{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T06:20:04Z","timestamp":1777357204026,"version":"3.51.4"},"reference-count":30,"publisher":"Impact Journals, LLC","issue":"40","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncotarget"],"published-print":{"date-parts":[[2018,5,25]]},"DOI":"10.18632\/oncotarget.25441","type":"journal-article","created":{"date-parts":[[2018,5,25]],"date-time":"2018-05-25T13:05:01Z","timestamp":1527253501000},"page":"26086-26095","source":"Crossref","is-referenced-by-count":6,"title":["Twenty-seven-nucleotide repeat insertion in the<i>rplV<\/i>gene confers specific resistance to macrolide antibiotics in<i>Staphylococcus aureus<\/i>"],"prefix":"10.18632","volume":"9","author":[{"given":"Dianpeng","family":"Han","sequence":"first","affiliation":[{"name":"Beijing Institute of Basic Medical Sciences, Beijing, China"},{"name":"State Key Laboratory of Toxicology and Medical Countermeasures, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Liu","sequence":"additional","affiliation":[{"name":"Beijing Institute of Basic Medical Sciences, Beijing, China"},{"name":"State Key Laboratory of Toxicology and Medical Countermeasures, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingjing","family":"Li","sequence":"additional","affiliation":[{"name":"Henan University School of Basic Medical Science, Kaifeng, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chenghua","family":"Liu","sequence":"additional","affiliation":[{"name":"Beijing Institute of Basic Medical Sciences, Beijing, China"},{"name":"State Key Laboratory of Toxicology and Medical Countermeasures, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaping","family":"Gao","sequence":"additional","affiliation":[{"name":"Beijing Institute of Basic Medical Sciences, Beijing, China"},{"name":"State Key Laboratory of Toxicology and Medical Countermeasures, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiannan","family":"Feng","sequence":"additional","affiliation":[{"name":"Beijing Institute of Basic Medical Sciences, Beijing, China"},{"name":"State Key Laboratory of Toxicology and Medical Countermeasures, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huizhe","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Applied Chemistry, College of Science, China Agricultural University, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guang","family":"Yang","sequence":"additional","affiliation":[{"name":"Beijing Institute of Basic Medical Sciences, Beijing, China"},{"name":"State Key Laboratory of Toxicology and Medical Countermeasures, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7892","published-online":{"date-parts":[[2018,5,25]]},"reference":[{"key":"1","first-page":"971","article-title":"A link between virulence and ecological abundance in natural populations of Staphylococcus aureus (Retraction of vol 292, 114, 2001)","volume":"295","author":"Feil","year":"2002","journal-title":"Science"},{"key":"2","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1086\/520289","article-title":"Staphylococcus aureus: a well-armed pathogen","volume":"26","author":"Archer","year":"1998","journal-title":"Clin Infect Dis"},{"key":"3","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1128\/CMR.00059-12","article-title":"Antimicrobial resistance and virulence: a successful or deleterious association in the bacterial world?","volume":"26","author":"Bou","year":"2013","journal-title":"Clin Microbiol Rev"},{"key":"4","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.1001\/jama.298.15.1763","article-title":"Invasive methicillin-resistant Staphylococcus aureus infections in the United States","volume":"298","author":"Fosheim","year":"2007","journal-title":"JAMA"},{"key":"5","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1086\/520655","article-title":"Perspectives on Daptomycin resistance, with emphasis on resistance in Staphylococcus aureus","volume":"45","author":"Sakoulas","year":"2007","journal-title":"Clin Infect Dis"},{"key":"6","doi-asserted-by":"crossref","first-page":"2260","DOI":"10.1001\/jama.2010.757","article-title":"Clinical outbreak of linezolid-resistant Staphylococcus aureus in an intensive care unit","volume":"303","author":"Picazo","year":"2010","journal-title":"JAMA"},{"key":"7","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1093\/jac\/22.Supplement_B.13","article-title":"Mechanism of action of spiramycin and other macrolides","volume":"22","author":"Courvalin","year":"1988","journal-title":"J Antimicrob Chemother"},{"key":"8","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1038\/35021219","article-title":"Molecular mechanisms that confer antibacterial drug resistance","volume":"406","author":"Walsh","year":"2000","journal-title":"Nature"},{"key":"9","doi-asserted-by":"crossref","first-page":"647","DOI":"10.7164\/antibiotics.46.647","article-title":"Chemical modification of erythromycins. IX. Selective methylation at the C-6 hydroxyl group of erythromycin A oxime derivatives and preparation of clarithromycin","volume":"46","author":"Asaka","year":"1993","journal-title":"J Antibiot (Tokyo)"},{"key":"10","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1097\/00006454-199704000-00025","article-title":"History of macrolide use in pediatrics","volume":"16","author":"Klein","year":"1997","journal-title":"Pediatr Infect Dis J"},{"key":"11","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1111\/j.1365-2958.2010.07325.x","article-title":"The conformation of a nascent polypeptide inside the ribosome tunnel affects protein targeting and protein folding","volume":"78","author":"Bernstein","year":"2010","journal-title":"Mol Microbiol"},{"key":"12","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1128\/AAC.21.5.811","article-title":"Erythromycin, carbomycin, and spiramycin inhibit protein synthesis by stimulating the dissociation of peptidyl-tRNA from ribosomes","volume":"21","author":"Otto","year":"1982","journal-title":"Antimicrob Agents Chemother"},{"key":"13","doi-asserted-by":"crossref","first-page":"949","DOI":"10.2174\/1568026033452159","article-title":"Macrolide antibiotics: binding site, mechanism of action, resistance","volume":"3","author":"Mankin","year":"2003","journal-title":"Curr Top Med Chem"},{"key":"14","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1128\/AAC.31.6.883","article-title":"Prevalence of macrolides-lincosamides-streptogramin B resistance and erm gene classes among clinical strains of staphylococci and streptococci","volume":"31","author":"Weinstein","year":"1987","journal-title":"Antimicrob Agents Chemother"},{"key":"15","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1128\/AAC.39.3.577","article-title":"Erythromycin resistance by ribosome modification","volume":"39","author":"Weisblum","year":"1995","journal-title":"Antimicrob Agents Chemother"},{"key":"16","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1126\/science.1220363","article-title":"TLR13 recognizes bacterial 23S rRNA devoid of erythromycin resistance-forming modification","volume":"337","author":"Kawai","year":"2012","journal-title":"Science"},{"key":"17","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/S0924-8579(03)00218-8","article-title":"Msr(A) and related macrolide\/streptogramin resistance determinants: incomplete transporters?","volume":"22","author":"Cove","year":"2003","journal-title":"Int J Antimicrob Agents"},{"key":"18","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/S0923-2508(01)01206-2","article-title":"ABC transporters of staphylococci","volume":"152","author":"Gotz","year":"2001","journal-title":"Res Microbiol"},{"key":"19","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1016\/j.addr.2005.04.002","article-title":"Bacterial resistance to antibiotics: enzymatic degradation and modification","volume":"57","author":"Wright","year":"2005","journal-title":"Adv Drug Deliv Rev"},{"key":"20","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/S0378-1097(03)00134-4","article-title":"Characteristic expression of three genes, msr(A), mph(C) and erm(Y), that confer resistance to macrolide antibiotics on Staphylococcus aureus","volume":"220","author":"Nakajima","year":"2003","journal-title":"FEMS Microbiol Lett"},{"key":"21","doi-asserted-by":"crossref","first-page":"6192","DOI":"10.1128\/JB.176.20.6192-6198.1994","article-title":"Ribosomal protein gene sequence changes in erythromycin-resistant mutants of Escherichia coli","volume":"176","author":"Champney","year":"1994","journal-title":"J Bacteriol"},{"key":"22","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1006\/jmbi.1999.2839","article-title":"Erythromycin resistance mutations in ribosomal proteins L22 and L4 perturb the higher order structure of 23 S ribosomal RNA","volume":"289","author":"Dahlberg","year":"1999","journal-title":"J Mol Biol"},{"key":"23","doi-asserted-by":"crossref","first-page":"2200","DOI":"10.1128\/AAC.46.7.2200-2207.2002","article-title":"Resistance to quinupristin-dalfopristin due to mutation of L22 ribosomal protein in Staphylococcus aureus","volume":"46","author":"Leclercq","year":"2002","journal-title":"Antimicrob Agents Chemother"},{"key":"24","volume-title":"Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically","author":"CLSI","year":"2012","edition":"9"},{"key":"25","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1007\/BF00333665","article-title":"Biochemical and genetic studies on two different types of erythromycin resistant mutants of Escherichia coli with altered ribosomal proteins","volume":"127","author":"Otaka","year":"1973","journal-title":"Mol Gen Genet"},{"key":"26","doi-asserted-by":"crossref","first-page":"18261","DOI":"10.1073\/pnas.0810357105","article-title":"Revisiting the mechanism of macrolide-antibiotic resistance mediated by ribosomal protein L22","volume":"105","author":"Sauer","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"27","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1128\/AAC.01927-12","article-title":"Mutational and transcriptomic changes involved in the development of macrolide resistance in Campylobacter jejuni","volume":"57","author":"Zhang","year":"2013","journal-title":"Antimicrob Agents Chemother"},{"key":"28","first-page":"e02188","article-title":"Ribosomal Mutations Conferring Macrolide Resistance in Legionella pneumophila","volume":"61","author":"Jarraud","year":"2017","journal-title":"Antimicrob Agents Chemother"},{"key":"29","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1089\/mdr.2005.11.18","article-title":"Mutation of L4 ribosomal protein conferring unusual macrolide resistance in two independent clinical isolates of Staphylococcus aureus","volume":"11","author":"Leclercq","year":"2005","journal-title":"Microb Drug Resist"},{"key":"30","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.molimm.2017.05.018","article-title":"Staphylococcus aureus VraX specifically inhibits the classical pathway of complement by binding to C1q","volume":"88","author":"Yang","year":"2017","journal-title":"Mol Immunol"}],"container-title":["Oncotarget"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.25441","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,7]],"date-time":"2024-07-07T00:37:03Z","timestamp":1720312623000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.25441"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5,25]]},"references-count":30,"journal-issue":{"issue":"40","published-print":{"date-parts":[[2018,5,25]]}},"alternative-id":["25441","29899844"],"URL":"https:\/\/doi.org\/10.18632\/oncotarget.25441","relation":{},"ISSN":["1949-2553"],"issn-type":[{"value":"1949-2553","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,5,25]]}}}