{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T04:43:56Z","timestamp":1790484236378,"version":"4.1.0"},"reference-count":137,"publisher":"Impact Journals, LLC","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncotarget"],"published-print":{"date-parts":[[2018,2,6]]},"DOI":"10.18632\/oncotarget.24183","type":"journal-article","created":{"date-parts":[[2018,1,12]],"date-time":"2018-01-12T10:31:02Z","timestamp":1515753062000},"page":"9177-9198","source":"Crossref","is-referenced-by-count":39,"title":["Multi-chaperone function modulation and association with cytoskeletal proteins are key features of the function of AIP in the pituitary gland"],"prefix":"10.18632","volume":"9","author":[{"given":"Laura C.","family":"Hern\u00e1ndez-Ram\u00edrez","sequence":"first","affiliation":[{"name":"Centre for Endocrinology, Barts and The London School of Medicine, Queen Mary University of London, London, EC1M 6BQ, UK"},{"name":"Present address: Section on Endocrinology and Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health (NIH), Bethesda, MD 20892-1862, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rhodri M.L.","family":"Morgan","sequence":"additional","affiliation":[{"name":"Genome Damage and Stability Centre, University of Sussex, Brighton, Falmer, BN1 9RQ, UK"},{"name":"Present address: Protein Crystallography Facility, Centre for Structural Biology, Flowers Building, Department of Life Sciences, Imperial College London, London, SW7 2AZ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sayka","family":"Barry","sequence":"additional","affiliation":[{"name":"Centre for Endocrinology, Barts and The London School of Medicine, Queen Mary University of London, London, EC1M 6BQ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fulvio","family":"D\u2019Acquisto","sequence":"additional","affiliation":[{"name":"Centre for Microvascular Research, Barts and The London School of Medicine, Queen Mary University of London, London, EC1M 6BQ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chrisostomos","family":"Prodromou","sequence":"additional","affiliation":[{"name":"Genome Damage and Stability Centre, University of Sussex, Brighton, Falmer, BN1 9RQ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e1rta","family":"Korbonits","sequence":"additional","affiliation":[{"name":"Centre for Endocrinology, Barts and The London School of Medicine, Queen Mary University of London, London, EC1M 6BQ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7892","published-online":{"date-parts":[[2018,1,11]]},"reference":[{"key":"1","doi-asserted-by":"publisher","first-page":"E1411","DOI":"10.1210\/jc.2012-1111","article-title":"Somatostatin analogs modulate AIP in somatotroph adenomas: the role of the ZAC1 pathway","volume":"97","author":"Karavitaki","year":"2012","journal-title":"J Clin Endocrinol Metab"},{"key":"2","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1530\/ERC-13-0043","article-title":"Aip regulates cAMP signalling and GH secretion in GH3 cells","volume":"20","author":"Vassallo","year":"2013","journal-title":"Endocr Relat Cancer"},{"key":"3","doi-asserted-by":"publisher","first-page":"1174","DOI":"10.1038\/onc.2014.50","article-title":"AIP inactivation leads to pituitary tumorigenesis through defective Galpha-cAMP signaling","volume":"34","author":"Arola","year":"2015","journal-title":"Oncogene"},{"key":"4","doi-asserted-by":"publisher","first-page":"1228","DOI":"10.1126\/science.1126100","article-title":"Pituitary adenoma predisposition caused by germline mutations in the AIP gene","volume":"312","author":"Makinen","year":"2006","journal-title":"Science"},{"key":"5","doi-asserted-by":"publisher","first-page":"E373","DOI":"10.1210\/jc.2009-2556","article-title":"Clinical characteristics and therapeutic responses in patients with germ-line AIP mutations and pituitary adenomas: an international collaborative study","volume":"95","author":"Montanana","year":"2010","journal-title":"J Clin Endocrinol Metab"},{"key":"6","doi-asserted-by":"publisher","first-page":"E1242","DOI":"10.1210\/jc.2015-1869","article-title":"Landscape of familial isolated and young-onset pituitary adenomas: prospective diagnosis in AIP mutation carriers","volume":"100","author":"Korbonits","year":"2015","journal-title":"J Clin Endocrinol Metab"},{"key":"7","doi-asserted-by":"publisher","first-page":"3144","DOI":"10.1210\/jc.2016-1307","article-title":"Rapid proteasomal degradation of mutant proteins is the primary mechanism leading to tumorigenesis in patients with missense AIP mutations","volume":"101","author":"Korbonits","year":"2016","journal-title":"J Clin Endocrinol Metab"},{"key":"8","doi-asserted-by":"publisher","first-page":"8878","DOI":"10.1074\/jbc.272.14.8878","article-title":"A novel cytoplasmic protein that interacts with the Ah receptor, contains tetratricopeptide repeat motifs, and augments the transcriptional response to 2,3,7,8-tetrachlorodibenzo-p-dioxin","volume":"272","author":"Whitlock","year":"1997","journal-title":"J Biol Chem"},{"key":"9","doi-asserted-by":"publisher","first-page":"33580","DOI":"10.1074\/jbc.273.50.33580","article-title":"Characterization of the Ah receptor-associated protein, ARA9","volume":"273","author":"Bradfield","year":"1998","journal-title":"J Biol Chem"},{"key":"10","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1007\/s12104-012-9359-0","article-title":"NMR assignments of the FKBP-type PPIase domain of the human aryl-hydrocarbon receptor-interacting protein (AIP)","volume":"6","author":"Lucke","year":"2012","journal-title":"Biomol NMR Assign"},{"key":"11","doi-asserted-by":"publisher","first-page":"e53339","DOI":"10.1371\/journal.pone.0053339","article-title":"Structure of the TPR domain of AIP: Lack of client protein interaction with the C-terminal alpha-7 helix of the TPR domain of AIP is sufficient for pituitary adenoma predisposition","volume":"7","author":"Prodromou","year":"2012","journal-title":"PLoS One"},{"key":"12","doi-asserted-by":"crossref","first-page":"D204","DOI":"10.1093\/nar\/gku989","article-title":"UniProt: a hub for protein information","volume":"43","author":"The Uniprot Consortium","year":"2015","journal-title":"Nucleic Acids Res"},{"key":"13","doi-asserted-by":"crossref","first-page":"13802","DOI":"10.1016\/S0021-9258(18)68314-0","article-title":"Association of the Ah receptor with the 90-kDa heat shock protein","volume":"263","author":"Perdew","year":"1988","journal-title":"J Biol Chem"},{"key":"14","doi-asserted-by":"crossref","first-page":"27554","DOI":"10.1016\/S0021-9258(18)47020-2","article-title":"Subunit composition of the heteromeric cytosolic aryl hydrocarbon receptor complex","volume":"269","author":"Perdew","year":"1994","journal-title":"J Biol Chem"},{"key":"15","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1379\/1466-1268(1996)001<0237:APOMCI>2.3.CO;2","article-title":"A pathway of multi-chaperone interactions common to diverse regulatory proteins: estrogen receptor, Fes tyrosine kinase, heat shock transcription factor Hsf1, and the aryl hydrocarbon receptor","volume":"1","author":"Smith","year":"1996","journal-title":"Cell Stress Chaperones"},{"key":"16","doi-asserted-by":"crossref","first-page":"11452","DOI":"10.1074\/jbc.272.17.11452","article-title":"Ligand-dependent interaction of the aryl hydrocarbon receptor with a novel immunophilin homolog","volume":"272","author":"Bradfield","year":"1997","journal-title":"J Biol Chem"},{"key":"17","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1128\/MCB.18.2.978","article-title":"Hepatitis B virus X-associated protein 2 is a subunit of the unliganded aryl hydrocarbon receptor core complex and exhibits transcriptional enhancer activity","volume":"18","author":"Perdew","year":"1998","journal-title":"Mol Cell Biol"},{"key":"18","doi-asserted-by":"publisher","first-page":"2594","DOI":"10.1128\/MCB.21.7.2594-2607.2001","article-title":"The hsp90 chaperone complex regulates intracellular localization of the dioxin receptor","volume":"21","author":"Pongratz","year":"2001","journal-title":"Mol Cell Biol"},{"key":"19","doi-asserted-by":"publisher","first-page":"700","DOI":"10.1021\/bi035827v","article-title":"Divergent roles of hepatitis B virus X-associated protein 2 (XAP2) in human versus mouse Ah receptor complexes","volume":"43","author":"Perdew","year":"2004","journal-title":"Biochemistry"},{"key":"20","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1083\/jcb.200305051","article-title":"AIP is a mitochondrial import mediator that binds to both import receptor Tom20 and preproteins","volume":"163","author":"Mori","year":"2003","journal-title":"J Cell Biol"},{"key":"21","doi-asserted-by":"publisher","first-page":"24721","DOI":"10.1074\/jbc.M603175200","article-title":"Regulation of survivin stability by the aryl hydrocarbon receptor-interacting protein","volume":"281","author":"Altieri","year":"2006","journal-title":"J Biol Chem"},{"key":"22","doi-asserted-by":"publisher","first-page":"16758","DOI":"10.1074\/jbc.M110.210120","article-title":"Developmental control of apoptosis by the immunophilin aryl hydrocarbon receptor-interacting protein (AIP) involves mitochondrial import of the survivin protein","volume":"286","author":"Altieri","year":"2011","journal-title":"J Biol Chem"},{"key":"23","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1530\/JOE-11-0054","article-title":"AIP and its interacting partners","volume":"210","author":"Korbonits","year":"2011","journal-title":"J Endocrinol"},{"key":"24","doi-asserted-by":"publisher","first-page":"4741","DOI":"10.1093\/nar\/24.23.4741","article-title":"XAP2, a novel hepatitis B virus X-associated protein that inhibits X transactivation","volume":"24","author":"Seto","year":"1996","journal-title":"Nucleic Acids Res"},{"key":"25","doi-asserted-by":"publisher","first-page":"1801","DOI":"10.1038\/sj.onc.1203501","article-title":"Epstein-Barr virus encoded nuclear protein EBNA-3 binds XAP-2, a protein associated with Hepatitis B virus X antigen","volume":"19","author":"Szekely","year":"2000","journal-title":"Oncogene"},{"key":"26","doi-asserted-by":"crossref","first-page":"D535","DOI":"10.1093\/nar\/gkj109","article-title":"BioGRID: a general repository for interaction datasets","volume":"34","author":"Tyers","year":"2006","journal-title":"Nucleic Acids Res"},{"key":"27","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/S0014-5793(04)00229-7","article-title":"Hsp90 isoforms: functions, expression and clinical importance","volume":"562","author":"Shen","year":"2004","journal-title":"FEBS Lett"},{"key":"28","doi-asserted-by":"publisher","first-page":"2045","DOI":"10.1002\/pro.5560031117","article-title":"Eukaryotic translation elongation factor 1 gamma contains a glutathione transferase domain--study of a diverse, ancient protein superfamily using motif search and structural modeling","volume":"3","author":"Valencia","year":"1994","journal-title":"Protein Sci"},{"key":"29","doi-asserted-by":"publisher","first-page":"R67","DOI":"10.1530\/JME-13-0172","article-title":"cAMP in the pituitary: an old messenger for multiple signals","volume":"52","author":"Spada","year":"2013","journal-title":"J Mol Endocrinol"},{"key":"30","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1530\/ERC-15-0205","article-title":"cAMP-specific PDE4 phosphodiesterases and AIP in the pathogenesis of pituitary tumors","volume":"23","author":"Ribeiro-Oliveira","year":"2016","journal-title":"Endocr Relat Cancer"},{"key":"31","doi-asserted-by":"publisher","first-page":"753","DOI":"10.1530\/ERC-12-0322","article-title":"Somatostatin analogues increase AIP expression in somatotropinomas, irrespective of Gsp mutations","volume":"20","author":"Daly","year":"2013","journal-title":"Endocr Relat Cancer"},{"key":"32","doi-asserted-by":"publisher","first-page":"966","DOI":"10.1038\/nrc1505","article-title":"The role of the unfolded protein response in tumour development: friend or foe?","volume":"4","author":"Hendershot","year":"2004","journal-title":"Nat Rev Cancer"},{"key":"33","doi-asserted-by":"publisher","first-page":"486","DOI":"10.1074\/jbc.274.1.486","article-title":"The dynamic role of GRP78\/BiP in the coordination of mRNA translation with protein processing","volume":"274","author":"Brostrom","year":"1999","journal-title":"J Biol Chem"},{"key":"34","doi-asserted-by":"publisher","first-page":"2092","DOI":"10.4049\/jimmunol.174.4.2092","article-title":"The role of MTJ-1 in cell surface translocation of GRP78, a receptor for alpha 2-macroglobulin-dependent signaling","volume":"174","author":"Pizzo","year":"2005","journal-title":"J Immunol"},{"key":"35","doi-asserted-by":"publisher","first-page":"741","DOI":"10.4161\/cbt.5.7.2970","article-title":"Glucose regulated proteins in cancer progression, drug resistance and immunotherapy","volume":"5","author":"Lee","year":"2006","journal-title":"Cancer Biol Ther"},{"key":"36","doi-asserted-by":"publisher","first-page":"13694","DOI":"10.1074\/jbc.M511694200","article-title":"Activation and cross-talk between Akt, NF-kappaB, and unfolded protein response signaling in 1-LN prostate cancer cells consequent to ligation of cell surface-associated GRP78","volume":"281","author":"Pizzo","year":"2006","journal-title":"J Biol Chem"},{"key":"37","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1111\/j.1365-2141.2011.08671.x","article-title":"Inducing apoptosis in chemotherapy-resistant B-lineage acute lymphoblastic leukaemia cells by targeting HSPA5, a master regulator of the anti-apoptotic unfolded protein response signalling network","volume":"153","author":"Janda","year":"2011","journal-title":"Br J Haematol"},{"key":"38","doi-asserted-by":"publisher","first-page":"10558","DOI":"10.18632\/oncotarget.2510","article-title":"De-acetylation and degradation of HSPA5 is critical for E1A metastasis suppression in breast cancer cells","volume":"5","author":"Su","year":"2014","journal-title":"Oncotarget"},{"key":"39","doi-asserted-by":"publisher","first-page":"1982","DOI":"10.1002\/jcp.24977","article-title":"OSU-03012 and Viagra treatment inhibits the activity of multiple chaperone proteins and disrupts the blood-brain barrier: Implications for anti-cancer therapies","volume":"230","author":"Dent","year":"2015","journal-title":"J Cell Physiol"},{"key":"40","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1074\/jbc.273.2.749","article-title":"Involvement of p38 mitogen-activated protein kinase signaling pathway in the rapid induction of the 78-kDa glucose-regulated protein in 9L rat brain tumor cells","volume":"273","author":"Lai","year":"1998","journal-title":"J Biol Chem"},{"key":"41","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1016\/S0006-291X(03)00226-2","article-title":"Mortalin-MPD (mevalonate pyrophosphate decarboxylase) interactions and their role in control of cellular proliferation","volume":"302","author":"Kaul","year":"2003","journal-title":"Biochem Biophys Res Commun"},{"key":"42","doi-asserted-by":"publisher","first-page":"2973","DOI":"10.1002\/ijc.21773","article-title":"Upregulation of mortalin\/mthsp70\/Grp75 contributes to human carcinogenesis","volume":"118","author":"Kaul","year":"2006","journal-title":"Int J Cancer"},{"key":"43","doi-asserted-by":"publisher","first-page":"1046","DOI":"10.1038\/cdd.2010.177","article-title":"Mortalin-p53 interaction in cancer cells is stress dependent and constitutes a selective target for cancer therapy","volume":"18","author":"Luk","year":"2011","journal-title":"Cell Death Differ"},{"key":"44","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1038\/348137a0","article-title":"Requirement for hsp70 in the mitochondrial matrix for translocation and folding of precursor proteins","volume":"348","author":"Pfanner","year":"1990","journal-title":"Nature"},{"key":"45","doi-asserted-by":"publisher","first-page":"8447","DOI":"10.1074\/jbc.M114.627463","article-title":"Functional significance of point mutations in stress chaperone mortalin and their relevance to Parkinson disease","volume":"290","author":"Kaul","year":"2015","journal-title":"J Biol Chem"},{"key":"46","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1016\/j.exphem.2014.12.005","article-title":"Reduced levels of Hspa9 attenuate Stat5 activation in mouse B cells","volume":"43","author":"Walter","year":"2015","journal-title":"Exp Hematol"},{"key":"47","doi-asserted-by":"publisher","first-page":"5377","DOI":"10.1038\/sj.onc.1209543","article-title":"Mortalin controls centrosome duplication via modulating centrosomal localization of p53","volume":"25","author":"Fukasawa","year":"2006","journal-title":"Oncogene"},{"key":"48","doi-asserted-by":"publisher","first-page":"4051","DOI":"10.1128\/MCB.00021-13","article-title":"A mortalin\/HSPA9-mediated switch in tumor-suppressive signaling of Raf\/MEK\/extracellular signal-regulated kinase","volume":"33","author":"Park","year":"2013","journal-title":"Mol Cell Biol"},{"key":"49","doi-asserted-by":"publisher","first-page":"4624","DOI":"10.1038\/onc.2014.392","article-title":"Mortalin (GRP75\/HSPA9) upregulation promotes survival and proliferation of medullary thyroid carcinoma cells","volume":"34","author":"Park","year":"2015","journal-title":"Oncogene"},{"key":"50","doi-asserted-by":"publisher","first-page":"24832","DOI":"10.1074\/jbc.M114.565929","article-title":"Identification and functional characterization of nuclear mortalin in human carcinogenesis","volume":"289","author":"Wadhwa","year":"2014","journal-title":"J Biol Chem"},{"key":"51","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1016\/j.tcb.2007.07.010","article-title":"Mitochondrial protein-import machinery: correlating structure with function","volume":"17","author":"Ryan","year":"2007","journal-title":"Trends Cell Biol"},{"key":"52","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1038\/nsmb.1965","article-title":"Mixed Hsp90-cochaperone complexes are important for the progression of the reaction cycle","volume":"18","author":"Buchner","year":"2011","journal-title":"Nat Struct Mol Biol"},{"key":"53","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1007\/978-3-319-11731-7_2","article-title":"Functions of the Hsp90-binding FKBP immunophilins","volume":"78","author":"Cox","year":"2015","journal-title":"Subcell Biochem"},{"key":"54","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1038\/nm.3776","article-title":"A C-terminal HSP90 inhibitor restores glucocorticoid sensitivity and relieves a mouse allograft model of Cushing disease","volume":"21","author":"Paez-Pereda","year":"2015","journal-title":"Nat Med"},{"key":"55","doi-asserted-by":"publisher","first-page":"36407","DOI":"10.1074\/jbc.M004236200","article-title":"Binding of aryl hydrocarbon receptor (AhR) to AhR-interacting protein. The role of hsp90","volume":"275","author":"Poland","year":"2000","journal-title":"J Biol Chem"},{"key":"56","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1379\/1466-1268(2000)005<0243:AHARLA>2.0.CO;2","article-title":"Aryl hydrocarbon (Ah) receptor levels are selectively modulated by hsp90-associated immunophilin homolog XAP2","volume":"5","author":"Perdew","year":"2000","journal-title":"Cell Stress Chaperones"},{"key":"57","doi-asserted-by":"publisher","first-page":"11795","DOI":"10.1074\/jbc.M200053200","article-title":"Two distinct regions of the immunophilin-like protein XAP2 regulate dioxin receptor function and interaction with hsp90","volume":"277","author":"Pongratz","year":"2002","journal-title":"J Biol Chem"},{"key":"58","doi-asserted-by":"publisher","first-page":"2097","DOI":"10.1021\/bi301649m","article-title":"The FKBP-type domain of the human aryl hydrocarbon receptor-interacting protein reveals an unusual Hsp90 interaction","volume":"52","author":"Lucke","year":"2013","journal-title":"Biochemistry"},{"key":"59","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1016\/j.pharmthera.2012.08.014","article-title":"Comprehensive review on the HSC70 functions, interactions with related molecules and involvement in clinical diseases and therapeutic potential","volume":"136","author":"Cao","year":"2012","journal-title":"Pharmacol Ther"},{"key":"60","doi-asserted-by":"publisher","first-page":"1308","DOI":"10.1016\/j.cell.2012.10.051","article-title":"CDK-dependent Hsp70 Phosphorylation controls G1 cyclin abundance and cell-cycle progression","volume":"151","author":"Kron","year":"2012","journal-title":"Cell"},{"key":"61","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1038\/nmeth.2400","article-title":"Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS","volume":"10","author":"Superti-Furga","year":"2013","journal-title":"Nat Methods"},{"key":"62","article-title":"Interaction between AIP and the cAMP-dependent protein kinase (PKA) pathway in pituitary tumor formation","volume":"36","author":"Stratakis","year":"2015","journal-title":"Endocr Rev"},{"key":"63","doi-asserted-by":"publisher","first-page":"13602","DOI":"10.1021\/bi020399z","article-title":"Binding of hsp90-associated immunophilins to cytoplasmic dynein: direct binding andevidence that the peptidylprolyl isomerase domain is a dynein interaction domain","volume":"41","author":"Pratt","year":"2002","journal-title":"Biochemistry"},{"key":"64","doi-asserted-by":"publisher","first-page":"32310","DOI":"10.1074\/jbc.M203351200","article-title":"Two parallel pathways mediate cytoplasmic localization of the dioxin (aryl hydrocarbon) receptor","volume":"277","author":"Pongratz","year":"2002","journal-title":"J Biol Chem"},{"key":"65","doi-asserted-by":"publisher","first-page":"2677","DOI":"10.1074\/jbc.M209331200","article-title":"The hsp90 Co-chaperone XAP2 alters importin beta recognition of the bipartite nuclear localization signal of the Ah receptor and represses transcriptional activity","volume":"278","author":"Perdew","year":"2003","journal-title":"J Biol Chem"},{"key":"66","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1038\/nrm2369","article-title":"Tracking the ends: a dynamic protein network controls the fate of microtubule tips","volume":"9","author":"Steinmetz","year":"2008","journal-title":"Nat Rev Mol Cell Biol"},{"key":"67","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1038\/nrc2803","article-title":"Microtubules and resistance to tubulin-binding agents","volume":"10","author":"Kavallaris","year":"2010","journal-title":"Nat Rev Cancer"},{"key":"68","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1002\/cm.21027","article-title":"The chemical complexity of cellular microtubules: tubulin post-translational modification enzymes and their roles in tuning microtubule functions","volume":"69","author":"Roll-Mecak","year":"2012","journal-title":"Cytoskeleton (Hoboken)"},{"key":"69","doi-asserted-by":"publisher","first-page":"187","DOI":"10.3389\/fendo.2015.00187","article-title":"Dopamine and somatostatin analogues resistance of pituitary tumors: Focus on cytoskeleton involvement","volume":"6","author":"Mantovani","year":"2015","journal-title":"Front Endocrinol (Lausanne)"},{"key":"70","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1111\/j.1432-0436.1989.tb00820.x","article-title":"Laminin induces formation of neurite-like processes and potentiates prolactin secretion by GH3 rat pituitary cells","volume":"40","author":"Tixier-Vidal","year":"1989","journal-title":"Differentiation"},{"key":"71","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1093\/jnci\/80.3.200","article-title":"Evidence for a novel gene associated with low tumor metastatic potential","volume":"80","author":"Sobel","year":"1988","journal-title":"J Natl Cancer Inst"},{"key":"72","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1186\/1750-2187-9-4","article-title":"The metastasis suppressor Nm23 as a modulator of Ras\/ERK signaling","volume":"9","author":"Takacs-Vellai","year":"2014","journal-title":"J Mol Signal"},{"key":"73","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1016\/j.canlet.2015.02.050","article-title":"Metastasis suppressors Nm23H1 and Nm23H2 differentially regulate neoplastic transformation and tumorigenesis","volume":"361","author":"Wong","year":"2015","journal-title":"Cancer Lett"},{"key":"74","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1023\/A:1010655419332","article-title":"Genetic basis of pituitary adenoma invasiveness: a review","volume":"52","author":"Rutka","year":"2001","journal-title":"J Neurooncol"},{"key":"75","doi-asserted-by":"publisher","first-page":"1064","DOI":"10.1016\/j.cellsig.2013.02.010","article-title":"RGS19 inhibits Ras signaling through Nm23H1\/2-mediated phosphorylation of the kinase suppressor of Ras","volume":"25","author":"Wong","year":"2013","journal-title":"Cell Signal"},{"key":"76","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/(SICI)1097-0215(20000120)89:1<1::AID-IJC1>3.0.CO;2-7","article-title":"Genomic alterations (LOH, MI) on chromosome 17q21-23 and prognosis of sporadic colorectal cancer","volume":"89","author":"Crowe","year":"2000","journal-title":"Int J Cancer"},{"key":"77","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1007\/s00210-011-0649-3","article-title":"Learning about the functions of NME\/NM23: lessons from knockout mice to silencing strategies","volume":"384","author":"Lacombe","year":"2011","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"78","doi-asserted-by":"publisher","first-page":"7710","DOI":"10.1158\/0008-5472.CAN-10-1887","article-title":"Implication of metastasis suppressor NM23-H1 in maintaining adherens junctions and limiting the invasive potential of human cancer cells","volume":"70","author":"Lacombe","year":"2010","journal-title":"Cancer Res"},{"key":"79","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1007\/s11060-004-6150-9","article-title":"Magnetic resonance imaging and biological markers in pituitary adenomas with invasion of the cavernous sinus space","volume":"74","author":"Zhao","year":"2005","journal-title":"J Neurooncol"},{"key":"80","first-page":"823","article-title":"Gene expression profiling of familial and sporadic pituitary adenomas","volume":"32","author":"Korbonits","year":"2013","journal-title":"Endocrine Abstracts.15th European Congress of Endocrinology, Copenhagen, Denmark"},{"key":"81","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1172\/JCI39104","article-title":"The basics of epithelial-mesenchymal transition","volume":"119","author":"Weinberg","year":"2009","journal-title":"J Clin Invest"},{"key":"82","doi-asserted-by":"publisher","first-page":"E1506","DOI":"10.1210\/jc.2012-1760","article-title":"Gene Expression Profiling Identifies ESRP1 as a Potential Regulator of Epithelial Mesenchymal Transition in Somatotroph Adenomas from a Large Cohort of Patients with Acromegaly","volume":"97","author":"Bollerslev","year":"2012","journal-title":"J Clin Endocrinol Metab"},{"key":"83","doi-asserted-by":"publisher","first-page":"15","DOI":"10.18632\/genesandcancer.4","article-title":"SOD1, an unexpected novel target for cancer therapy","volume":"5","author":"Germain","year":"2014","journal-title":"Genes Cancer"},{"key":"84","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1530\/eje.1.02213","article-title":"Somatostatin analogues stimulate p27 expression and inhibit the MAP kinase pathway in pituitary tumours","volume":"155","author":"Nagy","year":"2006","journal-title":"Eur J Endocrinol"},{"key":"85","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/j.bbrc.2008.08.110","article-title":"The Cu-Zn superoxide dismutase (SOD1) inhibits ERK phosphorylation by muscarinic receptor modulation in rat pituitary GH3 cells","volume":"376","author":"Mondola","year":"2008","journal-title":"Biochem Biophys Res Commun"},{"key":"86","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1038\/nrn1587","article-title":"Modulation of neurodegeneration by molecular chaperones","volume":"6","author":"Wacker","year":"2005","journal-title":"Nat Rev Neurosci"},{"key":"87","doi-asserted-by":"publisher","first-page":"1895","DOI":"10.1021\/ac0262560","article-title":"Tandem mass tags: a novel quantification strategy for comparative analysis of complex protein mixtures by MS\/MS","volume":"75","author":"Hamon","year":"2003","journal-title":"Anal Chem"},{"key":"88","doi-asserted-by":"crossref","first-page":"3551","DOI":"10.1002\/(SICI)1522-2683(19991201)20:18<3551::AID-ELPS3551>3.0.CO;2-2","article-title":"Probability-based protein identification by searching sequence databases using mass spectrometry data","volume":"20","author":"Cottrell","year":"1999","journal-title":"Electrophoresis"},{"key":"89","unstructured":"QIAGEN. Ingenuity Pathways Analysis. www.qiagen.com\/ingenuity. 2015. Access date: 12\/17\/2013."},{"key":"90","doi-asserted-by":"publisher","first-page":"2390","DOI":"10.1210\/jc.2007-2611","article-title":"The role of the aryl hydrocarbon receptor-interacting protein gene in familial and sporadic pituitary adenomas","volume":"93","author":"Wray","year":"2008","journal-title":"J Clin Endocrinol Metab"},{"key":"91","doi-asserted-by":"publisher","first-page":"518","DOI":"10.1002\/mrd.22489","article-title":"The ImageJ ecosystem: An open platform for biomedical image analysis","volume":"82","author":"Eliceiri","year":"2015","journal-title":"Mol Reprod Dev"},{"key":"92","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1111\/j.1365-2818.2006.01706.x","article-title":"A guided tour into subcellular colocalization analysis in light microscopy","volume":"224","author":"Cordelieres","year":"2006","journal-title":"J Microsc"},{"key":"93","doi-asserted-by":"publisher","first-page":"C723","DOI":"10.1152\/ajpcell.00462.2010","article-title":"A practical guide to evaluating colocalization in biological microscopy","volume":"300","author":"McDonald","year":"2011","journal-title":"Am J Physiol Cell Physiol"},{"key":"94","unstructured":"White, Kazimiers, Schindelin. Coloc 2 - Standardized, modular, pixel intensity correlation over space based colocalization analysis. http:\/\/imagej.net\/Coloc_2. 2015. Access date: 21-10-2016."},{"key":"95","doi-asserted-by":"publisher","first-page":"6970","DOI":"10.1073\/pnas.1322545111","article-title":"TRIM65 regulates microRNA activity by ubiquitination of TNRC6","volume":"111","author":"Dorf","year":"2014","journal-title":"Proc Natl Acad Sci USA"},{"key":"96","doi-asserted-by":"publisher","first-page":"37448","DOI":"10.1074\/jbc.M006873200","article-title":"Subcellular localization of the aryl hydrocarbon receptor is modulated by the immunophilin homolog hepatitis B virus X-associated protein 2","volume":"275","author":"Perdew","year":"2000","journal-title":"J Biol Chem"},{"key":"97","doi-asserted-by":"publisher","first-page":"41317","DOI":"10.1074\/jbc.M007765200","article-title":"The immunophilin-like protein XAP2 regulates ubiquitination and subcellular localization of the dioxin receptor","volume":"275","author":"Pongratz","year":"2000","journal-title":"J Biol Chem"},{"key":"98","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1124\/mol.106.024380","article-title":"The aryl hydrocarbon receptor signaling pathway is modified through interactions with a Kelch protein","volume":"70","author":"Bradfield","year":"2006","journal-title":"Mol Pharmacol"},{"key":"99","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1186\/s12964-014-0049-7","article-title":"AIP augments CARMA1-BCL10-MALT1 complex formation to facilitate NF-kappaB signaling upon T cell activation","volume":"12","author":"Krappmann","year":"2014","journal-title":"Cell Commun Signal"},{"key":"100","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1016\/j.cell.2015.06.043","article-title":"The BioPlex network: a systematic exploration of the human interactome","volume":"162","author":"Vaites","year":"2015","journal-title":"Cell"},{"key":"101","doi-asserted-by":"publisher","first-page":"434","DOI":"10.1016\/j.cell.2014.05.039","article-title":"A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways","volume":"158","author":"Lindquist","year":"2014","journal-title":"Cell"},{"key":"102","doi-asserted-by":"publisher","first-page":"536","DOI":"10.1038\/msb.2011.67","article-title":"Toward an understanding of the protein interaction network of the human liver","volume":"7","author":"Wei","year":"2011","journal-title":"Mol Syst Biol"},{"key":"103","doi-asserted-by":"publisher","first-page":"4632","DOI":"10.1002\/pmic.201100339","article-title":"A bead-based approach for large-scale identification ofkinase substrates","volume":"11","author":"Zou","year":"2011","journal-title":"Proteomics"},{"key":"104","doi-asserted-by":"publisher","first-page":"ra84","DOI":"10.1126\/scisignal.2000576","article-title":"Regulation of epidermal growth factor receptor trafficking by lysine deacetylase HDAC6","volume":"2","author":"Brown","year":"2009","journal-title":"Sci Signal"},{"key":"105","doi-asserted-by":"publisher","first-page":"907","DOI":"10.1038\/nmeth.2131","article-title":"A high-throughput approach for measuring temporal changes in the interactome","volume":"9","author":"Foster","year":"2012","journal-title":"Nat Methods"},{"key":"106","doi-asserted-by":"publisher","first-page":"e25201","DOI":"10.1371\/journal.pone.0025201","article-title":"The immunophilin-like protein XAP2 is a negative regulator of estrogen signaling through interaction with estrogen receptor alpha","volume":"6","author":"Pongratz","year":"2011","journal-title":"PLoS One"},{"key":"107","doi-asserted-by":"publisher","first-page":"1068","DOI":"10.1016\/j.cell.2012.08.011","article-title":"A census of human soluble protein complexes","volume":"150","author":"Hu","year":"2012","journal-title":"Cell"},{"key":"108","doi-asserted-by":"publisher","first-page":"622","DOI":"10.1038\/embor.2009.35","article-title":"G-protein signalling negatively regulates the stability of aryl hydrocarbon receptor","volume":"10","author":"Itoh","year":"2009","journal-title":"EMBO Rep"},{"key":"109","doi-asserted-by":"publisher","first-page":"8907","DOI":"10.1021\/bi982223w","article-title":"Characterization of the AhR-hsp90-XAP2 core complex and the role of the immunophilin-related protein XAP2 in AhR stabilization","volume":"38","author":"Perdew","year":"1999","journal-title":"Biochemistry"},{"key":"110","doi-asserted-by":"publisher","first-page":"1493","DOI":"10.1016\/j.febslet.2009.03.072","article-title":"XAP2 inhibits glucocorticoid receptor activity in mammalian cells","volume":"583","author":"Rein","year":"2009","journal-title":"FEBS Lett"},{"key":"111","doi-asserted-by":"publisher","first-page":"e11717","DOI":"10.1371\/journal.pone.0011717","article-title":"Differential impact of tetratricopeptide repeat proteins on the steroid hormone receptors","volume":"5","author":"Rein","year":"2010","journal-title":"PLoS One"},{"key":"112","doi-asserted-by":"publisher","first-page":"744","DOI":"10.1016\/j.cell.2010.01.044","article-title":"An atlas of combinatorial transcriptional regulation in mouse and man","volume":"140","author":"Forrest","year":"2010","journal-title":"Cell"},{"key":"113","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1016\/j.immuni.2011.06.014","article-title":"Mapping a dynamic innate immunity protein interaction network regulating type I interferon production","volume":"35","author":"Dorf","year":"2011","journal-title":"Immunity"},{"key":"114","doi-asserted-by":"publisher","first-page":"14729","DOI":"10.1074\/jbc.M114.633065","article-title":"Aryl hydrocarbon receptor interacting protein targets IRF7 to suppress antiviral signaling and the induction of type I interferon","volume":"290","author":"Harhaj","year":"2015","journal-title":"J Biol Chem"},{"key":"115","doi-asserted-by":"publisher","first-page":"3782","DOI":"10.1128\/MCB.24.9.3782-3793.2004","article-title":"Normal development and fertility of knockout mice lacking the tumor suppressor gene LRP1b suggest functional compensation by LRP1","volume":"24","author":"Herz","year":"2004","journal-title":"Mol Cell Biol"},{"key":"116","doi-asserted-by":"publisher","first-page":"1484","DOI":"10.1016\/j.cell.2015.10.065","article-title":"A dynamic protein interaction landscape of the human centrosome-cilium interface","volume":"163","author":"Knight","year":"2015","journal-title":"Cell"},{"key":"117","doi-asserted-by":"publisher","first-page":"33351","DOI":"10.1074\/jbc.M303269200","article-title":"Attenuation of the activity of the cAMP-specific phosphodiesterase PDE4A5 by interaction with the immunophilin XAP2","volume":"278","author":"Houslay","year":"2003","journal-title":"J Biol Chem"},{"key":"118","doi-asserted-by":"publisher","first-page":"13656","DOI":"10.1074\/jbc.M610942200","article-title":"Phosphodiesterase 2A forms a complex with the co-chaperone XAP2 and regulates nuclear translocation of the aryl hydrocarbon receptor","volume":"282","author":"Smolenski","year":"2007","journal-title":"J Biol Chem"},{"key":"119","unstructured":"Wan, Borgeson, Phanse, Tu, Drew, Clark, Xiong, Kagan, Kwan, Berzginov, Chessman, Pal, Cromar, et al. Panorama of ancient metazoan macromolecular complexes (pre-publication dataset)http:\/\/thebiogrid.org\/185267\/publication\/panorama-of-ancient-metazoan-macromolecular-complexes.html. 2015. Access date: 19\/08\/2016."},{"key":"120","doi-asserted-by":"publisher","first-page":"4467","DOI":"10.1074\/jbc.M211261200","article-title":"Evidence that peroxisome proliferator-activated receptor alpha is complexed with the 90-kDa heat shock protein and the hepatitis virus B X-associated protein 2","volume":"278","author":"Perdew","year":"2003","journal-title":"J Biol Chem"},{"key":"121","doi-asserted-by":"publisher","first-page":"rs15","DOI":"10.1126\/scisignal.2004712","article-title":"Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions","volume":"6","author":"Gingras","year":"2013","journal-title":"Sci Signal"},{"key":"122","doi-asserted-by":"publisher","first-page":"2571","DOI":"10.1210\/jc.2008-1980","article-title":"The tyrosine kinase receptor RET interactswith aryl hydrocarbon receptor-interacting protein to alter survivin availability","volume":"94","author":"Bonora","year":"2009","journal-title":"J Clin Endocrinol Metab"},{"key":"123","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1007\/s00109-003-0427-x","article-title":"Cloning and characterization of a novel cardiac-specific kinase that interacts specifically with cardiac troponin I","volume":"81","author":"Ding","year":"2003","journal-title":"J Mol Med (Berl)"},{"key":"124","doi-asserted-by":"publisher","first-page":"1035","DOI":"10.1038\/sj.embor.7400778","article-title":"The co-chaperone XAP2 is required for activation of hypothalamic thyrotropin-releasing hormone transcription","volume":"7","author":"Demeneix","year":"2006","journal-title":"EMBO Rep"},{"key":"125","doi-asserted-by":"publisher","first-page":"M110","DOI":"10.1074\/mcp.M110.003590","article-title":"Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level","volume":"10","author":"Nielsen","year":"2011","journal-title":"Mol Cell Proteomics"},{"key":"126","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1016\/j.molcel.2011.08.025","article-title":"Systematic and quantitative assessment of the ubiquitin-modified proteome","volume":"44","author":"Gygi","year":"2011","journal-title":"Mol Cell"},{"key":"127","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1074\/mcp.M111.016857","article-title":"Methods for quantification ofchanges in protein ubiquitination following proteasome and deubiquitinase inhibition","volume":"11","author":"Carr","year":"2012","journal-title":"Mol Cell Proteomics"},{"key":"128","doi-asserted-by":"publisher","first-page":"1089","DOI":"10.1038\/ncb2579","article-title":"Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass","volume":"14","author":"Choudhary","year":"2012","journal-title":"Nat Cell Biol"},{"key":"129","doi-asserted-by":"publisher","first-page":"3107","DOI":"10.1021\/pr4012443","article-title":"A COFRADIC protocol to study protein ubiquitination","volume":"13","author":"Gevaert","year":"2014","journal-title":"J Proteome Res"},{"key":"130","first-page":"249","article-title":"Loss of heterozygosity on chromosome 11q13 in two families with acromegaly\/gigantism is independent of mutations of the multiple endocrine neoplasia type I gene","volume":"84","author":"Frohman","year":"1999","journal-title":"J Clin Endocrinol Metab"},{"key":"131","doi-asserted-by":"publisher","first-page":"950","DOI":"10.1002\/humu.21292","article-title":"Characterization of aryl hydrocarbon receptor interacting protein (AIP) mutations in familial isolated pituitary adenoma families","volume":"31","author":"Kumar","year":"2010","journal-title":"Hum Mutat"},{"key":"132","article-title":"Functional homology between human and fruitfly AIP protein - anassay system to test the pathogenicity of AIP mutations","volume":"36","author":"Korbonits","year":"2015","journal-title":"Endocr Rev"},{"key":"133","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1056\/NEJMoa1008020","article-title":"AIP mutation in pituitary adenomas in the 18th century and today","volume":"364","author":"Akker","year":"2011","journal-title":"N Engl J Med"},{"key":"134","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1002\/humu.23121","article-title":"Increased Population Risk of AIP-Related Acromegaly and Gigantism in Ireland","volume":"38","author":"Hernandez-Ramirez","year":"2017","journal-title":"Hum Mutat"},{"key":"135","doi-asserted-by":"publisher","first-page":"800","DOI":"10.3275\/6956","article-title":"The R304X mutation of the aryl hydrocarbon receptor interacting protein gene in familial isolated pituitary adenomas: Mutational hot-spot or founder effect?","volume":"33","author":"Scaroni","year":"2010","journal-title":"J Endocrinol Invest"},{"key":"136","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1530\/ERC-16-0041","article-title":"AIP mutations impair AhR signaling in pituitary adenoma patients fibroblasts and in GH3 cells","volume":"23","author":"Kamenicky","year":"2016","journal-title":"Endocr Relat Cancer"},{"key":"137","doi-asserted-by":"publisher","first-page":"4101","DOI":"10.1073\/pnas.0700004104","article-title":"Molecular diagnosis of pituitary adenoma predisposition caused by aryl hydrocarbon receptor-interacting protein gene mutations","volume":"104","author":"De ME Weil","year":"2007","journal-title":"Proc Natl Acad Sci USA"}],"container-title":["Oncotarget"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.24183","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,12]],"date-time":"2022-08-12T10:29:11Z","timestamp":1660300151000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.24183"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1,11]]},"references-count":137,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2018,2,6]]}},"alternative-id":["24183","29507682"],"URL":"https:\/\/doi.org\/10.18632\/oncotarget.24183","relation":{},"ISSN":["1949-2553"],"issn-type":[{"value":"1949-2553","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1,11]]}}}