{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,22]],"date-time":"2024-07-22T19:13:02Z","timestamp":1721675582243},"reference-count":14,"publisher":"Impact Journals, LLC","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncotarget"],"published-print":{"date-parts":[[2018,1,19]]},"DOI":"10.18632\/oncotarget.23680","type":"journal-article","created":{"date-parts":[[2017,12,26]],"date-time":"2017-12-26T16:43:19Z","timestamp":1514306599000},"page":"6055-6061","source":"Crossref","is-referenced-by-count":4,"title":["Rapid development of myeloproliferative neoplasm in mice with <i>Ptpn11<\/i><i>D61Y<\/i> mutation and haploinsufficient for <i>Dnmt3a<\/i>"],"prefix":"10.18632","volume":"9","author":[{"given":"Lisa","family":"Deng","sequence":"first","affiliation":[{"name":"Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN, USA"},{"name":"Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Briana M.","family":"Richine","sequence":"additional","affiliation":[{"name":"Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN, USA"},{"name":"Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth L.","family":"Virts","sequence":"additional","affiliation":[{"name":"Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN, USA"},{"name":"Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victoria N.","family":"Jideonwo-Auman","sequence":"additional","affiliation":[{"name":"Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN, USA"},{"name":"Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebecca J.","family":"Chan","sequence":"additional","affiliation":[{"name":"Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN, USA"},{"name":"Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA"},{"name":"Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, USA"},{"name":"Gilead Sciences, Inc., Foster City, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reuben","family":"Kapur","sequence":"additional","affiliation":[{"name":"Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN, USA"},{"name":"Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA"},{"name":"Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN, USA"},{"name":"Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7892","published-online":{"date-parts":[[2017,12,26]]},"reference":[{"key":"1","doi-asserted-by":"crossref","first-page":"2424","DOI":"10.1056\/NEJMoa1005143","article-title":"DNMT3A mutations in acute myeloid leukemia","volume":"363","author":"Townsend","year":"2010","journal-title":"N Engl J Med"},{"key":"2","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1038\/leu.2011.44","article-title":"Recurrent DNMT3A mutations in patients with myelodysplastic syndromes","volume":"25","author":"Westervelt","year":"2011","journal-title":"Leukemia"},{"key":"3","doi-asserted-by":"crossref","first-page":"4086","DOI":"10.1182\/blood-2013-02-483487","article-title":"A DNMT3A mutation common in AML exhibits dominant-negative effects in murine ES cells","volume":"122","author":"Chen","year":"2013","journal-title":"Blood"},{"key":"4","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.1038\/nm.3733","article-title":"Age-related mutations associated with clonal hematopoietic expansion and malignancies","volume":"20","author":"Link","year":"2014","journal-title":"Nat Med"},{"key":"5","doi-asserted-by":"crossref","first-page":"12484","DOI":"10.1038\/ncomms12484","article-title":"Clonal haematopoiesis harbouring AML-associated mutations is ubiquitous in healthy adults","volume":"7","author":"Druley","year":"2016","journal-title":"Nat Commun"},{"key":"6","doi-asserted-by":"crossref","first-page":"2488","DOI":"10.1056\/NEJMoa1408617","article-title":"Age-related clonal hematopoiesis associated with adverse outcomes","volume":"371","author":"Kuo","year":"2014","journal-title":"N Engl J Med"},{"key":"7","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1182\/blood-2014-08-594648","article-title":"Dnmt3a loss predisposes murine hematopoietic stem cells to malignant transformation","volume":"125","author":"Goodell","year":"2015","journal-title":"Blood"},{"key":"8","doi-asserted-by":"crossref","first-page":"3657","DOI":"10.1172\/JCI93041","article-title":"Haploinsufficiency for DNA methyltransferase 3A predisposes hematopoietic cells to myeloid malignancies","volume":"127","author":"Chang","year":"2017","journal-title":"J Clin Invest"},{"key":"9","doi-asserted-by":"crossref","first-page":"4414","DOI":"10.1182\/blood-2008-10-182626","article-title":"Leukemogenic Ptpn11 causes fatal myeloproliferative disorder via cell-autonomous effects on multiple stages of hematopoiesis","volume":"113","author":"Neel","year":"2009","journal-title":"Blood"},{"key":"10","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1038\/leu.2015.18","article-title":"Mutated Ptpn11 alters leukemic stem cell frequency and reduces the sensitivity of acute myeloid leukemia cells to Mcl1 inhibition","volume":"29","author":"Abdel-Wahab","year":"2015","journal-title":"Leukemia"},{"key":"11","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1182\/blood-2011-07-369934","article-title":"DNMT3A mutations in acute myeloid leukemia: stability during disease evolution and clinical implications","volume":"119","author":"Liu","year":"2012","journal-title":"Blood"},{"key":"12","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1038\/ng.3400","article-title":"The genomic landscape of juvenile myelomonocytic leukemia","volume":"47","author":"Abusin","year":"2015","journal-title":"Nat Genet"},{"key":"13","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1073\/pnas.1103803109","article-title":"DNA methyltransferase 3a limits the expression of interleukin-13 in T helper 2 cells and allergic airway inflammation","volume":"109","author":"Kaplan","year":"2012","journal-title":"Proc Natl Acad Sci USA"},{"key":"14","doi-asserted-by":"crossref","first-page":"1847","DOI":"10.1038\/leu.2015.85","article-title":"Loss of Dnmt3a and endogenous Kras(G12D\/+) cooperate to regulate hematopoietic stem and progenitor cell functions in leukemogenesis","volume":"29","author":"Zhang","year":"2015","journal-title":"Leukemia"}],"container-title":["Oncotarget"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.23680","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T11:17:30Z","timestamp":1589023050000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.23680"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12,26]]},"references-count":14,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2018,1,19]]}},"alternative-id":["23680","29464054"],"URL":"https:\/\/doi.org\/10.18632\/oncotarget.23680","relation":{},"ISSN":["1949-2553"],"issn-type":[{"value":"1949-2553","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,12,26]]}}}