{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T06:02:14Z","timestamp":1784613734600,"version":"3.55.0"},"reference-count":33,"publisher":"Impact Journals, LLC","issue":"68","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncotarget"],"published-print":{"date-parts":[[2018,8,31]]},"DOI":"10.18632\/oncotarget.26004","type":"journal-article","created":{"date-parts":[[2018,8,31]],"date-time":"2018-08-31T16:45:00Z","timestamp":1535733900000},"page":"32900-32916","source":"Crossref","is-referenced-by-count":1,"title":["A new drug combination significantly reduces kidney tumor progression in kidney mouse model"],"prefix":"10.18632","volume":"9","author":[{"given":"Sitai","family":"Liang","sequence":"first","affiliation":[{"name":"Department of Cell Systems & Anatomy, University of Texas Health Science Center at San Antonio, Bio-X Institutes, San Antonio, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiffanie","family":"Cuellar","sequence":"additional","affiliation":[{"name":"Department of Cell Systems & Anatomy, University of Texas Health Science Center at San Antonio, Bio-X Institutes, San Antonio, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maciej","family":"Nowacki","sequence":"additional","affiliation":[{"name":"Department of Cell Systems & Anatomy, University of Texas Health Science Center at San Antonio, Bio-X Institutes, San Antonio, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bijaya K.","family":"Nayak","sequence":"additional","affiliation":[{"name":"Department of Cell Systems & Anatomy, University of Texas Health Science Center at San Antonio, Bio-X Institutes, San Antonio, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lily","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Cell Systems & Anatomy, University of Texas Health Science Center at San Antonio, Bio-X Institutes, San Antonio, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boajie","family":"Li","sequence":"additional","affiliation":[{"name":"Shanghai Jiao Tong University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kumar","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Texas Health Science Center at San Antonio, Bio-X Institutes, San Antonio, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samy L.","family":"Habib","sequence":"additional","affiliation":[{"name":"Department of Cell Systems & Anatomy, University of Texas Health Science Center at San Antonio, Bio-X Institutes, San Antonio, TX, USA"},{"name":"South Texas Veterans Health Care System, San Antonio, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7892","published-online":{"date-parts":[[2018,8,31]]},"reference":[{"key":"1","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1016\/S0140-6736(08)61279-9","article-title":"Tuberous sclerosis","volume":"372","author":"Jozwiak","year":"2008","journal-title":"Lancet"},{"key":"2","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1016\/S0022-5347(17)43234-4","article-title":"Renal lesions in tuberous sclerosis","volume":"138","author":"Kelalis","year":"1987","journal-title":"J Urol"},{"key":"3","doi-asserted-by":"publisher","first-page":"2208","DOI":"10.1002\/(SICI)1097-0142(19981115)83:103.0.CO;2-K","article-title":"Malignant tumors of the kidney, brain, and soft tissues in children and young adults with the tuberous sclerosis complex","volume":"83","author":"Henske","year":"1998","journal-title":"Cancer"},{"key":"4","doi-asserted-by":"publisher","first-page":"1471","DOI":"10.1183\/13993003.00412-2015","article-title":"The changing face of a rare disease: lymphangioleiomyomatosis","volume":"46","author":"Moss","year":"2015","journal-title":"Eur Respir J"},{"key":"5","doi-asserted-by":"publisher","first-page":"486","DOI":"10.1055\/s-0032-1325159","article-title":"Lymphangioleiomyomatosis: new concepts in pathogenesis, diagnosis, and treatment","volume":"33","author":"McCormack","year":"2012","journal-title":"Semin Respir Crit Care Med"},{"key":"6","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1016\/0090-4295(91)80261-5","article-title":"Malignant renal tumors in tuberous sclerosis","volume":"37","author":"Hanna","year":"1991","journal-title":"Urology"},{"key":"7","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1007\/978-3-642-60049-4","article-title":"Histological Typing of Lung and Pleural Tumours","volume":"54","author":"Brambilla","year":"2001","journal-title":"J Clin Pathol"},{"key":"8","doi-asserted-by":"publisher","first-page":"35364","DOI":"10.1074\/jbc.M205838200","article-title":"Phosphatidylinositol 3-kinase\/Akt pathway regulates tuberous sclerosis tumor suppressor complex by phosphorylation of tuberin","volume":"277","author":"Cheng","year":"2002","journal-title":"J Biol Chem"},{"key":"9","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/S1097-2765(02)00568-3","article-title":"Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase\/akt pathway","volume":"10","author":"Cantley","year":"2002","journal-title":"Mol Cell"},{"key":"10","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1038\/nm0603-677","article-title":"Regulation of angiogenesis by hypoxia: role of the HIF system","volume":"9","author":"Ratcliffe","year":"2003","journal-title":"Nat Med"},{"key":"11","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/j.gde.2006.12.006","article-title":"Hypoxia-inducible factors: central regulators of the tumor phenotype","volume":"17","author":"Simon","year":"2007","journal-title":"Curr Opin Genet Dev"},{"key":"12","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1093\/carcin\/bgl143","article-title":"Renal cancer cells lacking HIF-1\u03b1 expression maintains VEGF expression through HIF-2\u03b1","volume":"28","author":"Murai","year":"2007","journal-title":"Carcinogenesis"},{"key":"13","doi-asserted-by":"publisher","first-page":"e23379","DOI":"10.1371\/journal.pone.0023379","article-title":"Multicenter phase 2 trial of sirolimus for tuberous sclerosis: kidney angiomyolipomas and other tumors regress and VEGF- D levels decrease","volume":"6","author":"Fennessy","year":"2011","journal-title":"PLoS One"},{"key":"14","doi-asserted-by":"publisher","first-page":"1203","DOI":"10.1093\/ndt\/gfu013","article-title":"The effect of Everolimus on renal Angiomyolipoma in patients with TSC being treated for Subependymal Giant cell Astrocytoma: subgroup results from the randomized, placebo-controlled, Phase 3 trial EXIST-1","volume":"29","author":"Stein","year":"2014","journal-title":"Nephrol Dial Transplant"},{"key":"15","doi-asserted-by":"publisher","first-page":"1195","DOI":"10.1016\/j.jpeds.2013.12.053","article-title":"Mammalian target of rapamycin inhibitors for intractable epilepsy and subependymal giant cell astrocytomas in tuberous sclerosis complex","volume":"164","author":"Lawson","year":"2014","journal-title":"J Pediatr"},{"key":"16","doi-asserted-by":"publisher","first-page":"12932","DOI":"10.1073\/pnas.0906606106","article-title":"The AMPK agonist AICAR inhibits the growth of EGFRvIII-expressing glioblastomas by inhibiting lipogenesis","volume":"106","author":"Mischel","year":"2009","journal-title":"Proc Natl Acad Sci USA"},{"key":"17","doi-asserted-by":"publisher","first-page":"2806","DOI":"10.1016\/j.ejca.2010.06.117","article-title":"Novel mechanism of reducing tumourigenesis: upregulation of the DNA repair enzyme OGG1 by rapamycin-mediated AMPK activation and mTOR inhibition","volume":"46","author":"Velagapudi","year":"2010","journal-title":"Eur J Cancer"},{"key":"18","doi-asserted-by":"publisher","first-page":"L694","DOI":"10.1152\/ajplung.00204.2003","article-title":"Estradiol and tamoxifen stimulate LAM-associated angiomyolipoma cell growth and activate both genomic and nongenomic signaling pathways","volume":"286","author":"Henske","year":"2004","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"19","doi-asserted-by":"publisher","first-page":"2022","DOI":"10.1093\/carcin\/bgq189","article-title":"Novel mechanism of regulation of the DNA repair enzyme OGG1 in tuberin-deficient cells","volume":"31","author":"Abboud","year":"2010","journal-title":"Carcinogenesis"},{"key":"20","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1681\/ASN.2010040352","article-title":"The tuberin\/mTOR pathway promotes apoptosis of tubular epithelial cells in diabetes","volume":"22","author":"Habib","year":"2011","journal-title":"J Am Soc Nephrol"},{"key":"21","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1186\/1476-4598-8-13","article-title":"Insight into mechanism of oxidative DNA damage in angiomyolipomas from TSC patients","volume":"8","author":"Habib","year":"2009","journal-title":"Mol Cancer"},{"key":"22","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding","volume":"72","author":"Bradford","year":"1976","journal-title":"Anal Biochem"},{"key":"23","doi-asserted-by":"publisher","first-page":"1503","DOI":"10.1093\/carcin\/bgi120","article-title":"Regulation of AKT1 expression by beta-catenin\/Tcf\/Lef signaling in colorectal cancer cells","volume":"26","author":"von Knebel Doeberitz","year":"2005","journal-title":"Carcinogenesis"},{"key":"24","doi-asserted-by":"publisher","first-page":"F281","DOI":"10.1152\/ajprenal.00370.2007","article-title":"Tuberin regulates the DNA repair enzyme OGG1","volume":"294","author":"Abboud","year":"2008","journal-title":"Am J Physiol Renal Physiol"},{"key":"25","doi-asserted-by":"publisher","first-page":"e52852","DOI":"10.1371\/journal.pone.0052852","article-title":"Aminoimidazole carboxamide ribonucleotide (AICAR) inhibits the growth of retinoblastoma in vivo by decreasing angiogenesis and inducing apoptosis","volume":"8","author":"Vavvas","year":"2013","journal-title":"PLoS One"},{"key":"26","first-page":"204","article-title":"Urinary glutathione S-transferase as an early marker for renal dysfunction in patients admitted to intensive care with sepsis","volume":"11","author":"Marsh","year":"2009","journal-title":"Crit Care Resusc"},{"key":"27","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1186\/1476-4598-12-49","article-title":"Novel mechanism of regulation of fibrosis in kidney tumor with tuberous sclerosis","volume":"12","author":"Habib","year":"2013","journal-title":"Mol Cancer"},{"key":"28","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1007\/978-1-4419-6448-9_8","volume-title":"Diseases of DNA Repair","author":"Ahmad","year":"2010"},{"key":"29","doi-asserted-by":"publisher","first-page":"1226","DOI":"10.1054\/bjoc.2001.2072","article-title":"Analysis of the TSC1 and TSC2 genes in sporadic renal cell carcinomas","volume":"85","author":"Sampson","year":"2001","journal-title":"Br J Cancer"},{"key":"30","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/ijc.21542","article-title":"Hamartin and tuberin: working together for tumour suppression","volume":"118","author":"Jozwiak","year":"2006","journal-title":"Int J Cancer"},{"key":"31","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.pediatrneurol.2016.03.015","article-title":"Advances and Future Directions for Tuberous Sclerosis Complex Research: Recommendations From the 2015 Strategic Planning Conference","volume":"60","author":"Mamounas","year":"2016","journal-title":"Pediatr Neurol"},{"key":"32","doi-asserted-by":"publisher","first-page":"1621","DOI":"10.7150\/jca.14747","article-title":"Is mTOR Inhibitor Good Enough for Treatment All Tumors in TSC Patients?","volume":"7","author":"Liang","year":"2016","journal-title":"J Cancer"},{"key":"33","doi-asserted-by":"publisher","first-page":"e0172555","DOI":"10.1371\/journal.pone.0172555","article-title":"Concurrent inhibition of mTORC1 and mTORC2 by WYE-687 inhibits renal cell carcinoma cell growth in vitro and in vivo","volume":"12","author":"Shan","year":"2017","journal-title":"PLoS One"}],"container-title":["Oncotarget"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.26004","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T19:23:17Z","timestamp":1589052197000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.26004"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8,31]]},"references-count":33,"journal-issue":{"issue":"68","published-print":{"date-parts":[[2018,8,31]]}},"alternative-id":["26004","30250638"],"URL":"https:\/\/doi.org\/10.18632\/oncotarget.26004","relation":{},"ISSN":["1949-2553"],"issn-type":[{"value":"1949-2553","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,8,31]]}}}