{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T18:18:32Z","timestamp":1781806712344,"version":"3.54.5"},"reference-count":62,"publisher":"Impact Journals, LLC","issue":"60","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncotarget"],"published-print":{"date-parts":[[2019,11,5]]},"DOI":"10.18632\/oncotarget.27290","type":"journal-article","created":{"date-parts":[[2019,11,5]],"date-time":"2019-11-05T15:16:33Z","timestamp":1572966993000},"page":"6456-6465","source":"Crossref","is-referenced-by-count":16,"title":["Secretome of pleural effusions associated with non-small cell lung cancer (NSCLC) and malignant mesothelioma: therapeutic implications"],"prefix":"10.18632","volume":"10","author":[{"given":"Albert D.","family":"Donnenberg","sequence":"first","affiliation":[{"name":"University of Pittsburgh School of Medicine, Department of Medicine, Pittsburgh, PA, USA"},{"name":"UPMC Hillman Cancer Centers, Pittsburgh, PA, USA"},{"name":"McGowan Institute for Regenerative Medicine, Pittsburgh, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James D.","family":"Luketich","sequence":"additional","affiliation":[{"name":"UPMC Hillman Cancer Centers, Pittsburgh, PA, USA"},{"name":"University of Pittsburgh School of Medicine, Department of Cardiothoracic Surgery, Pittsburgh, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vera S.","family":"Donnenberg","sequence":"additional","affiliation":[{"name":"UPMC Hillman Cancer Centers, Pittsburgh, PA, USA"},{"name":"McGowan Institute for Regenerative Medicine, Pittsburgh, PA, USA"},{"name":"University of Pittsburgh School of Medicine, Department of Cardiothoracic Surgery, Pittsburgh, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7892","published-online":{"date-parts":[[2019,11,5]]},"reference":[{"key":"1","first-page":"1036","article-title":"Barrier function of human pleura mesothelium is constituted by tight junctions","volume":"25","author":"Fromm","year":"2011","journal-title":"FASEB J"},{"key":"2","doi-asserted-by":"publisher","first-page":"1515","DOI":"10.1164\/ajrccm.156.5.9702108","article-title":"Cytokines and Soluble Cytokine Receptors in Pleural Effusions from Septic and Nonseptic Patients","volume":"156","author":"Cavaillon","year":"1997","journal-title":"Am J Respir Crit Care Med"},{"key":"3","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1046\/j.1365-2249.1997.d01-889.x","article-title":"IL-6 and soluble IL-6 receptors (sIL-6R and sgp130) in human pleural effusions: massive IL-6 production independently of underlying diseases","volume":"107","author":"Lecron","year":"1997","journal-title":"Clin Exp Immunol"},{"key":"4","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1136\/thx.34.3.389","article-title":"Study of immunoglobulins in pleura and pleural effusions","volume":"34","author":"Chretien","year":"1979","journal-title":"Thorax"},{"key":"5","doi-asserted-by":"publisher","first-page":"825","DOI":"10.1164\/ajrccm\/140.3.825","article-title":"Pleural Liquid and Solute Exchange","volume":"140","author":"Giuntini","year":"1989","journal-title":"Am Rev Respir Dis"},{"key":"6","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1186\/s40425-019-0590-4","article-title":"Treatment of malignant pleural effusions: the case for localized immunotherapy","volume":"7","author":"Donnenberg","year":"2019","journal-title":"J Immunother Cancer"},{"key":"7","doi-asserted-by":"publisher","first-page":"804","DOI":"10.1182\/blood-2018-01-828343","article-title":"Preinfusion polyfunctional anti-CD19 chimeric antigen receptor T cells are associated with clinical outcomes in NHL","volume":"132","author":"Rosenberg","year":"2018","journal-title":"Blood"},{"key":"8","doi-asserted-by":"publisher","first-page":"6626","DOI":"10.18632\/oncotarget.6570","article-title":"IL-6 promotes growth and epithelial-mesenchymal transition of CD133+ cells of non-small cell lung cancer","volume":"7","author":"Chen","year":"2016","journal-title":"Oncotarget"},{"key":"9","doi-asserted-by":"publisher","first-page":"1105","DOI":"10.1038\/ncb3041","article-title":"A breast cancer stem cell niche supported by juxtacrine signalling from monocytes and macrophages","volume":"16","author":"Weinberg","year":"2014","journal-title":"Nat Cell Biol"},{"key":"10","doi-asserted-by":"publisher","first-page":"5296","DOI":"10.1158\/0008-5472.can-11-0156","article-title":"IL-8 Signaling Plays a Critical Role in the Epithelial\u2013Mesenchymal Transition of Human Carcinoma Cells","volume":"71","author":"Palena","year":"2011","journal-title":"Cancer Res"},{"key":"11","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1038\/cr.2009.5","article-title":"TGF-beta-induced epithelial to mesenchymal transition","volume":"19","author":"Derynck","year":"2009","journal-title":"Cell Res"},{"key":"12","doi-asserted-by":"publisher","first-page":"1023","DOI":"10.1164\/ajrccm.162.3.9910050","article-title":"Volume and cellular content of normal pleural fluid in humans examined by pleural lavage","volume":"162","author":"Vincken","year":"2000","journal-title":"Am J Respir Crit Care Med"},{"key":"13","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1182\/blood.V74.1.1.1","article-title":"The biology of interleukin-6","volume":"74","author":"Kishimoto","year":"1989","journal-title":"Blood"},{"key":"14","doi-asserted-by":"publisher","first-page":"878","DOI":"10.1016\/j.bbamcr.2011.01.034","article-title":"The pro- and anti-inflammatory properties of the cytokine interleukin-6","volume":"1813","author":"Rose-John","year":"2011","journal-title":"Biochim Biophys Acta"},{"key":"15","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1038\/ki.1993.36","article-title":"Human peritoneal mesothelial cells synthesize interleukin-6: Induction by IL-1\u03b2 and TNF\u03b1","volume":"43","author":"Williams","year":"1993","journal-title":"Kidney Int"},{"key":"16","doi-asserted-by":"publisher","first-page":"e35036","DOI":"10.1371\/journal.pone.0035036","article-title":"Macrophage-Associated Mesenchymal Stem Cells Assume an Activated, Migratory, Pro-Inflammatory Phenotype with Increased IL-6 and CXCL10 Secretion","volume":"7","author":"Glod","year":"2012","journal-title":"PLoS One"},{"key":"17","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/S1471-4906(02)00013-3","article-title":"IL-6: a regulator of the transition from neutrophil to monocyte recruitment during inflammation","volume":"24","author":"Farnarier","year":"2003","journal-title":"Trends Immunol"},{"key":"18","unstructured":"The Genotype-Tissue Expression (GTEx) Project. Office of the Director of the National Institutes of Health). 2019."},{"key":"19","doi-asserted-by":"publisher","first-page":"7102","DOI":"10.4049\/jimmunol.180.11.7102","article-title":"Cutting edge: soluble IL-6R is produced by IL-6R ectodomain shedding in activated CD4 T cells","volume":"180","author":"Rincon","year":"2008","journal-title":"J Immunol"},{"key":"20","doi-asserted-by":"publisher","first-page":"1945","DOI":"10.1002\/eji.1830240837","article-title":"Soluble interleukin-6 receptors released from T cell or granulocyte\/macrophage cell lines and human peripheral blood mononuclear cells are generated through an alternative splicing mechanism","volume":"24","author":"Yamamoto","year":"1994","journal-title":"Eur J Immunol"},{"key":"21","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1158\/0008-5472.CAN-10-1496","article-title":"IL-6 trans-signaling information and progression of malignant ascites in ovarian cancer","volume":"71","author":"Wei","year":"2011","journal-title":"Cancer Res"},{"key":"22","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1016\/j.cyto.2010.05.002","article-title":"Autocrine IL-6 regulates GRO-\u03b1 production in thymic epithelial cells","volume":"51","author":"Lin","year":"2010","journal-title":"Cytokine"},{"key":"23","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1002\/jlb.67.1.53","article-title":"The tumorigenic and angiogenic effects of MGSA\/GRO proteins in melanoma","volume":"67","author":"Richmond","year":"2000","journal-title":"J Leukoc Biol"},{"key":"24","doi-asserted-by":"publisher","first-page":"987","DOI":"10.1016\/S0140-6736(08)60453-5","article-title":"Effect of interleukin-6 receptor inhibition with tocilizumab in patients with rheumatoid arthritis (OPTION study): a double-blind, placebo-controlled, randomised trial","volume":"371","author":"Alten","year":"2008","journal-title":"Lancet"},{"key":"25","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1097\/ppo.0000000000000035","article-title":"Managing Cytokine Release Syndrome Associated With Novel T Cell-Engaging Therapies","volume":"20","author":"Grupp","year":"2014","journal-title":"Cancer J"},{"key":"26","doi-asserted-by":"publisher","first-page":"55","DOI":"10.3978\/j.issn.2218-6751.2014.07.01","article-title":"The role of interleukin-6 in malignant mesothelioma","volume":"4","author":"Coward","year":"2015","journal-title":"Transl Lung Cancer Res"},{"key":"27","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1111\/j.1365-2249.1992.tb03063.x","article-title":"IL-6 in malignant pleural effusions and its augmentation by intrapleural instillation of IL-2","volume":"88","author":"Ogura","year":"1992","journal-title":"Clin Exp Immunol"},{"key":"28","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1159\/000029256","article-title":"Proinflammatory Cytokine Levels in Patients with Lung Cancer and Carcinomatous Pleurisy","volume":"65","author":"Perruchoud","year":"1998","journal-title":"Respiration"},{"key":"29","doi-asserted-by":"publisher","first-page":"1303","DOI":"10.1002\/ijc.22006","article-title":"Interleukin-6 induces both cell growth and VEGF production in malignant mesotheliomas","volume":"119","author":"Nishimoto","year":"2006","journal-title":"Int J Cancer"},{"key":"30","doi-asserted-by":"crossref","first-page":"3846","DOI":"10.1172\/JCI31871","article-title":"Mutations in the EGFR kinase domain mediate STAT3 activation via IL-6 production in human lung adenocarcinomas","volume":"117","author":"Bromberg","year":"2007","journal-title":"J Clin Invest"},{"key":"31","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/j.ccr.2007.12.020","article-title":"Autocrine IL-6 Signaling: A Key Event in Tumorigenesis?","volume":"13","author":"Karin","year":"2008","journal-title":"Cancer Cell"},{"key":"32","doi-asserted-by":"publisher","first-page":"310","DOI":"10.3892\/ijo.2012.1447","article-title":"Blockade of interleukin-6 receptor suppresses the proliferation of H460 lung cancer stem cells","volume":"41","author":"Shin","year":"2012","journal-title":"Int J Oncol"},{"key":"33","doi-asserted-by":"publisher","first-page":"1853","DOI":"10.1172\/JCI73531","article-title":"IL-6R\/STAT3\/miR-34a feedback loop promotes EMT-mediated colorectal cancer invasion and metastasis","volume":"124","author":"Hermeking","year":"2014","journal-title":"J Clin Invest"},{"key":"34","doi-asserted-by":"publisher","first-page":"2918","DOI":"10.1038\/s41598-018-21061-1","article-title":"Epithelial-mesenchymal transition (EMT) signature is inversely associated with T-cell infiltration in non-small cell lung cancer (NSCLC)","volume":"8","author":"Cruz","year":"2018","journal-title":"Sci Rep"},{"key":"35","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.imlet.2014.03.004","article-title":"Enhanced invasion of lung adenocarcinoma cells after co-culture with THP-1-derived macrophages via the induction of EMT by IL-6","volume":"160","author":"Zhenjun","year":"2014","journal-title":"Immunol Lett"},{"key":"36","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/0167-4889(92)90201-L","article-title":"Excessive production of transforming growth-factor \u03b2 1 can play an important role in the development of tumorigenesis by its action for angiogenesis: validity of neutralizing antibodies to block tumor growth","volume":"1137","author":"Higashino","year":"1992","journal-title":"Biochim Biophys Acta"},{"key":"37","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1186\/1465-9921-6-56","article-title":"TGF-\u03b21 induces human alveolar epithelial to mesenchymal cell transition (EMT)","volume":"6","author":"Zhang","year":"2005","journal-title":"Respir Res"},{"key":"38","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1172\/JCI115821","article-title":"Transforming growth factor-beta in disease: the dark side of tissue repair","volume":"90","author":"Ruoslahti","year":"1992","journal-title":"J Clin Invest"},{"key":"39","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1097\/JTO.0b013e3181cbf761","article-title":"Changes of circulating transforming growth factor-beta1 level during radiation therapy are correlated with the prognosis of locally advanced non-small cell lung cancer","volume":"5","author":"Wang","year":"2010","journal-title":"J Thorac Oncol"},{"key":"40","doi-asserted-by":"publisher","first-page":"1875","DOI":"10.1084\/jem.20030152","article-title":"Conversion of Peripheral CD4+ CD25\u2212 Naive T Cells to CD4+ CD25+Regulatory T Cells by TGF-\u03b2 Induction of Transcription Factor Foxp3","volume":"198","author":"Wahl","year":"2003","journal-title":"J Exp Med"},{"key":"41","doi-asserted-by":"publisher","first-page":"1126","DOI":"10.1038\/ni735","article-title":"B cells and professional APCs recruit regulatory T cells via CCL4","volume":"2","author":"Betz","year":"2001","journal-title":"Nat Immunol"},{"key":"42","doi-asserted-by":"publisher","first-page":"847","DOI":"10.1084\/jem.194.6.847","article-title":"Unique chemotactic response profile and specific expression of chemokine receptors CCR4 and CCR8 by CD4(+)CD25(+) regulatory T cells","volume":"194","author":"D\u2019Ambrosio","year":"2001","journal-title":"J Exp Med"},{"key":"43","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1007\/5584_2014_78","article-title":"Circulating Thrombospondin-2 and FGF-2 in Patients with Advanced Non-small Cell Lung Cancer: correlation with Survival","volume":"833","author":"Nikli\u0144ski","year":"2015","journal-title":"Adv Exp Med Biol"},{"key":"44","doi-asserted-by":"publisher","first-page":"568","DOI":"10.1634\/stemcells.2005-0247","article-title":"Basic fibroblast growth factor support of human embryonic stem cell self-renewal","volume":"24","author":"Thomson","year":"2006","journal-title":"Stem Cells"},{"key":"45","doi-asserted-by":"publisher","first-page":"1659","DOI":"10.1083\/jcb.141.7.1659","article-title":"Fibroblast Growth Factor-2 (FGF-2) Induces Vascular Endothelial Growth Factor (VEGF) Expression in the Endothelial Cells of Forming Capillaries: An Autocrine Mechanism Contributing to Angiogenesis","volume":"141","author":"Mignatti","year":"1998","journal-title":"J Cell Biol"},{"key":"46","doi-asserted-by":"publisher","first-page":"295","DOI":"10.3389\/fonc.2019.00295","article-title":"A Novel Paradigm Between Leukocytosis, G-CSF Secretion, Neutrophil-to-Lymphocyte Ratio, Myeloid-Derived Suppressor Cells, and Prognosis in Non-small Cell Lung Cancer","volume":"9","author":"Mauro","year":"2019","journal-title":"Front Oncol"},{"key":"47","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1182\/blood.V74.3.940.940","article-title":"Expression of colony-stimulating factor genes by normal human mesothelial cells and human malignant mesothelioma cells lines","volume":"74","author":"Griffin","year":"1989","journal-title":"Blood"},{"key":"48","first-page":"365","article-title":"Effects of GM-CSF and M-CSF on tumor progression of lung cancer: roles of MEK1\/ERK and AKT\/PKB pathways","volume":"18","author":"Taguchi","year":"2006","journal-title":"Int J Mol Med"},{"key":"49","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1186\/s13073-017-0424-2","article-title":"Analysis of 100,000 human cancer genomes reveals the landscape of tumor mutational burden","volume":"9","author":"Sun","year":"2017","journal-title":"Genome Med"},{"key":"50","doi-asserted-by":"publisher","first-page":"3195","DOI":"10.4049\/jimmunol.168.7.3195","article-title":"IFN-\u03b3-Inducible Protein 10 (IP-10; CXCL10)-Deficient Mice Reveal a Role for IP-10 in Effector T Cell Generation and Trafficking","volume":"168","author":"Luster","year":"2002","journal-title":"J Immunol"},{"key":"51","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1084\/jem.182.1.155","article-title":"Human interferon-inducible protein 10 is a potent inhibitor of angiogenesis","volume":"182","author":"Tosato","year":"1995","journal-title":"J Exp Med"},{"key":"52","doi-asserted-by":"publisher","first-page":"3652","DOI":"10.1073\/pnas.91.9.3652","article-title":"Monocyte chemoattractant protein 1 acts as a T-lymphocyte chemoattractant","volume":"91","author":"Springer","year":"1994","journal-title":"Proc Natl Acad Sci U S A"},{"key":"53","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1002\/jlb.60.3.365","article-title":"Human recombinant monocyte chemotactic protein and other c-c chemokines bind and induce directional migration of dendritic cells","volume":"60","author":"Wang","year":"1996","journal-title":"J Leukoc Biol"},{"key":"54","doi-asserted-by":"publisher","first-page":"1413","DOI":"10.1084\/jem.188.8.1413","article-title":"Fractalkine and CX3CR1 Mediate a Novel Mechanism of Leukocyte Capture, Firm Adhesion, and Activation under Physiologic Flow","volume":"188","author":"Patel","year":"1998","journal-title":"J Exp Med"},{"key":"55","doi-asserted-by":"publisher","first-page":"1173","DOI":"10.1172\/JCI11517","article-title":"Fractalkine (CX3CL1) as an amplification circuit of polarized Th1 responses","volume":"107","author":"Mantovani","year":"2001","journal-title":"J Clin Invest"},{"key":"56","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1006\/excr.2001.5300","article-title":"Soluble Interleukin-6 Receptor \u03b1 Inhibits the Cytokine-Induced Fractalkine\/CX3CL1 Expression in Human Vascular Endothelial Cells in Culture","volume":"269","author":"Satoh","year":"2001","journal-title":"Exp Cell Res"},{"key":"57","doi-asserted-by":"publisher","first-page":"1758835918768238","DOI":"10.1177\/1758835918768238","article-title":"Tumour necrosis factor, interferon-gamma and interleukins as predictive markers of antiprogrammed cell-death protein-1 treatment in advanced non-small cell lung cancer: a pragmatic approach in clinical practice","volume":"10","author":"Kontakiotis","year":"2018","journal-title":"Ther Adv Med Oncol"},{"key":"58","doi-asserted-by":"publisher","first-page":"664","DOI":"10.1158\/2159-8290.CD-16-0040","article-title":"Identification of Predictive Biomarkers for Cytokine Release Syndrome after Chimeric Antigen Receptor T-cell Therapy for Acute Lymphoblastic Leukemia","volume":"6","author":"Fitzgerald","year":"2016","journal-title":"Cancer Discov"},{"key":"59","doi-asserted-by":"publisher","first-page":"224ra25","DOI":"10.1126\/scitranslmed.3008226","article-title":"Efficacy and toxicity management of 19-28z CAR T cell therapy in B cell acute lymphoblastic leukemia","volume":"6","author":"He","year":"2014","journal-title":"Sci Transl Med"},{"key":"60","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.jtho.2017.10.001","article-title":"Chimeric Antigen Receptor (CAR) T-Cell Therapy for Thoracic Malignancies","volume":"13","author":"Adusumilli","year":"2018","journal-title":"J Thorac Oncol"},{"key":"61","doi-asserted-by":"publisher","first-page":"CT036","DOI":"10.1158\/1538-7445.AM2019-CT036","article-title":"Abstract CT036: A phase I clinical trial of malignant pleural disease treated with regionally delivered autologous mesothelin-targeted CAR T cells: Safety and efficacy","volume":"79","author":"Pineda","year":"2019","journal-title":"Cancer Res"},{"key":"62","doi-asserted-by":"publisher","first-page":"762","DOI":"10.1097\/JTO.0b013e31820d614f","article-title":"Palliation and Pleurodesis in Malignant Pleural Effusion: The Role for Tunneled Pleural Catheters","volume":"6","author":"Adusumilli","year":"2011","journal-title":"J Thorac Oncol"}],"container-title":["Oncotarget"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.27290","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,6,6]],"date-time":"2020-06-06T15:16:38Z","timestamp":1591456598000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.27290"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11,5]]},"references-count":62,"journal-issue":{"issue":"60","published-print":{"date-parts":[[2019,11,5]]}},"alternative-id":["27290","31741710"],"URL":"https:\/\/doi.org\/10.18632\/oncotarget.27290","relation":{},"ISSN":["1949-2553"],"issn-type":[{"value":"1949-2553","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,11,5]]}}}