{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T18:00:45Z","timestamp":1780941645623,"version":"3.54.1"},"reference-count":38,"publisher":"Impact Journals, LLC","issue":"27","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncotarget"],"published-print":{"date-parts":[[2018,4,10]]},"DOI":"10.18632\/oncotarget.24787","type":"journal-article","created":{"date-parts":[[2018,4,9]],"date-time":"2018-04-09T09:08:58Z","timestamp":1523264938000},"page":"18844-18857","source":"Crossref","is-referenced-by-count":13,"title":["Isolated metastasis of an EGFR-L858R-mutated NSCLC of the meninges: the potential impact of CXCL12\/CXCR4 axis in EGFRmut NSCLC in diagnosis, follow-up and treatment"],"prefix":"10.18632","volume":"9","author":[{"given":"Florian","family":"L\u00fcke","sequence":"first","affiliation":[{"name":"Department of Internal Medicine III, University Hospital Regensburg, Regensburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raquel","family":"Blazquez","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine III, University Hospital Regensburg, Regensburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rezan Fahrioglu","family":"Yamaci","sequence":"additional","affiliation":[{"name":"Chair of Experimental Medicine and Therapy Research, University of Regensburg, Regensburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Lu","sequence":"additional","affiliation":[{"name":"Chair of Experimental Medicine and Therapy Research, University of Regensburg, Regensburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benedikt","family":"Pregler","sequence":"additional","affiliation":[{"name":"Institute of Radiology, University Hospital Regensburg, Regensburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Hannus","sequence":"additional","affiliation":[{"name":"Intana Bioscience GmbH, Martinsried, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin","family":"Menhart","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, University Hospital Regensburg, Regensburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk","family":"Hellwig","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, University Hospital Regensburg, Regensburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans-J\u00fcrgen","family":"Wester","sequence":"additional","affiliation":[{"name":"Chair of Pharmaceutical Radiochemistry, Technische Universit\u00e4t M\u00fcnchen, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saskia","family":"Kropf","sequence":"additional","affiliation":[{"name":"SCINTOMICS GmbH, Fuerstenfeldbruck, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Heudobler","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine III, University Hospital Regensburg, Regensburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jirka","family":"Grosse","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, University Hospital Regensburg, Regensburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jutta","family":"Moosbauer","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, University Hospital Regensburg, Regensburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Hutterer","sequence":"additional","affiliation":[{"name":"Department of Neurology, University Hospital Regensburg, Regensburg, Germany"},{"name":"Wilhelm Sander-Neurooncology Unit, University Hospital Regensburg, Regensburg, Germany"},{"name":"Department of Neurology 1, NeuroMed Campus, Kepler University Hospital Linz, Linz, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Hau","sequence":"additional","affiliation":[{"name":"Department of Neurology, University Hospital Regensburg, Regensburg, Germany"},{"name":"Wilhelm Sander-Neurooncology Unit, University Hospital Regensburg, Regensburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus J.","family":"Riemenschneider","sequence":"additional","affiliation":[{"name":"Department of Neuropathology, University Hospital Regensburg, Regensburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michaela","family":"Bayerlov\u00e1","sequence":"additional","affiliation":[{"name":"University Medical Center G\u00f6ttingen, Department of Medical Statistics, G\u00f6ttingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annalen","family":"Bleckmann","sequence":"additional","affiliation":[{"name":"University Medical Center G\u00f6ttingen, Department of Medical Statistics, G\u00f6ttingen, Germany"},{"name":"University Medical Center G\u00f6ttingen, Department of Hematology and Oncology, G\u00f6ttingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernhard","family":"Polzer","sequence":"additional","affiliation":[{"name":"Division Personalized Tumor Therapy, Fraunhofer Institute for Toxicology and Experimental Medicine, Regensburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim","family":"Bei\u00dfbarth","sequence":"additional","affiliation":[{"name":"University Medical Center G\u00f6ttingen, Department of Medical Statistics, G\u00f6ttingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph A.","family":"Klein","sequence":"additional","affiliation":[{"name":"Chair of Experimental Medicine and Therapy Research, University of Regensburg, Regensburg, Germany"},{"name":"Division Personalized Tumor Therapy, Fraunhofer Institute for Toxicology and Experimental Medicine, Regensburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Pukrop","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine III, University Hospital Regensburg, Regensburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7892","published-online":{"date-parts":[[2018,4,10]]},"reference":[{"key":"1","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/j.bbcan.2015.08.002","article-title":"Lung cancer: biology and treatment options","volume":"1856","author":"Buchanan","year":"2015","journal-title":"Biochimica et biophysica acta"},{"key":"2","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1038\/nrclinonc.2017.14","article-title":"Integrating liquid biopsies into the management of cancer","volume":"14","author":"Bardelli","year":"2017","journal-title":"Nat Rev Clin Oncol"},{"key":"3","doi-asserted-by":"publisher","first-page":"8760","DOI":"10.1038\/ncomms9760","article-title":"Multifocal clonal evolution characterized using circulating tumour DNA in a case of metastatic breast cancer","volume":"6","author":"Contente-Cuomo","year":"2015","journal-title":"Nat Commun"},{"key":"4","doi-asserted-by":"publisher","first-page":"2404","DOI":"10.1200\/JCO.2016.66.6487","article-title":"Evaluating Cancer of the Central Nervous System Through Next-Generation Sequencing of Cerebrospinal Fluid","volume":"34","author":"Selcuklu","year":"2016","journal-title":"J Clin Oncol"},{"key":"5","doi-asserted-by":"publisher","first-page":"5480","DOI":"10.1158\/1078-0432.CCR-17-0047","article-title":"Detection of Driver and Resistance Mutations in Leptomeningeal Metastases of NSCLC by Next-Generation Sequencing of Cerebrospinal Fluid Circulating Tumor Cells","volume":"23","author":"Zhou","year":"2017","journal-title":"Clin Cancer Res"},{"key":"6","doi-asserted-by":"publisher","first-page":"v1","DOI":"10.1093\/annonc\/mdw326","article-title":"Metastatic non-small-cell lung cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up","volume":"27","author":"Peters","year":"2016","journal-title":"Ann Oncol"},{"key":"7","article-title":"Lungenkarzinom-nicht-kleinzellig-nsclc","author":"Wolf","year":"2017","journal-title":"Onkopedia Leitlinien"},{"key":"8","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1097\/mcp.0000000000000182","article-title":"Update on F-18-fluoro-deoxy-glucose-PET\/computed tomography in nonsmall cell lung cancer","volume":"21","author":"Oyen","year":"2015","journal-title":"Current Opinion in Pulmonary Medicine"},{"key":"9","doi-asserted-by":"publisher","first-page":"1331","DOI":"10.1002\/glia.22518","article-title":"Carcinoma cells misuse the host tissue damage response to invade the brain","volume":"61","author":"Hanisch","year":"2013","journal-title":"Glia"},{"key":"10","doi-asserted-by":"publisher","first-page":"13574","DOI":"10.1038\/srep13574","article-title":"EGFR-L858R mutant enhances lung adenocarcinoma cell invasive ability and promotes malignant pleural effusion formation through activation of the CXCL12-CXCR4 pathway","volume":"5","author":"Shih","year":"2015","journal-title":"Sci Rep"},{"key":"11","doi-asserted-by":"publisher","first-page":"5022","DOI":"10.18632\/oncotarget.3217","article-title":"CXCR4 over-expression and survival in cancer: A system review and meta-analysis","volume":"6","author":"Zhao","year":"2015","journal-title":"Oncotarget"},{"key":"12","first-page":"47","volume-title":"Advances in Immunology","author":"Frederick","year":"2017"},{"key":"13","doi-asserted-by":"publisher","first-page":"618","DOI":"10.7150\/thno.11251","article-title":"Disclosing the CXCR4 expression in lymphoproliferative diseases by targeted molecular imaging","volume":"5","author":"Kessler","year":"2015","journal-title":"Theranostics"},{"key":"14","doi-asserted-by":"publisher","first-page":"1803","DOI":"10.2967\/jnumed.111.098798","article-title":"PET of CXCR4 expression by a (68)Ga-labeled highly specific targeted contrast agent","volume":"52","author":"Wester","year":"2011","journal-title":"J Nucl Med"},{"key":"15","doi-asserted-by":"publisher","first-page":"205","DOI":"10.7150\/thno.16576","article-title":"[68Ga]Pentixafor-PET\/CT for imaging of chemokine receptor CXCR4 expression in multiple myeloma - Comparison to [18F]FDG and laboratory values","volume":"7","author":"Luckerath","year":"2017","journal-title":"Theranostics"},{"key":"16","doi-asserted-by":"publisher","first-page":"477","DOI":"10.15252\/emmm.201404698","article-title":"molecular imaging of chemokine receptor CXCR4 expression in patients with advanced multiple myeloma","volume":"7","author":"Lapa","year":"2015","journal-title":"EMBO Mol Med"},{"key":"17","doi-asserted-by":"publisher","first-page":"741","DOI":"10.2967\/jnumed.115.161034","article-title":"First Experience with Chemokine Receptor CXCR4-Targeted PET Imaging of Patients with Solid Cancers","volume":"57","author":"Schwaiger","year":"2016","journal-title":"Journal of Nuclear Medicine"},{"key":"18","doi-asserted-by":"publisher","first-page":"9288","DOI":"10.18632\/oncotarget.7063","article-title":"[68Ga]Pentixafor-PET\/CT for imaging of chemokine receptor 4 expression in small cell lung cancer\u2014initial experience","volume":"7","author":"Herrmann","year":"2016","journal-title":"Oncotarget"},{"key":"19","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1006\/geno.1993.1251","article-title":"Molecular Cloning of the cDNA and Chromosomal Localization of the Gene for a Putative Seven-Transmembrane Segment (7-TMS) Receptor Isolated from Human Spleen","volume":"16","author":"Jirik","year":"1993","journal-title":"Genomics"},{"key":"20","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1038\/382829a0","article-title":"The lymphocyte chemoattractant SDF-1 is a ligand for LESTR\/fusin and blocks HIV-1 entry","volume":"382","author":"Springer","year":"1996","journal-title":"Nature"},{"key":"21","doi-asserted-by":"publisher","first-page":"6246","DOI":"10.1038\/onc.2016.160","article-title":"MIF-CD74 signaling impedes microglial M1 polarization and facilitates brain tumorigenesis","volume":"35","author":"Eyupoglu","year":"2016","journal-title":"Oncogene"},{"key":"22","doi-asserted-by":"crossref","first-page":"59","DOI":"10.2174\/1871520615666150824153032","article-title":"CXCR4 and Glioblastoma","volume":"16","author":"Richardson","year":"2016","journal-title":"Anticancer Agents Med Chem"},{"key":"23","first-page":"3833","article-title":"The chemokine receptor CXCR4 is required for outgrowth of colon carcinoma micrometastases","volume":"63","author":"Roos","year":"2003","journal-title":"Cancer Res"},{"key":"24","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/j.cyto.2013.12.008","article-title":"CXC chemokine receptor 4 signaling upon co-activation with stromal cell-derived factor-1alpha and ubiquitin","volume":"65","author":"Majetschak","year":"2014","journal-title":"Cytokine"},{"key":"25","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s11010-017-3044-7","article-title":"Functional and structural consequences of chemokine (C-X-C motif) receptor 4 activation with cognate and non-cognate agonists","author":"Majetschak","year":"2017","journal-title":"Molecular and Cellular Biochemistry"},{"key":"26","doi-asserted-by":"publisher","first-page":"1371","DOI":"10.15252\/emmm.201404033","article-title":"Molecular profiling of single circulating tumor cells with diagnostic intention","volume":"6","author":"Sergio","year":"2014","journal-title":"EMBO Mol Med"},{"key":"27","doi-asserted-by":"publisher","first-page":"1882","DOI":"10.1182\/blood-2002-03-0918","article-title":"Extracellular ubiquitin inhibits the TNF-alpha response to endotoxin in peripheral blood mononuclear cells and regulates endotoxin hyporesponsiveness in critical illness","volume":"101","author":"Obertacke","year":"2003","journal-title":"Blood"},{"key":"28","doi-asserted-by":"publisher","first-page":"1544","DOI":"10.1097\/01.tp.0000236057.56721.d0","article-title":"Prolongation of skin graft survival by exogenous ubiquitin","volume":"82","author":"Majetschak","year":"2006","journal-title":"Transplantation"},{"key":"29","doi-asserted-by":"publisher","first-page":"4184","DOI":"10.1021\/bi400254f","article-title":"Modulation of the CXC chemokine receptor 4 agonist activity of ubiquitin through C-terminal protein modification","volume":"52","author":"Majetschak","year":"2013","journal-title":"Biochemistry"},{"key":"30","doi-asserted-by":"publisher","first-page":"15566","DOI":"10.1074\/jbc.M110.103408","article-title":"CXC chemokine receptor 4 is a cell surface receptor for extracellular ubiquitin","volume":"285","author":"Majetschak","year":"2010","journal-title":"J Biol Chem"},{"key":"31","doi-asserted-by":"publisher","first-page":"44145","DOI":"10.1074\/jbc.M111.298505","article-title":"Structural determinants of ubiquitin-CXC chemokine receptor 4 interaction","volume":"286","author":"Majetschak","year":"2011","journal-title":"J Biol Chem"},{"key":"32","doi-asserted-by":"publisher","first-page":"33466","DOI":"10.1074\/jbc.M111.233742","article-title":"The CXC chemokine receptor 4 ligands ubiquitin and stromal cell-derived factor-1alpha function through distinct receptor interactions","volume":"286","author":"Majetschak","year":"2011","journal-title":"J Biol Chem"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.3390\/ijms17060971","article-title":"New Insights into Mechanisms and Functions of Chemokine (C-X-C Motif) Receptor 4 Heteromerization in Vascular Smooth Muscle","volume":"17","author":"Majetschak","year":"2016","journal-title":"Int J Mol Sci"},{"key":"34","doi-asserted-by":"publisher","first-page":"96732","DOI":"10.18632\/oncotarget.18235","article-title":"Targeting CXCR4 with [(68)Ga]Pentixafor: a suitable theranostic approach in pleural mesothelioma?","volume":"8","author":"Luckerath","year":"2017","journal-title":"Oncotarget"},{"key":"35","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1007\/s11060-017-2452-6","article-title":"Diagnosis and treatment patterns for patients with leptomeningeal metastasis from solid tumors across Europe","volume":"133","author":"Weller","year":"2017","journal-title":"J Neurooncol"},{"key":"36","doi-asserted-by":"publisher","first-page":"209ra153","DOI":"10.1126\/scitranslmed.3006802","article-title":"A genomics-based classification of human lung tumors","volume":"5","author":"Clinical Lung Cancer Genome Project (CLCGP); Network Genomic Medicine (NGM)","year":"2013","journal-title":"Sci Transl Med"},{"key":"37","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.ab.2016.02.017","article-title":"Homogeneous time-resolved G protein-coupled receptor-ligand binding assay based on fluorescence cross-correlation spectroscopy","volume":"502","author":"Hannus","year":"2016","journal-title":"Anal Biochem"},{"key":"38","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/j.nucmedbio.2013.09.002","article-title":"Cationic eluate pretreatment for automated synthesis of [(6)(8)Ga]CPCR4.2","volume":"41","author":"Wester","year":"2014","journal-title":"Nucl Med Biol"}],"container-title":["Oncotarget"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.24787","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T16:24:50Z","timestamp":1589041490000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.24787"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4,10]]},"references-count":38,"journal-issue":{"issue":"27","published-print":{"date-parts":[[2018,4,10]]}},"alternative-id":["24787","29721166"],"URL":"https:\/\/doi.org\/10.18632\/oncotarget.24787","relation":{},"ISSN":["1949-2553"],"issn-type":[{"value":"1949-2553","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,4,10]]}}}