{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T01:26:39Z","timestamp":1778635599942,"version":"3.51.4"},"reference-count":49,"publisher":"Impact Journals, LLC","issue":"44","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncotarget"],"published-print":{"date-parts":[[2019,7,16]]},"DOI":"10.18632\/oncotarget.27068","type":"journal-article","created":{"date-parts":[[2019,7,16]],"date-time":"2019-07-16T13:21:43Z","timestamp":1563283303000},"page":"4570-4586","source":"Crossref","is-referenced-by-count":17,"title":["Polyphenols enhance the activity of alkylating agents in leukaemia cell lines"],"prefix":"10.18632","volume":"10","author":[{"given":"Amani A.","family":"Mahbub","sequence":"first","affiliation":[{"name":"Faculty of Applied Medical Sciences, Laboratory Medicine Department, Umm Al Qura University, Makkah, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine L. Le","family":"Maitre","sequence":"additional","affiliation":[{"name":"Biomolecular Sciences Research Centre, Sheffield Hallam University, Sheffield, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Haywood-Small","sequence":"additional","affiliation":[{"name":"Biomolecular Sciences Research Centre, Sheffield Hallam University, Sheffield, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neil A.","family":"Cross","sequence":"additional","affiliation":[{"name":"Biomolecular Sciences Research Centre, Sheffield Hallam University, Sheffield, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicola","family":"Jordan-Mahy","sequence":"additional","affiliation":[{"name":"Biomolecular Sciences Research Centre, Sheffield Hallam University, Sheffield, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7892","published-online":{"date-parts":[[2019,7,16]]},"reference":[{"key":"1","unstructured":"Cancer Research UK. Available at: https:\/\/www.cancerresearchuk.org\/about-cancer\/type\/all\/treatment. (accessed 01 January 2018)."},{"key":"2","unstructured":"Leukaemia and Lymphoma Society. Available at: https:\/\/www.lls.org\/leukemia. (Accessed 01 January 2018)."},{"key":"3","doi-asserted-by":"publisher","first-page":"2291","DOI":"10.1002\/cncr.22662","article-title":"Pentostatin, cyclophosphamide, and rituximab regimen in older patients with chronic lymphocytic leukemia","volume":"10","author":"Kay","year":"2007","journal-title":"Cancer"},{"key":"4","first-page":"397","article-title":"Leukaemia: A Review Article","volume":"2","author":"Pokharel","year":"2012","journal-title":"IJARPB"},{"key":"5","doi-asserted-by":"publisher","first-page":"1750","DOI":"10.1056\/NEJM200012143432402","article-title":"Fludarabine compared with chlorambucil as primary therapy for chronic lymphocytic leukemia","volume":"34","author":"Schiffer","year":"2000","journal-title":"N Engl J Med"},{"key":"6","doi-asserted-by":"publisher","first-page":"7265","DOI":"10.1038\/sj.onc.1206933","article-title":"Cisplatin: mode of cytotoxic action and molecular basis of resistance","volume":"2","author":"Siddik","year":"2003","journal-title":"Oncogene"},{"key":"7","doi-asserted-by":"publisher","first-page":"1457","DOI":"10.1200\/JCO.1989.7.10.1457","article-title":"Long-term neurotoxicity in patients treated with cisplatin, vinblastine, and bleomycin for metastatic germ cell cancer","volume":"7","author":"Trojaborg","year":"1989","journal-title":"J Clin Oncol"},{"key":"8","doi-asserted-by":"publisher","first-page":"1351","DOI":"10.3390\/cancers3011351","article-title":"Cisplatin as an anti-tumor drug: cellular mechanisms of activity, drug resistance and induced side effects","volume":"3","author":"B\u00fcsselberg","year":"2011","journal-title":"Cancers (Basel)"},{"key":"9","doi-asserted-by":"publisher","first-page":"1120","DOI":"10.1002\/art.1780380815","article-title":"Effects of cyclophosphamide on the development of malignancy and on long-term survival of patients with rheumatoid arthritis. A 20-year followup study","volume":"3","author":"Kwoh","year":"1995","journal-title":"Arthritis Rheum"},{"key":"10","first-page":"462","article-title":"Teratogenic effects of first-trimester cyclophosphamide therapy","volume":"7","author":"McCabe","year":"1988","journal-title":"Obstet Gynecol"},{"key":"11","doi-asserted-by":"publisher","first-page":"1601","DOI":"10.2174\/18715206113139990303","article-title":"Differential effects of polyphenols on proliferation and apoptosis in human myeloid and lymphoid leukemia cell lines","volume":"1","author":"Jordan-Mahy","year":"2013","journal-title":"Anticancer Agents Med Chem"},{"key":"12","first-page":"25","article-title":"A review of phytochemistry and pharmacology of flavonoids","volume":"1","author":"Sharma","year":"2011","journal-title":"Internationale Pharmaceutica Sciencia"},{"key":"13","doi-asserted-by":"publisher","first-page":"758","DOI":"10.1016\/j.foodchem.2009.07.030","article-title":"Effect of different cooking regimes on rhubarb polyphenols","volume":"11","author":"Jordan-Mahy","year":"2010","journal-title":"Food Chem"},{"key":"14","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1002\/med.20094","article-title":"Anti-cancer properties of anthraquinones from rhubarb","volume":"2","author":"Ong","year":"2007","journal-title":"Med Res Rev"},{"key":"15","doi-asserted-by":"publisher","first-page":"950","DOI":"10.3390\/i8090950","article-title":"Dietary polyphenols and their biological significance","volume":"8","author":"Lou","year":"2007","journal-title":"Int J Mol Sci"},{"key":"16","doi-asserted-by":"publisher","first-page":"7313","DOI":"10.3390\/molecules15107313","article-title":"Plant phenolics: extraction, analysis and their antioxidant and anticancer properties","volume":"1","author":"Mumper","year":"2010","journal-title":"Molecules"},{"key":"17","doi-asserted-by":"publisher","first-page":"15043","DOI":"10.1038\/cddiscovery.2015.43","article-title":"Polyphenols act synergistically with doxorubicin and etoposide in leukaemia cell lines","volume":"1","author":"Jordan-Mahy","year":"2015","journal-title":"Cell Death Discov"},{"key":"18","first-page":"103","article-title":"The effects of quercetin vs cisplatin on proliferation and the apoptotic process in A549 and SW1271 cell lines inconditions","volume":"6","author":"Zabel","year":"2004","journal-title":"Folia Morphol (Warsz)"},{"key":"19","first-page":"1297","article-title":"Role of mitochondria in quercetin-enhanced chemotherapeutic response in human non-small cell lung carcinoma H-520 cells","volume":"2","author":"Singh","year":"2006","journal-title":"Anticancer Res"},{"key":"20","doi-asserted-by":"publisher","first-page":"121","DOI":"10.29685\/JCM.200708.0004","article-title":"[Curcumin and quercetin combined with cisplatin to induce apoptosis in human laryngeal carcinoma hep-2 cells through the mitochondrial pathway]","volume":"3","author":"Singh","year":"2007","journal-title":"Journal of Cancer Molecules"},{"key":"21","doi-asserted-by":"publisher","first-page":"851589","DOI":"10.1155\/2010\/851589","article-title":"The investigation of effects of quercetin and its combination with Cisplatin on malignant mesothelioma cells","volume":"201","author":"Yanikkaya-Demirel","year":"2010","journal-title":"J Biomed Biotechnol"},{"key":"22","first-page":"3789","article-title":"Synergism from combinations of cisplatin and oxaliplatin with quercetin and thymoquinone in human ovarian tumour models","volume":"3","author":"Huq","year":"2011","journal-title":"Anticancer Res"},{"key":"23","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1186\/1475-2867-12-34","article-title":"Quercetin-induced inhibition and synergistic activity with cisplatin - a chemotherapeutic strategy for nasopharyngeal carcinoma cells","volume":"1","author":"Khoo","year":"2012","journal-title":"Cancer Cell Int"},{"key":"24","doi-asserted-by":"publisher","first-page":"784","DOI":"10.1007\/s12010-013-0561-z","article-title":"Synergistic growth-suppressive effects of quercetin and cisplatin on HepG2 human hepatocellular carcinoma cells","volume":"17","author":"Jiao","year":"2014","journal-title":"Appl Biochem Biotechnol"},{"key":"25","doi-asserted-by":"publisher","first-page":"1081","DOI":"10.1016\/j.bbagen.2012.04.013","article-title":"Apigenin induces apoptosis via tumor necrosis factor receptor- and Bcl-2-mediated pathway and enhances susceptibility of head and neck squamous cell carcinoma to 5-fluorouracil and cisplatin","volume":"182","author":"Liang","year":"2012","journal-title":"Biochim Biophys Acta"},{"key":"26","doi-asserted-by":"publisher","first-page":"88","DOI":"10.3969\/j.issn.1001-1978.2012.021","article-title":"[Chemosensitization effects of apigenin on cisplatin in human nasopharyngeal carcinoma CNE-2Z cells]","volume":"2","author":"Huang","year":"2012","journal-title":"Chinese Pharmacological Bulletin"},{"key":"27","first-page":"3938","article-title":"Apigenin suppresses GLUT-1 and p-AKT expression to enhance the chemosensitivity to cisplatin of laryngeal carcinoma Hep-2 cells: anstudy","volume":"7","author":"Huang","year":"2014","journal-title":"Int J Clin Exp Pathol"},{"key":"28","first-page":"571","article-title":"Sensitization of HER-2\/neu-overexpressing non-small cell lung cancer cells to chemotherapeutic drugs by tyrosine kinase inhibitor emodin","volume":"1","author":"Hung","year":"1996","journal-title":"Oncogene"},{"key":"29","doi-asserted-by":"publisher","first-page":"213","DOI":"10.3892\/or.11.1.213","article-title":"Combined effect of aloe-emodin and chemotherapeutic agents on the proliferation of an adherent variant cell line of Merkel cell carcinoma","volume":"1","author":"Wasserman","year":"2004","journal-title":"Oncol Rep"},{"key":"30","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1007\/s00280-009-1045-2","article-title":"Protein kinase inhibitors emodin and dichloro-ribofuranosylbenzimidazole modulate the cellular accumulation and cytotoxicity of cisplatin in a schedule-dependent manner","volume":"6","author":"Siddik","year":"2010","journal-title":"Cancer Chemother Pharmacol"},{"key":"31","doi-asserted-by":"publisher","first-page":"1134","DOI":"10.1016\/j.bcp.2009.12.006","article-title":"Emodin enhances sensitivity of gallbladder cancer cells to platinum drugs via glutathion depletion and MRP1 downregulation","volume":"7","author":"Wang","year":"2010","journal-title":"Biochem Pharmacol"},{"key":"32","doi-asserted-by":"publisher","first-page":"1143","DOI":"10.3892\/or.2011.1390","article-title":"Emodin potentiates the anticancer effect of cisplatin on gallbladder cancer cells through the generation of reactive oxygen species and the inhibition of survivin expression","volume":"2","author":"Wang","year":"2011","journal-title":"Oncol Rep"},{"key":"33","doi-asserted-by":"publisher","first-page":"1276","DOI":"10.1038\/sj.leu.2401812","article-title":"Protease inhibitor-induced apoptosis: accumulation of wt p53, p21WAF1\/CIP1, and induction of apoptosis are independent markers of proteasome inhibition","volume":"1","author":"Blagosklonny","year":"2000","journal-title":"Leukemia"},{"key":"34","doi-asserted-by":"publisher","first-page":"2165","DOI":"10.1038\/sj.leu.2402647","article-title":"Lack of p53 expression in human myeloid leukemias is not due to mutations in transcriptional regulatory regions of the gene","volume":"1","author":"Reisman","year":"2002","journal-title":"Leukemia"},{"key":"35","doi-asserted-by":"publisher","first-page":"2429","DOI":"10.1038\/sj.onc.1201399","article-title":"p53-induced apoptosis in the human T-ALL cell line CCRF-CEM","volume":"1","author":"Kofler","year":"1997","journal-title":"Oncogene"},{"key":"36","unstructured":"Kuo, Yang. Gamma-H2AX - a novel biomarker for DNA double-strand breaks. In Vivo. 2008; 22:305\u201309."},{"key":"37","doi-asserted-by":"publisher","first-page":"1853","DOI":"10.4161\/cc.8.12.8865","article-title":"The apoptotic ring: a novel entity with phosphorylated histones H2AX and H2B and activated DNA damage response kinases","volume":"8","author":"Pommier","year":"2009","journal-title":"Cell Cycle"},{"key":"38","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1186\/1868-7083-3-4","article-title":"Dietary phytochemicals, HDAC inhibition, and DNA damage\/repair defects in cancer cells","volume":"3","author":"Dashwood","year":"2011","journal-title":"Clin Epigenetics"},{"key":"39","doi-asserted-by":"publisher","first-page":"1045","DOI":"10.1016\/S0271-5317(03)00078-2","article-title":"Differential modulation of cisplatin and doxorubicin efficacies in leukemia cells by flavonoids","volume":"2","author":"Rauko","year":"2003","journal-title":"Nutr Res"},{"key":"40","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1111\/j.1365-2141.2009.07752.x","article-title":"Natural polyphenols antagonize the antimyeloma activity of proteasome inhibitor bortezomib by direct chemical interaction","volume":"14","author":"Lee","year":"2009","journal-title":"Br J Haematol"},{"key":"41","doi-asserted-by":"publisher","first-page":"1231","DOI":"10.3390\/nu2121231","article-title":"Chemistry and biochemistry of dietary polyphenols","volume":"2","author":"Tsao","year":"2010","journal-title":"Nutrients"},{"key":"42","doi-asserted-by":"publisher","first-page":"972913","DOI":"10.1155\/2013\/972913","article-title":"Role of glutathione in cancer progression and chemoresistance","volume":"201","author":"Domenicotti","year":"2013","journal-title":"Oxid Med Cell Longev"},{"key":"43","doi-asserted-by":"publisher","first-page":"1349","DOI":"10.1089\/ars.2011.4258","article-title":"Redox control of leukemia: from molecular mechanisms to therapeutic opportunities","volume":"1","author":"Chandra","year":"2013","journal-title":"Antioxid Redox Signal"},{"key":"44","doi-asserted-by":"publisher","first-page":"e100314","DOI":"10.1371\/journal.pone.0100314","article-title":"Low concentration of quercetin antagonizes the cytotoxic effects of anti-neoplastic drugs in ovarian cancer","volume":"9","author":"Weng","year":"2014","journal-title":"PLoS One"},{"key":"45","doi-asserted-by":"publisher","first-page":"e2028","DOI":"10.1038\/cddis.2015.379","article-title":"Glutathione is key to the synergistic enhancement of doxorubicin and etoposide by polyphenols in leukaemia cell lines","volume":"6","author":"Jordan-Mahy","year":"2015","journal-title":"Cell Death Dis"},{"key":"46","doi-asserted-by":"publisher","first-page":"1303","DOI":"10.1038\/cdd.2009.107","article-title":"Apoptosis and glutathione: beyond an antioxidant","volume":"1","author":"Cidlowski","year":"2009","journal-title":"Cell Death Differ"},{"key":"47","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1093\/annonc\/mdl280","article-title":"Chemoresistance in solid tumours","volume":"1","author":"Johnston","year":"2006","journal-title":"Ann Oncol"},{"key":"48","doi-asserted-by":"publisher","first-page":"1285","DOI":"10.3390\/cancers3011285","article-title":"Glutathione in cancer cell death","volume":"3","author":"Estrela","year":"2011","journal-title":"Cancers (Basel)"},{"key":"49","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.taap.2011.08.004","article-title":"Chrysin enhances doxorubicin-induced cytotoxicity in human lung epithelial cancer cell lines: the role of glutathione","volume":"25","author":"Day","year":"2012","journal-title":"Toxicol Appl Pharmacol"}],"container-title":["Oncotarget"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.27068","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,11,3]],"date-time":"2020-11-03T16:45:55Z","timestamp":1604421955000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.27068"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,16]]},"references-count":49,"journal-issue":{"issue":"44","published-print":{"date-parts":[[2019,7,16]]}},"alternative-id":["27068","31360305"],"URL":"https:\/\/doi.org\/10.18632\/oncotarget.27068","relation":{},"ISSN":["1949-2553"],"issn-type":[{"value":"1949-2553","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7,16]]}}}