{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T16:35:07Z","timestamp":1785688507565,"version":"3.56.0"},"reference-count":30,"publisher":"Impact Journals, LLC","issue":"22","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncotarget"],"published-print":{"date-parts":[[2014,11,30]]},"DOI":"10.18632\/oncotarget.2596","type":"journal-article","created":{"date-parts":[[2015,9,15]],"date-time":"2015-09-15T23:36:57Z","timestamp":1442360217000},"page":"11576-11587","source":"Crossref","is-referenced-by-count":64,"title":["Suppression of esophageal tumor growth and chemoresistance by directly targeting the PI3K\/AKT pathway"],"prefix":"10.18632","volume":"5","author":[{"given":"Bin","family":"Li","sequence":"first","affiliation":[{"name":"Department of Anatomy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China"},{"name":"Centre for Cancer Research, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China"},{"name":"The University of Hong Kong-Shenzhen Institute of Research and Innovation (HKU-SIRI), China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China"},{"name":"Present Address: Research Center for Molecular Medicine of The Austrian Academy of Sciences, Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen Wen","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China"},{"name":"The University of Hong Kong-Shenzhen Institute of Research and Innovation (HKU-SIRI), China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin Yuan","family":"Guan","sequence":"additional","affiliation":[{"name":"Centre for Cancer Research, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China"},{"name":"Department of Clinical Oncology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan Ru","family":"Qin","sequence":"additional","affiliation":[{"name":"Department of Clinical Oncology, First Affiliated Hospital, Zhengzhou University, Zhengzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li Yi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Clinical Oncology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Law","sequence":"additional","affiliation":[{"name":"Centre for Cancer Research, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China"},{"name":"Department of Surgery, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sai Wah","family":"Tsao","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China"},{"name":"Centre for Cancer Research, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annie L.M.","family":"Cheung","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China"},{"name":"Centre for Cancer Research, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China"},{"name":"The University of Hong Kong-Shenzhen Institute of Research and Innovation (HKU-SIRI), China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7892","published-online":{"date-parts":[[2014,10,18]]},"reference":[{"key":"1","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1002\/ijc.27711","article-title":"Global estimates of cancer prevalence for 27 sites in the adult population in 2008","volume":"132","author":"Ferlay","year":"2013","journal-title":"Int J Cancer"},{"key":"2","volume-title":"GLOBOCAN 2012 v1.0, Cancer Incidence and Mortality Worldwide: IARC CancerBase No. 11 [Internet]","author":"Bray","year":"2013"},{"key":"3","doi-asserted-by":"crossref","first-page":"1979","DOI":"10.1056\/NEJM199812313392704","article-title":"Chemotherapy followed by surgery compared with surgery alone for localized esophageal cancer","volume":"339","author":"Roth","year":"1998","journal-title":"N Engl J Med"},{"key":"4","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1007\/s002689900228","article-title":"Pattern of recurrence after extended radical esophagectomy with three-field lymph node dissection for squamous cell carcinoma in the thoracic esophagus","volume":"21","author":"Shirouzu","year":"1997","journal-title":"World J Surg"},{"key":"5","first-page":"115","article-title":"Pattern of recurrence after extended esophagectomy for squamous cell carcinoma of the esophagus","volume":"50","author":"Nagasue","year":"2003","journal-title":"Hepatogastroenterology"},{"key":"6","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1038\/nrd2926","article-title":"Targeting the phosphoinositide 3-kinase pathway in cancer","volume":"8","author":"Zhao","year":"2009","journal-title":"Nat Rev Drug Discov"},{"key":"7","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1038\/nrc2664","article-title":"Targeting PI3K signalling in cancer: opportunities, challenges and limitations","volume":"9","author":"Engelman","year":"2009","journal-title":"Nat Rev Cancer"},{"key":"8","doi-asserted-by":"crossref","first-page":"135","DOI":"10.18632\/oncotarget.240","article-title":"Ras\/Raf\/MEK\/ERK and PI3K\/PTEN\/Akt\/mTOR inhibitors: rationale and importance to inhibiting these pathways in human health","volume":"2","author":"Nicoletti","year":"2011","journal-title":"Oncotarget"},{"key":"9","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.18632\/oncotarget.802","article-title":"Advances in targeting signal transduction pathways","volume":"3","author":"Candido","year":"2012","journal-title":"Oncotarget"},{"key":"10","doi-asserted-by":"crossref","first-page":"2576","DOI":"10.1002\/ijc.24675","article-title":"Id-1 promotes tumorigenicity and metastasis of human esophageal cancer cells through activation of PI3K\/AKT signaling pathway","volume":"125","author":"Cheung","year":"2009","journal-title":"Int J Cancer"},{"key":"11","doi-asserted-by":"crossref","first-page":"2651","DOI":"10.1158\/1078-0432.CCR-13-2735","article-title":"Id1-Induced IGF-II and Its Autocrine\/Endocrine Promotion of Esophageal Cancer Progression and Chemoresistance--Implications for IGF-II and IGF-IR-Targeted Therapy","volume":"20","author":"Cheung","year":"2014","journal-title":"Clin Cancer Res"},{"key":"12","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1517\/14728222.2011.644788","article-title":"Targeting the PI3K signaling pathway in cancer therapy","volume":"16","author":"Gonzalez-Angulo","year":"2012","journal-title":"Expert Opin Ther Targets"},{"key":"13","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1200\/JCO.2008.17.6297","article-title":"Genetic variations in the PI3K\/PTEN\/AKT\/mTOR pathway are associated with clinical outcomes in esophageal cancer patients treated with chemoradiotherapy","volume":"27","author":"Wu","year":"2009","journal-title":"J Clin Oncol"},{"key":"14","doi-asserted-by":"crossref","first-page":"2313","DOI":"10.1093\/carcin\/bgm152","article-title":"Id-1 activation of PI3K\/Akt\/NFkappaB signaling pathway and its significance in promoting survival of esophageal cancer cells","volume":"28","author":"Cheung","year":"2007","journal-title":"Carcinogenesis"},{"key":"15","doi-asserted-by":"crossref","first-page":"5130","DOI":"10.1158\/0008-5472.CAN-05-1469","article-title":"The phosphoinositide 3-kinase\/Akt pathway: a new target in human renal cell carcinoma therapy","volume":"66","author":"Massfelder","year":"2006","journal-title":"Cancer Res"},{"key":"16","doi-asserted-by":"crossref","first-page":"e31331","DOI":"10.1371\/journal.pone.0031331","article-title":"Multi-level targeting of the phosphatidylinositol-3-kinase pathway in non-small cell lung cancer cells","volume":"7","author":"Chao","year":"2012","journal-title":"PLoS One"},{"key":"17","doi-asserted-by":"crossref","first-page":"3193","DOI":"10.1158\/1078-0432.CCR-10-1694","article-title":"Antitumor efficacy of PKI-587, a highly potent dual PI3K\/mTOR kinase inhibitor","volume":"17","author":"Hollander","year":"2011","journal-title":"Clin Cancer Res"},{"key":"18","doi-asserted-by":"crossref","first-page":"833","DOI":"10.18632\/oncotarget.346","article-title":"Abrogation of PIK3CA or PIK3R1 reduces proliferation, migration, and invasion in glioblastoma multiforme cells","volume":"2","author":"Riggins","year":"2011","journal-title":"Oncotarget"},{"key":"19","doi-asserted-by":"crossref","first-page":"3233","DOI":"10.1158\/1078-0432.CCR-10-2530","article-title":"Targeting aberrant PI3K\/Akt activation by PI103 restores sensitivity to TRAIL-induced apoptosis in neuroblastoma","volume":"17","author":"Fulda","year":"2011","journal-title":"Clin Cancer Res"},{"key":"20","doi-asserted-by":"crossref","first-page":"4173","DOI":"10.1158\/1078-0432.CCR-12-0714","article-title":"A multicenter phase I trial of PX-866, an oral irreversible phosphatidylinositol 3-kinase inhibitor, in patients with advanced solid tumors","volume":"18","author":"Kurzrock","year":"2012","journal-title":"Clin Cancer Res"},{"key":"21","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1200\/JCO.2011.36.1196","article-title":"PI3K\/AKT\/mTOR inhibitors in patients with breast and gynecologic malignancies harboring PIK3CA mutations","volume":"30","author":"Lu","year":"2012","journal-title":"J Clin Oncol"},{"key":"22","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1271\/bbb.90787","article-title":"The adenovirus-mediated transfer of PTEN inhibits the growth of esophageal cancer cellsand","volume":"74","author":"Li","year":"2010","journal-title":"Biosci Biotechnol Biochem"},{"key":"23","doi-asserted-by":"crossref","first-page":"5523","DOI":"10.1038\/onc.2010.288","article-title":"The inhibition of Bid expression by Akt leads to resistance to TRAIL-induced apoptosis in ovarian cancer cells","volume":"29","author":"Piche","year":"2010","journal-title":"Oncogene"},{"key":"24","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.18632\/oncotarget.1236","article-title":"The AKT inhibitor MK-2206 is cytotoxic in hepatocarcinoma cells displaying hyperphosphorylated AKT-1 and synergizes with conventional chemotherapy","volume":"4","author":"Neri","year":"2013","journal-title":"Oncotarget"},{"key":"25","first-page":"1099","article-title":"The activation of Akt during preoperative chemotherapy for esophageal cancer correlates with poor prognosis","volume":"19","author":"Monden","year":"2008","journal-title":"Oncol Rep"},{"key":"26","doi-asserted-by":"crossref","first-page":"954","DOI":"10.18632\/oncotarget.652","article-title":"Mutations and deregulation of Ras\/Raf\/MEK\/ERK and PI3K\/PTEN\/Akt\/mTOR cascades which alter therapy response","volume":"3","author":"Mijatovic","year":"2012","journal-title":"Oncotarget"},{"key":"27","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1002\/1097-0142(19920115)69:2<277::AID-CNCR2820690202>3.0.CO;2-C","article-title":"Characterization of 21 newly established esophageal cancer cell lines","volume":"69","author":"Tobe","year":"1992","journal-title":"Cancer"},{"key":"28","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/S0165-4608(99)00193-4","article-title":"Establishment and characterization of HKESC-1, a new cancer cell line from human esophageal squamous cell carcinoma","volume":"118","author":"Srivastava","year":"2000","journal-title":"Cancer Genet Cytogenet"},{"key":"29","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1111\/j.1349-7006.2003.tb01505.x","article-title":"Identification of genes differentially expressed in a newly isolated human metastasizing esophageal cancer cell line, T. Tn-AT1, by cDNA microarray","volume":"94","author":"Fujimori","year":"2003","journal-title":"Cancer Sci"},{"key":"30","doi-asserted-by":"crossref","first-page":"2635","DOI":"10.1158\/1535-7163.MCT-09-0162","article-title":"Targeting NF-kappaB signaling pathway suppresses tumor growth, angiogenesis, and metastasis of human esophageal cancer","volume":"8","author":"Cheung","year":"2009","journal-title":"Mol Cancer Ther"}],"container-title":["Oncotarget"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.2596","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,8]],"date-time":"2020-09-08T10:29:19Z","timestamp":1599560959000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.2596"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10,18]]},"references-count":30,"journal-issue":{"issue":"22","published-print":{"date-parts":[[2014,11,30]]}},"alternative-id":["2596","25344912"],"URL":"https:\/\/doi.org\/10.18632\/oncotarget.2596","relation":{},"ISSN":["1949-2553"],"issn-type":[{"value":"1949-2553","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,10,18]]}}}