in primary biliary cirrhosis and primary sclerosing cholangitis: an immunohistochemical study","volume":"186","author":"Nakanuma","year":"1998","journal-title":"J Pathol"},{"key":"10","doi-asserted-by":"crossref","first-page":"3627","DOI":"10.1172\/JCI76031","article-title":"Selective Treg reconstitution during lymphopenia normalizes DC costimulation and prevents graft-versus-host disease","volume":"125","author":"Fazekas de St Groth","year":"2015","journal-title":"J Clin Invest"},{"key":"11","doi-asserted-by":"crossref","first-page":"e1001833","DOI":"10.1371\/journal.pbio.1001833","article-title":"CD4CD8alphaalpha lymphocytes, a novel human regulatory T cell subset induced by colonic bacteria and deficient in patients with inflammatory bowel disease","volume":"12","author":"Jotereau","year":"2014","journal-title":"PLoS Biol"},{"key":"12","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1084\/jem.20100799","article-title":"Defective IL-10 signaling in hyper-IgE syndrome results in impaired generation of tolerogenic dendritic cells and induced regulatory T cells","volume":"208","author":"Minegishi","year":"2011","journal-title":"J Exp Med"},{"key":"13","doi-asserted-by":"crossref","first-page":"1482","DOI":"10.1128\/IAI.73.3.1482-1490.2005","article-title":"Natural killer cells and Helicobacter pylori infection: bacterial antigens and interleukin-12 act synergistically to induce gamma interferon production","volume":"73","author":"Lundin","year":"2005","journal-title":"Infect Immun"},{"key":"14","doi-asserted-by":"crossref","first-page":"4676","DOI":"10.4049\/jimmunol.172.8.4676","article-title":"Cutting edge: Human CD4(+)CD25(+) T cells restrain the maturation and antigen-presenting function of dendritic cells","volume":"172","author":"Kaveri","year":"2004","journal-title":"J Immunol"},{"key":"15","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1084\/jem.182.4.1045","article-title":"Requirement for natural killer cell-produced interferon gamma in defense against murine cytomegalovirus infection and enhancement of this defense pathway by interleukin 12 administration","volume":"182","author":"Biron","year":"1995","journal-title":"J Exp Med"},{"key":"16","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1900\/RDS.2005.2.9","article-title":"The role of regulatory T cell defects in type I diabetes and the potential of these cells for therapy","volume":"2","author":"Cooke","year":"2005","journal-title":"Rev Diabet Stud"},{"key":"17","doi-asserted-by":"crossref","first-page":"1624","DOI":"10.1182\/blood-2011-11-390708","article-title":"Intrinsic impairment of CD4(+)CD25(+) regulatory T cells in acquired aplastic anemia","volume":"120","author":"Zheng","year":"2012","journal-title":"Blood"},{"key":"18","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.jaut.2010.06.018","article-title":"Pathogenetic aspects of systemic lupus erythematosus with an emphasis on regulatory T cells","volume":"35","author":"Smolen","year":"2010","journal-title":"J Autoimmun"},{"key":"19","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.jaut.2016.03.011","article-title":"Regulatory T cell therapy for type 1 diabetes: May the force be with you","volume":"71","author":"Bluestone","year":"2016","journal-title":"J Autoimmun"},{"key":"20","doi-asserted-by":"crossref","first-page":"19078","DOI":"10.1073\/pnas.0907396106","article-title":"Adoptive therapy with redirected primary regulatory T cells results in antigen-specific suppression of arthritis","volume":"106","author":"Stauss","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"21","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1111\/cei.12415","article-title":"Successful immunotherapy of autoimmune cholangitis by adoptive transfer of forkhead box protein 3(+) regulatory T cells","volume":"178","author":"Gershwin","year":"2014","journal-title":"Clin Exp Immunol"},{"key":"22","first-page":"A772","article-title":"Marked depletion of Foxp3-positive regulatory T cells around the damaged bile ducts in primary biliary cirrhosis","volume":"128","author":"Takano","year":"2005","journal-title":"Gastroenterology"},{"key":"23","first-page":"469A","article-title":"Decreased frequency of CD4+CD25high regulatory T cells in patients with primary biliary cirrhosis and their first-degree relatives","volume":"42","author":"Gershwin","year":"2005","journal-title":"Hepatology"},{"key":"24","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.immuni.2013.03.002","article-title":"Development and maintenance of regulatory T cells","volume":"38","author":"Sakaguchi","year":"2013","journal-title":"Immunity"},{"key":"25","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1038\/nrrheum.2010.155","article-title":"Inflammation: TREG cell control of autoimmune inflammation: a matter of timing?","volume":"6","author":"Skapenko","year":"2010","journal-title":"Nat Rev Rheumatol"},{"key":"26","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1002\/hep.21123","article-title":"Liver-targeted and peripheral blood alterations of regulatory T cells in primary biliary cirrhosis","volume":"43","author":"Takano","year":"2006","journal-title":"Hepatology"},{"key":"27","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1111\/j.1440-1746.1997.tb00474.x","article-title":"B7-2 positive cells around interlobular bile ducts in primary biliary cirrhosis and chronic hepatitis C","volume":"12","author":"Kobayashi","year":"1997","journal-title":"J Gastroenterol Hepatol"},{"key":"28","doi-asserted-by":"crossref","first-page":"2200","DOI":"10.1053\/j.gastro.2011.08.008","article-title":"Accelerated and Progressive and Lethal Liver Fibrosis in Mice That Lack Interleukin (IL)-10, IL-12p40, and IL-13R alpha 2","volume":"141","author":"Wynn","year":"2011","journal-title":"Gastroenterology"},{"key":"29","first-page":"745A","article-title":"Bone Marrow-Derived Suppressor Cells Ameliorate Liver Fibrosis Via Enhanced Il-10 Expression and Expansion of Intrahepatic Regulatory T Cells in Mouse Liver","volume":"54","author":"Jeong","year":"2011","journal-title":"Hepatology"},{"key":"30","doi-asserted-by":"crossref","first-page":"e1004315","DOI":"10.1371\/journal.ppat.1004315","article-title":"Late engagement of CD86 after influenza virus clearance promotes recovery in a FoxP3+ regulatory T cell dependent manner","volume":"10","author":"Braciale","year":"2014","journal-title":"PLoS Pathog"},{"key":"31","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.jaut.2015.08.020","article-title":"Immunity, tolerance and autoimmunity in the liver: A comprehensive review","volume":"66","author":"Doherty","year":"2016","journal-title":"J Autoimmun"},{"key":"32","doi-asserted-by":"crossref","first-page":"10058","DOI":"10.1158\/0008-5472.CAN-07-0573","article-title":"Live attenuated Listeria monocytogenes effectively treats hepatic colorectal cancer metastases and is strongly enhanced by depletion of regulatory T cells","volume":"67","author":"Schulick","year":"2007","journal-title":"Cancer Res"},{"key":"33","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1084\/jem.20160951","article-title":"DC subset-specific induction of T cell responses upon antigen uptake via Fcgamma receptors in vivo","volume":"214","author":"Soulat","year":"2017","journal-title":"J Exp Med"},{"key":"34","doi-asserted-by":"crossref","first-page":"4212","DOI":"10.1172\/JCI81151","article-title":"Sodium chloride inhibits the suppressive function of FOXP3+ regulatory T cells","volume":"125","author":"Hafler","year":"2015","journal-title":"J Clin Invest"},{"key":"35","doi-asserted-by":"crossref","first-page":"1944","DOI":"10.1002\/hep.26979","article-title":"IL-12\/Th1 and IL-23\/Th17 biliary microenvironment in primary biliary cirrhosis: implications for therapy","volume":"59","author":"Gershwin","year":"2014","journal-title":"Hepatology"},{"key":"36","doi-asserted-by":"crossref","first-page":"2031","DOI":"10.1053\/j.gastro.2011.03.009","article-title":"Interleukin-12 converts Foxp3+ regulatory T cells to interferon-gamma-producing Foxp3+ T cells that inhibit colitis","volume":"140","author":"Cong","year":"2011","journal-title":"Gastroenterology"},{"key":"37","doi-asserted-by":"crossref","first-page":"1570","DOI":"10.1016\/0016-5085(94)90575-4","article-title":"Primary biliary cirrhosis trials and Mayo risk score","volume":"107","author":"Henley","year":"1994","journal-title":"Gastroenterology"},{"key":"38","doi-asserted-by":"crossref","first-page":"7259","DOI":"10.1038\/srep07259","article-title":"Natural killer T cells play a necessary role in modulating of immune-mediated liver injury by gut microbiota","volume":"4","author":"Diao","year":"2014","journal-title":"Sci Rep"}],"container-title":["Oncotarget"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.22658","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T06:38:02Z","timestamp":1693291082000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.22658"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11,26]]},"references-count":38,"journal-issue":{"issue":"65","published-print":{"date-parts":[[2017,12,12]]}},"alternative-id":["22658","29312539"],"URL":"https:\/\/doi.org\/10.18632\/oncotarget.22658","relation":{},"ISSN":["1949-2553"],"issn-type":[{"value":"1949-2553","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,11,26]]}}}