{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T12:13:15Z","timestamp":1772626395458,"version":"3.50.1"},"reference-count":40,"publisher":"Impact Journals, LLC","issue":"68","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncotarget"],"published-print":{"date-parts":[[2017,12,22]]},"DOI":"10.18632\/oncotarget.22889","type":"journal-article","created":{"date-parts":[[2017,12,4]],"date-time":"2017-12-04T18:15:36Z","timestamp":1512411336000},"page":"112907-112916","source":"Crossref","is-referenced-by-count":19,"title":["Genome-wide transcriptional profiling identifies potential signatures in discriminating active tuberculosis from latent infection"],"prefix":"10.18632","volume":"8","author":[{"given":"Liping","family":"Pan","sequence":"first","affiliation":[{"name":"Beijing Chest Hospital, Capital Medical University, Beijing Key Laboratory for Drug Resistant Tuberculosis Research, Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing 101149, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Na","family":"Wei","sequence":"additional","affiliation":[{"name":"Medical Laboratory, Linyi Chest Hospital, Linyi 276000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongyan","family":"Jia","sequence":"additional","affiliation":[{"name":"Beijing Chest Hospital, Capital Medical University, Beijing Key Laboratory for Drug Resistant Tuberculosis Research, Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing 101149, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mengqiu","family":"Gao","sequence":"additional","affiliation":[{"name":"Tuberculosis Department, Beijing Chest Hospital, Capital Medical University, Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing 101149, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoyou","family":"Chen","sequence":"additional","affiliation":[{"name":"Tuberculosis Department, Beijing Chest Hospital, Capital Medical University, Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing 101149, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rongrong","family":"Wei","sequence":"additional","affiliation":[{"name":"Beijing Chest Hospital, Capital Medical University, Beijing Key Laboratory for Drug Resistant Tuberculosis Research, Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing 101149, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qi","family":"Sun","sequence":"additional","affiliation":[{"name":"Beijing Chest Hospital, Capital Medical University, Beijing Key Laboratory for Drug Resistant Tuberculosis Research, Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing 101149, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuxiang","family":"Gu","sequence":"additional","affiliation":[{"name":"Beijing Chest Hospital, Capital Medical University, Beijing Key Laboratory for Drug Resistant Tuberculosis Research, Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing 101149, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Boping","family":"Du","sequence":"additional","affiliation":[{"name":"Beijing Chest Hospital, Capital Medical University, Beijing Key Laboratory for Drug Resistant Tuberculosis Research, Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing 101149, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aiying","family":"Xing","sequence":"additional","affiliation":[{"name":"Beijing Chest Hospital, Capital Medical University, Beijing Key Laboratory for Drug Resistant Tuberculosis Research, Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing 101149, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zongde","family":"Zhang","sequence":"additional","affiliation":[{"name":"Beijing Chest Hospital, Capital Medical University, Beijing Key Laboratory for Drug Resistant Tuberculosis Research, Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing 101149, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7892","published-online":{"date-parts":[[2017,12,4]]},"reference":[{"key":"1","unstructured":"WHO. World Health Organization: Global Tuberculosis Report. 2014."},{"key":"2","unstructured":"WHO. World Health Organization: Global Tuberculosis Report. 2015."},{"key":"3","unstructured":"WHO. World Health Organization: Global Tuberculosis Report. 2016."},{"key":"4","doi-asserted-by":"crossref","first-page":"2127","DOI":"10.1056\/NEJMra1405427","article-title":"Latent Mycobacterium tuberculosis infection","volume":"372","author":"Raviglione","year":"2015","journal-title":"N Engl J Med"},{"key":"5","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1038\/nrmicro2236","article-title":"The spectrum of latent tuberculosis: rethinking the biology and intervention strategies","volume":"7","author":"Young","year":"2009","journal-title":"Nat Rev Microbiol"},{"key":"6","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1038\/nri2960","article-title":"Immunological biomarkers of tuberculosis","volume":"11","author":"Zumla","year":"2011","journal-title":"Nat Rev Immunol"},{"key":"7","doi-asserted-by":"crossref","first-page":"e25098","DOI":"10.1371\/journal.pone.0025098","article-title":"Burden of new and recurrent tuberculosis in a major South African city stratified by age and HIV-status","volume":"6","author":"Bekker","year":"2011","journal-title":"PLoS One"},{"key":"8","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1183\/09031936.00115110","article-title":"Interferon-gamma release assays for the diagnosis of latent Mycobacterium tuberculosis infection: a systematic review and meta-analysis","volume":"37","author":"Wagner","year":"2011","journal-title":"Eur Respir J"},{"key":"9","doi-asserted-by":"crossref","first-page":"e26545","DOI":"10.1371\/journal.pone.0026545","article-title":"Multiple cytokines are released when blood from patients with tuberculosis is stimulated with Mycobacterium tuberculosis antigens","volume":"6","author":"Campbell","year":"2011","journal-title":"PLoS One"},{"key":"10","doi-asserted-by":"crossref","first-page":"e0148885","DOI":"10.1371\/journal.pone.0148885","article-title":"Analysis of Plasma Cytokine and Chemokine Profiles in Patients with and without Tuberculosis by Liquid Array-Based Multiplexed Immunoassays","volume":"11","author":"Ma","year":"2016","journal-title":"PLoS One"},{"key":"11","doi-asserted-by":"crossref","first-page":"e44944","DOI":"10.1371\/journal.pone.0044944","article-title":"Different patterns of cytokines and chemokines combined with IFN-gamma production reflect Mycobacterium tuberculosis infection and disease","volume":"7","author":"Liu","year":"2012","journal-title":"PLoS One"},{"issue":"Suppl 1","key":"12","first-page":"S94","article-title":"Transcriptional profiling in infectious diseases: ready for prime time?","volume":"68","author":"Ramilo","year":"2013","journal-title":"J Infect"},{"key":"13","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1007\/s00109-007-0157-6","article-title":"Candidate biomarkers for discrimination between infection and disease caused by Mycobacterium tuberculosis","volume":"85","author":"Kaufmann","year":"2007","journal-title":"J Mol Med (Berl)"},{"key":"14","doi-asserted-by":"crossref","first-page":"e45839","DOI":"10.1371\/journal.pone.0045839","article-title":"Genome-wide expression profiling identifies type 1 interferon response pathways in active tuberculosis","volume":"7","author":"Hibberd","year":"2012","journal-title":"PLoS One"},{"key":"15","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1038\/nature09247","article-title":"An interferon-inducible neutrophil-driven blood transcriptional signature in human tuberculosis","volume":"466","author":"Dhawan","year":"2010","journal-title":"Nature"},{"key":"16","doi-asserted-by":"crossref","first-page":"e1001538","DOI":"10.1371\/journal.pmed.1001538","article-title":"Detection of tuberculosis in HIV-infected and -uninfected African adults using whole blood RNA expression signatures: a case-control study","volume":"10","author":"Hibberd","year":"2013","journal-title":"PLoS Med"},{"key":"17","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1038\/gene.2010.51","article-title":"Human gene expression profiles of susceptibility and resistance in tuberculosis","volume":"12","author":"Kaufmann","year":"2011","journal-title":"Genes Immun"},{"key":"18","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1086\/510397","article-title":"Gene-expression patterns in whole blood identify subjects at risk for recurrent tuberculosis","volume":"195","author":"Lukey","year":"2007","journal-title":"J Infect Dis"},{"key":"19","doi-asserted-by":"crossref","first-page":"20130427","DOI":"10.1098\/rstb.2013.0427","article-title":"The application of transcriptional blood signatures to enhance our understanding of the host response to infection: the example of tuberculosis","volume":"369","author":"O\u2019Garra","year":"2014","journal-title":"Philos Trans R Soc Lond B Biol Sci"},{"key":"20","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1016\/j.cell.2012.10.012","article-title":"Revisiting global gene expression analysis","volume":"151","author":"Young","year":"2012","journal-title":"Cell"},{"key":"21","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1136\/bmj.2.5972.684-c","article-title":"Letter: Racial differences in leucoyte count","volume":"2","author":"Boisson","year":"1975","journal-title":"Br Med J"},{"key":"22","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/S2213-2600(16)30436-2","article-title":"Safety and efficacy of the C-Tb skin test to diagnose Mycobacterium tuberculosis infection, compared with an interferon gamma release assay and the tuberculin skin test: a phase 3, double-blind, randomised, controlled trial","volume":"5","author":"Rodrigo-Pendas","year":"2017","journal-title":"Lancet Respir Med"},{"key":"23","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1097\/INF.0b013e318214b915","article-title":"The utility of an interferon gamma release assay for diagnosis of latent tuberculosis infection and disease in children: a systematic review and meta-analysis","volume":"30","author":"Mahomed","year":"2011","journal-title":"Pediatr Infect Dis J"},{"key":"24","doi-asserted-by":"crossref","first-page":"e38429","DOI":"10.1371\/journal.pone.0038429","article-title":"Increased levels of BAFF and APRIL related to human active pulmonary tuberculosis","volume":"7","author":"Liu","year":"2012","journal-title":"PLoS One"},{"key":"25","doi-asserted-by":"crossref","first-page":"e24290","DOI":"10.1371\/journal.pone.0024290","article-title":"Novel biomarkers distinguishing active tuberculosis from latent infection identified by gene expression profile of peripheral blood mononuclear cells","volume":"6","author":"Zhang","year":"2011","journal-title":"PLoS One"},{"key":"26","doi-asserted-by":"crossref","first-page":"2312","DOI":"10.1016\/S0140-6736(15)01316-1","article-title":"A blood RNA signature for tuberculosis disease risk: a prospective cohort study","volume":"387","author":"Hawkridge","year":"2016","journal-title":"Lancet"},{"key":"27","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1073\/pnas.98.2.502","article-title":"A family of tissue-specific resistin-like molecules","volume":"98","author":"Lazar","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"key":"28","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.cca.2014.07.043","article-title":"Resistin: insulin resistance to malignancy","volume":"438","author":"Alonso-Iglesias","year":"2015","journal-title":"Clin Chim Acta"},{"key":"29","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.clim.2009.07.013","article-title":"The role of resistin as a regulator of inflammation: Implications for various human pathologies","volume":"133","author":"Senolt","year":"2009","journal-title":"Clin Immunol"},{"key":"30","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1038\/s41598-017-00138-3","article-title":"Serum resistin is causally related to mortality risk in patients with type 2 diabetes: preliminary evidences from genetic data","volume":"7","author":"Menzaghi","year":"2017","journal-title":"Sci Rep"},{"key":"31","first-page":"e64729","article-title":"Serum resistin, cardiovascular disease and all-cause mortality in patients with type 2 diabetes","volume":"8","author":"Kanagaki","year":"2014","journal-title":"PLoS One"},{"key":"32","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.atherosclerosis.2017.02.021","article-title":"PKC-epsilon and TLR4 synergistically regulate resistin-mediated inflammation in human macrophages","volume":"259","author":"Zhou","year":"2017","journal-title":"Atherosclerosis"},{"key":"33","doi-asserted-by":"crossref","first-page":"5789","DOI":"10.4049\/jimmunol.174.9.5789","article-title":"Resistin, an adipokine with potent proinflammatory properties","volume":"174","author":"Tarkowski","year":"2005","journal-title":"J Immunol"},{"key":"34","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1016\/j.bbrc.2005.06.202","article-title":"Human resistin stimulates the pro-inflammatory cytokines TNF-alpha and IL-12 in macrophages by NF-kappaB-dependent pathway","volume":"334","author":"Ehtesham","year":"2005","journal-title":"Biochem Biophys Res Commun"},{"key":"35","doi-asserted-by":"crossref","first-page":"32989","DOI":"10.1074\/jbc.R109.027946","article-title":"Functional roles of human kallikrein-related peptidases","volume":"284","author":"Diamandis","year":"2009","journal-title":"J Biol Chem"},{"key":"36","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1515\/BC.2008.077","article-title":"Kallikreins and proteinase-mediated signaling: proteinase-activated receptors (PARs) and the pathophysiology of inflammatory diseases and cancer","volume":"389","author":"Diamandis","year":"2008","journal-title":"Biol Chem"},{"key":"37","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.bmcl.2016.11.051","article-title":"Discovery of a new isomannide-based peptidomimetic synthetized by Ugi multicomponent reaction as human tissue kallikrein 1 inhibitor","volume":"27","author":"Muri","year":"2017","journal-title":"Bioorg Med Chem Lett"},{"key":"38","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1172\/JCI36728","article-title":"Kallikrein genes are associated with lupus and glomerular basement membrane-specific antibody-induced nephritis in mice and humans","volume":"119","author":"Xie","year":"2009","journal-title":"J Clin Invest"},{"key":"39","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.vetimm.2014.12.001","article-title":"Transcriptome changes uponchallenge with Mycobacterium bovis in monocyte-derived macrophages from bovine tuberculosis-infected and healthy cows","volume":"163","author":"Zhou","year":"2015","journal-title":"Vet Immunol Immunopathol"},{"key":"40","doi-asserted-by":"crossref","first-page":"1920","DOI":"10.1016\/S0140-6736(10)60359-5","article-title":"Biomarkers and diagnostics for tuberculosis: progress, needs, and translation into practice","volume":"375","author":"Zumla","year":"2010","journal-title":"Lancet"}],"container-title":["Oncotarget"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.22889","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,9]],"date-time":"2022-08-09T21:56:26Z","timestamp":1660082186000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.22889"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12,4]]},"references-count":40,"journal-issue":{"issue":"68","published-print":{"date-parts":[[2017,12,22]]}},"alternative-id":["22889","29348876"],"URL":"https:\/\/doi.org\/10.18632\/oncotarget.22889","relation":{},"ISSN":["1949-2553"],"issn-type":[{"value":"1949-2553","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,12,4]]}}}