{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T21:33:02Z","timestamp":1789939982256,"version":"4.0.1"},"reference-count":29,"publisher":"Impact Journals, LLC","issue":"27","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncotarget"],"published-print":{"date-parts":[[2018,4,10]]},"DOI":"10.18632\/oncotarget.25018","type":"journal-article","created":{"date-parts":[[2018,4,9]],"date-time":"2018-04-09T09:08:58Z","timestamp":1523264938000},"page":"19273-19282","source":"Crossref","is-referenced-by-count":11,"title":["Antitumor efficacy of Kisspeptin in human malignant mesothelioma cells"],"prefix":"10.18632","volume":"9","author":[{"given":"Vincenza","family":"Ciaramella","sequence":"first","affiliation":[{"name":"Oncologia Medica, Dipartimento di Internistica Clinica e Sperimentale \u201cF. Magrassi\u201d, Universit\u00e0 degli Studi della Campania Luigi Vanvitelli, Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carminia Maria","family":"Della Corte","sequence":"additional","affiliation":[{"name":"Oncologia Medica, Dipartimento di Internistica Clinica e Sperimentale \u201cF. Magrassi\u201d, Universit\u00e0 degli Studi della Campania Luigi Vanvitelli, Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Concetta","family":"Di Mauro","sequence":"additional","affiliation":[{"name":"Oncologia Medica, Dipartimento di Medicina Clinica e Chirurgia, Universit\u00e0 degli Studi di Napoli \u201cFederico II\u201d, Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Tomassi","sequence":"additional","affiliation":[{"name":"DISTABIF, Universit\u00e0 degli Studi della Campania Luigi Vanvitelli, Caserta, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvatore","family":"Di Maro","sequence":"additional","affiliation":[{"name":"DISTABIF, Universit\u00e0 degli Studi della Campania Luigi Vanvitelli, Caserta, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Troiani","sequence":"additional","affiliation":[{"name":"Oncologia Medica, Dipartimento di Internistica Clinica e Sperimentale \u201cF. Magrassi\u201d, Universit\u00e0 degli Studi della Campania Luigi Vanvitelli, Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erika","family":"Martinelli","sequence":"additional","affiliation":[{"name":"Oncologia Medica, Dipartimento di Internistica Clinica e Sperimentale \u201cF. Magrassi\u201d, Universit\u00e0 degli Studi della Campania Luigi Vanvitelli, Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Bianco","sequence":"additional","affiliation":[{"name":"Oncologia Medica, Dipartimento di Medicina Clinica e Chirurgia, Universit\u00e0 degli Studi di Napoli \u201cFederico II\u201d, Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandro","family":"Cosconati","sequence":"additional","affiliation":[{"name":"DISTABIF, Universit\u00e0 degli Studi della Campania Luigi Vanvitelli, Caserta, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riccardo","family":"Pierantoni","sequence":"additional","affiliation":[{"name":"Dipartimento di Medicina Sperimentale sez \u2018F. Bottazzi\u2019, Universit\u00e0 degli Studi della Campania Luigi Vanvitelli, Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosaria","family":"Meccariello","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Motorie e del Benessere, Universit\u00e0 di Napoli Parthenope, Napoli, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosanna","family":"Chianese","sequence":"additional","affiliation":[{"name":"Dipartimento di Medicina Sperimentale sez \u2018F. Bottazzi\u2019, Universit\u00e0 degli Studi della Campania Luigi Vanvitelli, Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fortunato","family":"Ciardiello","sequence":"additional","affiliation":[{"name":"Oncologia Medica, Dipartimento di Internistica Clinica e Sperimentale \u201cF. Magrassi\u201d, Universit\u00e0 degli Studi della Campania Luigi Vanvitelli, Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Floriana","family":"Morgillo","sequence":"additional","affiliation":[{"name":"Oncologia Medica, Dipartimento di Internistica Clinica e Sperimentale \u201cF. Magrassi\u201d, Universit\u00e0 degli Studi della Campania Luigi Vanvitelli, Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7892","published-online":{"date-parts":[[2018,4,10]]},"reference":[{"key":"1","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1183\/09031936.98.12040972","article-title":"Malignant pleural mesothelioma","volume":"12","author":"Astoul","year":"1998","journal-title":"Eur Respir J"},{"key":"2","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1378\/chest.125.3.1103","article-title":"Asbestos and the pleura: a review","volume":"125","author":"Kamp","year":"2004","journal-title":"Chest"},{"key":"3","doi-asserted-by":"crossref","unstructured":"Fuhrer, Lazarus. Mesothelioma. Dis Mon. 2011; 57:40\u201354.","DOI":"10.1016\/j.disamonth.2010.12.004"},{"key":"4","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1016\/j.ajpath.2012.12.028","article-title":"New Insights into understanding the mechanisms, pathogenensis and management of malignant mesothelioma","volume":"182","author":"Hassan","year":"2013","journal-title":"Am J Pathol"},{"key":"5","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1097\/CPM.0b013e318272ce61","article-title":"Mesothelioma update on diagnosticstrategies","volume":"19","author":"Kamp","year":"2012","journal-title":"Clin Pulm Med"},{"key":"6","first-page":"143","article-title":"Malignant mesothelioma biomarkers-from discovery to use in clinical practice for diagnosis, monitoring, screening and treatment","volume":"152","author":"Robinson","year":"2017","journal-title":"Chest"},{"key":"7","doi-asserted-by":"crossref","first-page":"7360","DOI":"10.1158\/0008-5472.CAN-10-1208","article-title":"AACR special conference on epithelial-mesenchymal transition and cancer progression and treatment","volume":"70","author":"Condeelis","year":"2010","journal-title":"Cancer Res"},{"key":"8","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1038\/nrc822","article-title":"Epithelial-mesenchymal transitions in tumour progression","volume":"2","author":"Thiery","year":"2002","journal-title":"Nat Rev Cancer"},{"key":"9","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1016\/j.devcel.2008.05.009","article-title":"Epithelial-mesenchymal transition: at the crossroads of development and tumor metastasis","volume":"14","author":"Weinberg","year":"2008","journal-title":"Dev Cell"},{"key":"10","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1016\/j.cell.2009.11.007","article-title":"Epithelial-mesenchymal transitions in development and disease","volume":"139","author":"Nieto","year":"2009","journal-title":"Cell"},{"key":"11","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1038\/35079135","article-title":"Metastasis suppressor gene Kiss-1 encodes peptide ligand of a G-protein-coupled receptor","volume":"411","author":"Asada","year":"2001","journal-title":"Nature"},{"key":"12","doi-asserted-by":"crossref","first-page":"34631","DOI":"10.1074\/jbc.M104847200","article-title":"The metastasis suppressor gene KiSS-1 encodes kisspeptins, the natural ligand of the orphan G protein-coupled receptor GPR54","volume":"276","author":"Vassart","year":"2001","journal-title":"J Biol Chem"},{"key":"13","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1093\/jnci\/88.23.1731","article-title":"KiSS-1, a novel human malignant melanoma metastasis-suppressor gene","volume":"88","author":"Welch","year":"1996","journal-title":"J Natl Cancer Inst"},{"key":"14","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1002\/(SICI)1097-0215(19970611)71:6<1035::AID-IJC20>3.0.CO;2-B","article-title":"Identification of highly expressed genes in metastasis-suppressed chromosome 6\/human malignant melanoma hybrid cells using subtractive hybridization and differential display","volume":"71","author":"Welch","year":"1997","journal-title":"Int J Cancer"},{"key":"15","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1016\/j.ejca.2007.03.004","article-title":"Expression of metastin and G-protein coupled receptor (AXOR12) in epithelial ovarian cancer","volume":"43","author":"Hoshiai","year":"2007","journal-title":"Eur J Cancer"},{"key":"16","first-page":"868","article-title":"Down regulation of KiSS1 expression is responsible for tumor invasion and worse prognosis in gastric carcinoma","volume":"10","author":"Nagasue","year":"2004","journal-title":"Int J Cancer"},{"key":"17","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/S0002-9440(10)63854-0","article-title":"Tumor suppressor role of KiSS-1 in bladder cancer: loss of KiSS-1 expression is associated with bladder cancer progression and clinical out come","volume":"162","author":"Cordon-Cardo","year":"2003","journal-title":"Am J Pathol"},{"key":"18","first-page":"5399","article-title":"Identification and characterization of mouse metastasis-suppressor KiSS-1 and its G-protein coupled receptor","volume":"62","author":"Liu","year":"2002","journal-title":"Cancer Res"},{"key":"19","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/0003-2697(70)90146-6","article-title":"Color test for detection of free terminal amino groups in the solid-phase synthesis of peptides","volume":"34","author":"Cook","year":"1970","journal-title":"Anal Biochem"},{"key":"20","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/0003-2697(76)90034-8","article-title":"A new micro-test for the detection of incomplete coupling reactions in solid-phase peptide synthesis using 2,4,6-trinitrobenzenesulphonic acid","volume":"71","author":"Battersby","year":"1976","journal-title":"Anal Biochem"},{"key":"21","doi-asserted-by":"crossref","first-page":"6639","DOI":"10.1021\/jm800959f","article-title":"Efficient Solid-Phase Synthesis of FK228 Analogues as Potent Antitumoral Agents","volume":"51","author":"Ahn","year":"2008","journal-title":"J Med Chem"},{"key":"22","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.lungcan.2010.06.005","article-title":"Antitumor activity of bortezomib in human cancer cells with acquired resistance to anti-epidermal growth factor receptor tyrosine kinase inhibitors","volume":"71","author":"Ciardiello","year":"2011","journal-title":"Lung Cancer"},{"key":"23","doi-asserted-by":"crossref","first-page":"e40480","DOI":"10.1371\/journal.pone.0040480","article-title":"Schisandrin B attenuates cancer invasion and metastasis via inhibiting epithelial-mesenchymal transition","volume":"7","author":"Hu","year":"2012","journal-title":"PloS One"},{"key":"24","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1023\/A:1020992411420","article-title":"Quantification of human Alu sequences by real-time PCR an improved method to measure therapeutic efficacy of anti-metastatic drugs in human xenotransplants","volume":"19","author":"Scheuer","year":"2002","journal-title":"Clin Exp Metastasis"},{"key":"25","doi-asserted-by":"crossref","first-page":"7645","DOI":"10.1021\/jm800930w","article-title":"Development of novel G-protein- coupled receptor 54 agonists with resistance to degradation by matrix metalloproteinase","volume":"51","author":"Fujii","year":"2008","journal-title":"J Med Chem"},{"key":"26","doi-asserted-by":"crossref","first-page":"747","DOI":"10.3892\/ijmm.2013.1472","article-title":"The Kiss-1\/Kiss-1R complex as a negative regulator of cell motility and cancer metastasis (Review)","volume":"32","author":"Jiang","year":"2013","journal-title":"Int J Mol Med"},{"key":"27","first-page":"536","article-title":"Levels of matrix metalloproteases in bladder cancer correlate with tumor grade and invasion","volume":"53","author":"Balkwill","year":"1993","journal-title":"Cancer Res"},{"key":"28","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1093\/jnci\/85.7.574","article-title":"Association between expression of activated 72-kilodalton gelatinase and tumor spread in non-small-cell lung carcinoma","volume":"85","author":"Carmichael","year":"1993","journal-title":"J Natl Cancer Inst"},{"key":"29","first-page":"3263","article-title":"Expression of Membrane-Type Matrix Metalloproteinase in Human Gastric Carcinomas","volume":"55","author":"Okada","year":"1995","journal-title":"Cancer Res"}],"container-title":["Oncotarget"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.25018","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T16:33:04Z","timestamp":1589041984000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.25018"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4,10]]},"references-count":29,"journal-issue":{"issue":"27","published-print":{"date-parts":[[2018,4,10]]}},"alternative-id":["25018","29721201"],"URL":"https:\/\/doi.org\/10.18632\/oncotarget.25018","relation":{},"ISSN":["1949-2553"],"issn-type":[{"value":"1949-2553","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,4,10]]}}}