{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T13:06:14Z","timestamp":1770901574139,"version":"3.50.1"},"reference-count":28,"publisher":"Impact Journals, LLC","issue":"13","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncotarget"],"published-print":{"date-parts":[[2018,2,16]]},"DOI":"10.18632\/oncotarget.24371","type":"journal-article","created":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T13:05:50Z","timestamp":1517490350000},"page":"11258-11267","source":"Crossref","is-referenced-by-count":4,"title":["Regulatory effects of Nr4a2 on Th2 cells from patients with pemphigus vulgaris"],"prefix":"10.18632","volume":"9","author":[{"given":"Jianbo","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Dermatology, Hunan Key Laboratory of Medical Epigenomics, The Second Xiangya Hospital of Central South University, Changsha 410011, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Hunan Key Laboratory of Medical Epigenomics, The Second Xiangya Hospital of Central South University, Changsha 410011, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunsheng","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Hunan Key Laboratory of Medical Epigenomics, The Second Xiangya Hospital of Central South University, Changsha 410011, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Hunan Key Laboratory of Medical Epigenomics, The Second Xiangya Hospital of Central South University, Changsha 410011, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hai","family":"Long","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Hunan Key Laboratory of Medical Epigenomics, The Second Xiangya Hospital of Central South University, Changsha 410011, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rong","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Hunan Key Laboratory of Medical Epigenomics, The Second Xiangya Hospital of Central South University, Changsha 410011, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haijing","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Hunan Key Laboratory of Medical Epigenomics, The Second Xiangya Hospital of Central South University, Changsha 410011, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jieyue","family":"Liao","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Hunan Key Laboratory of Medical Epigenomics, The Second Xiangya Hospital of Central South University, Changsha 410011, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuaihantian","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Hunan Key Laboratory of Medical Epigenomics, The Second Xiangya Hospital of Central South University, Changsha 410011, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guiying","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Hunan Key Laboratory of Medical Epigenomics, The Second Xiangya Hospital of Central South University, Changsha 410011, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qianjin","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Hunan Key Laboratory of Medical Epigenomics, The Second Xiangya Hospital of Central South University, Changsha 410011, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7892","published-online":{"date-parts":[[2018,2,1]]},"reference":[{"key":"1","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1007\/s10875-011-9597-4","article-title":"Cognate Th2-B cell interaction is essential for the autoantibody production in pemphigus vulgaris","volume":"32","author":"Pan","year":"2012","journal-title":"J Clin Immunol"},{"key":"2","doi-asserted-by":"crossref","first-page":"6468","DOI":"10.4049\/jimmunol.172.10.6468","article-title":"Type I regulatory T cells specific for desmoglein 3 are more frequently detected in healthy individuals than in patients with pemphigus vulgaris","volume":"172","author":"Hertl","year":"2004","journal-title":"J Immunol"},{"key":"3","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1111\/exd.12011","article-title":"Evidence for pathogenicity of autoreactive T cells in autoimmune bullous diseases shown by animal disease models","volume":"21","author":"Shimizu","year":"2012","journal-title":"Exp Dermatol"},{"key":"4","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1111\/exd.12229","article-title":"Autoreactive T cells in the immune pathogenesis of pemphigus vulgaris","volume":"22","author":"Hertl","year":"2013","journal-title":"Exp Dermatol"},{"key":"5","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.clim.2009.11.006","article-title":"Clinical activity of pemphigus vulgaris relates to IgE autoantibodies against desmoglein 3","volume":"134","author":"Hertl","year":"2010","journal-title":"Clin Immunol"},{"key":"6","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.tracli.2007.10.003","article-title":"Pemphigus and HLA in Morocco","volume":"14","author":"Essakalli","year":"2007","journal-title":"Transfus Clin Biol"},{"key":"7","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1111\/j.1365-2230.2005.01836.x","article-title":"Direct characterization of human T cells in pemphigus vulgaris reveals elevated autoantigen-specific Th2 activity in association with active disease","volume":"30","author":"Sinha","year":"2005","journal-title":"Clin Exp Dermatol"},{"key":"8","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.immuni.2014.06.006","article-title":"GATA-3 function in innate and adaptive immunity","volume":"41","author":"Hendriks","year":"2014","journal-title":"Immunity"},{"key":"9","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1038\/ncomms2260","article-title":"T-bet and GATA3 orchestrate Th1 and Th2 differentiation through lineage-specific targeting of distal regulatory elements","volume":"3","author":"Jenner","year":"2012","journal-title":"Nat Commun"},{"key":"10","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1146\/annurev.immunol.23.021704.115821","article-title":"Regulation of Th2 differentiation and Il4 locus accessibility","volume":"24","author":"Rao","year":"2006","journal-title":"Annu Rev Immunol"},{"key":"11","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1080\/08820130902943097","article-title":"Involvement of TH1\/TH2 cytokines in the pathogenesis of autoimmune skin disease\u2014pemphigus vulgaris","volume":"38","author":"Sharma","year":"2009","journal-title":"Immunol Invest"},{"key":"12","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1189\/jlb.1107782","article-title":"Pivotal Advance: Th-1 cytokines inhibit, and Th-2 cytokines promote fibrocyte differentiation","volume":"83","author":"Pilling","year":"2008","journal-title":"J Leukoc Biol"},{"key":"13","first-page":"223","article-title":"Th1\/Th2 balance: the hypothesis, its limitations, and implications for health and disease","volume":"8","author":"Kidd","year":"2003","journal-title":"Altern Med Rev"},{"key":"14","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1111\/j.1365-2567.2008.02932.x","article-title":"Desmoglein 3-specific T regulatory 1 cells consist of two subpopulations with differential expression of the transcription factor Foxp3","volume":"127","author":"Hertl","year":"2009","journal-title":"Immunology"},{"key":"15","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1038\/nature01645","article-title":"Structure and function of Nurr1 identifies a class of ligand-independent nuclear receptors","volume":"423","author":"Perlmann","year":"2003","journal-title":"Nature"},{"key":"16","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1038\/nrd1551","article-title":"Principles for modulation of the nuclear receptor superfamily","volume":"3","author":"Laudet","year":"2004","journal-title":"Nat Rev Drug Discov"},{"key":"17","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.cell.2009.01.038","article-title":"A Nurr1\/CoREST pathway in microglia and astrocytes protects dopaminergic neurons from inflammation-induced death","volume":"137","author":"Glass","year":"2009","journal-title":"Cell"},{"key":"18","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1038\/ni.2546","article-title":"'Nurr'ishing Treg cells: Nr4a transcription factors control Foxp3 expression","volume":"14","author":"Rao","year":"2013","journal-title":"Nat Immunol"},{"key":"19","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1038\/ni.2520","article-title":"Nr4a receptors are essential for thymic regulatory T cell development and immune homeostasis","volume":"14","author":"Yoshimura","year":"2013","journal-title":"Nat Immunol"},{"key":"20","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1111\/j.1346-8138.2009.00797.x","article-title":"Immune dysregulation of pemphigus in humans and mice","volume":"37","author":"Amagai","year":"2010","journal-title":"J Dermatol"},{"key":"21","doi-asserted-by":"crossref","first-page":"S12","DOI":"10.1007\/s00403-002-0367-2","article-title":"History of the establishment and revision of diagnostic criteria, severity index and therapeutic guidelines for pemphigus in Japan","volume":"295","author":"Ogawa","year":"2003","journal-title":"Arch Dermatol Res"},{"key":"22","doi-asserted-by":"crossref","first-page":"1740","DOI":"10.4049\/jimmunol.182.3.1740","article-title":"A single helper T cell clone is sufficient to commit polyclonal naive B cells to produce pathogenic IgG in experimental pemphigus vulgaris","volume":"182","author":"Amagai","year":"2009","journal-title":"J Immunol"},{"key":"23","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.4049\/jimmunol.181.2.1526","article-title":"Novel system evaluatingpathogenicity of desmoglein 3-reactive T cell clones using murine pemphigus vulgaris","volume":"181","author":"Kuwana","year":"2008","journal-title":"J Immunol"},{"key":"24","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1046\/j.0022-202x.2001.01505.x","article-title":"Skin-homing interleukin-4 and -13-producing cells contribute to bullous pemphigoid: remission of disease is associated with increased frequency ofinterleukin-10-producing cells","volume":"117","author":"Shiohara","year":"2001","journal-title":"J Invest Dermatol"},{"key":"25","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.immuni.2011.08.007","article-title":"Genome-wide analyses of transcription factor GATA3-mediated gene regulation in distinct T cell types","volume":"35","author":"Zhao","year":"2011","journal-title":"Immunity"},{"key":"26","doi-asserted-by":"crossref","first-page":"e1001633","DOI":"10.1371\/journal.pbio.1001633","article-title":"Stable T-bet(+)GATA-3(+) Th1\/Th2 hybrid cells arise, can develop directly from naive precursors, and limit immunopathologic inflammation","volume":"11","author":"L\u00f6hning","year":"2013","journal-title":"PLoS Biol"},{"key":"27","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S0022-1759(03)00200-X","article-title":"T-bet\/GATA-3 ratio as a measure of the Th1\/Th2 cytokine profile in mixed cell populations: predominant role of GATA-3","volume":"278","author":"Scott","year":"2003","journal-title":"J Immunol Methods"},{"key":"28","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1006\/clim.2000.4974","article-title":"Further support for a role for Th2-like cytokines in blister formation of pemphigus","volume":"98","author":"Fabbri","year":"2001","journal-title":"Clin Immunol"}],"container-title":["Oncotarget"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.24371","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T11:59:12Z","timestamp":1589025552000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.24371"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2,1]]},"references-count":28,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2018,2,16]]}},"alternative-id":["24371","29541411"],"URL":"https:\/\/doi.org\/10.18632\/oncotarget.24371","relation":{},"ISSN":["1949-2553"],"issn-type":[{"value":"1949-2553","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,2,1]]}}}