{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T20:46:25Z","timestamp":1790023585496,"version":"4.0.1"},"reference-count":35,"publisher":"Impact Journals, LLC","issue":"33","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncotarget"],"published-print":{"date-parts":[[2018,5,1]]},"DOI":"10.18632\/oncotarget.25094","type":"journal-article","created":{"date-parts":[[2018,5,1]],"date-time":"2018-05-01T16:24:14Z","timestamp":1525191854000},"page":"22886-22894","source":"Crossref","is-referenced-by-count":19,"title":["Analysis of KIT gene mutations in patients with melanoma of the head and neck mucosa: a retrospective clinical report"],"prefix":"10.18632","volume":"9","author":[{"given":"Ullyanov Bezerra","family":"Toscano de Mendon\u00e7a","sequence":"first","affiliation":[{"name":"Department of Head and Neck Surgery, Instituto Nacional do Cancer do Rio de Janeiro, Rio de Janeiro, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio Roberto","family":"Cernea","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery, School of Medicine, University of S\u00e3o Paulo, Sao Paulo-SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leandro Luongo","family":"Matos","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery, School of Medicine, University of S\u00e3o Paulo, Sao Paulo-SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto Rego","family":"Monteiro de Araujo Lima","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery, Instituto Nacional do Cancer do Rio de Janeiro, Rio de Janeiro, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7892","published-online":{"date-parts":[[2018,5,1]]},"reference":[{"key":"1","doi-asserted-by":"publisher","first-page":"472","DOI":"10.1093\/jnci\/djj103","article-title":"Gene expression profiling of primary cutaneous melanoma and clinical outcome","volume":"98","author":"Sarasin","year":"2006","journal-title":"J Natl Cancer Inst"},{"key":"2","doi-asserted-by":"publisher","first-page":"4340","DOI":"10.1200\/JCO.2006.06.2984","article-title":"Somatic activation of KIT in distinct subtypes of melanoma","volume":"24","author":"Bastian","year":"2006","journal-title":"J Clin Oncol"},{"key":"3","doi-asserted-by":"publisher","first-page":"949","DOI":"10.1038\/nature00766","article-title":"Mutations of the BRAF gene in human cancer","volume":"417","author":"Ewing","year":"2002","journal-title":"Nature"},{"key":"4","doi-asserted-by":"publisher","first-page":"2149","DOI":"10.1101\/gad.1437206","article-title":"Malignant melanoma: genetics and therapeutics in the genomic era","volume":"20","author":"Fisher","year":"2006","journal-title":"Genes Dev"},{"key":"5","unstructured":"Kanda. Mucosal melanoma of head and neck: survival analysis and clinicopathological prognostic factors. [Article in Portuguese] (Doctoral dissertation) S\u00e3o Paulo; s.n; 2003. Available from http:\/\/repositorio.unifesp.br\/handle\/11600\/19753."},{"key":"6","doi-asserted-by":"publisher","first-page":"979","DOI":"10.1080\/00016480127369","article-title":"Primary mucosal melanoma of the nasal cavity and paranasal sinuses","volume":"121","author":"Ferlito","year":"2001","journal-title":"Acta Otolaryngol"},{"key":"7","doi-asserted-by":"publisher","first-page":"1066","DOI":"10.1002\/hed.23079","article-title":"Sinonasal mucosal melanoma: molecular profile and therapeutic implications from a series of 32 cases","volume":"35","author":"Kutzner","year":"2013","journal-title":"Head Neck"},{"key":"8","doi-asserted-by":"publisher","first-page":"2904","DOI":"10.1200\/JCO.2010.33.9275","article-title":"Phase II, open-label, single-arm trial of imatinib mesylate in patients with metastatic melanoma harboring c-Kit mutation or amplification","volume":"29","author":"Li","year":"2011","journal-title":"J Clin Oncol"},{"key":"9","doi-asserted-by":"publisher","first-page":"1664","DOI":"10.1002\/(SICI)1097-0142(19981015)83:8%3C1664::AID-CNCR23%3E3.0.CO;2-G","article-title":"The National Cancer Data Base report on cutaneous and noncutaneous melanoma: a summary of 84,836 cases from the past decade","volume":"83","author":"Menck","year":"1998","journal-title":"Cancer"},{"key":"10","doi-asserted-by":"publisher","first-page":"2026","DOI":"10.1002\/lary.21925","article-title":"Demographics and treatment trends in sinonasal mucosal melanoma","volume":"121","author":"Huang","year":"2011","journal-title":"Laryngoscope"},{"key":"11","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1046\/j.1365-2273.1998.00099.x","article-title":"Mucosal melanoma of the head and neck","volume":"23","author":"Jones","year":"1998","journal-title":"Clin Otolaryngol Allied Sci"},{"key":"12","doi-asserted-by":"publisher","first-page":"864","DOI":"10.1001\/archotol.129.8.864","article-title":"The role of postoperative adjuvant radiation therapy in the treatment of mucosal melanomas of the head and neck region","volume":"129","author":"Myers","year":"2003","journal-title":"Arch Otolaryngol Head Neck Surg"},{"key":"13","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1007\/s00405-011-1664-1","article-title":"The value of 18F-FDG-PET\/CT imaging for sinonasal malignant melanoma","volume":"269","author":"Holzmann","year":"2012","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"14","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1097\/00000478-200305000-00004","article-title":"Sinonasal tract and nasopharyngeal melanomas: a clinicopathologic study of 115 cases with a proposed staging system","volume":"27","author":"Miettinen","year":"2003","journal-title":"Am J Surg Pathol"},{"key":"15","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1097\/MOO.0b013e3283374d31","article-title":"Management of mucosal melanomas of the head and neck: did we make any progress?","volume":"18","author":"Hanna","year":"2010","journal-title":"Curr Opin Otolaryngol Head Neck Surg"},{"key":"16","doi-asserted-by":"publisher","first-page":"993","DOI":"10.1097\/01.mlg.0000217236.06585.a9","article-title":"Primary mucosal melanoma of head and neck: prognostic value of clear margins","volume":"116","author":"Lefebvre","year":"2006","journal-title":"Laryngoscope"},{"key":"17","doi-asserted-by":"publisher","first-page":"2215","DOI":"10.1002\/cncr.24976","article-title":"Mucosal melanoma of the nose and paranasal sinuses, a contemporary experience from the M. D. Anderson Cancer Center","volume":"116","author":"Hanna","year":"2010","journal-title":"Cancer"},{"key":"18","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1016\/j.humpath.2005.03.015","article-title":"Human malignant melanoma: detection of BRAF- and c-kit-activating mutations by high-resolution amplicon melting analysis","volume":"36","author":"Layfield","year":"2005","journal-title":"Hum Pathol"},{"key":"19","doi-asserted-by":"publisher","first-page":"1398","DOI":"10.1038\/sj.bjc.6602529","article-title":"Lack of clinical efficacy of imatinib in metastatic melanoma","volume":"92","author":"Schadendorf","year":"2005","journal-title":"Br J Cancer"},{"key":"20","doi-asserted-by":"publisher","first-page":"2005","DOI":"10.1002\/cncr.21834","article-title":"Multicenter phase II trial of high- dose imatinib mesylate in metastatic melanoma: significant toxicity with no clinical efficacy","volume":"106","author":"Sosman","year":"2006","journal-title":"Cancer"},{"key":"21","doi-asserted-by":"publisher","first-page":"e9","DOI":"10.1200\/JCO.2006.08.9664","article-title":"Imatinib in melanoma: a selective treatment option based on KIT mutation status?","volume":"25","author":"Ugurel","year":"2007","journal-title":"J Clin Oncol"},{"key":"22","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1002\/ijc.22681","article-title":"L576P KIT mutation in anal melanomas correlates with KIT protein expression and is sensitive to specific kinase inhibition","volume":"121","author":"Weiser","year":"2007","journal-title":"Int J Cancer"},{"key":"23","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1007\/s00428-007-0524-2","article-title":"C-kit protein expression correlated with activating mutations in KIT gene in oral mucosal melanoma","volume":"452","author":"Nagai","year":"2008","journal-title":"Virchows Arch"},{"key":"24","first-page":"657","article-title":"Heparanase and vascular endothelial growth factor expression in the progression of oral mucosal melanoma","volume":"19","author":"Nagai","year":"2008","journal-title":"Oncol Rep"},{"key":"25","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.cancergencyto.2008.11.002","article-title":"Mutations of the KIT gene and loss of heterozygosity of the PTEN region in a primary malignant melanoma arising from a mature cystic teratoma of the ovary","volume":"190","author":"Mitsuya","year":"2009","journal-title":"Cancer Genet Cytogenet"},{"key":"26","doi-asserted-by":"publisher","first-page":"1759","DOI":"10.1038\/jid.2008.422","article-title":"Cutaneous melanoma in childhood and adolescence shows frequent loss of INK4A and gain of KIT.","volume":"129","author":"Parmiani","year":"2009","journal-title":"J Invest Dermatol"},{"key":"27","doi-asserted-by":"publisher","first-page":"6821","DOI":"10.1158\/1078-0432.CCR-08-0575","article-title":"KIT gene mutations and copy number in melanoma subtypes","volume":"14","author":"West","year":"2008","journal-title":"Clin Cancer Res"},{"key":"28","doi-asserted-by":"publisher","first-page":"2327","DOI":"10.1001\/jama.2011.746","article-title":"KIT as a therapeutic target in metastatic melanoma","volume":"305","author":"Cane","year":"2011","journal-title":"JAMA"},{"key":"29","doi-asserted-by":"publisher","first-page":"1842","DOI":"10.1016\/j.ejca.2012.02.049","article-title":"Sinonasal, gen ital and acrolentiginous melanomas show distinct characteristics of KIT expression and mutations","volume":"48","author":"Dummer","year":"2012","journal-title":"Eur J Cancer"},{"key":"30","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1038\/bjc.2013.373","article-title":"KIT, NRAS and BRAF mutations in sinonasal mucosal melanoma: a study of 56 cases","volume":"109","author":"Hansson","year":"2013","journal-title":"Br J Cancer"},{"key":"31","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1111\/j.1365-2559.2008.02977.x","article-title":"Clinical significance of oncogenic KIT and PDGFRA mutations in gastrointestinal stromal tumors","volume":"53","author":"Miettinen","year":"2008","journal-title":"Histopathology"},{"key":"32","doi-asserted-by":"publisher","first-page":"3182","DOI":"10.1200\/JCO.2012.47.7836","article-title":"Imatinib for melanomas harboring mutationally activated or amplified KIT arising on mucosal, acral, and chronically sun-damaged skin","volume":"31","author":"Lawrence","year":"2013","journal-title":"J Clin Oncol"},{"key":"33","doi-asserted-by":"publisher","first-page":"1312","DOI":"10.1634\/theoncologist.2015-0161","article-title":"Phase II trial of nilotinib in patients with metastatic malignant melanoma harboring KIT gene aberration: A multicenter trial of Korean Cancer Study Group (UN10-06)","volume":"20","author":"Lee","year":"2015","journal-title":"Oncologist"},{"key":"34","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1111\/j.1600-0463.2011.02737.x","article-title":"KIT amplification and gene mutations in acral\/mucosal melanoma in Korea","volume":"119","author":"Kim","year":"2011","journal-title":"APMIS"},{"key":"35","doi-asserted-by":"publisher","first-page":"3898","DOI":"10.1200\/JCO.2002.03.095","article-title":"Prognostic value of KIT mutation type, mitotic activity, and histologic subtype in gastrointestinal stromal tumors","volume":"20","author":"Fletcher","year":"2002","journal-title":"J Clin Oncol"}],"container-title":["Oncotarget"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.25094","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T16:42:20Z","timestamp":1589042540000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.25094"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5,1]]},"references-count":35,"journal-issue":{"issue":"33","published-print":{"date-parts":[[2018,5,1]]}},"alternative-id":["25094","29796159"],"URL":"https:\/\/doi.org\/10.18632\/oncotarget.25094","relation":{},"ISSN":["1949-2553"],"issn-type":[{"value":"1949-2553","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,5,1]]}}}