{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T01:58:43Z","timestamp":1792634323484,"version":"4.5.0"},"reference-count":72,"publisher":"Impact Journals, LLC","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncotarget"],"published-print":{"date-parts":[[2018,1,19]]},"DOI":"10.18632\/oncotarget.23640","type":"journal-article","created":{"date-parts":[[2017,12,23]],"date-time":"2017-12-23T10:48:39Z","timestamp":1514026119000},"page":"6128-6143","source":"Crossref","is-referenced-by-count":144,"title":["Drp1\/Fis1 interaction mediates mitochondrial dysfunction, bioenergetic failure and cognitive decline in Alzheimer's disease"],"prefix":"10.18632","volume":"9","author":[{"given":"Amit U.","family":"Joshi","sequence":"first","affiliation":[{"name":"Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA 94305, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nay L.","family":"Saw","sequence":"additional","affiliation":[{"name":"Behavioral and Functional Neuroscience Laboratory, Department of Neurosurgery, Stanford University School of Medicine, Stanford, CA 94305, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehrdad","family":"Shamloo","sequence":"additional","affiliation":[{"name":"Behavioral and Functional Neuroscience Laboratory, Department of Neurosurgery, Stanford University School of Medicine, Stanford, CA 94305, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daria","family":"Mochly-Rosen","sequence":"additional","affiliation":[{"name":"Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA 94305, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7892","published-online":{"date-parts":[[2017,12,22]]},"reference":[{"key":"1","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1007\/s10522-015-9618-4","article-title":"Mitochondrial dysfunction: the missing link between aging and sporadic Alzheimer\u2019s disease","volume":"17","author":"Eckert","year":"2016","journal-title":"Biogerontology"},{"key":"2","doi-asserted-by":"crossref","first-page":"101","DOI":"10.3233\/JAD-2006-9202","article-title":"The key role of mitochondria in Alzheimer\u2019s disease","volume":"9","author":"Oliveira","year":"2006","journal-title":"J Alzheimers Dis"},{"key":"3","doi-asserted-by":"publisher","first-page":"925050","DOI":"10.4061\/2011\/925050","article-title":"Amyloid-Beta interaction with mitochondria","volume":"2011","author":"Eckert","year":"2011","journal-title":"Int J Alzheimers Dis"},{"key":"4","doi-asserted-by":"publisher","first-page":"324968","DOI":"10.1155\/2012\/324968","article-title":"New insights in the amyloid-Beta interaction with mitochondria","volume":"2012","author":"Navarro","year":"2012","journal-title":"J Aging Res"},{"key":"5","doi-asserted-by":"publisher","first-page":"1145","DOI":"10.1016\/j.cell.2012.02.035","article-title":"Mitochondria: in sickness and in health","volume":"148","author":"Suomalainen","year":"2012","journal-title":"Cell"},{"key":"6","doi-asserted-by":"publisher","first-page":"883","DOI":"10.1016\/j.neuron.2015.03.035","article-title":"A cellular perspective on brain energy metabolism and functional imaging","volume":"86","author":"Allaman","year":"2015","journal-title":"Neuron"},{"key":"7","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1016\/j.ceca.2016.04.010","article-title":"The entangled ER-mitochondrial axis as a potential therapeutic strategy in neurodegeneration: A tangled duo unchained","volume":"60","author":"Mochly-Rosen","year":"2016","journal-title":"Cell Calcium"},{"key":"8","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1091\/mbc.E12-10-0721","article-title":"Fis1, Mff, MiD49, and MiD51 mediate Drp1 recruitment in mitochondrial fission","volume":"24","author":"Chan","year":"2013","journal-title":"Mol Biol Cell"},{"key":"9","doi-asserted-by":"publisher","first-page":"27584","DOI":"10.1074\/jbc.M113.479873","article-title":"Adaptor proteins MiD49 and MiD51 can act independently of Mff and Fis1 in Drp1 recruitment and are specific for mitochondrial fission","volume":"288","author":"Ryan","year":"2013","journal-title":"J Biol Chem"},{"key":"10","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1038\/embor.2011.54","article-title":"MiD49 and MiD51, new components of the mitochondrial fission machinery","volume":"12","author":"Ryan","year":"2011","journal-title":"EMBO Rep"},{"key":"11","doi-asserted-by":"publisher","first-page":"R169","DOI":"10.1093\/hmg\/ddp326","article-title":"Mitochondrial dynamics--fusion, fission, movement, and mitophagy\u2014in neurodegenerative diseases","volume":"18","author":"Chan","year":"2009","journal-title":"Hum Mol Genet"},{"key":"12","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1038\/nrn2417","article-title":"Mitochondrial fragmentation in neurodegeneration","volume":"9","author":"Bossy-Wetzel","year":"2008","journal-title":"Nat Rev Neurosci"},{"key":"13","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1016\/j.bbadis.2013.11.009","article-title":"Inhibition of ERK-DLP1 signaling and mitochondrial division alleviates mitochondrial dysfunction in Alzheimer\u2019s disease cybrid cell","volume":"1842","author":"Yan","year":"2014","journal-title":"Biochim Biophys Acta"},{"key":"14","doi-asserted-by":"crossref","first-page":"6440","DOI":"10.2174\/1381612811319360005","article-title":"Key role of mitochondria in Alzheimer\u2019s disease synaptic dysfunction","volume":"19","author":"D\u2019Amelio","year":"2013","journal-title":"Curr Pharm Des"},{"key":"15","doi-asserted-by":"crossref","first-page":"525","DOI":"10.2174\/156720508786898451","article-title":"Oxidative stress signaling in Alzheimer\u2019s disease","volume":"5","author":"Zhu","year":"2008","journal-title":"Curr Alzheimer Res"},{"key":"16","doi-asserted-by":"crossref","first-page":"339","DOI":"10.2174\/156720506778249489","article-title":"Oxidative stress, mitochondrial dysfunction, and stress signaling in Alzheimer\u2019s disease","volume":"3","author":"Khan","year":"2006","journal-title":"Curr Alzheimer Res"},{"key":"17","doi-asserted-by":"crossref","first-page":"3017","DOI":"10.1523\/JNEUROSCI.21-09-03017.2001","article-title":"Mitochondrial abnormalities in Alzheimer\u2019s disease","volume":"21","author":"Siedlak","year":"2001","journal-title":"J Neurosci"},{"key":"18","doi-asserted-by":"publisher","first-page":"2495","DOI":"10.1093\/hmg\/ddr139","article-title":"Impaired mitochondrial dynamics and abnormal interaction of amyloid beta with mitochondrial protein Drp1 in neurons from patients with Alzheimer\u2019s disease: implications for neuronal damage","volume":"20","author":"Reddy","year":"2011","journal-title":"Hum Mol Genet"},{"key":"19","doi-asserted-by":"publisher","first-page":"2538","DOI":"10.1093\/hmg\/dds072","article-title":"Abnormal interaction between the mitochondrial fission protein Drp1 and hyperphosphorylated tau in Alzheimer\u2019s disease neurons: implications for mitochondrial dysfunction and neuronal damage","volume":"21","author":"Reddy","year":"2012","journal-title":"Hum Mol Genet"},{"key":"20","doi-asserted-by":"publisher","first-page":"162152","DOI":"10.1155\/2013\/162152","article-title":"Deconstructing mitochondrial dysfunction in Alzheimer disease","volume":"2013","author":"Avila","year":"2013","journal-title":"Oxid Med Cell Longev"},{"key":"21","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1007\/s00702-015-1367-7","article-title":"Cerebrovascular and mitochondrial abnormalities in Alzheimer\u2019s disease: a brief overview","volume":"123","author":"Moreira","year":"2016","journal-title":"J Neural Transm (Vienna)"},{"key":"22","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/j.brainresrev.2010.11.004","article-title":"Dynamin-related protein 1 and mitochondrial fragmentation in neurodegenerative diseases","volume":"67","author":"Mao","year":"2011","journal-title":"Brain Res Rev"},{"key":"23","doi-asserted-by":"publisher","first-page":"S609","DOI":"10.3233\/JAD-2010-100564","article-title":"Mitochondria-targeted antioxidants protect against amyloid-beta toxicity in Alzheimer\u2019s disease neurons","volume":"20","author":"Reddy","year":"2010","journal-title":"J Alzheimers Dis"},{"key":"24","doi-asserted-by":"publisher","first-page":"6078","DOI":"10.1007\/s12035-015-9515-5","article-title":"Mechanisms of Mitochondrial Dysfunction in Alzheimer\u2019s Disease","volume":"53","author":"Albensi","year":"2016","journal-title":"Mol Neurobiol"},{"key":"25","doi-asserted-by":"publisher","first-page":"19318","DOI":"10.1073\/pnas.0804871105","article-title":"Amyloid-beta overproduction causes abnormal mitochondrial dynamics via differential modulation of mitochondrial fission\/fusion proteins","volume":"105","author":"Zhu","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"26","doi-asserted-by":"publisher","first-page":"9090","DOI":"10.1523\/JNEUROSCI.1357-09.2009","article-title":"Impaired balance of mitochondrial fission and fusion in Alzheimer\u2019s disease","volume":"29","author":"Zhu","year":"2009","journal-title":"J Neurosci"},{"key":"27","doi-asserted-by":"publisher","first-page":"4515","DOI":"10.1093\/hmg\/ddr381","article-title":"Impaired mitochondrial biogenesis, defective axonal transport of mitochondria, abnormal mitochondrial dynamics and synaptic degeneration in a mouse model of Alzheimer\u2019s disease","volume":"20","author":"Reddy","year":"2011","journal-title":"Hum Mol Genet"},{"key":"28","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1016\/j.steroids.2006.05.003","article-title":"The spirostenol (22R, 25R)-20alpha-spirost-5-en-3beta-yl hexanoate blocks mitochondrial uptake of Abeta in neuronal cells and prevents Abeta-induced impairment of mitochondrial function","volume":"71","author":"Papadopoulos","year":"2006","journal-title":"Steroids"},{"key":"29","doi-asserted-by":"publisher","first-page":"4135","DOI":"10.1021\/jm3017317","article-title":"Progress and developments in tau aggregation inhibitors for Alzheimer disease","volume":"56","author":"Mandelkow","year":"2013","journal-title":"J Med Chem"},{"key":"30","doi-asserted-by":"publisher","first-page":"18754","DOI":"10.1074\/jbc.M808908200","article-title":"Caspase-cleaved tau expression induces mitochondrial dysfunction in immortalized cortical neurons: implications for the pathogenesis of Alzheimer disease","volume":"284","author":"Johnson","year":"2009","journal-title":"J Biol Chem"},{"key":"31","first-page":"211","article-title":"Efficacy and safety of donepezil, galantamine, and rivastigmine for the treatment of Alzheimer\u2019s disease: a systematic review and meta-analysis","volume":"3","author":"Jonas","year":"2008","journal-title":"Clin Interv Aging"},{"key":"32","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/j.devcel.2007.11.019","article-title":"Chemical inhibition of the mitochondrial division dynamin reveals its role in Bax\/Bak-dependent mitochondrial outer membrane permeabilization","volume":"14","author":"Nunnari","year":"2008","journal-title":"Dev Cell"},{"key":"33","doi-asserted-by":"publisher","first-page":"5099","DOI":"10.1523\/JNEUROSCI.2385-16.2017","article-title":"Inhibition of Drp1 Ameliorates Synaptic Depression, Abeta Deposition, and Cognitive Impairment in an Alzheimer\u2019s Disease Model","volume":"37","author":"Jo","year":"2017","journal-title":"J Neurosci"},{"key":"34","doi-asserted-by":"publisher","first-page":"e00235","DOI":"10.1002\/prp2.235","article-title":"Mitochondrial fission - a drug target for cytoprotection or cytodestruction?","volume":"4","author":"Lim","year":"2016","journal-title":"Pharmacol Res Perspect"},{"key":"35","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1016\/j.devcel.2017.02.020","article-title":"The Putative Drp1 Inhibitor mdivi-1 Is a Reversible Mitochondrial Complex I Inhibitor that Modulates Reactive Oxygen Species","volume":"40","author":"Picton","year":"2017","journal-title":"Dev Cell"},{"key":"36","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1242\/jcs.114439","article-title":"A novel Drp1 inhibitor diminishes aberrant mitochondrial fission and neurotoxicity","volume":"126","author":"Mochly-Rosen","year":"2013","journal-title":"J Cell Sci"},{"key":"37","doi-asserted-by":"publisher","first-page":"14670","DOI":"10.1073\/pnas.0903563106","article-title":"Mitochondrial bioenergetic deficit precedes Alzheimer\u2019s pathology in female mouse model of Alzheimer\u2019s disease","volume":"106","author":"Brinton","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"38","doi-asserted-by":"publisher","first-page":"201","DOI":"10.14336\/AD.2015.1007","article-title":"Mitochondrial Dysfunction in Alzheimer\u2019s Disease and the Rationale for Bioenergetics Based Therapies","volume":"7","author":"Khan","year":"2016","journal-title":"Aging Dis"},{"key":"39","doi-asserted-by":"publisher","first-page":"375","DOI":"10.3233\/JAD-141890","article-title":"Characterization of ATP alternations in an Alzheimer\u2019s disease transgenic mouse model","volume":"44","author":"Feng","year":"2015","journal-title":"J Alzheimers Dis"},{"key":"40","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1111\/j.1471-4159.1990.tb02325.x","article-title":"Mitochondrial complex I deficiency in Parkinson\u2019s disease","volume":"54","author":"Marsden","year":"1990","journal-title":"J Neurochem"},{"key":"41","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1016\/S1474-4422(13)70117-0","article-title":"Pramipexole in patients with early Parkinson\u2019s disease (PROUD): a randomised delayed-start trial","volume":"12","author":"Marek","year":"2013","journal-title":"Lancet Neurol"},{"key":"42","doi-asserted-by":"crossref","first-page":"9390","DOI":"10.1074\/jbc.271.16.9390","article-title":"Metabolism of the \u201cSwedish\u201d amyloid precursor protein variant in neuro2a (N2a) cells. Evidence that cleavage at the \u201cbeta-secretase\u201d site occurs in the golgi apparatus","volume":"271","author":"Sisodia","year":"1996","journal-title":"J Biol Chem"},{"key":"43","doi-asserted-by":"publisher","first-page":"7132","DOI":"10.1093\/hmg\/ddv413","article-title":"APP overexpression in the absence of NPC1 exacerbates metabolism of amyloidogenic proteins of Alzheimer\u2019s disease","volume":"24","author":"Kar","year":"2015","journal-title":"Hum Mol Genet"},{"key":"44","doi-asserted-by":"publisher","first-page":"1256","DOI":"10.1016\/j.bbamcr.2013.02.002","article-title":"New insights into the function and regulation of mitochondrial fission","volume":"1833","author":"Mihara","year":"2013","journal-title":"Biochim Biophys Acta"},{"key":"45","doi-asserted-by":"publisher","first-page":"799","DOI":"10.1152\/physrev.00030.2008","article-title":"Mitochondrial dynamics in mammalian health and disease","volume":"89","author":"Zorzano","year":"2009","journal-title":"Physiol Rev"},{"key":"46","doi-asserted-by":"publisher","first-page":"678","DOI":"10.1038\/embor.2010.115","article-title":"Mitochondrial shape changes: orchestrating cell pathophysiology","volume":"11","author":"Scorrano","year":"2010","journal-title":"EMBO Rep"},{"key":"47","doi-asserted-by":"publisher","first-page":"1607","DOI":"10.1016\/j.neurobiolaging.2007.04.014","article-title":"Abeta inhibits the proteasome and enhances amyloid and tau accumulation","volume":"29","author":"LaFerla","year":"2008","journal-title":"Neurobiol Aging"},{"key":"48","doi-asserted-by":"crossref","first-page":"8209","DOI":"10.1073\/pnas.90.17.8209","article-title":"Potassium channel dysfunction in fibroblasts identifies patients with Alzheimer disease","volume":"90","author":"Alkon","year":"1993","journal-title":"Proc Natl Acad Sci U S A"},{"key":"49","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1073\/pnas.91.2.534","article-title":"Internal Ca2+ mobilization is altered in fibroblasts from patients with Alzheimer disease","volume":"91","author":"Alkon","year":"1994","journal-title":"Proc Natl Acad Sci U S A"},{"key":"50","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/0022-510X(91)90147-Y","article-title":"Enhanced proteolytic activities in cultured fibroblasts of Alzheimer patients are revealed by peculiar transketolase alterations","volume":"105","author":"Mocali","year":"1991","journal-title":"J Neurol Sci"},{"key":"51","doi-asserted-by":"publisher","first-page":"165","DOI":"10.3233\/JAD-2012-120745","article-title":"Spatiotemporal complexity of fibroblast networks screens for Alzheimer\u2019s disease","volume":"33","author":"Alkon","year":"2013","journal-title":"J Alzheimers Dis"},{"key":"52","doi-asserted-by":"publisher","first-page":"1117","DOI":"10.1038\/nprot.2006.170","article-title":"Assessing nest building in mice","volume":"1","author":"Deacon","year":"2006","journal-title":"Nat Protoc"},{"key":"53","doi-asserted-by":"publisher","first-page":"825157","DOI":"10.1155\/2015\/825157","article-title":"Limited effects of an eIF2alphaS51A allele on neurological impairments in the 5xFAD mouse model of Alzheimer\u2019s disease","volume":"2015","author":"Weiergraber","year":"2015","journal-title":"Neural Plast"},{"key":"54","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1242\/jcs.114439","article-title":"A novel Drp1 inhibitor diminishes aberrant mitochondrial fission and neurotoxicity","volume":"126","author":"Mochly-Rosen","year":"2013","journal-title":"Journal of Cell Science"},{"key":"55","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1038\/nm996","article-title":"Transducible TAT-HA fusogenic peptide enhances escape of TAT-fusion proteins after lipid raft macropinocytosis","volume":"10","author":"Dowdy","year":"2004","journal-title":"Nat Med"},{"key":"56","doi-asserted-by":"publisher","first-page":"1946","DOI":"10.1124\/dmd.111.040725","article-title":"Distribution of KAI-9803, a novel delta-protein kinase C inhibitor, after intravenous administration to rats","volume":"39","author":"Okazaki","year":"2011","journal-title":"Drug Metab Dispos"},{"key":"57","doi-asserted-by":"publisher","first-page":"e0139652","DOI":"10.1371\/journal.pone.0139652","article-title":"Cell-Penetrating Peptides Selectively Cross the Blood-Brain Barrier","volume":"10","author":"De Spiegeleer","year":"2015","journal-title":"PLoS One"},{"key":"58","doi-asserted-by":"publisher","first-page":"5371","DOI":"10.1172\/JCI70911","article-title":"Inhibition of mitochondrial fragmentation diminishes Huntington\u2019s disease-associated neurodegeneration","volume":"123","author":"Qi","year":"2013","journal-title":"J Clin Invest"},{"key":"59","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1186\/alzrt269","article-title":"Alzheimer\u2019s disease drug-development pipeline: few candidates, frequent failures","volume":"6","author":"Zhong","year":"2014","journal-title":"Alzheimers Res Ther"},{"key":"60","doi-asserted-by":"publisher","first-page":"2236","DOI":"10.1056\/NEJMra1215233","article-title":"Mitochondrial dynamics\u2014mitochondrial fission and fusion in human diseases","volume":"369","author":"Archer","year":"2013","journal-title":"N Engl J Med"},{"key":"61","doi-asserted-by":"publisher","first-page":"1835","DOI":"10.1161\/CIRCRESAHA.116.306374","article-title":"How mitochondrial dynamism orchestrates mitophagy","volume":"116","author":"Dorn","year":"2015","journal-title":"Circ Res"},{"key":"62","doi-asserted-by":"publisher","first-page":"e32737","DOI":"10.1371\/journal.pone.0032737","article-title":"Defects in mitochondrial dynamics and metabolomic signatures of evolving energetic stress in mouse models of familial Alzheimer\u2019s disease","volume":"7","author":"Poduslo","year":"2012","journal-title":"PLoS One"},{"key":"63","doi-asserted-by":"publisher","first-page":"1087","DOI":"10.1083\/jcb.201312123","article-title":"Mitochondrial trafficking and anchoring in neurons: New insight and implications","volume":"204","author":"Sheng","year":"2014","journal-title":"J Cell Biol"},{"key":"64","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1016\/j.bbadis.2011.01.007","article-title":"Amyloid beta impairs mitochondrial anterograde transport and degenerates synapses in Alzheimer\u2019s disease neurons","volume":"1812","author":"Reddy","year":"2011","journal-title":"Biochim Biophys Acta"},{"key":"65","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1111\/jnc.12984","article-title":"Loss of mitofusin 2 links beta-amyloid-mediated mitochondrial fragmentation and Cdk5-induced oxidative stress in neuron cells","volume":"132","author":"Lee","year":"2015","journal-title":"J Neurochem"},{"key":"66","doi-asserted-by":"publisher","first-page":"e000461","DOI":"10.1161\/JAHA.113.000461","article-title":"Acute inhibition of excessive mitochondrial fission after myocardial infarction prevents long-term cardiac dysfunction","volume":"2","author":"Mochly-Rosen","year":"2013","journal-title":"J Am Heart Assoc"},{"key":"67","doi-asserted-by":"publisher","first-page":"2655","DOI":"10.1084\/jem.20160776","article-title":"Potential biomarkers to follow the progression and treatment response of Huntington\u2019s disease","volume":"213","author":"Mochly-Rosen","year":"2016","journal-title":"J Exp Med"},{"key":"68","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/j.jneumeth.2010.05.001","article-title":"An improved method for generating consistent soluble amyloid-beta oligomer preparations forneurotoxicity studies","volume":"190","author":"Bowers","year":"2010","journal-title":"J Neurosci Methods"},{"key":"69","doi-asserted-by":"publisher","first-page":"13843","DOI":"10.1074\/jbc.M808515200","article-title":"Loss of PINK1 function promotes mitophagy through effects on oxidative stress and mitochondrial fission","volume":"284","author":"Chu","year":"2009","journal-title":"J Biol Chem"},{"key":"70","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/j.jneumeth.2016.01.008","article-title":"Quantification of mitochondrial morphology in neurites of dopaminergic neurons using multiple parameters","volume":"262","author":"Lee","year":"2016","journal-title":"J Neurosci Methods"},{"key":"71","doi-asserted-by":"publisher","first-page":"1307","DOI":"10.15252\/emmm.201505256","article-title":"Impaired GAPDH-induced mitophagy contributes to the pathology of Huntington\u2019s disease","volume":"7","author":"Mochly-Rosen","year":"2015","journal-title":"EMBO Mol Med"},{"key":"72","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1096\/fj.12-217497","article-title":"A truncated peptide from p35, a Cdk5 activator, prevents Alzheimer\u2019s disease phenotypes in model mice","volume":"27","author":"Pant","year":"2013","journal-title":"FASEB J"}],"container-title":["Oncotarget"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.23640","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T07:15:56Z","timestamp":1589008556000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.23640"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12,22]]},"references-count":72,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2018,1,19]]}},"alternative-id":["23640","29464060"],"URL":"https:\/\/doi.org\/10.18632\/oncotarget.23640","relation":{},"ISSN":["1949-2553"],"issn-type":[{"value":"1949-2553","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,12,22]]}}}