{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T02:09:52Z","timestamp":1789610992152,"version":"build-2803163510"},"reference-count":45,"publisher":"Impact Journals, LLC","issue":"20","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncotarget"],"published-print":{"date-parts":[[2014,10,30]]},"DOI":"10.18632\/oncotarget.2390","type":"journal-article","created":{"date-parts":[[2015,9,15]],"date-time":"2015-09-15T23:37:39Z","timestamp":1442360259000},"page":"9770-9782","source":"Crossref","is-referenced-by-count":29,"title":["Methylation of <i>miR-155-3p<\/i> in mantle cell lymphoma and other non-Hodgkin's lymphomas"],"prefix":"10.18632","volume":"5","author":[{"given":"Rita Lh","family":"Yim","sequence":"first","affiliation":[{"name":"Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwan Yeung","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yok Lam","family":"Kwong","sequence":"additional","affiliation":[{"name":"Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florence","family":"Loong","sequence":"additional","affiliation":[{"name":"Department of Pathology, Queen Mary Hospital, Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chung Ying","family":"Leung","sequence":"additional","affiliation":[{"name":"Department of Pathology, United Christian Hospital, Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond","family":"Chu","sequence":"additional","affiliation":[{"name":"Department of Pathology, Pamela Youde Nethersole Eastern Hospital, Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William Wai Lung","family":"Lam","sequence":"additional","affiliation":[{"name":"Department of Pathology, Princess Margaret Hospital, Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pak Kwan","family":"Hui","sequence":"additional","affiliation":[{"name":"Department of Pathology, Kwong Wah Hospital, Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond","family":"Lai","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chor Sang","family":"Chim","sequence":"additional","affiliation":[{"name":"Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7892","published-online":{"date-parts":[[2014,11,11]]},"reference":[{"key":"1","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1038\/nrc2230","article-title":"Genetic and molecular pathogenesis of mantle cell lymphoma: perspectives for new targeted therapeutics","volume":"7","author":"Campo","year":"2007","journal-title":"Nature Reviews Cancer"},{"key":"2","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1182\/blood-2010-04-189977","article-title":"Mantle cell lymphoma: biology, pathogenesis, and the molecular basis of treatment in the genomic era","volume":"117","author":"Wiestner","year":"2011","journal-title":"Blood"},{"key":"3","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1093\/annonc\/mdi037","article-title":"Clinicopathologic features and treatment outcome of mature T-cell and natural killer-cell lymphomas diagnosed according to the World Health Organization classification scheme: a single center experience of 10 years","volume":"16","author":"Kwong","year":"2005","journal-title":"Annals of Oncology"},{"key":"4","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1002\/(SICI)1096-8652(199812)59:4<295::AID-AJH5>3.0.CO;2-N","article-title":"Mantle cell lymphoma in the Chinese: Clinicopathological features and treatment outcome","volume":"59","author":"Liang","year":"1998","journal-title":"American Journal of Hematology"},{"key":"5","article-title":"DNA Methylation of Tumor Suppressive miRNAs in Non-Hodgkin's Lymphomas","volume":"3","author":"Chim","year":"2012","journal-title":"Frontiers in Genetics"},{"key":"6","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1182\/blood.V89.1.272","article-title":"Deletions and Loss of Expression of P16INK4a and P21Waf1 Genes Are Associated With Aggressive Variants of Mantle Cell Lymphomas","volume":"89","author":"Campo","year":"1997","journal-title":"Blood"},{"key":"7","doi-asserted-by":"crossref","first-page":"2977","DOI":"10.1182\/blood.V91.8.2977.2977_2977_2984","article-title":"p16INK4a Gene Inactivation by Deletions, Mutations, and Hypermethylation Is Associated With Transformed and Aggressive Variants of Non-Hodgkin's Lymphomas","volume":"91","author":"Campo","year":"1998","journal-title":"Blood"},{"key":"8","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1038\/890","article-title":"Cloning and characterization of a family of novel mammalian DNA (cytosine-5) methyltransferases","volume":"19","author":"Li","year":"1998","journal-title":"Nat Genet"},{"key":"9","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1038\/nrc3130","article-title":"A decade of exploring the cancer epigenome\u2014biological and translational implications","volume":"11","author":"Jones","year":"2011","journal-title":"Nature Reviews Cancer"},{"key":"10","doi-asserted-by":"crossref","unstructured":"Xie, Ritz, Leith\u00e4user, Guan, F\u00e4rbinger, Weitzer, Gehringer, Bruederlein, Holzmann, Vogel. FOXO1 downregulation contributes to the oncogenic program of primary mediastinal B-cell lymphoma. Oncotarget. 2014.","DOI":"10.18632\/oncotarget.2107"},{"key":"11","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1182\/blood.V122.21.83.83","article-title":"Diffuse Large B-Cell Lymphoma With Combined TP53 mutation and MIR34A methylation: Another \u201cdouble hit\u201d Lymphoma With Very Poor Outcome?","volume":"122","author":"Gr\u00f8nb\u00e6k","year":"2013","journal-title":"Blood"},{"key":"12","doi-asserted-by":"crossref","first-page":"4443","DOI":"10.1158\/0008-5472.CAN-08-4025","article-title":"Epigenetic silencing of the tumor suppressor MicroRNA Hsa-miR-124a Regulates CDK6 expression and confers a poor prognosis in acute lymphoblastic leukemia","volume":"69","author":"Fortes","year":"2009","journal-title":"Cancer Res"},{"key":"13","first-page":"149","article-title":"CDKN2B methylation is an independent poor prognostic factor in newly diagnosed acute promyelocytic leukemia","volume":"20","author":"Kwong","year":"2005","journal-title":"Leukemia"},{"key":"14","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1038\/onc.2011.354","article-title":"DNA methylation-associated silencing of tumor-suppressor microRNAs in cancer","volume":"31","author":"Esteller","year":"2012","journal-title":"Oncogene"},{"key":"15","doi-asserted-by":"crossref","first-page":"2760","DOI":"10.1111\/j.1582-4934.2011.01274.x","article-title":"Epigenetic inactivation of the hsa-miR-203 in haematological malignancies","volume":"15","author":"Yu","year":"2011","journal-title":"Journal of Cellular and Molecular Medicine"},{"key":"16","doi-asserted-by":"crossref","first-page":"e19027","DOI":"10.1371\/journal.pone.0019027","article-title":"Epigenetic inactivation of the miR-124-1 in haematological malignancies","volume":"6","author":"Chim","year":"2011","journal-title":"PLoS One"},{"key":"17","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/1756-8722-6-16","article-title":"Epigenetic inactivation of the MIR129-2 in hematological malignancies","volume":"6","author":"Chim","year":"2013","journal-title":"Journal of Hematology & Oncology"},{"key":"18","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1093\/carcin\/bgq033","article-title":"Epigenetic inactivation of the miR-34a in hematological malignancies","volume":"31","author":"Liang","year":"2010","journal-title":"Carcinogenesis"},{"key":"19","doi-asserted-by":"crossref","first-page":"6627","DOI":"10.1182\/blood-2010-09-301994","article-title":"MiR-29a down-regulation in ALK-positive anaplastic large cell lymphomas contributes to apoptosis blockade through MCL-1 overexpression","volume":"117","author":"Lamant","year":"2011","journal-title":"Blood"},{"key":"20","doi-asserted-by":"crossref","first-page":"4761","DOI":"10.1158\/1078-0432.CCR-11-0494","article-title":"MicroRNA-146a Downregulates NF\u03baB Activity via Targeting TRAF6 and Functions as a Tumor Suppressor Having Strong Prognostic Implications in NK\/T Cell Lymphoma","volume":"17","author":"Kim","year":"2011","journal-title":"Clinical Cancer Research"},{"key":"21","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1038\/nri2832","article-title":"New insights into the development of lymphoid tissues","volume":"10","author":"Mebius","year":"2010","journal-title":"Nature Reviews Immunology"},{"key":"22","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1038\/nri1054","article-title":"Organogenesis of lymphoid tissues","volume":"3","author":"Mebius","year":"2003","journal-title":"Nat Rev Immunol"},{"key":"23","doi-asserted-by":"crossref","first-page":"9302","DOI":"10.1073\/pnas.94.17.9302","article-title":"Abnormal development of secondary lymphoid tissues in lymphotoxin \u03b2-deficient mice","volume":"94","author":"Pfeffer","year":"1997","journal-title":"Proceedings of the National Academy of Sciences"},{"key":"24","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/S1074-7613(00)80292-7","article-title":"Distinct Roles in Lymphoid Organogenesis for Lymphotoxins \u03b1 and \u03b2 Revealed in Lymphotoxin \u03b2-Deficient Mice","volume":"6","author":"Flavell","year":"1997","journal-title":"Immunity"},{"key":"25","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1038\/nature08782","article-title":"B-cell-derived lymphotoxin promotes castration-resistant prostate cancer","volume":"464","author":"Karin","year":"2010","journal-title":"Nature"},{"key":"26","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1007\/s002620000127","article-title":"Expression of genes coding for the tumor necrosis factor and lymphotoxin ligand-receptor system in non-Hodgkin's lymphomas","volume":"49","author":"Salles","year":"2000","journal-title":"Cancer Immunology, Immunotherapy"},{"key":"27","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.cytogfr.2011.11.007","article-title":"Biology and signal transduction pathways of the Lymphotoxin-\u03b1\u03b2\/LT\u03b2R system","volume":"22","author":"Dejardin","year":"2011","journal-title":"Cytokine & growth factor reviews"},{"key":"28","doi-asserted-by":"crossref","first-page":"2319","DOI":"10.1158\/1078-0432.CCR-12-3151","article-title":"NIK Controls Classical and Alternative NF-\u03baB Activation and Is Necessary for the Survival of Human T-cell Lymphoma Cells","volume":"19","author":"Franjo","year":"2013","journal-title":"Clinical Cancer Research"},{"key":"29","doi-asserted-by":"crossref","first-page":"10252","DOI":"10.1074\/jbc.M608817200","article-title":"CD30 Activates Both the Canonical and Alternative NF-\u03baB Pathways in Anaplastic Large Cell Lymphoma Cells","volume":"282","author":"Duckett","year":"2007","journal-title":"Journal of Biological Chemistry"},{"key":"30","doi-asserted-by":"crossref","first-page":"1861","DOI":"10.1084\/jem.194.12.1861","article-title":"Constitutive Nuclear Factor \u03baB Activity Is Required for Survival of Activated B Cell-like Diffuse Large B Cell Lymphoma Cells","volume":"194","author":"Staudt","year":"2001","journal-title":"The Journal of Experimental Medicine"},{"key":"31","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1182\/blood-2010-11-321265","article-title":"Cooperative function of CCR7 and lymphotoxin in the formation of a lymphoma-permissive niche within murine secondary lymphoid organs","volume":"118","author":"H\u00f6pken","year":"2011","journal-title":"Blood"},{"key":"32","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1016\/j.cell.2007.10.032","article-title":"Dual Role for Argonautes in MicroRNA Processing and Posttranscriptional Regulation of MicroRNA Expression","volume":"131","author":"Haber","year":"2007","journal-title":"Cell"},{"key":"33","unstructured":"Guo, Liu, Yao, Ma, Chang, Li, Song, Chen. miR-338-3p suppresses progression of gastric cancer through PTEN-AKT signaling pathways by targeting P-REX2a. Molecular Cancer Research. 2013."},{"key":"34","doi-asserted-by":"crossref","first-page":"e60369","DOI":"10.1371\/journal.pone.0060369","article-title":"MicroRNA-219-2-3p Functions as a Tumor Suppressor in Gastric Cancer and Is Regulated by DNA Methylation","volume":"8","author":"Li","year":"2013","journal-title":"PLoS ONE"},{"key":"35","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1093\/jjco\/hyt181","article-title":"MicroRNA-338-3p Inhibits Colorectal Carcinoma Cell Invasion and Migration by Targeting Smoothened","volume":"44","author":"Li","year":"2014","journal-title":"Japanese Journal of Clinical Oncology"},{"key":"36","doi-asserted-by":"crossref","first-page":"e58929","DOI":"10.1371\/journal.pone.0058929","article-title":"Genistein Up-Regulates Tumor Suppressor MicroRNA-574-3p in Prostate Cancer","volume":"8","author":"Dahiya","year":"2013","journal-title":"PLoS ONE"},{"key":"37","doi-asserted-by":"crossref","first-page":"3729","DOI":"10.1016\/j.febslet.2013.09.044","article-title":"miR-338-3p suppresses neuroblastoma proliferation, invasion and migration through targeting PREX2a","volume":"587","author":"Dong","year":"2013","journal-title":"FEBS Letters"},{"key":"38","doi-asserted-by":"crossref","first-page":"446","DOI":"10.4161\/cbt.9.6.10894","article-title":"Identification of miRNAs that are associated with tumor metastasis in Neuroblastoma","volume":"9","author":"Zhang","year":"2010","journal-title":"Cancer Biology & Therapy"},{"key":"39","doi-asserted-by":"crossref","first-page":"e66782","DOI":"10.1371\/journal.pone.0066782","article-title":"Epigenetic Silencing of miR-338-3p Contributes to Tumorigenicity in Gastric Cancer by Targeting SSX2IP","volume":"8","author":"Zhu","year":"2013","journal-title":"PLoS ONE"},{"key":"40","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1016\/j.humpath.2007.05.009","article-title":"Frequent epigenetic inactivation of Rb1 in addition to p15 and p16 in mantle cell and follicular lymphoma","volume":"38","author":"Srivastava","year":"2007","journal-title":"Human pathology"},{"key":"41","volume-title":"WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues","author":"Vardiman","year":"2008"},{"key":"42","doi-asserted-by":"crossref","first-page":"5901","DOI":"10.1182\/blood-2011-06-361022","article-title":"Epigenetic inactivation of the MIR34B\/C in multiple myeloma","volume":"118","author":"Chim","year":"2011","journal-title":"Blood"},{"key":"43","doi-asserted-by":"crossref","first-page":"6608","DOI":"10.1093\/nar\/gkn666","article-title":"Epstein-Barr virus latent membrane protein 1 trans-activates miR-155 transcription through the NF-\u03baB pathway","volume":"36","author":"Mallardo","year":"2008","journal-title":"Nucleic Acids Research"},{"key":"44","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/1471-2199-14-24","article-title":"Identification of an NF-kappaB p50\/p65-responsive site in the human MIR155HG promoter","volume":"14","author":"Gilmore","year":"2013","journal-title":"BMC Molecular Biology"},{"key":"45","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.1053\/j.gastro.2006.09.050","article-title":"Correlation Between the Single-Site CpG Methylation and Expression Silencing of the XAF1 Gene in Human Gastric and Colon Cancers","volume":"131","author":"Wong","year":"2006","journal-title":"Gastroenterology"}],"container-title":["Oncotarget"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.2390","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,15]],"date-time":"2020-07-15T14:56:05Z","timestamp":1594824965000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.2390"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10,30]]},"references-count":45,"journal-issue":{"issue":"20","published-print":{"date-parts":[[2014,10,30]]}},"alternative-id":["2390","25211095"],"URL":"https:\/\/doi.org\/10.18632\/oncotarget.2390","relation":{},"ISSN":["1949-2553"],"issn-type":[{"value":"1949-2553","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,10,30]]}}}