{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T04:55:42Z","timestamp":1789275342607,"version":"build-2803163510"},"reference-count":135,"publisher":"Impact Journals, LLC","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncotarget"],"published-print":{"date-parts":[[2018,1,30]]},"DOI":"10.18632\/oncotarget.22742","type":"journal-article","created":{"date-parts":[[2017,11,28]],"date-time":"2017-11-28T18:25:53Z","timestamp":1511893553000},"page":"8165-8178","source":"Crossref","is-referenced-by-count":72,"title":["FOXC1, the new player in the cancer sandbox"],"prefix":"10.18632","volume":"9","author":[{"given":"Fahed A.","family":"Elian","sequence":"first","affiliation":[{"name":"Department of Medical Genetics, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael A.","family":"Walter","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7892","published-online":{"date-parts":[[2017,11,28]]},"reference":[{"key":"1","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/S0168-9525(03)00111-2","article-title":"Fox's in development and disease","volume":"19","author":"Bhattacharya","year":"2003","journal-title":"Trends Genet"},{"key":"2","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1038\/nrc3539","article-title":"Forkhead box proteins: tuning forks for transcriptional harmony","volume":"13","author":"Koo","year":"2013","journal-title":"Nat Rev Cancer"},{"key":"3","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1038\/nrc2223","article-title":"The emerging roles of forkhead box (Fox) proteins in cancer","volume":"7","author":"Lam","year":"2007","journal-title":"Nat Rev Cancer"},{"key":"4","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.ydbio.2004.08.022","article-title":"The mouse Forkhead Box m1 transcription factor is essential for hepatoblast mitosis and development of intrahepatic bile ducts and vessels during liver morphogenesis","volume":"276","author":"Costa","year":"2004","journal-title":"Dev Biol"},{"key":"5","doi-asserted-by":"crossref","first-page":"1712","DOI":"10.1158\/0008-5472.CAN-05-3138","article-title":"Increased levels of the FoxM1 transcription factor accelerate development and progression of prostate carcinomas in both TRAMP and LADY transgenic mice","volume":"66","author":"Costa","year":"2006","journal-title":"Cancer Res"},{"key":"6","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.cell.2006.12.029","article-title":"FoxOs are lineage-restricted redundant tumor suppressors and regulate endothelial cell homeostasis","volume":"128","author":"Chin","year":"2007","journal-title":"Cell"},{"key":"7","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1016\/j.celrep.2015.09.063","article-title":"FOXC1 Activates Smoothened-Independent Hedgehog Signaling in Basal-like Breast Cancer","volume":"13","author":"Jensen","year":"2015","journal-title":"Cell Reports"},{"key":"8","first-page":"161","article-title":"FOXC1 is a critical mediator of EGFR function in human basal-like breast cancer","volume":"19","author":"Cui","year":"2015","journal-title":"Ann Surg Oncol"},{"key":"9","doi-asserted-by":"crossref","first-page":"10069","DOI":"10.1073\/pnas.0703900104","article-title":"Mesenchyme Forkhead 1 (FOXC2) plays a key role in metastasis and is associated with aggressive basal-like breast cancers","volume":"104","author":"Weinberg","year":"2007","journal-title":"Proc Natl Acad Sci USA"},{"key":"10","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1038\/nrg2523","article-title":"The evolution of Fox genes and their role in development and disease","volume":"10","author":"Kaestner","year":"2009","journal-title":"Nat Rev Genet"},{"key":"11","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.lfs.2015.12.001","article-title":"Forkhead box transcription factors in embryonic heart development and congenital heart disease","volume":"144","author":"Zhu","year":"2016","journal-title":"Life Sci"},{"key":"12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1006\/dbio.2002.0780","article-title":"Forkhead transcription factors: key players in development and metabolism","volume":"250","author":"Mahlapuu","year":"2002","journal-title":"Dev Biol"},{"key":"13","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/0092-8674(89)90133-5","article-title":"The homeotic gene fork head encodes a nuclear protein and is expressed in the terminal regions of the Drosophila embryo","volume":"57","author":"J\u00e4ckle","year":"1989","journal-title":"Cell"},{"key":"14","doi-asserted-by":"crossref","first-page":"5002","DOI":"10.1002\/j.1460-2075.1994.tb06827.x","article-title":"Cloning and characterization of seven human forkhead proteins: binding site specificity and DNA bending","volume":"13","author":"Carlsson","year":"1994","journal-title":"EMBO J"},{"key":"15","doi-asserted-by":"crossref","first-page":"10292","DOI":"10.1074\/jbc.M110266200","article-title":"FOXC1 transcriptional regulation is mediated by N- and C-terminal activation domains and contains a phosphorylated transcriptional inhibitory domain","volume":"277","author":"Walter","year":"2002","journal-title":"J Biol Chem"},{"key":"16","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1016\/S0092-8674(00)81204-0","article-title":"The forkhead\/winged helix gene Mf1 is disrupted in the pleiotropic mouse mutation congenital hydrocephalus","volume":"93","author":"Hogan","year":"1998","journal-title":"Cell"},{"key":"17","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1093\/hmg\/8.4.625","article-title":"Pleiotropic skeletal and ocular phenotypes of the mouse mutation congenital hydrocephalus (ch\/Mf1) arise from a winged helix\/forkhead transcriptionfactor gene","volume":"8","author":"Chakravarti","year":"1999","journal-title":"Hum Mol Genet"},{"key":"18","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1086\/302109","article-title":"Mutations of the forkhead\/winged-helix gene, FKHL7, in patients with Axenfeld-Rieger anomaly","volume":"63","author":"Pearce","year":"1998","journal-title":"Am J Hum Genet"},{"key":"19","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1086\/318183","article-title":"A spectrum of FOXC1 mutations suggests gene dosage as a mechanism for developmental defects of the anterior chamber of the eye","volume":"68","author":"Sheffield","year":"2001","journal-title":"Am J Hum Genet"},{"key":"20","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.survophthal.2015.01.004","article-title":"The interactions of genes, age, and environment in glaucoma pathogenesis","volume":"60","author":"Walter","year":"2015","journal-title":"Surv Ophthalmol"},{"key":"21","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1001\/archopht.122.10.1527","article-title":"Axenfeld-Rieger anomaly: a novel mutation in the forkhead box C1 (FOXC1) gene in a 4-generation family","volume":"122","author":"Raymond","year":"2004","journal-title":"Arch Ophthalmol"},{"key":"22","doi-asserted-by":"crossref","first-page":"10098","DOI":"10.1074\/jbc.M513629200","article-title":"Regulation of FOXC1 stability and transcriptional activity by an epidermal growth factor-activated mitogen-activated protein kinase signaling cascade","volume":"281","author":"Walter","year":"2006","journal-title":"J Biol Chem"},{"key":"23","doi-asserted-by":"crossref","first-page":"e1131355","DOI":"10.1080\/23723556.2015.1131355","article-title":"Tissue-inappropriate derepression of FOXC1 is frequent and functional in human acute myeloid leukemia","volume":"3","author":"Somervaille","year":"2016","journal-title":"Mol Cell Oncol"},{"key":"24","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1242\/dev.127.7.1387","article-title":"Murine forkhead\/winged helix genes Foxc1 (Mf1) and Foxc2 (Mfh1) are required for the early organogenesis of the kidney and urinary tract","volume":"127","author":"Hogan","year":"2000","journal-title":"Development"},{"key":"25","doi-asserted-by":"crossref","first-page":"3957","DOI":"10.1038\/onc.2017.48","article-title":"FOXC1: an emerging marker and therapeutic target for cancer","volume":"36","author":"Cui","year":"2017","journal-title":"Oncogene"},{"key":"26","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1002\/hep.26029","article-title":"Overexpression of forkhead box C1 promotes tumor metastasis and indicates poor prognosis in hepatocellular carcinoma","volume":"57","author":"Wu","year":"2013","journal-title":"Hepatology"},{"key":"27","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1053\/j.gastro.2015.05.058","article-title":"Interleukin-8 Induces Expression of FOXC1 to Promote Transactivation of CXCR1 and CCL2 in Hepatocellular Carcinoma Cell Lines and Formation of Metastases in Mice","volume":"149","author":"Xia","year":"2015","journal-title":"Gastroenterology"},{"key":"28","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1002\/ijc.26060","article-title":"Dysregulation of microRNA-204 mediates migration and invasion of endometrial cancer by regulating FOXC1","volume":"130","author":"Wong","year":"2012","journal-title":"Int J Cancer"},{"key":"29","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/s13277-015-3686-6","article-title":"MicroRNA-495 downregulates FOXC1 expression to suppress cell growth and migration in endometrial cancer","volume":"37","author":"Yin","year":"2016","journal-title":"Tumour Biol"},{"key":"30","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1006\/abio.1995.1384","article-title":"Selection of high-affinity binding sites for sequence-specific, DNA binding proteins from random sequence oligonucleotides","volume":"229","author":"Carlsson","year":"1995","journal-title":"Anal Biochem"},{"key":"31","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1038\/364412a0","article-title":"Co-crystal structure of the HNF-3\/fork head DNA-recognition motif resembles histone H5","volume":"364","author":"Burley","year":"1993","journal-title":"Nature"},{"key":"32","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1093\/hmg\/11.10.1177","article-title":"Molecular genetics of Axenfeld-Rieger malformations","volume":"11","author":"Walter","year":"2002","journal-title":"Hum Mol Genet"},{"key":"33","doi-asserted-by":"crossref","first-page":"2993","DOI":"10.1093\/hmg\/ddg324","article-title":"Structural and functional analyses of disease-causing missense mutations in the forkhead domain of FOXC1","volume":"12","author":"Walter","year":"2003","journal-title":"Hum Mol Genet"},{"key":"34","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1001\/archopht.125.1.128","article-title":"Analyses of a novel L130F missense mutation in FOXC1","volume":"125","author":"Walter","year":"2007","journal-title":"Arch Ophthalmol"},{"key":"35","doi-asserted-by":"crossref","first-page":"3573","DOI":"10.1167\/iovs.08-3032","article-title":"Severe molecular defects of a novel FOXC1 W152G mutation result in aniridia","volume":"50","author":"Walter","year":"2009","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"36","doi-asserted-by":"crossref","first-page":"2531","DOI":"10.1167\/iovs.04-0167","article-title":"The wing 2 region of the FOXC1 forkhead domain is necessary for normal DNA-binding and transactivation functions","volume":"45","author":"Walter","year":"2004","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"37","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1086\/318792","article-title":"Analyses of the effects that disease-causing missense mutations have on the structure and function of the winged-helix protein FOXC1","volume":"68","author":"Walter","year":"2001","journal-title":"Am J Hum Genet"},{"key":"38","doi-asserted-by":"crossref","first-page":"4182","DOI":"10.1093\/nar\/gkh742","article-title":"Essential structural and functional determinants within the forkhead domain of FOXC1","volume":"32","author":"Walter","year":"2004","journal-title":"Nucleic Acids Res"},{"key":"39","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1111\/j.1399-0004.2009.01210.x","article-title":"Characterization of a novel FOXC1 mutation, P297S, identified in two individuals with anterior segment dysgenesis","volume":"76","author":"Walter","year":"2009","journal-title":"Clin Genet"},{"key":"40","doi-asserted-by":"crossref","first-page":"e0119272","DOI":"10.1371\/journal.pone.0119272","article-title":"Hypo- and hypermorphic FOXC1 mutations in dominant glaucoma: transactivation and phenotypic variability","volume":"10","author":"Escribano","year":"2015","journal-title":"PLoS One"},{"key":"41","doi-asserted-by":"crossref","first-page":"4608","DOI":"10.1167\/iovs.03-0090","article-title":"Identification and analysis of a novel mutation in the FOXC1 forkhead domain","volume":"44","author":"Walter","year":"2003","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"42","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1002\/humu.23141","article-title":"Comparison of Bioinformatics Prediction, Molecular Modeling, and Functional Analyses of FOXC1 Mutations in Patients with Axenfeld-Rieger Syndrome","volume":"38","author":"Walter","year":"2017","journal-title":"Hum Mutat"},{"key":"43","doi-asserted-by":"publisher","first-page":"54228","DOI":"10.18632\/oncotarget.9797","article-title":"FOXC2 disease-mutations identified in lymphedema-distichiasis patients cause both loss and gain of protein function","volume":"7","author":"Bertelli","year":"2016","journal-title":"Oncotarget"},{"key":"44","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1038\/modpathol.2010.200","article-title":"Basal-like and triple-negative breast cancers: a critical review with an emphasis on the implications for pathologists and oncologists","volume":"24","author":"Richardson","year":"2011","journal-title":"Mod Pathol"},{"key":"45","doi-asserted-by":"crossref","first-page":"3108","DOI":"10.1158\/0008-5472.CAN-07-5644","article-title":"Subtypes of breast cancer show preferential site of relapse","volume":"68","author":"Martens","year":"2008","journal-title":"Cancer Res"},{"key":"46","first-page":"1","article-title":"Diagnosis of Basal-Like Breast Cancer Using a FOXC1-Based Assay","volume":"107","author":"Ray","year":"2015","journal-title":"J Natl Cancer Inst"},{"key":"47","doi-asserted-by":"crossref","first-page":"5367","DOI":"10.1158\/1078-0432.CCR-04-0220","article-title":"Immunohistochemical and clinical characterization of the basal-like subtype of invasive breast carcinoma","volume":"10","author":"Gown","year":"2004","journal-title":"Clin Cancer Res"},{"key":"48","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1038\/sj.bjc.6604463","article-title":"Caveolin 1 and Caveolin 2 are associated with breast cancer basal-like and triple-negative immunophenotype","volume":"99","author":"Ellis","year":"2008","journal-title":"Br J Cancer"},{"key":"49","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1038\/modpathol.3800528","article-title":"Phenotypic evaluation of the basal-like subtype of invasive breast carcinoma","volume":"19","author":"Perou","year":"2006","journal-title":"Mod Pathol"},{"key":"50","doi-asserted-by":"crossref","first-page":"3870","DOI":"10.1158\/0008-5472.CAN-09-4120","article-title":"FOXC1 is a potential prognostic biomarker with functional significance in basal-like breast cancer","volume":"70","author":"Richardson","year":"2010","journal-title":"Cancer Res"},{"key":"51","doi-asserted-by":"crossref","first-page":"3839","DOI":"10.1245\/s10434-011-1657-8","article-title":"Basal-like breast cancer defined by FOXC1 expression offers superior prognostic value: a retrospective immunohistochemical study","volume":"18","author":"Giuliano","year":"2011","journal-title":"Ann Surg Oncol"},{"key":"52","doi-asserted-by":"crossref","first-page":"4798","DOI":"10.1038\/onc.2011.635","article-title":"FOXC1 regulates the functions of human basal-like breast cancer cells by activating NF-\u03baB signaling","volume":"31","author":"Cui","year":"2012","journal-title":"Oncogene"},{"key":"53","doi-asserted-by":"crossref","first-page":"2557","DOI":"10.1053\/j.gastro.2007.04.061","article-title":"Hepatocellular carcinoma: epidemiology and molecular carcinogenesis","volume":"132","author":"Rudolph","year":"2007","journal-title":"Gastroenterology"},{"key":"54","unstructured":"American Cancer Society. Cancer Facts & Figures. 2016. Cancer Facts Fig. 2016. 2016:1\u20139."},{"key":"55","doi-asserted-by":"crossref","first-page":"1752","DOI":"10.1053\/j.gastro.2008.02.090","article-title":"Diagnosis and treatment of hepatocellular carcinoma","volume":"134","author":"Reddy","year":"2008","journal-title":"Gastroenterology"},{"key":"56","first-page":"756","article-title":"Cirrhosis and chronic liver failure: part I. Diagnosis and evaluation","volume":"74","author":"Bruderly","year":"2006","journal-title":"Am Fam Physician"},{"key":"57","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1056\/NEJMra1001683","article-title":"Hepatocellular carcinoma","volume":"365","author":"El-Serag","year":"2011","journal-title":"N Engl J Med"},{"key":"58","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.7150\/ijbs.4769","article-title":"FOXC1 contributes to microvascular invasion in primary hepatocellular carcinoma via regulating epithelial-mesenchymal transition","volume":"8","author":"Zheng","year":"2012","journal-title":"Int J Biol Sci"},{"key":"59","doi-asserted-by":"crossref","first-page":"e26003","DOI":"10.1371\/journal.pone.0026003","article-title":"Genetic variations in plasma circulating DNA of HBV-related hepatocellular carcinoma patients predict recurrence after liver transplantation","volume":"6","author":"Yang","year":"2011","journal-title":"PLoS One"},{"key":"60","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1053\/jlts.2002.34892","article-title":"Liver transplantation for hepatocellular carcinoma: comparison of the proposed UCSF criteria with the Milan criteria and the Pittsburgh modified TNM criteria","volume":"8","author":"Roberts","year":"2002","journal-title":"Liver Transpl"},{"key":"61","doi-asserted-by":"crossref","first-page":"15449","DOI":"10.1073\/pnas.1004900107","article-title":"Core epithelial-to-mesenchymal transition interactome gene-expression signature is associated with claudin-low and metaplastic breast cancer subtypes","volume":"107","author":"Lander","year":"2010","journal-title":"Proc Natl Acad Sci USA"},{"key":"62","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/S0898-6568(96)00122-2","article-title":"Signalling to the nucleus by members of the transforming growth factor-beta (TGF-beta) superfamily","volume":"8","author":"Hill","year":"1996","journal-title":"Cell Signal"},{"key":"63","doi-asserted-by":"crossref","first-page":"28623","DOI":"10.1074\/jbc.270.48.28623","article-title":"Functional analysis of the transforming growth factor beta responsive elements in the WAF1\/Cip1\/p21 promoter","volume":"270","author":"Wang","year":"1995","journal-title":"J Biol Chem"},{"key":"64","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1038\/371257a0","article-title":"p15INK4B is a potential effector of TGF-beta-induced cell cycle arrest","volume":"371","author":"Beach","year":"1994","journal-title":"Nature"},{"key":"65","doi-asserted-by":"crossref","first-page":"4386","DOI":"10.1091\/mbc.e05-03-0186","article-title":"Transendothelial migration of melanoma cells involves N-cadherin-mediated adhesion and activation of the \u03b2-catenin signaling pathway","volume":"16","author":"Siu","year":"2005","journal-title":"Mol Biol Cell"},{"key":"66","doi-asserted-by":"crossref","first-page":"6735","DOI":"10.1158\/1078-0432.CCR-07-4843","article-title":"The interleukin-8 pathway in cancer","volume":"14","author":"Wilson","year":"2008","journal-title":"Clin Cancer Res"},{"key":"67","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1038\/nm0603-677","article-title":"Regulation of angiogenesis by hypoxia: role of the HIF system","volume":"9","author":"Ratcliffe","year":"2003","journal-title":"Nat Med"},{"key":"68","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1038\/nrc1187","article-title":"Targeting HIF-1 for cancer therapy","volume":"3","author":"Semenza","year":"2003","journal-title":"Nat Rev Cancer"},{"key":"69","doi-asserted-by":"crossref","first-page":"2260","DOI":"10.1182\/blood.V92.7.2260","article-title":"Induction of endothelial PAS domain protein-1 by hypoxia: characterization and comparison with hypoxia-inducible factor-1alpha","volume":"92","author":"Maxwell","year":"1998","journal-title":"Blood"},{"key":"70","doi-asserted-by":"crossref","first-page":"4604","DOI":"10.1128\/MCB.16.9.4604","article-title":"Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1","volume":"16","author":"Semenza","year":"1996","journal-title":"Mol Cell Biol"},{"key":"71","doi-asserted-by":"crossref","first-page":"5447","DOI":"10.1128\/MCB.12.12.5447","article-title":"A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation","volume":"12","author":"Wang","year":"1992","journal-title":"Mol Cell Biol"},{"key":"72","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/S0002-9440(10)64554-3","article-title":"The expression and distribution of the hypoxia-inducible factors HIF-1\u03b1 and HIF-2\u03b1 in normal human tissues, cancers, and tumor-associated macrophages","volume":"157","author":"Harris","year":"2000","journal-title":"Am J Pathol"},{"key":"73","first-page":"5830","article-title":"Overexpression of hypoxia-inducible factor 1\u03b1 in common human cancers and their metastases","volume":"59","author":"Simons","year":"1999","journal-title":"Cancer Res"},{"key":"74","first-page":"1047","article-title":"Vascular endothelial growth factor (VEGF) and its effect on angiogenesis","volume":"6","author":"Hendryk","year":"2000","journal-title":"Med Sci Monit"},{"key":"75","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1096\/fasebj.13.1.9","article-title":"Vascular endothelial growth factor (VEGF) and its receptors","volume":"13","author":"Poltorak","year":"1999","journal-title":"FASEB J"},{"key":"76","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/S0008-6363(00)00281-9","article-title":"Molecular mechanisms of blood vessel growth","volume":"49","author":"Carmeliet","year":"2001","journal-title":"Cardiovasc Res"},{"key":"77","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/j.ydbio.2006.03.035","article-title":"The forkhead transcription factors, Foxc1 and Foxc2, are required for arterial specification and lymphatic sprouting during vascular development","volume":"294","author":"Kume","year":"2006","journal-title":"Dev Biol"},{"key":"78","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1038\/nature10138","article-title":"CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis","volume":"475","author":"Pollard","year":"2011","journal-title":"Nature"},{"key":"79","doi-asserted-by":"crossref","first-page":"11","DOI":"10.3322\/caac.21166","article-title":"Cancer statistics, 2013","volume":"63","author":"Jemal","year":"2013","journal-title":"CA Cancer J Clin"},{"key":"80","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1056\/NEJM199608293350907","article-title":"Endometrial carcinoma","volume":"335","author":"Rose","year":"1996","journal-title":"N Engl J Med"},{"key":"81","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/0090-8258(83)90111-7","article-title":"Two pathogenetic types of endometrial carcinoma","volume":"15","author":"Bokhman","year":"1983","journal-title":"Gynecol Oncol"},{"key":"82","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.ygyno.2010.02.007","article-title":"Treatment options for advanced endometrial carcinoma","volume":"117","author":"Dizon","year":"2010","journal-title":"Gynecol Oncol"},{"key":"83","doi-asserted-by":"crossref","first-page":"1971","DOI":"10.1038\/sj.onc.1209986","article-title":"Identification of molecular markers and signaling pathway in endometrial cancer in Hong Kong Chinese women by genome-wide gene expression profiling","volume":"26","author":"Bonome","year":"2007","journal-title":"Oncogene"},{"key":"84","doi-asserted-by":"crossref","first-page":"2463","DOI":"10.1038\/onc.2010.618","article-title":"miR-495 is upregulated by E12\/E47 in breast cancer stem cells, and promotes oncogenesis and hypoxia resistance via downregulation of E-cadherin and REDD1","volume":"30","author":"Lee","year":"2011","journal-title":"Oncogene"},{"key":"85","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1007\/s10555-008-9121-3","article-title":"PRL PTPs: mediators and markers of cancer progression","volume":"27","author":"Pallen","year":"2008","journal-title":"Cancer Metastasis Rev"},{"key":"86","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.canlet.2012.03.029","article-title":"miR-495 and miR-551a inhibit the migration and invasion of human gastric cancer cells by directly interacting with PRL-3","volume":"323","author":"Park","year":"2012","journal-title":"Cancer Lett"},{"key":"87","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1093\/annonc\/mdr167","article-title":"Epidemiology of adult non-Hodgkin lymphoma","volume":"22","author":"Boffetta","year":"2011","journal-title":"Ann Oncol"},{"key":"88","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1200\/JCO.2013.53.1194","article-title":"Treatment of Hodgkin lymphoma: a 50-year perspective","volume":"32","author":"Devita","year":"2014","journal-title":"J Clin Oncol"},{"key":"89","doi-asserted-by":"crossref","first-page":"3439","DOI":"10.1172\/JCI61245","article-title":"Hodgkin lymphoma","volume":"122","author":"Hansmann","year":"2012","journal-title":"J Clin Invest"},{"key":"90","doi-asserted-by":"crossref","first-page":"484","DOI":"10.6004\/jnccn.2011.0046","article-title":"Non-Hodgkin's lymphomas","volume":"9","author":"Harris","year":"2011","journal-title":"J Natl Compr Canc Netw"},{"key":"91","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1093\/annonc\/mdu181","article-title":"Hodgkin's lymphoma: ESMO clinical practice guidelines for diagnosis, treatment and follow-up","volume":"25","author":"Ladetto","year":"2014","journal-title":"Ann Oncol"},{"key":"92","first-page":"1063","article-title":"The pathology and nomenclature of Hodgkin's disease","volume":"26","author":"Butler","year":"1966","journal-title":"Cancer Res"},{"key":"93","unstructured":"Swerdlow, Camop, Harris, Jaffe, Pileri, Stein, Thiele, Vardiman. World Health Organization Calssification of Tumours of Haematopoietic and Lymphoid Tissue. 2008; p. 2."},{"key":"94","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1093\/aje\/kwp383","article-title":"Tumor necrosis factor (TNF) and lymphotoxin-\u03b1 (LTA) polymorphisms and risk of non-Hodgkin lymphoma in the InterLymph Consortium","volume":"171","author":"Schenk","year":"2010","journal-title":"Am J Epidemiol"},{"key":"95","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S1470-2045(05)70434-4","article-title":"Genetic variation in TNF and IL10 and risk of non-Hodgkin lymphoma: a report from the InterLymph Consortium","volume":"7","author":"Brooks-Wilson","year":"2006","journal-title":"Lancet Oncol"},{"key":"96","doi-asserted-by":"crossref","first-page":"1893","DOI":"10.3109\/10428194.2013.864762","article-title":"Oncogenic deregulation of NKL homeobox gene MSX1 in mantle cell lymphoma","volume":"55","author":"MacLeod","year":"2014","journal-title":"Leuk Lymphoma"},{"key":"97","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1002\/gcc.22204","article-title":"Deregulated FOX genes in Hodgkin lymphoma","volume":"53","author":"MacLeod","year":"2014","journal-title":"Genes Chromosomes Cancer"},{"key":"98","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.leukres.2011.10.019","article-title":"Transcriptional deregulation of homeobox gene ZHX2 in Hodgkin lymphoma","volume":"36","author":"Macleod","year":"2012","journal-title":"Leuk Res"},{"key":"99","doi-asserted-by":"crossref","first-page":"e49095","DOI":"10.1371\/journal.pone.0049095","article-title":"Initiation of early osteoblast differentiation events through the direct transcriptional regulation of Msx2 by FOXC1","volume":"7","author":"Berry","year":"2012","journal-title":"PLoS One"},{"key":"100","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1111\/j.1365-2141.2007.06956.x","article-title":"Low expression of ZHX2, but not RCBTB2 or RAN, is associated with poor outcome in multiple myeloma","volume":"141","author":"Orf\u00e3o","year":"2008","journal-title":"Br J Haematol"},{"key":"101","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1002\/gcc.20920","article-title":"t(4;8)(q27;q24) in Hodgkin lymphoma cells targets phosphodiesterase PDE5A and homeobox gene ZHX2","volume":"50","author":"MacLeod","year":"2011","journal-title":"Genes Chromosomes Cancer"},{"key":"102","doi-asserted-by":"crossref","first-page":"3898","DOI":"10.1182\/blood-2005-01-0355","article-title":"Notch signaling is a potent inducer of growth arrest and apoptosis in a wide range of B-cell malignancies","volume":"106","author":"Pear","year":"2005","journal-title":"Blood"},{"key":"103","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1002\/jcp.10208","article-title":"HES and HERP families: multiple effectors of the Notch signaling pathway","volume":"194","author":"Hamamori","year":"2003","journal-title":"J Cell Physiol"},{"key":"104","doi-asserted-by":"crossref","first-page":"1967","DOI":"10.1038\/sj.leu.2404396","article-title":"Identification of Notch target genes in uncommitted T-cell progenitors: no direct induction of a T-cell specific gene program","volume":"20","author":"Staal","year":"2006","journal-title":"Leukemia"},{"key":"105","doi-asserted-by":"crossref","first-page":"e0138416","DOI":"10.1371\/journal.pone.0138416","article-title":"Aberrantly expressed OTX homeobox genes deregulate B-cell differentiation in Hodgkin lymphoma","volume":"10","author":"MacLeod","year":"2015","journal-title":"PLoS One"},{"key":"106","doi-asserted-by":"crossref","first-page":"5965","DOI":"10.1242\/jcs.01589","article-title":"AP-1 subunits: quarrel and harmony among siblings","volume":"117","author":"Schorpp-Kistner","year":"2004","journal-title":"J Cell Sci"},{"key":"107","doi-asserted-by":"crossref","first-page":"4104","DOI":"10.1093\/emboj\/cdf389","article-title":"Aberrantly expressed c-Jun and JunB are a hallmark of Hodgkin lymphoma cells, stimulate proliferation and synergize with NF-\u03ba B","volume":"21","author":"Scheidereit","year":"2002","journal-title":"EMBO J"},{"key":"108","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1038\/35000501","article-title":"Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling","volume":"403","author":"Marti","year":"2000","journal-title":"Nature"},{"key":"109","first-page":"5499","article-title":"Interleukin (IL)-10 and IL-6 are produced in vivo by non-Hodgkin's lymphoma cells and act as cooperative growth factors","volume":"56","author":"Blay","year":"1996","journal-title":"Cancer Res"},{"key":"110","doi-asserted-by":"crossref","first-page":"1890","DOI":"10.1073\/pnas.89.5.1890","article-title":"Interleukin 10 is a potent growth and differentiation factor for activated human B lymphocytes","volume":"89","author":"Banchereau","year":"1992","journal-title":"Proc Natl Acad Sci USA"},{"key":"111","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1016\/j.cell.2010.01.025","article-title":"Immunity, inflammation, and cancer","volume":"140","author":"Karin","year":"2010","journal-title":"Cell"},{"key":"112","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1159\/000343436","article-title":"Relationship between the expression of the extracellular matrix genes SPARC, SPP1, FN1, ITGA5 and ITGAV and clinicopathological parameters of tumor progression and colorectal cancer dissemination","volume":"84","author":"Waisberg","year":"2013","journal-title":"Oncology"},{"key":"113","doi-asserted-by":"crossref","first-page":"1900","DOI":"10.1182\/blood.V95.6.1900","article-title":"Cell adhesion receptors in lymphoma dissemination","volume":"95","author":"Pals","year":"2000","journal-title":"Blood"},{"key":"114","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.1158\/0008-5472.CAN-07-1315","article-title":"CX3CR1 is expressed by prostate epithelial cells and androgens regulate the levels of CX3CL1\/fractalkine in the bone marrow: potential role in prostate cancer bone tropism","volume":"68","author":"Fatatis","year":"2008","journal-title":"Cancer Res"},{"key":"115","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.canlet.2008.07.029","article-title":"The involvement of the fractalkine receptor in the transmigration of neuroblastoma cells through bone-marrow endothelial cells","volume":"273","author":"Witz","year":"2009","journal-title":"Cancer Lett"},{"key":"116","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1023\/A:1023039230052","article-title":"MT1-MMP and MMP-7 in invasion and metastasis of human cancers","volume":"22","author":"Okada","year":"2003","journal-title":"Cancer Metastasis Rev"},{"key":"117","doi-asserted-by":"crossref","first-page":"24631","DOI":"10.1074\/jbc.M112.375865","article-title":"The forkhead box transcription factor FOXC1 promotes breast cancer invasion by inducing matrix metalloprotease 7 (MMP7) expression","volume":"287","author":"Keri","year":"2012","journal-title":"J Biol Chem"},{"key":"118","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.urolonc.2012.12.006","article-title":"Expression of CX3CR1 associates with cellular migration, metastasis, and prognosis in human clear cell renal cell carcinoma","volume":"32","author":"Liu","year":"2014","journal-title":"Urol Oncol"},{"key":"119","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1182\/blood-2014-04-568188","article-title":"Jun-regulated genes promote interaction of diffuse large B-cell lymphoma with the microenvironment","volume":"125","author":"Lin","year":"2015","journal-title":"Blood"},{"key":"120","doi-asserted-by":"crossref","first-page":"1861","DOI":"10.1084\/jem.194.12.1861","article-title":"Constitutive nuclear factor kappaB activity is required for survival of activated B cell-like diffuse large B cell lymphoma cells","volume":"194","author":"Staudt","year":"2001","journal-title":"J Exp Med"},{"key":"121","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1158\/1078-0432.28.11.1","article-title":"Small molecule inhibitors of IkappaB kinase are selectively toxic for subgroups of diffuse large B-cell lymphoma defined by gene expression profiling","volume":"11","author":"Staudt","year":"2005","journal-title":"Clin Cancer Res"},{"key":"122","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/cr.2010.182","article-title":"NF-\u03baB signaling pathways regulated by CARMA family of scaffold proteins","volume":"21","author":"Lin","year":"2011","journal-title":"Cell Res"},{"key":"123","doi-asserted-by":"crossref","first-page":"11877","DOI":"10.1074\/jbc.M010512200","article-title":"CARD11 and CARD14 are novel caspase recruitment domain (CARD)\/membrane-associated guanylate kinase (MAGUK) family members that interact with BCL10 and activate NF-kappa B","volume":"276","author":"Alnemri","year":"2001","journal-title":"J Biol Chem"},{"key":"124","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1038\/ni824","article-title":"A requirement for CARMA1 in TCR-induced NF-kappa B activation","volume":"3","author":"Lin","year":"2002","journal-title":"Nat Immunol"},{"key":"125","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1016\/S0960-9822(03)00491-3","article-title":"Requirement for CARMA1 in antigen receptor-induced NF-\u03ba B activation and lymphocyte proliferation","volume":"13","author":"Littman","year":"2003","journal-title":"Curr Biol"},{"key":"126","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1016\/S1074-7613(03)00148-1","article-title":"The MAGUK family protein CARD11 is essential for lymphocyte activation","volume":"18","author":"Yeh","year":"2003","journal-title":"Immunity"},{"key":"127","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1016\/S0960-9822(03)00458-5","article-title":"Mice lacking the CARD of CARMA1 exhibit defective B lymphocyte development and impaired proliferation of their B and T lymphocytes","volume":"13","author":"Dixit","year":"2003","journal-title":"Curr Biol"},{"key":"128","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1038\/ni830","article-title":"CARMA1 is a critical lipid raft-associated regulator of TCR-induced NF-kappa B activation","volume":"3","author":"Thome","year":"2002","journal-title":"Nat Immunol"},{"key":"129","doi-asserted-by":"crossref","first-page":"3904","DOI":"10.1167\/iovs.04-0628","article-title":"Identification of target genes regulated by FOXC1 using nickel agarose-based chromatin enrichment","volume":"45","author":"Walter","year":"2004","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"130","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/s12964-017-0180-3","article-title":"Identification of EGF-NF-\u03baB-FOXC1 signaling axis in basal-like breast cancer","volume":"15","author":"Cui","year":"2017","journal-title":"Cell Commun Signal"},{"key":"131","doi-asserted-by":"crossref","first-page":"1981","DOI":"10.1158\/0008-5472.CAN-12-2962","article-title":"FOXC2 expression links epithelial-mesenchymal transition and stem cell properties in breast cancer","volume":"73","author":"Chang","year":"2013","journal-title":"Cancer Res"},{"key":"132","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/s12943-016-0579-2","article-title":"EMT and stemness: flexible processes tuned by alternative splicing in development and cancer progression","volume":"16","author":"Ghigna","year":"2017","journal-title":"Mol Cancer"},{"key":"133","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1016\/S1097-2765(03)00490-8","article-title":"Regulation of NF-kappaB signaling by Pin1-dependent prolyl isomerization and ubiquitin-mediated proteolysis of p65\/RelA","volume":"12","author":"Lu","year":"2003","journal-title":"Mol Cell"},{"key":"134","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1101\/gad.183434.111","article-title":"NF-\u03baB, the first quarter-century: remarkable progress and outstanding questions","volume":"26","author":"Ghosh","year":"2012","journal-title":"Genes Dev"},{"key":"135","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/S1535-6108(03)00218-6","article-title":"Prolyl isomerase Pin1 as a molecular target for cancer diagnostics and therapeutics","volume":"4","author":"Lu","year":"2003","journal-title":"Cancer Cell"}],"container-title":["Oncotarget"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.22742","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,9]],"date-time":"2022-08-09T14:04:47Z","timestamp":1660053887000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.22742"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11,28]]},"references-count":135,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2018,1,30]]}},"alternative-id":["22742","29487724"],"URL":"https:\/\/doi.org\/10.18632\/oncotarget.22742","relation":{},"ISSN":["1949-2553"],"issn-type":[{"value":"1949-2553","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,11,28]]}}}