{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T03:25:46Z","timestamp":1777519546638,"version":"3.51.4"},"reference-count":31,"publisher":"Impact Journals, LLC","issue":"16","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncotarget"],"published-print":{"date-parts":[[2018,2,27]]},"DOI":"10.18632\/oncotarget.23035","type":"journal-article","created":{"date-parts":[[2017,12,8]],"date-time":"2017-12-08T15:07:03Z","timestamp":1512745623000},"page":"12609-12619","source":"Crossref","is-referenced-by-count":28,"title":["Reconstitution of high-grade serous ovarian carcinoma from primary fallopian tube secretory epithelial cells"],"prefix":"10.18632","volume":"9","author":[{"given":"Kohei","family":"Nakamura","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Shimane University School of Medicine, 6938501, Izumo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kentaro","family":"Nakayama","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Shimane University School of Medicine, 6938501, Izumo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noriyoshi","family":"Ishikawa","sequence":"additional","affiliation":[{"name":"Department of Organ Pathology, Shimane University School of Medicine, 6938501, Izumo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masako","family":"Ishikawa","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Shimane University School of Medicine, 6938501, Izumo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Razia","family":"Sultana","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Shimane University School of Medicine, 6938501, Izumo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tohru","family":"Kiyono","sequence":"additional","affiliation":[{"name":"Division of Carcinogenesis and Cancer Prevention, National Cancer Center Research Institute, 1040045, Tsukiji, Chuo-ku, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoru","family":"Kyo","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Shimane University School of Medicine, 6938501, Izumo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7892","published-online":{"date-parts":[[2017,12,8]]},"reference":[{"key":"1","first-page":"8","article-title":"Cancer statistics 1995","volume":"45","author":"Bolden","year":"1995","journal-title":"CA: A CA Cancer J Clin"},{"key":"2","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1097\/PAS.0b013e3181ef7b16","article-title":"Are all pelvic (nonuterine) serous carcinomas of tubal origin?","volume":"34","author":"Vang","year":"2010","journal-title":"Am J Surg Pathol"},{"key":"3","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1097\/01.pas.0000213335.40358.47","article-title":"Intraepithelial carcinoma of the fimbria and pelvic serous carcinoma: Evidence for a causal relationship","volume":"31","author":"Crum","year":"2007","journal-title":"Am J Surg Pathol"},{"key":"4","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1097\/PGP.0b013e31822ea955","article-title":"Frequency of serous tubal intraepithelial carcinoma in various gynecologic malignancies: A study of 300 consecutive cases","volume":"31","author":"Daya","year":"2012","journal-title":"Int J Gynecol Pathol"},{"key":"5","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/j.ajpath.2015.11.011","article-title":"The dualistic model of ovarian carcinogenesis revisited, revised, and expandecd","volume":"186","author":"Shih Ie","year":"2016","journal-title":"Am J Pathol"},{"key":"6","first-page":"932371","article-title":"Ovarian cancer pathogenesis: A model in evolution","author":"Drapkin","year":"2010","journal-title":"J Oncol"},{"key":"7","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1097\/01.pas.0000180854.28831.77","article-title":"The tubal fimbria is a preferred site for early adenocarcinoma in women with familial ovarian cancer syndrome","volume":"30","author":"Crum","year":"2006","journal-title":"Am J Surg Pathol"},{"key":"8","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1002\/path.2091","article-title":"A candidate precursor to serous carcinoma that originates in the distal fallopian tube","volume":"211","author":"Crum","year":"2007","journal-title":"J Pathol"},{"key":"9","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1097\/01.pas.0000213335.40358.47","article-title":"Intraepithelial carcinoma of the fimbriae and pelvic serous carcinoma: Evidence for a causal relationship","volume":"31","author":"Crum","year":"2007","journal-title":"Am J Surg Pathol"},{"key":"10","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.ygyno.2008.01.012","article-title":"A candidate precursor to pelvic serous cancer (p53 signature) and its prevalence in ovaries and fallopian tubes from women with BRCA mutations","volume":"109","author":"Crum","year":"2008","journal-title":"Gynecol Oncol"},{"key":"11","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1038\/nature10166","article-title":"Integrated genomic analyses of ovarian carcinoma","volume":"474","author":"Cancer Genome Atlas Research Network","year":"2011","journal-title":"Nature"},{"key":"12","doi-asserted-by":"crossref","first-page":"1755","DOI":"10.1038\/nprot.2012.097","article-title":"Primary culture and immortalization of human fallopian tube secretory epithelial cells","volume":"7","author":"Drapkin","year":"2012","journal-title":"Nat Protoc"},{"key":"13","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1038\/gt.2011.44","article-title":"CDK4 and cyclin D1 allow human myogenic cells to recapture growth property without compromising differentiation potential","volume":"18","author":"Hashimoto","year":"2011","journal-title":"Gene Ther"},{"key":"14","doi-asserted-by":"crossref","first-page":"8150","DOI":"10.1128\/JVI.72.10.8150-8157.1998","article-title":"Development of a self-inactivating lentivirus vector","volume":"72","author":"Verma","year":"1998","journal-title":"J Virol"},{"key":"15","doi-asserted-by":"crossref","first-page":"4656","DOI":"10.1128\/JVI.68.7.4656-4661.1994","article-title":"Inhibition of p53-mediated transactivation by E6 of type 1, but not type 5, 8, or 47, human papillomavirus of cutaneous origin","volume":"68","author":"Ishibashi","year":"1994","journal-title":"J Virol"},{"key":"16","doi-asserted-by":"crossref","first-page":"5699","DOI":"10.1158\/0008-5472.CAN-07-6862","article-title":"An in vitro multistep carcinogenesis model for human cervical cancer","volume":"68","author":"Kiyono","year":"2008","journal-title":"Cancer Res"},{"key":"17","doi-asserted-by":"crossref","first-page":"296","DOI":"10.4161\/cbt.18942","article-title":"Effects of bisphenol A exposure on the proliferation and senescence of normal human mammary epithelial cells","volume":"13","author":"Sone","year":"2012","journal-title":"Cancer Biol Ther"},{"key":"18","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.cancergencyto.2007.10.011","article-title":"Interrelationship between MYC gene numerical aberrations and protein expression in individuals from northern Brazil with early gastric adenocarcinoma","volume":"181","author":"Burbano","year":"2008","journal-title":"Cancer Genet Cytogenet"},{"key":"19","volume-title":"WHO Classification of Tumours of Female Reproductive Organs","author":"Young","year":"2014"},{"key":"20","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.ijgo.2009.02.012","article-title":"Revised FIGO staging for carcinoma of the vulva, cervix, and endometrium","volume":"105","author":"Pecorelli","year":"2009","journal-title":"Int J Gynecol Obstet"},{"key":"21","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1093\/carcin\/bgp007","article-title":"Oncogenic transformation of human ovarian surface epithelial cells with defined cellular oncogenes","volume":"30","author":"Kiyono","year":"2009","journal-title":"Carcinogenesis"},{"key":"22","doi-asserted-by":"crossref","first-page":"7547","DOI":"10.1073\/pnas.1017300108","article-title":"Modeling high-grade serous ovarian carcinogenesis from the fallopian tube","volume":"108","author":"Drapkin","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"23","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1038\/modpathol.2010.119","article-title":"High-grade fimbrial-ovarian carcinomas are unified by altered p53, PTEN and PAX2 expression","volume":"23","author":"Crum","year":"2010","journal-title":"Mod Pathol"},{"key":"24","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1038\/modpathol.2016.101","article-title":"CCNE1 amplification and centrosome number abnormality in serous tubal intraepithelial carcinoma: further evidence supporting its role as a precursor of ovarian high-grade serous carcinoma","volume":"29","author":"Shih","year":"2016","journal-title":"Mod Pathol"},{"key":"25","doi-asserted-by":"crossref","first-page":"5673","DOI":"10.1038\/sj.onc.1209575","article-title":"Creation of tumorigenic human endometrial epithelial cells with intact chromosomes by introducing defined genetic elements","volume":"25","author":"Kiyono","year":"2006","journal-title":"Oncogene"},{"key":"26","doi-asserted-by":"crossref","first-page":"2066","DOI":"10.1038\/sj.onc.1205243","article-title":"Identification of signal transduction pathways involved in constitutive NF-kappaB activation in breast cancer cells","volume":"21","author":"Nakshatri","year":"2002","journal-title":"Oncogene"},{"key":"27","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1073\/pnas.1421839112","article-title":"Only three driver gene mutations are required for the development of lung and colorectal cancers","volume":"112","author":"Vogelstein","year":"2015","journal-title":"Proc Natl Acad Sci U S A"},{"key":"28","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.1056\/NEJMp1508811","article-title":"The path to Cancer -Three strikes and you\u2019re out","volume":"373","author":"Kinzler","year":"2015","journal-title":"N Engl J Med"},{"key":"29","doi-asserted-by":"crossref","first-page":"2501","DOI":"10.1101\/gad.836800","article-title":"Multiple Ras-dependent phosphorylation pathways regulate Myc protein stability","volume":"14","author":"Nevins","year":"2000","journal-title":"Genes Dev"},{"key":"30","doi-asserted-by":"crossref","first-page":"2020","DOI":"10.1038\/sj.bjc.6604783","article-title":"KRAS or BRAF mutation status is a useful predictor of sensitivity to MEK inhibition in ovarian cancer","volume":"99","author":"Miyazaki","year":"2008","journal-title":"Br J Cancer"},{"key":"31","doi-asserted-by":"crossref","first-page":"2197","DOI":"10.1016\/j.humpath.2012.03.011","article-title":"Clinicopathologic and biological analysis of PIK3CA mutation in ovarian clear cell carcinoma","volume":"43","author":"Miyazaki","year":"2012","journal-title":"Hum Pathol"}],"container-title":["Oncotarget"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.23035","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T14:37:41Z","timestamp":1589035061000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.23035"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12,8]]},"references-count":31,"journal-issue":{"issue":"16","published-print":{"date-parts":[[2018,2,27]]}},"alternative-id":["23035","29560094"],"URL":"https:\/\/doi.org\/10.18632\/oncotarget.23035","relation":{},"ISSN":["1949-2553"],"issn-type":[{"value":"1949-2553","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,12,8]]}}}