{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T20:00:50Z","timestamp":1785873650877,"version":"3.56.0"},"reference-count":90,"publisher":"Impact Journals, LLC","issue":"20","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncotarget"],"published-print":{"date-parts":[[2020,5,19]]},"DOI":"10.18632\/oncotarget.27551","type":"journal-article","created":{"date-parts":[[2020,5,20]],"date-time":"2020-05-20T23:53:37Z","timestamp":1590018817000},"page":"1816-1831","source":"Crossref","is-referenced-by-count":6,"title":["Pineal gland protects against chemically induced oral carcinogenesis and inhibits tumor progression in rats"],"prefix":"10.18632","volume":"11","author":[{"given":"Giseli Mitsuy","family":"Kayahara","sequence":"first","affiliation":[{"name":"Psychoneuroimmunology Laboratory, Psychosomatic Research Center, Oral Oncology Center, S\u00e3o Paulo State University (Unesp), School of Dentistry, SP 15050-015, Ara\u00e7atuba, S\u00e3o Paulo, Brazil"},{"name":"Department of Diagnosis and Surgery, S\u00e3o Paulo State University (Unesp), School of Dentistry, SP 15050-015, Ara\u00e7atuba, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vitor Bonetti","family":"Valente","sequence":"additional","affiliation":[{"name":"Psychoneuroimmunology Laboratory, Psychosomatic Research Center, Oral Oncology Center, S\u00e3o Paulo State University (Unesp), School of Dentistry, SP 15050-015, Ara\u00e7atuba, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosani Belzunces","family":"Pereira","sequence":"additional","affiliation":[{"name":"Psychoneuroimmunology Laboratory, Psychosomatic Research Center, Oral Oncology Center, S\u00e3o Paulo State University (Unesp), School of Dentistry, SP 15050-015, Ara\u00e7atuba, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felipe Yudi Kabeya","family":"Lopes","sequence":"additional","affiliation":[{"name":"Psychoneuroimmunology Laboratory, Psychosomatic Research Center, Oral Oncology Center, S\u00e3o Paulo State University (Unesp), School of Dentistry, SP 15050-015, Ara\u00e7atuba, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo Macedo","family":"Crivelini","sequence":"additional","affiliation":[{"name":"Department of Diagnosis and Surgery, S\u00e3o Paulo State University (Unesp), School of Dentistry, SP 15050-015, Ara\u00e7atuba, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glauco Issamu","family":"Miyahara","sequence":"additional","affiliation":[{"name":"Psychoneuroimmunology Laboratory, Psychosomatic Research Center, Oral Oncology Center, S\u00e3o Paulo State University (Unesp), School of Dentistry, SP 15050-015, Ara\u00e7atuba, S\u00e3o Paulo, Brazil"},{"name":"Department of Diagnosis and Surgery, S\u00e3o Paulo State University (Unesp), School of Dentistry, SP 15050-015, Ara\u00e7atuba, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c9der Ricardo","family":"Biasoli","sequence":"additional","affiliation":[{"name":"Psychoneuroimmunology Laboratory, Psychosomatic Research Center, Oral Oncology Center, S\u00e3o Paulo State University (Unesp), School of Dentistry, SP 15050-015, Ara\u00e7atuba, S\u00e3o Paulo, Brazil"},{"name":"Department of Diagnosis and Surgery, S\u00e3o Paulo State University (Unesp), School of Dentistry, SP 15050-015, Ara\u00e7atuba, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra Helena Penha","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Psychoneuroimmunology Laboratory, Psychosomatic Research Center, Oral Oncology Center, S\u00e3o Paulo State University (Unesp), School of Dentistry, SP 15050-015, Ara\u00e7atuba, S\u00e3o Paulo, Brazil"},{"name":"Laboratory of Immunopharmacology, Department of Basic Sciences, S\u00e3o Paulo State University (Unesp), School of Dentistry, SP 15050-015, Ara\u00e7atuba, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel Galera","family":"Bernab\u00e9","sequence":"additional","affiliation":[{"name":"Psychoneuroimmunology Laboratory, Psychosomatic Research Center, Oral Oncology Center, S\u00e3o Paulo State University (Unesp), School of Dentistry, SP 15050-015, Ara\u00e7atuba, S\u00e3o Paulo, Brazil"},{"name":"Department of Diagnosis and Surgery, S\u00e3o Paulo State University (Unesp), School of Dentistry, SP 15050-015, Ara\u00e7atuba, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7892","published-online":{"date-parts":[[2020,5,19]]},"reference":[{"key":"1","doi-asserted-by":"publisher","first-page":"394","DOI":"10.3322\/caac.21492","article-title":"Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"6","author":"Jemal","year":"2018","journal-title":"CA Cancer J Clin"},{"key":"2","doi-asserted-by":"publisher","first-page":"39896","DOI":"10.18632\/oncotarget.16379","article-title":"Melatonin for the prevention and treatment of cancer","volume":"8","author":"Li","year":"2017","journal-title":"Oncotarget"},{"key":"3","doi-asserted-by":"publisher","first-page":"e2432","DOI":"10.1038\/cddis.2016.330","article-title":"Melatonin enhances sensitivity to fluorouracil in oesophageal squamous cell carcinoma through inhibition of Erk and Akt pathway","volume":"10","author":"Wang","year":"2016","journal-title":"Cell Death Dis"},{"key":"4","doi-asserted-by":"publisher","first-page":"1688","DOI":"10.1016\/S0959-8049(99)00159-8","article-title":"Decreased toxicity and increased efficacy of cancer chemotherapy using the pineal hormone melatonin in metastatic solid tumour patients with poor clinical status","volume":"12","author":"Tancini","year":"1999","journal-title":"Eur J Cancer"},{"key":"5","doi-asserted-by":"publisher","first-page":"44","DOI":"10.32794\/mr11250011","article-title":"Mitochondria: the birth place, battle ground and the site of melatonin metabolism in cells","volume":"2","author":"Reiter","year":"2019","journal-title":"Melatonin Research"},{"key":"6","doi-asserted-by":"publisher","first-page":"18886","DOI":"10.3390\/molecules201018886","article-title":"Melatonin as a Potent and Inducible Endogenous Antioxidant: Synthesis and Metabolism","volume":"10","author":"Reiter","year":"2015","journal-title":"Molecules"},{"key":"7","doi-asserted-by":"publisher","first-page":"894","DOI":"10.2174\/1568026615666150220120946","article-title":"Antioxidant properties of melatonin and its potential action in diseases","volume":"9","author":"Suzen","year":"2015","journal-title":"Curr Top Med Chem"},{"key":"8","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1111\/j.1600-079x.1997.tb00322.x","article-title":"The validity of melatonin as an oncostatic agent","volume":"4","author":"Viljoen","year":"1997","journal-title":"J Pineal Res"},{"key":"9","doi-asserted-by":"publisher","first-page":"109018","DOI":"10.1016\/j.biopha.2019.109018","article-title":"Melatonin inhibits lung metastasis of gastric cancer","volume":"117","author":"Huang","year":"2019","journal-title":"Biomed Pharmacother"},{"key":"10","doi-asserted-by":"publisher","first-page":"1051","DOI":"10.1093\/carcin\/bgt025","article-title":"Blockage of melatonin receptors impairs p53-mediated prevention of DNA damage accumulation","volume":"34","author":"Strano","year":"2013","journal-title":"Carcinogenesis"},{"key":"11","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1111\/j.1742-4658.2009.07366.x","article-title":"ERK and cell death: mechanisms of ERK-induced cell death\u2013apoptosis, autophagy and senescence","volume":"1","author":"Chambard","year":"2010","journal-title":"FEBS J"},{"key":"12","doi-asserted-by":"publisher","first-page":"2885","DOI":"10.3390\/ijms20122885","article-title":"Extracellular-Signal Regulated Kinase: A Central Molecule Driving Epithelial-Mesenchymal Transition in Cancer","volume":"20","author":"Navarro-Tito","year":"2019","journal-title":"Int J Mol Sci"},{"key":"13","doi-asserted-by":"publisher","first-page":"1419","DOI":"10.1093\/carcin\/bgv132","article-title":"Mutagenic, surviving and tumorigenic effects of follicular fluid in the context of p53 loss: initiation of fimbria carcinogenesis","volume":"11","author":"Chu","year":"2015","journal-title":"Carcinogenesis"},{"key":"14","doi-asserted-by":"publisher","first-page":"3510970","DOI":"10.1155\/2018\/3510970","article-title":"Melatonin Inhibits Reactive Oxygen Species-Driven Proliferation, Epithelial-Mesenchymal Transition, and Vasculogenic Mimicry in Oral Cancer","volume":"2018","author":"Nie","year":"2018","journal-title":"Oxid Med Cell Longev"},{"key":"15","doi-asserted-by":"publisher","first-page":"860","DOI":"10.1038\/nature01322","article-title":"Inflammation and cancer","volume":"6917","author":"Werb","year":"2002","journal-title":"Nature"},{"key":"16","doi-asserted-by":"publisher","first-page":"4471","DOI":"10.2147\/CMAR.S197623","article-title":"Prognostic significance of systemic immune-inflammation index in triple-negative breast cancer","volume":"11","author":"Cheng","year":"2019","journal-title":"Cancer Manag Res"},{"key":"17","doi-asserted-by":"publisher","first-page":"4185","DOI":"10.2147\/CMAR.S190006","article-title":"Clinical significance of systemic immune-inflammation index (SII) and C-reactive protein-to-albumin ratio (CAR) in patients with esophageal cancer: a meta-analysis","volume":"11","author":"Wang","year":"2019","journal-title":"Cancer Manag Res"},{"key":"18","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1007\/s10787-017-0332-5","article-title":"Melatonin as an anti-inflammatory agent in radiotherapy","volume":"25","author":"Rezapoor","year":"2017","journal-title":"Inflammopharmacology"},{"key":"19","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1186\/s12885-015-1032-4","article-title":"Melatonin attenuates the TLR4-mediated inflammatory response through MyD88- and TRIF-dependent signaling pathways in anmodel of ovarian cancer","volume":"15","author":"Martinez","year":"2015","journal-title":"BMC Cancer"},{"key":"20","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1016\/j.pharep.2017.07.017","article-title":"Melatonin suppresses eosinophils and Th17 cells in hamsters treated with a combination of human liver fluke infection and a chemical carcinogen","volume":"1","author":"Pinlaor","year":"2018","journal-title":"Pharmacol Rep"},{"key":"21","doi-asserted-by":"publisher","first-page":"21952","DOI":"10.18632\/oncotarget.8009","article-title":"Melatonin inhibits TPA-induced oral cancer cell migration by suppressing matrix metalloproteinase-9 activation through the histone acetylation","volume":"7","author":"Yang","year":"2016","journal-title":"Oncotarget"},{"key":"22","doi-asserted-by":"publisher","first-page":"1302","DOI":"10.2174\/1871520614666140812110246","article-title":"Molecular markers of angiogenesis and metastasis in lines of oral carcinoma after treatment with melatonin","volume":"9","author":"Zuccari","year":"2014","journal-title":"Anticancer Agents Med Chem"},{"key":"23","first-page":"4432","article-title":"Melatonin inhibition and pinealectomy enhancement of 7,12-dimethylbenz(a)anthracene-induced mammary tumors in the rat","volume":"41","author":"Chabner","year":"1981","journal-title":"Cancer Res"},{"key":"24","first-page":"3403","article-title":"Effect of melatonin on mammary carcinogenesis in intact and pinealectomized rats in varying photoperiods","volume":"44","author":"Kothari","year":"1984","journal-title":"Cancer Res"},{"key":"25","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1210\/jcem-50-1-204","article-title":"Pinealectomy abolishes plasma melatonin in the rat","volume":"50","author":"Kopin","year":"1980","journal-title":"J Clin Endocrinol Metab"},{"key":"26","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1177\/074873049200700402","article-title":"The effect of pinealectomy on circadian plasma melatonin levels in house sparrows and European starlings","volume":"7","author":"Gwinner","year":"1992","journal-title":"J Biol Rhythms"},{"key":"27","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1111\/j.1600-079x.1992.tb00036.x","article-title":"Circadian rhythms of plasma melatonin in the ruin lizard Podarcis sicula: effects of pinealectomy","volume":"12","author":"Minutini","year":"1992","journal-title":"J Pineal Res"},{"key":"28","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1159\/000109107","article-title":"Pinealectomy reduces melatonin levels in the serum but not in the gastrointestinal tract of rats","volume":"6","author":"Brown","year":"1997","journal-title":"Biol Signals"},{"key":"29","doi-asserted-by":"publisher","first-page":"1363","DOI":"10.1007\/s10753-013-9676-1","article-title":"The expression of inflammatory cytokines on the aorta endothelia are up-regulated in pinealectomized rats","volume":"36","author":"Yan","year":"2013","journal-title":"Inflammation"},{"key":"30","doi-asserted-by":"publisher","first-page":"548","DOI":"10.1080\/07420528.2019.1566740","article-title":"Effect of pinealectomy on the circadian clock of the chick retina under different monochromatic lights","volume":"36","author":"Chen","year":"2019","journal-title":"Chronobiol Int"},{"key":"31","doi-asserted-by":"publisher","first-page":"1525","DOI":"10.1016\/j.bbadis.2019.03.002","article-title":"Pinealectomy or light exposure exacerbates biliary damage and liver fibrosis in cholestatic rats through decreased melatonin synthesis","volume":"1865","author":"Fabris","year":"2019","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"key":"32","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1002\/jso.2930080303","article-title":"The influence of pineal ablation and administration of melatonin on growth and spread of hamster melanoma","volume":"3","author":"Das Gupta","year":"1976","journal-title":"J Surg Oncol"},{"key":"33","doi-asserted-by":"publisher","first-page":"e12585","DOI":"10.1111\/jpi.12585","article-title":"Ameliorative effects of melatonin against solid Ehrlich carcinoma progression in female mice","volume":"8","author":"Ismail","year":"2019","journal-title":"J Pineal Res"},{"key":"34","doi-asserted-by":"publisher","first-page":"105","DOI":"10.32794\/mr11250033","article-title":"Inhibition of mitochondrial pyruvate dehydrogenase kinase: a proposed mechanism by which melatonin causes cancer cells to overcome cytosolic glycolysis, reduce tumor biomass and reverse insensitivity to chemotherapy","volume":"2","author":"Escames","year":"2019","journal-title":"Melatonin Research"},{"key":"35","doi-asserted-by":"publisher","first-page":"e102776","DOI":"10.1371\/journal.pone.0102776","article-title":"Light exposure at night disrupts host\/cancer circadian regulatory dynamics: impact on the Warburg effect, lipid signaling and tumor growth prevention","volume":"9","author":"Davidson","year":"2014","journal-title":"PLoS One"},{"key":"36","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1158\/1055-9965.EPI-16-0630","article-title":"Urinary Melatonin in Relation to Postmenopausal Breast Cancer Risk According to Melatonin 1 Receptor Status","volume":"3","author":"Schernhammer","year":"2017","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"37","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1111\/j.1600-079X.2005.00235.x","article-title":"Potent therapeutic effect of melatonin on aging skin in pinealectomized rats","volume":"3","author":"Uyumlu","year":"2005","journal-title":"J Pineal Res"},{"key":"38","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/jcp.10119","article-title":"Cellular response to oxidative stress: signaling for suicide and survival","volume":"192","author":"Holbrook","year":"2002","journal-title":"J Cell Physiol"},{"key":"39","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1016\/S1368-8375(98)00022-0","article-title":"Possible mechanisms by which alcohol may influence the development of oral cancer\u2013a review","volume":"6","author":"Ogden","year":"1998","journal-title":"Oral Oncol"},{"key":"40","doi-asserted-by":"publisher","first-page":"654","DOI":"10.1111\/j.1600-0714.1985.tb00543.x","article-title":"A histological analysis of the early effects of alcohol and tobacco usage on human lingual epithelium","volume":"14","author":"St Hill","year":"1985","journal-title":"J Oral Pathol"},{"key":"41","doi-asserted-by":"publisher","first-page":"1014","DOI":"10.1038\/ni.2703","article-title":"Innate and adaptive immune cells in the tumor microenvironment","volume":"10","author":"Fu","year":"2013","journal-title":"Nat Immunol"},{"key":"42","doi-asserted-by":"publisher","first-page":"1299","DOI":"10.1016\/j.fertnstert.2007.03.050","article-title":"Effects of melatonin on the endometrial morphology and embryo implantation in rats","volume":"89","author":"Soares","year":"2008","journal-title":"Fertil Steril"},{"key":"43","doi-asserted-by":"publisher","first-page":"1191","DOI":"10.3892\/ijo.2017.3883","article-title":"Inflammatory peroxidases promote breast cancer progression in mice via regulation of the tumour microenvironment","volume":"4","author":"Evdokiou","year":"2017","journal-title":"Int J Oncol"},{"key":"44","doi-asserted-by":"publisher","first-page":"31084","DOI":"10.1016\/j.ijom.2019.04.004","article-title":"Regulatory T cells and M2-polarized tumour-associated macrophages are associated with the oncogenesis and progression of oral squamous cell carcinoma","volume":"19","author":"Kumamoto","year":"2019","journal-title":"Int J Oral Maxillofac Surg"},{"key":"45","doi-asserted-by":"publisher","first-page":"1123","DOI":"10.1002\/lary.27413","article-title":"Clinical Implications of Tumor-Associated Tissue Eosinophilia in Tongue Squamous Cell Carcinoma","volume":"5","author":"Huang","year":"2019","journal-title":"Laryngoscope"},{"key":"46","doi-asserted-by":"publisher","first-page":"2702","DOI":"10.1111\/bph.13536","article-title":"Update on melatonin receptors: IUPHAR Review 20","volume":"173","author":"Zlotos","year":"2016","journal-title":"Br J Pharmacol"},{"key":"47","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1111\/jpi.12191","article-title":"Melatonin blunts the mitochondrial\/NLRP3 connection and protects against radiation-induced oral mucositis","volume":"58","author":"Escames","year":"2015","journal-title":"J Pineal Res"},{"key":"48","doi-asserted-by":"publisher","first-page":"1390","DOI":"10.1111\/j.1349-7006.2008.00838.x","article-title":"Frequent silencing of a putative tumor suppressor gene melatonin receptor 1 A (MTNR1A) in oral squamous-cell carcinoma","volume":"99","author":"Imoto","year":"2008","journal-title":"Cancer Sci"},{"key":"49","doi-asserted-by":"publisher","first-page":"2221","DOI":"10.3892\/ijmm.2018.3788","article-title":"Melatonin inhibits epithelial-to-mesenchymal transition in gastric cancer cells via attenuation of IL-1\u03b2\/NF-\u03baB\/MMP2\/MMP9 signaling","volume":"4","author":"Huang","year":"2018","journal-title":"Int J Mol Med"},{"key":"50","doi-asserted-by":"publisher","first-page":"1688","DOI":"10.2174\/1871520618666180131112304","article-title":"Melatonin Differentially Modulates NF-\u03baB Expression in Breast and Liver Cancer Cells","volume":"12","author":"Zuccari","year":"2018","journal-title":"Anticancer Agents Med Chem"},{"key":"51","doi-asserted-by":"publisher","first-page":"1168","DOI":"10.4161\/cc.8.8.8147","article-title":"How ERK1\/2 activation controls cell proliferation and cell death: Is subcellular localization the answer?","volume":"8","author":"Tesfaigzi","year":"2009","journal-title":"Cell Cycle"},{"key":"52","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1080\/10799893.2020.1719151","article-title":"Melatonin receptor protects cardiomyocyte against oxidative stress-induced apoptosis through the MAPK-ERK signaling pathway","volume":"40","author":"Tu","year":"2020","journal-title":"J Recept Signal Transduct Res"},{"key":"53","doi-asserted-by":"publisher","first-page":"5120275","DOI":"10.1155\/2019\/5120275","article-title":"Melatonin Protects Intervertebral Disc from Degeneration by Improving Cell Survival and Function via Activation of the ERK1\/2 Signaling pathway","volume":"2019","author":"Zou","year":"2019","journal-title":"Oxid Med Cell Longev"},{"key":"54","doi-asserted-by":"publisher","first-page":"19082","DOI":"10.1038\/s41598-019-55663-0","article-title":"Interaction of melatonin and Bmal1 in the regulation of PI3K\/AKT pathway components and cellular survival","volume":"9","author":"Kilic","year":"2019","journal-title":"Sci Rep"},{"key":"55","doi-asserted-by":"publisher","first-page":"3291","DOI":"10.1038\/sj.onc.1210422","article-title":"Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer","volume":"26","author":"Der","year":"2007","journal-title":"Oncogene"},{"key":"56","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1038\/nrc3911","article-title":"A RASopathy gene commonly mutated in cancer: the neurofibromatosis type 1 tumour suppressor","volume":"15","author":"Miller","year":"2015","journal-title":"Nat Rev Cancer"},{"key":"57","doi-asserted-by":"publisher","first-page":"33756","DOI":"10.18632\/oncotarget.16808","article-title":"Melatonin exerts anti-oral cancer effect via suppressing LSD1 in patient-derived tumor xenograft models","volume":"8","author":"Chen","year":"2017","journal-title":"Oncotarget"},{"key":"58","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1042\/CS20180945","article-title":"Melatonin suppresses lung cancer metastasis by inhibition of epithelial-mesenchymal transition through targeting to Twist","volume":"133","author":"Tang","year":"2019","journal-title":"Clin Sci (Lond)"},{"key":"59","doi-asserted-by":"publisher","first-page":"e12467","DOI":"10.1111\/jpi.12467","article-title":"Increase in motility and invasiveness of MCF7 cancer cells induced by nicotine is abolished by melatonin through inhibition of ERK phosphorylation","volume":"64","author":"Bizzarri","year":"2018","journal-title":"J Pineal Res"},{"key":"60","doi-asserted-by":"publisher","first-page":"e12507","DOI":"10.1111\/jpi.12507","article-title":"Melatonin attenuates osteosarcoma cell invasion by suppression of C-C motif chemokine ligand 24 through inhibition of the c-Jun N-terminal kinase pathway","volume":"65","author":"Yang","year":"2018","journal-title":"J Pineal Res"},{"key":"61","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1111\/j.1600-079X.2009.00686.x","article-title":"Antineoplastic effects of melatonin on a rare malignancy of mesenchymal origin: melatonin receptor-mediated inhibition of signal transduction, linoleic acid metabolism and growth in issue-isolated human leiomyosarcoma xenografts","volume":"47","author":"Sauer","year":"2009","journal-title":"J Pineal Res"},{"key":"62","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1038\/35042675","article-title":"Surfing the p53 network","volume":"408","author":"Levine","year":"2000","journal-title":"Nature"},{"key":"63","doi-asserted-by":"publisher","first-page":"1127","DOI":"10.1038\/nature07986","article-title":"Cytoplasmic functions of the tumour suppressor p53","volume":"458","author":"Kroemer","year":"2009","journal-title":"Nature"},{"key":"64","doi-asserted-by":"publisher","first-page":"646","DOI":"10.1016\/j.cell.2011.02.013","article-title":"Hallmarks of cancer: the next generation","volume":"144","author":"Weinberg","year":"2011","journal-title":"Cell"},{"key":"65","doi-asserted-by":"publisher","first-page":"156","DOI":"10.4161\/cbt.3.2.614","article-title":"The functional interactions between the p53 and MAPK signaling pathways","volume":"3","author":"Wu","year":"2004","journal-title":"Cancer Biol Ther"},{"key":"66","first-page":"1777","article-title":"p53 Antibodies in the sera of patients with various types of cancer: a review","volume":"60","author":"Soussi","year":"2000","journal-title":"Cancer Res"},{"key":"67","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1002\/(SICI)1096-9896(200003)190:4<417::AID-PATH544>3.0.CO;2-G","article-title":"p53 gene mutations in sequential oral epithelial dysplasias and squamous cell carcinomas","volume":"190","author":"Jordan","year":"2000","journal-title":"J Pathol"},{"key":"68","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/j.pnpbp.2014.01.015","article-title":"Anxiolytic-like effects of a new 1-N substituted analog of melatonin in pinealectomized rats","volume":"51","author":"Picazo","year":"2014","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"69","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.bbr.2015.12.043","article-title":"Consequences of long-term treatment with agomelatine on depressive-like behavior and neurobiological abnormalities in pinealectomized rats","volume":"302","author":"Lazarov","year":"2016","journal-title":"Behav Brain Res"},{"key":"70","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1177\/1099800417714069","article-title":"Measuring Light at Night and Melatonin Levels in Shift Workers: A Review of the Literature","volume":"4","author":"Figueiro","year":"2017","journal-title":"Biol Res Nurs"},{"key":"71","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1016\/j.lfs.2017.02.008","article-title":"Association between light at night, melatonin secretion, sleep deprivation, and the internal clock: Health impacts and mechanisms of circadian disruption","volume":"173","author":"Touitou","year":"2017","journal-title":"Life Sci"},{"key":"72","doi-asserted-by":"publisher","first-page":"1177","DOI":"10.1158\/1055-9965.EPI-18-1018","article-title":"Shift Work, Chronotype, and Melatonin Rhythm in Nurses","volume":"28","author":"Schernhammer","year":"2019","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"73","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1191\/0748233705th211oa","article-title":"Active smoking causes oxidative stress and decreases blood melatonin levels","volume":"21","author":"Cesur","year":"2005","journal-title":"Toxicol Ind Health"},{"key":"74","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1111\/j.1600-079X.2005.00285.x","article-title":"Urinary 6-sulfatoxymelatonin levels and their correlations with lifestyle factors and steroid hormone levels","volume":"40","author":"Hankinson","year":"2006","journal-title":"J Pineal Res"},{"key":"75","doi-asserted-by":"publisher","first-page":"35","DOI":"10.3109\/07420528.2011.636852","article-title":"Dim light melatonin onset in alcohol-dependent men and women compared with healthy controls","volume":"29","author":"Brower","year":"2012","journal-title":"Chronobiol Int"},{"key":"76","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1016\/j.lfs.2018.09.056","article-title":"Melatonin promotes reduction in TNF levels and improves the lipid profile and insulin sensitivity in pinealectomized rats with periodontal disease","volume":"213","author":"Sumida","year":"2018","journal-title":"Life Sci"},{"key":"77","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/S0047-6374(99)00058-5","article-title":"Augmentation of indices of oxidative damage in life-long melatonin-deficient rats","volume":"110","author":"Rouvier-Garay","year":"1999","journal-title":"Mech Ageing Dev"},{"key":"78","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1002\/ar.1091530103","article-title":"Rapid pinealectomy in hamsters and other small rodents","volume":"1","author":"Reiter","year":"1965","journal-title":"Anat Rec"},{"key":"79","first-page":"327","article-title":"Behavioral despair in mice: a primary screening test for antidepressants","volume":"229","author":"Jalfre","year":"1977","journal-title":"Arch Int Pharmacodyn Ther"},{"key":"80","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1007\/bf02244871","article-title":"Behavioural and pharmacological characterization of the elevated \u201czero-maze\u201d as an animal model of anxiety","volume":"1","author":"Dourish","year":"1994","journal-title":"Psychopharmacology (Berl)"},{"key":"81","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1016\/j.oraloncology.2005.10.013","article-title":"4-nitroquinoline-1-oxide induced experimental oral carcinogenesis","volume":"7","author":"Vaidya","year":"2006","journal-title":"Oral Oncol"},{"key":"82","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1016\/j.psyneuen.2017.11.001","article-title":"Stress hormones concentrations in the normal microenvironment predict risk for chemically induced cancer in rats","volume":"89","author":"Bernab\u00e9","year":"2018","journal-title":"Psychoneuroendocrinology"},{"key":"83","unstructured":"El-Naggar, Chan, Grandis, Takata, Slootweg. WHO classification of head and neck tumours, 9th ed. Lyon: IARC; 2017."},{"key":"84","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1016\/S1368-8375(97)00002-X","article-title":"Oral leukoplakia: a clinicopathological review","volume":"5","author":"Smeele","year":"1997","journal-title":"Oral Oncol"},{"key":"85","doi-asserted-by":"publisher","first-page":"1776","DOI":"10.1016\/j.jsxm.2018.10.009","article-title":"Structure of Epithelial and Stromal Compartments of Vulvar and Vaginal Tissue From Women With Vulvo-Vaginal Atrophy Taking Ospemifene","volume":"15","author":"Meriggiola","year":"2018","journal-title":"J Sex Med"},{"key":"86","doi-asserted-by":"publisher","first-page":"6321","DOI":"10.1007\/s13277-015-3318-1","article-title":"VEGFA isoforms play a vital role in oral cancer progression","volume":"36","author":"Patel","year":"2015","journal-title":"Tumour Biol"},{"key":"87","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.biopha.2013.10.005","article-title":"MicroRNA-29a upregulates MMP2 in oral squamous cell carcinoma to promote cancer invasion and anti-apoptosis","volume":"68","author":"Zhi","year":"2014","journal-title":"Biomed Pharmacother"},{"key":"88","doi-asserted-by":"publisher","first-page":"530","DOI":"10.7150\/ijms.19024","article-title":"KLF6 inhibited oral cancer migration and invasion via downregulation of mesenchymal markers and inhibition of MMP-9 activities","volume":"14","author":"Chen","year":"2017","journal-title":"Int J Med Sci"},{"key":"89","doi-asserted-by":"publisher","first-page":"887","DOI":"10.1002\/ijc.28727","article-title":"Differential mechanisms of CDKN2A (p16) alteration in oral tongue squamous cell carcinomas and correlation with patient outcome","volume":"135","author":"Fox","year":"2014","journal-title":"Int J Cancer"},{"key":"90","doi-asserted-by":"publisher","first-page":"2840","DOI":"10.1002\/ijc.22262","article-title":"Differential expression and activation of NF-kappaB family proteins during oral carcinogenesis: Role of high risk human papillomavirus infection","volume":"119","author":"Das","year":"2006","journal-title":"Int J Cancer"}],"container-title":["Oncotarget"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.27551","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,6,8]],"date-time":"2020-06-08T10:56:26Z","timestamp":1591613786000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.27551"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5,19]]},"references-count":90,"journal-issue":{"issue":"20","published-print":{"date-parts":[[2020,5,19]]}},"alternative-id":["27551","32499868"],"URL":"https:\/\/doi.org\/10.18632\/oncotarget.27551","relation":{},"ISSN":["1949-2553"],"issn-type":[{"value":"1949-2553","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,5,19]]}}}