{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,27]],"date-time":"2025-04-27T16:41:08Z","timestamp":1745772068064},"reference-count":38,"publisher":"Impact Journals, LLC","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncotarget"],"published-print":{"date-parts":[[2018,1,12]]},"DOI":"10.18632\/oncotarget.23828","type":"journal-article","created":{"date-parts":[[2018,1,2]],"date-time":"2018-01-02T15:38:04Z","timestamp":1514907484000},"page":"5263-5273","source":"Crossref","is-referenced-by-count":1,"title":["Prostate-selective \u03b1 antagonists increase fracture risk in prostate cancer patients with and without a history of androgen deprivation therapy: a nationwide population-based study"],"prefix":"10.18632","volume":"9","author":[{"given":"Wei-Heng","family":"Kao","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology, Chang Gung Memorial Hospital, Taoyuan, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chang-Fu","family":"Kuo","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Allergy and Immunology, Department of Internal Medicine, Chang Gung Memorial Hospital, Taoyuan, Taiwan"},{"name":"Division of Rheumatology, Orthopaedics and Dermatology, School of Medicine, University of Nottingham, Nottingham, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I-Jun","family":"Chou","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Chang Gung Memorial Hospital, Taoyuan, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lai-Chu","family":"See","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Allergy and Immunology, Department of Internal Medicine, Chang Gung Memorial Hospital, Taoyuan, Taiwan"},{"name":"Department of Public Health, College of Medicine, Chang Gung University, Taoyuan, Taiwan"},{"name":"Biostatistics Core Laboratory, Molecular Medicine Research Center, Chang Gung University, Taoyuan, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen-Kuan","family":"Huang","sequence":"additional","affiliation":[{"name":"Division of Hematology-Oncology, Department of Internal Medicine, Chang Gung Memorial Hospital, Taoyuan, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meng-Jiun","family":"Chiou","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Allergy and Immunology, Department of Internal Medicine, Chang Gung Memorial Hospital, Taoyuan, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weiya","family":"Zhang","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Orthopaedics and Dermatology, School of Medicine, University of Nottingham, Nottingham, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Doherty","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Orthopaedics and Dermatology, School of Medicine, University of Nottingham, Nottingham, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun-Chieh","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Chang Gung Memorial Hospital, Taoyuan, Taiwan"},{"name":"Department of Medical Imaging and Radiological Science, Chang Gung University, Taoyuan, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun-Te","family":"Hsu","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Chang Gung Memorial Hospital, Taoyuan, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hsien-Hsin","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Chang Gung Memorial Hospital, Taoyuan, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji-Hong","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Chang Gung Memorial Hospital, Taoyuan, Taiwan"},{"name":"Department of Medical Imaging and Radiological Science, Chang Gung University, Taoyuan, Taiwan"},{"name":"Radiation Biology Research Center, Institute for Radiological Research, Chang Gung University\/Chang Gung Memorial Hospital, Taoyuan, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7892","published-online":{"date-parts":[[2018,1,2]]},"reference":[{"key":"1","volume-title":"Ministry of Health and Welfare","author":"Cancer Registry Annual Report, 2012","year":"2015"},{"key":"2","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S0140-6736(02)09408-4","article-title":"Long-term results with immediate androgen suppression and external irradiation in patients with locally advanced prostate cancer (an EORTC study): a phase III randomised trial","volume":"360","author":"Pfeffer","year":"2002","journal-title":"Lancet"},{"key":"3","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1200\/JCO.2007.13.9881","article-title":"Short-term neoadjuvant androgen deprivation therapy and external-beam radiotherapy for locally advanced prostate cancer: long-term results of RTOG 8610","volume":"26","author":"Pilepich","year":"2008","journal-title":"J Clin Oncol"},{"key":"4","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1016\/S1470-2045(11)70063-8","article-title":"Short-term neoadjuvant androgen deprivation and radiotherapy for locally advanced prostate cancer: 10-year data from the TROG 96.01 randomised trial","volume":"12","author":"D'Este","year":"2011","journal-title":"Lancet Oncol"},{"key":"5","doi-asserted-by":"publisher","first-page":"S34","DOI":"10.1016\/j.juro.2012.11.017","article-title":"Metabolic complications of androgen deprivation therapy for prostate cancer","volume":"189","author":"Smith","year":"2013","journal-title":"J Urol"},{"key":"6","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1016\/j.urology.2015.08.029","article-title":"Long-term impact of androgen-deprivation therapy on cardiovascular morbidity after radiotherapy for clinically localized prostate cancer","volume":"87","author":"Zelefsky","year":"2016","journal-title":"Urology"},{"key":"7","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1016\/j.eururo.2004.08.016","article-title":"Skeletal morbidity in men with prostate cancer: quality-of-life considerations throughout the continuum of care","volume":"46","author":"Schulman","year":"2004","journal-title":"Eur Urol"},{"key":"8","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1056\/NEJMoa041943","article-title":"Risk of fracture after androgen deprivation for prostate cancer","volume":"352","author":"Goodwin","year":"2005","journal-title":"N Engl J Med"},{"key":"9","doi-asserted-by":"publisher","first-page":"7897","DOI":"10.1200\/JCO.2004.00.6908","article-title":"Gonadotropin-releasing hormone agonists and fracture risk: a claims-based cohort study of men with nonmetastatic prostate cancer","volume":"23","author":"Pashos","year":"2005","journal-title":"J Clin Oncol"},{"key":"10","doi-asserted-by":"publisher","first-page":"837","DOI":"10.1186\/s12885-015-1843-3","article-title":"Risk of fracture in men with prostate cancer on androgen deprivation therapy: a population-based cohort study in New Zealand","volume":"15","author":"Lawrenson","year":"2015","journal-title":"BMC Cancer"},{"key":"11","doi-asserted-by":"publisher","first-page":"2281","DOI":"10.1007\/s00198-015-3135-9","article-title":"Androgen deprivation increases the risk of fracture in prostate cancer patients: a population-based study in Chinese patients","volume":"26","author":"Chen","year":"2015","journal-title":"Osteoporos Int"},{"key":"12","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1016\/s0149-2918(01)80022-9","article-title":"Initiation of nonselective alpha1-antagonist therapy and occurrence of hypotension-related adverse events among men with benign prostatic hyperplasia: a retrospective cohort study","volume":"23","author":"Chrischilles","year":"2001","journal-title":"Clin Ther"},{"key":"13","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1001\/jama.2009.2024","article-title":"The patient who falls: \u201cIt's always a trade-off\u201d","volume":"303","author":"Kumar","year":"2010","journal-title":"JAMA"},{"key":"14","doi-asserted-by":"crossref","first-page":"135","DOI":"10.2165\/00002512-200219020-00004","article-title":"Tamsulosin: a review of its pharmacology and therapeutic efficacy in the management of lower urinary tract symptoms","volume":"19","author":"Faulds","year":"2002","journal-title":"Drugs Aging"},{"key":"15","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1517\/14656566.7.5.583","article-title":"Alfuzosin: an alpha1-receptor blocker for the treatment of lower urinary tract symptoms associated with benign prostatic hyperplasia","volume":"7","author":"Elhilali","year":"2006","journal-title":"Expert Opin Pharmacother"},{"key":"16","doi-asserted-by":"publisher","first-page":"2085","DOI":"10.1517\/14656566.2012.714368","article-title":"Silodosin : a new subtype selective alpha-1 antagonist for the treatment of lower urinary tract symptoms in patients with benign prostatic hyperplasia","volume":"13","author":"Montorsi","year":"2012","journal-title":"Expert Opin Pharmacother"},{"key":"17","doi-asserted-by":"publisher","first-page":"f6320","DOI":"10.1136\/bmj.f6320","article-title":"Tamsulosin treatment for benign prostatic hyperplasia and risk of severe hypotension in men aged 40-85 years in the United States: risk window analyses using between and within patient methodology","volume":"347","author":"Hartzema","year":"2013","journal-title":"BMJ"},{"key":"18","doi-asserted-by":"publisher","first-page":"h5398","DOI":"10.1136\/bmj.h5398","article-title":"The risk of fall and fracture with the initiation of a prostate-selective alpha antagonist: a population based cohort study","volume":"351","author":"Ordon","year":"2015","journal-title":"BMJ"},{"key":"19","doi-asserted-by":"publisher","first-page":"802","DOI":"10.1111\/bju.12906","article-title":"Individual patient data from registrational trials of silodosin in the treatment of non-neurogenic male lower urinary tract symptoms (LUTS) associated with benign prostatic hyperplasia (BPH): subgroup analyses of efficacy and safety data","volume":"115","author":"Montorsi","year":"2015","journal-title":"BJU Int"},{"key":"20","doi-asserted-by":"publisher","first-page":"1078","DOI":"10.1200\/JCO.2014.60.2557","article-title":"Prostate cancer survivorship care guideline: American Society of Clinical Oncology Clinical Practice Guideline endorsement","volume":"33","author":"Penson","year":"2015","journal-title":"J Clin Oncol"},{"key":"21","doi-asserted-by":"publisher","first-page":"548","DOI":"10.1111\/j.1365-2796.2003.01227.x","article-title":"Use of alpha-blockers and the risk of hip\/femur fractures","volume":"254","author":"Leufkens","year":"2003","journal-title":"J Intern Med"},{"key":"22","doi-asserted-by":"publisher","first-page":"901","DOI":"10.1002\/pds.1402","article-title":"Comparative study of modified release alpha-blocker exposure in elderly patients with fractures","volume":"16","author":"McMahon","year":"2007","journal-title":"Pharmacoepidemiol Drug Saf"},{"key":"23","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1007\/s00198-010-1320-4","article-title":"Risk of fractures associated with treatment for benign prostate hyperplasia in men","volume":"22","author":"Mosekilde","year":"2011","journal-title":"Osteoporos Int"},{"key":"24","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1016\/S0022-5347(01)62386-3","article-title":"A second phase III multicenter placebo controlled study of 2 dosages of modified release tamsulosin in patients with symptoms of benign prostatic hyperplasia","volume":"160","author":"Tewari","year":"1998","journal-title":"J Urol"},{"key":"25","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1046\/j.1464-410x.2000.00546.x","article-title":"The pharmacovigilance of tamsulosin: event data on 12484 patients","volume":"85","author":"Wilton","year":"2000","journal-title":"BJU Int"},{"key":"26","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1016\/j.juro.2010.03.034","article-title":"Skeletal related events, bone metastasis and survival of prostate cancer: a population based cohort study in Denmark (1999 to 2007)","volume":"184","author":"Sorensen","year":"2010","journal-title":"J Urol"},{"key":"27","doi-asserted-by":"publisher","first-page":"818","DOI":"10.1016\/j.ijrobp.2009.05.059","article-title":"Insufficiency fractures after pelvic radiotherapy in patients with prostate cancer","volume":"77","author":"Okkan","year":"2010","journal-title":"Int J Radiat Oncol Biol Phy"},{"key":"28","volume-title":"National Health Insurance Administration","author":"The National Health Insurance Statistics, 2013","year":"2014"},{"key":"29","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1111\/j.1528-1167.2011.03332.x","article-title":"Geographic variation in the age- and gender-specific prevalence and incidence of epilepsy: analysis of Taiwanese National Health Insurance-based data","volume":"53","author":"Liou","year":"2012","journal-title":"Epilepsia"},{"key":"30","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/j.ijcard.2015.07.075","article-title":"Validity of in-hospital mortality data among patients with acute myocardial infarction or stroke in National Health Insurance Research Database in Taiwan","volume":"201","author":"Yang","year":"2015","journal-title":"Int J Cardiol"},{"key":"31","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1002\/pds.2087","article-title":"Validation of the National Health Insurance Research Database with ischemic stroke cases in Taiwan","volume":"20","author":"Lai","year":"2011","journal-title":"Pharmacoepidemiol Drug Saf"},{"key":"32","doi-asserted-by":"crossref","first-page":"500","DOI":"10.2188\/jea.JE20140076","article-title":"Validation of acute myocardial infarction cases in the national health insurance research database in taiwan","volume":"24","author":"Yang","year":"2014","journal-title":"J Epidemiol"},{"key":"33","first-page":"157","article-title":"Accuracy of diabetes diagnosis in health insurance claims data in Taiwan","volume":"104","author":"Tseng","year":"2005","journal-title":"J Formos Med Assoc"},{"key":"34","doi-asserted-by":"crossref","unstructured":"Kao, Hong, See, Yu, Hsu, Chou, Chou, Chiou, Wang, Kuo. Validity of cancer diagnosis in the National Health Insurance database compared with the linked National Cancer Registry in Taiwan. Pharmacoepidemiol Drug Saf. 2017. https:\/\/doi.org\/10.1002\/pds.4267.","DOI":"10.1002\/pds.4267"},{"key":"35","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1016\/j.urology.2010.02.069","article-title":"Prediction of mortality after radical prostatectomy by Charlson comorbidity index","volume":"76","author":"Han","year":"2010","journal-title":"Urology"},{"key":"36","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1136\/bmj.315.7116.1151","article-title":"Confounding and indication for treatment in evaluation of drug treatment for hypertension","volume":"315","author":"Hoes","year":"1997","journal-title":"BMJ"},{"key":"37","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1093\/biomet\/70.1.41","article-title":"The central role of the propensity score in observational studies for causal effects","volume":"70","author":"Rubin","year":"1983","journal-title":"Biometrika"},{"key":"38","doi-asserted-by":"publisher","first-page":"516","DOI":"10.1080\/01621459.1984.10478078","article-title":"Reducing bias in observational studies using subclassification on the propensity score","volume":"79","author":"Rubin","year":"1984","journal-title":"J Am Stat Assoc"}],"container-title":["Oncotarget"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.23828","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T11:16:22Z","timestamp":1589022982000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.23828"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1,2]]},"references-count":38,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,1,12]]}},"alternative-id":["23828","29435177"],"URL":"https:\/\/doi.org\/10.18632\/oncotarget.23828","relation":{},"ISSN":["1949-2553"],"issn-type":[{"value":"1949-2553","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1,2]]}}}