{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T16:02:03Z","timestamp":1788451323189,"version":"build-2803163510"},"reference-count":27,"publisher":"Impact Journals, LLC","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncotarget"],"published-print":{"date-parts":[[2021,2,2]]},"DOI":"10.18632\/oncotarget.27876","type":"journal-article","created":{"date-parts":[[2021,2,2]],"date-time":"2021-02-02T12:21:53Z","timestamp":1612268513000},"page":"199-208","source":"Crossref","is-referenced-by-count":31,"title":["Testosterone deficiency in men receiving immunotherapy for malignant melanoma"],"prefix":"10.18632","volume":"12","author":[{"given":"Madeline","family":"Peters","sequence":"first","affiliation":[{"name":"Carver College of Medicine, University of Iowa, Iowa City, IA, 52242, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Pearlman","sequence":"additional","affiliation":[{"name":"Department of Urology, University of Iowa, Iowa City, IA, 52242, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Terry","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Iowa, Iowa City, IA, 52242, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah L.","family":"Mott","sequence":"additional","affiliation":[{"name":"Holden Comprehensive Cancer Center, University of Iowa, Iowa City, IA, 52242, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Varun","family":"Monga","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Iowa, Iowa City, IA, 52242, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7892","reference":[{"key":"1","unstructured":"Melanoma Skin Cancer Statistics. American Cancer Society. 2020. https:\/\/www.cancer.org\/cancer\/melanoma-skin-cancer\/about\/key-statistics.html."},{"key":"2","first-page":"228","article-title":"Melanoma: Molecular Pathogenesis and Therapeutic Management","volume":"6","author":"Sheikh","year":"2014","journal-title":"Mol Cell Pharmacol"},{"key":"3","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1001\/jamaoncol.2017.3064","article-title":"Incidence of Endocrine Dysfunction Following the Use of Different Immune Checkpoint Inhibitor Regimens","volume":"4","author":"Tolaney","year":"2018","journal-title":"JAMA Oncol"},{"key":"4","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1007\/s13539-012-0065-7","article-title":"Hypogonadism in male cancer patients","volume":"3","author":"Garcia","year":"2012","journal-title":"J Cachexia Sarcopenia Muscle"},{"key":"5","doi-asserted-by":"publisher","first-page":"1592","DOI":"10.1002\/cncr.24898","article-title":"Quality of life, self-esteem, fatigue, and sexual function in young men after cancer","volume":"11","author":"Ross","year":"2010","journal-title":"Cancer"},{"key":"6","doi-asserted-by":"publisher","first-page":"1250","DOI":"10.1158\/2159-8290.CD-18-0280","article-title":"SD-101 in Combination with Pembrolizumab in Advanced Melanoma: Results of a Phase Ib, Multicenter Study","volume":"8","author":"Leung","year":"2018","journal-title":"Cancer Discov"},{"key":"7","doi-asserted-by":"publisher","first-page":"2438","DOI":"10.18632\/oncotarget.27646","article-title":"Indoximod opposes the immunosuppressive effects mediated by IDO and TDO via modulation of AhR function and activation of mTORC1","volume":"1","author":"Mautino","year":"2020","journal-title":"Oncotarget"},{"key":"8","doi-asserted-by":"publisher","first-page":"370","DOI":"10.3389\/fonc.2018.00370","article-title":"Indoximod: An Immunometabolic Adjuvant That Empowers T Cell Activity in Cancer","volume":"8","author":"Prendergast","year":"2018","journal-title":"Front Oncol"},{"key":"9","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1038\/s41573-018-0006-z","article-title":"Delivery technologies for cancer immunotherapy","volume":"1","author":"Mitchell","year":"2019","journal-title":"Nat Rev Drug Discov"},{"key":"10","doi-asserted-by":"publisher","first-page":"pky021","DOI":"10.1093\/jncics\/pky021","article-title":"The Current Understanding of the Endocrine Effects From Immune Checkpoint Inhibitors and Recommendations for Management","volume":"2","author":"Gravell","year":"2018","journal-title":"JNCI Cancer Spectr"},{"key":"11","doi-asserted-by":"publisher","first-page":"1454","DOI":"10.3390\/ijms21041454","article-title":"Exposure to Chemotherapy During Childhood or Adulthood and Consequences on Spermatogenesis and Male Fertility","volume":"2","author":"Rives","year":"2020","journal-title":"Int J Mol Sci"},{"key":"12","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1200\/JOP.18.00005","article-title":"Management of Immune-Related Adverse Events in Patients Treated With Immune Checkpoint Inhibitor Therapy: American Society of Clinical Oncology Clinical Practice Guideline Summary","volume":"1","author":"Thompson","year":"2018","journal-title":"J Oncol Pract"},{"key":"13","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1210\/er.2018-00006","article-title":"Endocrine Toxicity of Cancer Immunotherapy Targeting Immune Checkpoints","volume":"4","author":"Min","year":"2019","journal-title":"Endocr Rev"},{"key":"14","doi-asserted-by":"publisher","first-page":"T331","DOI":"10.1530\/ERC-17-0358","article-title":"Endocrine side effects of cancer immunotherapy","volume":"2","author":"Hoff","year":"2017","journal-title":"Endocr Relat Cancer"},{"key":"15","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1530\/ERC-13-0499","article-title":"Endocrine-related adverse events following ipilimumab in patients with advanced melanoma: a comprehensive retrospective review from a single institution","volume":"2","author":"Fagin","year":"2014","journal-title":"Endocr Relat Cancer"},{"key":"16","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1158\/1078-0432.CCR-14-2353","article-title":"Systemic High-Dose Corticosteroid Treatment Does Not Improve the Outcome of Ipilimumab-Related Hypophysitis: A Retrospective Cohort Study","volume":"2","author":"Kaiser","year":"2015","journal-title":"Clin Cancer Res"},{"key":"17","doi-asserted-by":"publisher","first-page":"4078","DOI":"10.1210\/jc.2014-2306","article-title":"Ipilimumab-Induced Hypophysitis: A Detailed Longitudinal Analysis in a Large Cohort of Patients With Metastatic Melanoma","volume":"9","author":"Nachtigall","year":"2014","journal-title":"J Clin Endocrinol Metab"},{"key":"18","doi-asserted-by":"publisher","first-page":"297","DOI":"10.4103\/0110-5558.72420","article-title":"Male hypogonadism: Symptoms and treatment","volume":"1","author":"Patidar","year":"2010","journal-title":"J Adv Pharm Technol Res"},{"key":"19","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/j.eururo.2007.02.034","article-title":"Testosterone and Erectile Function: From Basic Research to a New Clinical Paradigm for Managing Men with Androgen Insufficiency and Erectile Dysfunction","volume":"5","author":"Kim","year":"2007","journal-title":"Eur Urol"},{"key":"20","doi-asserted-by":"publisher","first-page":"528","DOI":"10.1016\/j.jaad.2016.04.031","article-title":"Oncofertility considerations in adolescents and young adults given a diagnosis of melanoma: Fertility risk of Food and Drug Administration-approved systemic therapies","volume":"7","author":"Woodruff","year":"2016","journal-title":"J Am Acad Dermatol"},{"key":"21","doi-asserted-by":"publisher","first-page":"pkz031","DOI":"10.1093\/jncics\/pkz031","article-title":"Emerging Cancer Survival Trends, Disparities, and Priorities in Adolescents and Young Adults: A California Cancer Registry-Based Study","volume":"3","author":"Deapen","year":"2019","journal-title":"JNCI Cancer Spectr"},{"key":"22","unstructured":"Bleyer, O\u2019Leary, Barr, Ries (eds). Cancer Epidemiology in Older Adolescents and Young Adults 15 to 29 Years of Age, Including SEER Incidence and Survival: 1975-2000. National Cancer Institute, NIH Pub. No. 06\u20135767. 2006."},{"key":"23","doi-asserted-by":"publisher","first-page":"e15114","DOI":"10.1200\/JCO.2018.36.15_suppl.e15114","article-title":"Testicular histopathology after immunotherapy for metastatic melanoma","volume":"3","author":"Herati","year":"2018","journal-title":"J Clin Oncol"},{"key":"24","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1634\/theoncologist.2019-0837","article-title":"It Is Time to Talk About Fertility and Immunotherapy","volume":"2","author":"Lambertini","year":"2020","journal-title":"Oncologist"},{"key":"25","doi-asserted-by":"publisher","first-page":"iv264","DOI":"10.1093\/annonc\/mdy162","article-title":"Corrections to \u201cManagement of toxicities from immunotherapy: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up","volume":"2","author":"Jordan","year":"2018","journal-title":"Ann Oncol"},{"key":"26","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1111\/obr.12282","article-title":"Testosterone and obesity","volume":"1","author":"Jones","year":"2015","journal-title":"Obes Rev"},{"key":"27","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1016\/j.juro.2018.03.115","article-title":"Evaluation and Management of Testosterone Deficiency: AUA Guideline","volume":"20","author":"Lewis","year":"2018","journal-title":"J Urol"}],"container-title":["Oncotarget"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.27876","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,2,2]],"date-time":"2021-02-02T12:22:34Z","timestamp":1612268554000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.27876"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,2]]},"references-count":27,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,2,2]]}},"alternative-id":["27876"],"URL":"https:\/\/doi.org\/10.18632\/oncotarget.27876","relation":{},"ISSN":["1949-2553"],"issn-type":[{"value":"1949-2553","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2,2]]}}}