{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:28:19Z","timestamp":1787066899567,"version":"build-2736575974"},"reference-count":66,"publisher":"Impact Journals, LLC","issue":"25","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncotarget"],"published-print":{"date-parts":[[2019,3,29]]},"DOI":"10.18632\/oncotarget.26764","type":"journal-article","created":{"date-parts":[[2019,3,29]],"date-time":"2019-03-29T14:44:01Z","timestamp":1553870641000},"page":"2435-2450","source":"Crossref","is-referenced-by-count":11,"title":["Development and characterization of a cancer cachexia model employing a rare human duodenal neuroendocrine carcinoma-originating cell line"],"prefix":"10.18632","volume":"10","author":[{"given":"Kazuyoshi","family":"Yanagihara","sequence":"first","affiliation":[{"name":"Division of Biomarker Discovery, Exploratory Oncology and Clinical Trial Center, National Cancer Center, Chiba, Japan"},{"name":"Division of Pathology, Department of Pathology, Kobe University Graduate School of Medicine, Kobe, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takanori","family":"Kubo","sequence":"additional","affiliation":[{"name":"Department of Life Sciences, Yasuda Women\u2019s University Faculty of Pharmacy, Hiroshima, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Iino","sequence":"additional","affiliation":[{"name":"Division of Biomarker Discovery, Exploratory Oncology and Clinical Trial Center, National Cancer Center, Chiba, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keichiro","family":"Mihara","sequence":"additional","affiliation":[{"name":"Department of Hematology\/Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chie","family":"Morimoto","sequence":"additional","affiliation":[{"name":"Department of Living Science Nutrition Course, Matsuyama Shinonome Junior College, Matsuyama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshio","family":"Seyama","sequence":"additional","affiliation":[{"name":"Department of Life Sciences, Yasuda Women\u2019s University Faculty of Pharmacy, Hiroshima, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Kuwata","sequence":"additional","affiliation":[{"name":"Department of Pathology and Clinical Laboratories, National Cancer Center Hospital East, Chiba, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Ochiai","sequence":"additional","affiliation":[{"name":"Division of Biomarker Discovery, Exploratory Oncology and Clinical Trial Center, National Cancer Center, Chiba, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Yokozaki","sequence":"additional","affiliation":[{"name":"Division of Pathology, Department of Pathology, Kobe University Graduate School of Medicine, Kobe, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7892","published-online":{"date-parts":[[2019,3,29]]},"reference":[{"key":"1","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1152\/physrev.00016.2008","article-title":"Mechanisms of cancer cachexia","volume":"89","author":"Tisdale","year":"2009","journal-title":"Physiol Rev"},{"key":"2","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1038\/nrclinonc.2012.209","article-title":"Understanding the mechanisms and treatment options in cancer cachexia","volume":"10","author":"Baracos","year":"2013","journal-title":"Nat Rev Clin Oncol"},{"key":"3","first-page":"251","volume-title":"Clinics in Oncology","author":"Fearon","year":"1986"},{"key":"4","first-page":"754","article-title":"Cancer cachexia: understanding the molecular basis","volume":"1","author":"L\u00f3pez-Soriano","year":"2014","journal-title":"Nat Rev Cancer"},{"key":"5","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s11912-017-0562-0","article-title":"Update on management of cancer-related cachexia","volume":"19","author":"Garcia","year":"2017","journal-title":"Curr Oncol Rep"},{"key":"6","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1016\/j.clinbiochem.2007.07.013","article-title":"Impact of weight loss on circulating IL-1, IL-6, IL-8, TNF-alpha, VEGF-A, VEGF-C and midkine in gastroesophageal cancer patients","volume":"40","author":"Banas","year":"2007","journal-title":"Clin Biochem"},{"key":"7","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1186\/1477-7819-8-85","article-title":"The relationship among acute-phase response proteins, cytokines and hormones in cachectic patients with colon cancer","volume":"8","author":"Tuzun","year":"2010","journal-title":"World J Surg Oncol"},{"key":"8","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1038\/bjc.2016.3","article-title":"Identification of neutrophil-derived proteases and angiotensin II as biomarkers of cancer cachexia","volume":"114","author":"Tremblay","year":"2016","journal-title":"Br J Cancer"},{"key":"9","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1007\/s12031-007-0004-9","article-title":"Elevated serum ghrelin exerts an orexigenic effect that may maintain body mass index in patients with metastatic neuroendocrine tumors","volume":"33","author":"Pisegna","year":"2007","journal-title":"J Mol Neurosci"},{"key":"10","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1007\/s10147-008-0856-1","article-title":"Ghrelin and leptin levels in cachectic patients with cancer of the digestive organs","volume":"14","author":"Wakabayashi","year":"2009","journal-title":"Int J Clin Oncol"},{"key":"11","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1007\/s00520-010-0972-0","article-title":"Animal models of the cancer anorexia-cachexia syndrome","volume":"19","author":"Walsh","year":"2011","journal-title":"Support Care Cancer"},{"key":"12","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.semcdb.2015.09.002","article-title":"Experimental cancer cachexia: evolving strategies for getting closer to the human scenario","volume":"54","author":"Argil\u00e9s","year":"2016","journal-title":"Semin Cell Dev Biol"},{"key":"13","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.ijcard.2017.03.154","article-title":"Animal models of cachexia and sarcopenia in chronic illness: Cardiac function, body composition changes and therapeutic results","volume":"238","author":"Springer","year":"2017","journal-title":"Int J Cardiol"},{"key":"14","doi-asserted-by":"publisher","first-page":"1177","DOI":"10.18632\/oncotarget.13593","article-title":"Human pancreatic cancer xenografts recapitulate key aspects of cancer cachexia","volume":"8","author":"Trevino","year":"2017","journal-title":"Oncotarget"},{"key":"15","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1002\/jcsm.12225","article-title":"Establishment and characterization of a novel murine model of pancreatic cancer cachexia","volume":"8","author":"Marks","year":"2017","journal-title":"J Cachexia Sarcopenia Muscle"},{"key":"16","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1023\/A:1006326203858","article-title":"Orthotopic metastatic mouse models for anticancer drug discavery and evaluation: a bridge to the clinic","volume":"17","author":"Hoffman","year":"1999","journal-title":"Invest New Drugs"},{"key":"17","first-page":"937","article-title":"Pancreatic cancer-induced cachexia and relevant mouse models","volume":"478","author":"Mace","year":"2018","journal-title":"Pancreas"},{"key":"18","doi-asserted-by":"crossref","first-page":"7532","DOI":"10.1158\/0008-5472.CAN-05-3259","article-title":"A photon counting technique for quantitatively evaluating progression of peritoneal tumor dissemination","volume":"66","author":"Ochiya","year":"2006","journal-title":"Cancer Res"},{"key":"19","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1080\/01635581.2013.776089","article-title":"Inhibitory effects of isoflavones on tumor growth and cachexia in newly established cachectic mouse models carrying human stomach cancers","volume":"65","author":"Seyama","year":"2013","journal-title":"Nutr Cancer"},{"key":"20","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1007\/s00535-009-0194-8","article-title":"Epidemiological study of gastroenteropancreatic neuroendocrine tumors in Japan","volume":"45","author":"Nishida","year":"2010","journal-title":"J Gastroenterol"},{"key":"21","doi-asserted-by":"crossref","first-page":"133","DOI":"10.4253\/wjge.v3.i7.133","article-title":"Management of early gastrointestinal neuroendocrine neoplasms","volume":"3","author":"Kl\u00f6ppel","year":"2011","journal-title":"World J Gastrointest Endosc"},{"key":"22","doi-asserted-by":"crossref","first-page":"6817","DOI":"10.3748\/wjg.v22.i30.6817","article-title":"Management of gastric and duodenal neuroendocrine tumors","volume":"22","author":"Terai","year":"2016","journal-title":"World J Gastroenterol"},{"key":"23","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1159\/000338793","article-title":"The role of cell lines in the study of neuroendocrine tumors","volume":"96","author":"Rubinfeld","year":"2012","journal-title":"Neuroendocrinology"},{"key":"24","doi-asserted-by":"publisher","first-page":"36503","DOI":"10.18632\/oncotarget.26367","article-title":"Establishment of a novel cell line from a rare human duodenal poorly diffrentiated neuroendocrine carconoma","volume":"9","author":"Yokozaki","year":"2018","journal-title":"Oncotarget"},{"key":"25","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1038\/nrc3972","article-title":"Patient-derived orthotopic xenografts: better mimic of metastasis than subcutaneous xenografts","volume":"15","author":"Hoffman","year":"2015","journal-title":"Nat Rev Cancer"},{"key":"26","doi-asserted-by":"crossref","first-page":"E373","DOI":"10.1152\/ajpendo.00116.2013","article-title":"New cancer cachexia rat model generated by implantation of a peritoneal dissemination-derived human stomach cancer cell line","volume":"306","author":"Uezono","year":"2014","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"27","doi-asserted-by":"crossref","first-page":"e0173113","DOI":"10.1371\/journal.pone.0173113","article-title":"Development of ghrelin resistance in a cancer cachexia rat model using human gastric cancer-derived 85As2 cells and the palliative effects of the Kampo medicine rikkunshito on the model","volume":"12","author":"Hattori","year":"2017","journal-title":"PLoS One"},{"key":"28","doi-asserted-by":"publisher","first-page":"34748","DOI":"10.18632\/oncotarget.26190","article-title":"Leukemia inhibitory factor via the Toll-like receptor 5 signaling pathway involves aggravation of cachexia induced by human gastric cancer-derived 85As2 cells in rats","volume":"9","author":"Uezono","year":"2018","journal-title":"Oncotarget"},{"key":"29","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/2049-3002-2-18","article-title":"Metabolic reprogramming induced by ketone bodies diminishes pancreatic cancer cachexia","volume":"2","author":"Singh","year":"2014","journal-title":"Cancer Metab"},{"key":"30","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1002\/jcp.24580","article-title":"Pancreatic cancer-induced cachexia is Jak2-dependent in mice","volume":"229","author":"Iovanna","year":"2014","journal-title":"J Cell Physiol"},{"key":"31","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.3892\/ol.2016.4737","article-title":"Rapid progression of mixed neuroendocrine carcinoma-acinar adenocarcinoma of the prostate: A case report","volume":"12","author":"He","year":"2016","journal-title":"Oncol Lett"},{"key":"32","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/j.surg.2015.03.042","article-title":"Increasing incidence of duodenal neuroendocrine tumors: Incidental discovery of indolent disease?","volume":"158","author":"Zervos","year":"2015","journal-title":"Surgery"},{"key":"33","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/j.bpg.2005.05.009","article-title":"Duodenal neuroendocrine tumors: Classification, functional syndromes, diagnosis and medical treatment","volume":"19","author":"Jensen","year":"2005","journal-title":"Best Pract Res Clin Gastroenterol"},{"key":"34","doi-asserted-by":"crossref","first-page":"325","DOI":"10.4253\/wjge.v2.i10.325","article-title":"Neuroendocrine tumors of the small bowels are on the rise: early aspects and management","volume":"2","author":"Kl\u00f6ppel","year":"2010","journal-title":"World J Gastrointest Endosc"},{"key":"35","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1111\/cas.12473","article-title":"Multicenter retrospective analysis of systemic chemotherapy for advanced neuroendocrine carcinoma of the digestive system","volume":"105","author":"Okusaka","year":"2014","journal-title":"Cancer Sci"},{"key":"36","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.ctrv.2016.08.006","article-title":"Heterogeneity of grade 3 gastroenteropancreatic neuroendocrine carcinomas: New insights and treatment implications","volume":"50","author":"Milione","year":"2016","journal-title":"Cancer Treat Rev"},{"key":"37","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/j.humpath.2013.03.016","article-title":"Extrapulmonary neuroendocrine small and large cell carcinomas: a review of controversial diagnostic and therapeutic issues","volume":"45","author":"Papotti","year":"2014","journal-title":"Hum Pathol"},{"key":"38","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1016\/j.neo.2017.09.002","article-title":"Nothing but NET: a review of neuroendocrine tumors and carcinomas","volume":"19","author":"Carter","year":"2017","journal-title":"Neoplasia"},{"key":"39","doi-asserted-by":"publisher","first-page":"21086","DOI":"10.18632\/oncotarget.24930","article-title":"Establishment of preclinical chemotherapy models for gastroenteropancreatic neuroendocrine carcinoma","volume":"9","author":"Yachida","year":"2018","journal-title":"Oncotarget"},{"key":"40","first-page":"601434","article-title":"Cancer cachexia: mechanisms and clinical implications","volume":"2011","author":"Reynolds","year":"2011","journal-title":"Gastroenterol Res Pract"},{"key":"41","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1097\/MPA.0000000000000843","article-title":"Orthotopic patient-derived pancreatic cancer xenografts engraft into the pancreatic parenchyma, metastasize, and induce muscle wasting to recapitulate the human disease","volume":"46","author":"Trevino","year":"2017","journal-title":"Pancreas"},{"key":"42","doi-asserted-by":"crossref","first-page":"119","DOI":"10.3390\/diagnostics5020119","article-title":"Neuroendocrine carcinomas of the gastroenteropancreatic system: a comprehensive review","volume":"5","author":"Knigge","year":"2015","journal-title":"Diagnostics (Basel)"},{"key":"43","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1242\/dmm.030403","article-title":"Mouse models of metastasis: progress and prospects","volume":"10","author":"Brunton","year":"2017","journal-title":"Dis Model Mech"},{"key":"44","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/s00441-008-0642-4","article-title":"Microvascular endothelial cell heterogeneity: general concepts and pharmacological consequences for anti-angiogenic therapy of cancer","volume":"335","author":"Molema","year":"2009","journal-title":"Cell Tissue Res"},{"key":"45","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1038\/nm.2537","article-title":"Tumor angiogenesis: molecular pathways and therapeutic targets","volume":"17","author":"Cheresh","year":"2011","journal-title":"Nat Med"},{"key":"46","doi-asserted-by":"crossref","first-page":"1514","DOI":"10.1038\/nm.2454","article-title":"Tumor grafts derived from women with breast cancer authentically reflect tumor pathology, growth, metastasis and disease outcomes","volume":"17","author":"Stijleman","year":"2011","journal-title":"Nat Med"},{"key":"47","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.canlet.2016.04.038","article-title":"Tumor microenvironment: the culprit for ovarian cancer metastasi?","volume":"377","author":"Yi","year":"2016","journal-title":"Cancer Lett"},{"key":"48","doi-asserted-by":"publisher","first-page":"32718","DOI":"10.18632\/oncotarget.26024","article-title":"A patient-derived orthotopic xenograft model enabling human high-grade urothelial cell carcinoma of the bladder tumor implantation, growth, angiogenesis, and metastasis","volume":"9","author":"Shuh","year":"2018","journal-title":"Oncotarget"},{"key":"49","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S0304-3835(00)00421-3","article-title":"Establishment of a new human pancreatic cancer cell line, NOR-P1, with high angiogenic activity and metastatic potential","volume":"155","author":"Tanaka","year":"2000","journal-title":"Cancer Lett"},{"key":"50","doi-asserted-by":"crossref","first-page":"1","DOI":"10.21873\/cgp.20015","article-title":"The multiple roles of exosomes in metastasis","volume":"14","author":"R\u00fcger","year":"2017","journal-title":"Cancer Genomics Proteomics"},{"key":"51","doi-asserted-by":"crossref","first-page":"6480","DOI":"10.1158\/0008-5472.CAN-17-0994","article-title":"The biology of cancer exosomes: insights and new perspectives","volume":"77","author":"Melo","year":"2017","journal-title":"Cancer Res"},{"key":"52","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1038\/sj.bjc.6603360","article-title":"Adipose atrophy in cancer cachexia: morphologic and molecular analysis of adipose tissue in tumour-bearing mice","volume":"95","author":"Jenkins","year":"2006","journal-title":"Br J Cancer"},{"key":"53","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1038\/nm.3361","article-title":"Brown and beige fat; development, function and therapeutic potential","volume":"19","author":"Seale","year":"2013","journal-title":"Nat Med"},{"key":"54","doi-asserted-by":"crossref","first-page":"4372","DOI":"10.1158\/0008-5472.CAN-11-3536","article-title":"Activation of thermogenesis in brown adipose tissue and dysregulated lipid metabolism associated with cancer cachexia in mice","volume":"72","author":"Robertson","year":"2012","journal-title":"Cancer Res"},{"key":"55","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.cmet.2014.06.011","article-title":"A switch from white to brown fat increases energy expenditure in cancer-associated cachexia","volume":"20","author":"Wagner","year":"2014","journal-title":"Cell Metab"},{"key":"56","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1038\/nature13528","article-title":"Tumour-derived PTH-related protein triggers adipose tissue browning and cancer cachexia","volume":"513","author":"Spiegelman","year":"2014","journal-title":"Nature"},{"key":"57","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1177\/1535370216683282","article-title":"The role of adipose tissue in cancer-associated cachexia","volume":"242","author":"Celi","year":"2017","journal-title":"Exp Biol Med (Maywood)"},{"key":"58","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/S1470-2045(10)70218-7","article-title":"Definition and classification of cancer cachexia: an international consensus","volume":"12","author":"Ottery","year":"2011","journal-title":"Lancet Oncol"},{"key":"59","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/S1479-666X(06)80004-1","article-title":"The molecular mechanisms of skeletal muscle wasting: implications for therapy","volume":"4","author":"Fearon","year":"2006","journal-title":"Surgeon"},{"key":"60","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.cmet.2012.06.011","article-title":"Cancer cachexia: mediators, signaling, and metabolic pathways","volume":"16","author":"Guttridge","year":"2012","journal-title":"Cell Metab"},{"key":"61","doi-asserted-by":"crossref","first-page":"69","DOI":"10.3389\/fnut.2017.00069","article-title":"Role of exosomal microRNAs and myomiRs in the development of cancer cachexia-associated muscle wasting","volume":"4","author":"Seelaender","year":"2018","journal-title":"Front Nutr"},{"key":"62","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1186\/s12943-018-0899-5","article-title":"Tumour-originated exosomal miR-155 triggers cancer-associated cachexia to promote tumour progression","volume":"17","author":"Sun","year":"2018","journal-title":"Mol Cancer"},{"key":"63","doi-asserted-by":"crossref","first-page":"2038","DOI":"10.1002\/ijc.25562","article-title":"Interleukin-8 is associated with proliferation, migration, angiogenesis and chemosensitivity in vitro and in vivo in colon cancer cell line models","volume":"128","author":"Lenz","year":"2011","journal-title":"Int J Cancer"},{"key":"64","doi-asserted-by":"crossref","first-page":"6735","DOI":"10.1158\/1078-0432.CCR-07-4843","article-title":"The interleukin-8 pathway in cancer","volume":"14","author":"Wilson","year":"2008","journal-title":"Clin Cancer Res"},{"key":"65","first-page":"117","article-title":"The role of CXC chemokines in the transition of chronic inflammation to esophageal and gastric cancer","volume":"1825","author":"Struyf","year":"2012","journal-title":"Biochim Biophys Acta"},{"key":"66","doi-asserted-by":"crossref","first-page":"2835","DOI":"10.1002\/ijc.25002","article-title":"An orthotopic implantation mouse model of human malignant pleural mesothelioma for in vivo photon counting analysis and evaluation of the effect of S-1 therapy","volume":"126","author":"Seyama","year":"2010","journal-title":"Int J Cancer"}],"container-title":["Oncotarget"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.26764","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,16]],"date-time":"2024-07-16T07:02:29Z","timestamp":1721113349000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.26764"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3,29]]},"references-count":66,"journal-issue":{"issue":"25","published-print":{"date-parts":[[2019,3,29]]}},"alternative-id":["26764","31069007"],"URL":"https:\/\/doi.org\/10.18632\/oncotarget.26764","relation":{},"ISSN":["1949-2553"],"issn-type":[{"value":"1949-2553","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,3,29]]}}}