{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T05:24:15Z","timestamp":1778822655194,"version":"3.51.4"},"reference-count":48,"publisher":"Impact Journals, LLC","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncotarget"],"published-print":{"date-parts":[[2022,10,20]]},"DOI":"10.18632\/oncotarget.28300","type":"journal-article","created":{"date-parts":[[2022,10,20]],"date-time":"2022-10-20T14:16:35Z","timestamp":1666275395000},"page":"1175-1186","source":"Crossref","is-referenced-by-count":1,"title":["The serine protease matriptase inhibits migration and proliferation in multiple myeloma cells"],"prefix":"10.18632","volume":"13","author":[{"given":"Ida","family":"Steiro","sequence":"first","affiliation":[{"name":"Center for Myeloma Research, Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), Trondheim, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esten N.","family":"Vandsemb","sequence":"additional","affiliation":[{"name":"Center for Myeloma Research, Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), Trondheim, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samah","family":"Elsaadi","sequence":"additional","affiliation":[{"name":"Center for Myeloma Research, Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), Trondheim, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristine","family":"Misund","sequence":"additional","affiliation":[{"name":"Center for Myeloma Research, Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), Trondheim, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne-Marit","family":"Sponaas","sequence":"additional","affiliation":[{"name":"Center for Myeloma Research, Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), Trondheim, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magne","family":"B\u00f8rset","sequence":"additional","affiliation":[{"name":"Center for Myeloma Research, Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), Trondheim, Norway"},{"name":"Department of Immunology and Transfusion Medicine, St. Olav's University Hospital, Trondheim, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pegah","family":"Abdollahi","sequence":"additional","affiliation":[{"name":"Center for Myeloma Research, Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), Trondheim, Norway"},{"name":"Laboratory Clinic, St. Olav's University Hospital, Trondheim, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tobias S.","family":"Sl\u00f8rdahl","sequence":"additional","affiliation":[{"name":"Center for Myeloma Research, Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), Trondheim, Norway"},{"name":"Department of Hematology, St. Olav's University Hospital, Trondheim, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7892","published-online":{"date-parts":[[2022,10,20]]},"reference":[{"key":"1","first-page":"2306","article-title":"Characterization of adhesion molecules on human myeloma cell lines","volume":"8","author":"Anderson","year":"1992","journal-title":"Blood"},{"key":"2","doi-asserted-by":"publisher","first-page":"1272","DOI":"10.3892\/or.2019.7261","article-title":"The impact of the bone marrow microenvironment on multiple myeloma (Review)","volume":"4","author":"Yang","year":"2019","journal-title":"Oncol Rep"},{"key":"3","first-page":"1658","article-title":"Cell adhesion mediated drug resistance (CAM-DR): role of integrins and resistance to apoptosis in human myeloma cell lines","volume":"9","author":"Dalton","year":"1999","journal-title":"Blood"},{"key":"4","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1007\/s40265-017-0841-y","article-title":"Current and New Therapeutic Strategies for Relapsed and Refractory Multiple Myeloma: An Update","volume":"7","author":"Lokhorst","year":"2018","journal-title":"Drugs"},{"key":"5","doi-asserted-by":"publisher","first-page":"1017","DOI":"10.1177\/002215540305100805","article-title":"Characterization of matriptase expression in normal human tissues","volume":"5","author":"Lin","year":"2003","journal-title":"J Histochem Cytochem"},{"key":"6","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1007\/s10555-019-09811-7","article-title":"Cell surface-anchored serine proteases in cancer progression and metastasis","volume":"3","author":"List","year":"2019","journal-title":"Cancer Metastasis Rev"},{"key":"7","doi-asserted-by":"publisher","first-page":"1934","DOI":"10.1101\/gad.1300705","article-title":"Deregulated matriptase causes ras-independent multistage carcinogenesis and promotes ras-mediated malignant transformation","volume":"1","author":"Bugge","year":"2005","journal-title":"Genes Dev"},{"key":"8","doi-asserted-by":"publisher","first-page":"1439","DOI":"10.1046\/j.1432-1327.2001.02016.x","article-title":"Regulation of the activity of matriptase on epithelial cell surfaces by a blood-derived factor","volume":"26","author":"Lin","year":"2001","journal-title":"Eur J Biochem"},{"key":"9","doi-asserted-by":"publisher","first-page":"26773","DOI":"10.1074\/jbc.M304282200","article-title":"The activation of matriptase requires its noncatalytic domains, serine protease domain, and its cognate inhibitor","volume":"27","author":"Lin","year":"2003","journal-title":"J Biol Chem"},{"key":"10","doi-asserted-by":"publisher","first-page":"C462","DOI":"10.1152\/ajpcell.00076.2005","article-title":"HAI-1 regulates activation and expression of matriptase, a membrane-bound serine protease","volume":"28","author":"Lin","year":"2005","journal-title":"Am J Physiol Cell Physiol"},{"key":"11","doi-asserted-by":"publisher","first-page":"27558","DOI":"10.1074\/jbc.272.44.27558","article-title":"Purification and cloning of hepatocyte growth factor activator inhibitor type 2, a Kunitz-type serine protease inhibitor","volume":"27","author":"Kitamura","year":"1997","journal-title":"J Biol Chem"},{"key":"12","doi-asserted-by":"publisher","first-page":"29495","DOI":"10.1074\/jbc.M801970200","article-title":"Potent inhibition and global co-localization implicate the transmembrane Kunitz-type serine protease inhibitor hepatocyte growth factor activator inhibitor-2 in the regulation of epithelial matriptase activity","volume":"28","author":"Bugge","year":"2008","journal-title":"J Biol Chem"},{"key":"13","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1111\/tra.12482","article-title":"HAI-2 stabilizes, inhibits and regulates SEA-cleavage-dependent secretory transport of matriptase","volume":"1","author":"Vogel","year":"2017","journal-title":"Traffic"},{"key":"14","doi-asserted-by":"publisher","first-page":"22319","DOI":"10.1074\/jbc.M114.574400","article-title":"The protease inhibitor HAI-2, but not HAI-1, regulates matriptase activation and shedding through prostasin","volume":"28","author":"Bugge","year":"2014","journal-title":"J Biol Chem"},{"key":"15","doi-asserted-by":"publisher","first-page":"1","DOI":"10.2119\/2006-00022.List","article-title":"Matriptase: potent proteolysis on the cell surface","volume":"1","author":"Szabo","year":"2006","journal-title":"Mol Med"},{"key":"16","doi-asserted-by":"publisher","first-page":"12682","DOI":"10.18632\/oncotarget.23913","article-title":"Regulation of matriptase and HAI-1 system, a novel therapeutic target in human endometrial cancer cells","volume":"9","author":"Sehouli","year":"2018","journal-title":"Oncotarget"},{"key":"17","doi-asserted-by":"publisher","first-page":"36720","DOI":"10.1074\/jbc.M007802200","article-title":"Activation of hepatocyte growth factor and urokinase\/plasminogen activator by matriptase, an epithelial membrane serine protease","volume":"27","author":"Lin","year":"2000","journal-title":"J Biol Chem"},{"key":"18","doi-asserted-by":"publisher","first-page":"5771","DOI":"10.1073\/pnas.0606514104","article-title":"Coordinate expression and functional profiling identify an extracellular proteolytic signaling pathway","volume":"10","author":"Craik","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"key":"19","doi-asserted-by":"publisher","first-page":"1301","DOI":"10.1016\/S0002-9440(10)64081-3","article-title":"Matriptase and HAI-1 are expressed by normal and malignant epithelial cellsand","volume":"15","author":"Lin","year":"2001","journal-title":"Am J Pathol"},{"key":"20","doi-asserted-by":"publisher","first-page":"692","DOI":"10.1080\/14756366.2019.1577831","article-title":"Aberrant regulation favours matriptase proteolysis in neoplastic B-cells that co-express HAI-2","volume":"3","author":"Lin","year":"2019","journal-title":"J Enzyme Inhib Med Chem"},{"key":"21","doi-asserted-by":"publisher","first-page":"1306","DOI":"10.1016\/j.ajpath.2013.06.024","article-title":"Imbalanced matriptase pericellular proteolysis contributes to the pathogenesis of malignant B-cell lymphomas","volume":"18","author":"Lin","year":"2013","journal-title":"Am J Pathol"},{"key":"22","doi-asserted-by":"publisher","first-page":"1191","DOI":"10.1038\/leu.2012.289","article-title":"Matriptase is highly upregulated in chronic lymphocytic leukemia and promotes cancer cell invasion","volume":"2","author":"Wu","year":"2013","journal-title":"Leukemia"},{"key":"23","first-page":"753","article-title":"[Expression level and Clinical Significance of Serum SE-CAD and Matriptase in Patients with Acute Myeloid Leukemia]","volume":"2","author":"Zhong","year":"2019","journal-title":"Zhongguo Shi Yan Xue Ye Xue Za Zhi"},{"key":"24","doi-asserted-by":"publisher","first-page":"2616","DOI":"10.1182\/blood-2006-02-001073","article-title":"Initiation of plasminogen activation on the surface of monocytes expressing the type II transmembrane serine protease matriptase","volume":"10","author":"Ellis","year":"2006","journal-title":"Blood"},{"key":"25","doi-asserted-by":"publisher","first-page":"4","DOI":"10.13055\/ojhmt_3_s1_04.120221","article-title":"Cell Trafficking in Multiple Myeloma","volume":"3","author":"Roccaro","year":"2012","journal-title":"Open J Hematol"},{"key":"26","doi-asserted-by":"publisher","first-page":"646","DOI":"10.1016\/j.exphem.2013.03.002","article-title":"HGF and IGF-1 synergize with SDF-1\u03b1 in promoting migration of myeloma cells by cooperative activation of p21-activated kinase","volume":"4","author":"B\u00f8rset","year":"2013","journal-title":"Exp Hematol"},{"key":"27","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.yjmcc.2015.01.024","article-title":"A critical role of Src family kinase in SDF-1\/CXCR4-mediated bone-marrow progenitor cell recruitment to the ischemic heart","volume":"8","author":"Qin","year":"2015","journal-title":"J Mol Cell Cardiol"},{"key":"28","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1038\/sj.onc.1206910","article-title":"Regulation of CXCR4-mediated chemotaxis and chemoinvasion of breast cancer cells","volume":"2","author":"Ganju","year":"2004","journal-title":"Oncogene"},{"key":"29","doi-asserted-by":"publisher","first-page":"169","DOI":"10.3390\/cancers9120169","article-title":"Activated HGF-c-Met Axis in Head and Neck Cancer","volume":"9","author":"Thomas","year":"2017","journal-title":"Cancers (Basel)"},{"key":"30","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1023\/a:1023772912750","article-title":"Src family kinases in tumor progression and metastasis","volume":"2","author":"Gallick","year":"2003","journal-title":"Cancer Metastasis Rev"},{"key":"31","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1038\/nrclinonc.2009.129","article-title":"Src kinases as therapeutic targets for cancer","volume":"6","author":"Haura","year":"2009","journal-title":"Nat Rev Clin Oncol"},{"key":"32","doi-asserted-by":"publisher","first-page":"C453","DOI":"10.1152\/ajpcell.00344.2011","article-title":"Mechanisms for the control of matriptase activity in the absence of sufficient HAI-1","volume":"30","author":"Lin","year":"2012","journal-title":"Am J Physiol Cell Physiol"},{"key":"33","doi-asserted-by":"publisher","first-page":"619","DOI":"10.3324\/haematol.11867","article-title":"Hepatocyte growth factor promotes migration of human myeloma cells","volume":"9","author":"B\u00f8rset","year":"2008","journal-title":"Haematologica"},{"key":"34","doi-asserted-by":"publisher","first-page":"1465","DOI":"10.3892\/mmr.2016.5435","article-title":"Decreasing the ratio of matriptase\/HAI-1 by downregulation of matriptase as a potential adjuvant therapy in ovarian cancer","volume":"1","author":"Mustea","year":"2016","journal-title":"Mol Med Rep"},{"key":"35","doi-asserted-by":"publisher","first-page":"4643","DOI":"10.1038\/onc.2013.412","article-title":"HAI-2 suppresses the invasive growth and metastasis of prostate cancer through regulation of matriptase","volume":"3","author":"Lee","year":"2014","journal-title":"Oncogene"},{"key":"36","doi-asserted-by":"publisher","first-page":"1346","DOI":"10.1182\/blood-2007-10-116590","article-title":"Validation of PDGFRbeta and c-Src tyrosine kinases as tumor\/vessel targets in patients with multiple myeloma: preclinical efficacy of the novel, orally available inhibitor dasatinib","volume":"11","author":"Vacca","year":"2008","journal-title":"Blood"},{"key":"37","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/j.leukres.2013.10.017","article-title":"By inhibiting Src, verapamil and dasatinib overcome multidrug resistance via increased expression of Bim and decreased expressions of MDR1 and survivin in human multidrug-resistant myeloma cells","volume":"3","author":"Nishida","year":"2014","journal-title":"Leuk Res"},{"key":"38","doi-asserted-by":"publisher","first-page":"2103","DOI":"10.3892\/ol.2017.6389","article-title":"CXCL12\/SDF-1\u03b1 induces migration via SRC-mediated CXCR4-EGFR cross-talk in gastric cancer cells","volume":"1","author":"Liu","year":"2017","journal-title":"Oncol Lett"},{"key":"39","doi-asserted-by":"publisher","first-page":"26333","DOI":"10.1074\/jbc.M002941200","article-title":"Cellular localization of membrane-type serine protease 1 and identification of protease-activated receptor-2 and single-chain urokinase-type plasminogen activator as substrates","volume":"27","author":"Craik","year":"2000","journal-title":"J Biol Chem"},{"key":"40","doi-asserted-by":"publisher","first-page":"901","DOI":"10.1083\/jcb.200304161","article-title":"Loss of proteolytically processed filaggrin caused by epidermal deletion of Matriptase\/MT-SP1","volume":"16","author":"Bugge","year":"2003","journal-title":"J Cell Biol"},{"key":"41","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1038\/jid.2013.320","article-title":"Matriptase regulates proliferation and early, but not terminal, differentiation of human keratinocytes","volume":"13","author":"Lin","year":"2014","journal-title":"J Invest Dermatol"},{"key":"42","doi-asserted-by":"publisher","first-page":"6776","DOI":"10.1038\/ncomms7776","article-title":"Targeting matriptase in breast cancer abrogates tumour progression via impairment of stromal-epithelial growth factor signalling","volume":"6","author":"List","year":"2015","journal-title":"Nat Commun"},{"key":"43","doi-asserted-by":"publisher","first-page":"1741","DOI":"10.3892\/ol.2017.5600","article-title":"Expression and prognostic value of matriptase in ovarian serous adenocarcinoma","volume":"1","author":"Wang","year":"2017","journal-title":"Oncol Lett"},{"key":"44","doi-asserted-by":"publisher","first-page":"3679","DOI":"10.1038\/onc.2011.545","article-title":"Suppression of Tumorigenicity-14, encoding matriptase, is a critical suppressor of colitis and colitis-associated colon carcinogenesis","volume":"3","author":"Bugge","year":"2012","journal-title":"Oncogene"},{"key":"45","doi-asserted-by":"publisher","first-page":"3145","DOI":"10.2353\/ajpath.2010.100228","article-title":"Matriptase is involved in ErbB-2-induced prostate cancer cell invasion","volume":"17","author":"Lee","year":"2010","journal-title":"Am J Pathol"},{"key":"46","doi-asserted-by":"publisher","first-page":"3708","DOI":"10.3390\/ijms19123708","article-title":"Matriptase-Induced Phosphorylation of MET is Significantly Associated with Poor Prognosis in Invasive Bladder Cancer; an Immunohistochemical Analysis","volume":"1","author":"Kamoto","year":"2018","journal-title":"Int J Mol Sci"},{"key":"47","doi-asserted-by":"publisher","first-page":"e6529","DOI":"10.1371\/journal.pone.0006529","article-title":"A versatile viral system for expression and depletion of proteins in mammalian cells","volume":"4","author":"Kaufman","year":"2009","journal-title":"PLoS One"},{"key":"48","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1111\/ejh.12185","article-title":"Anti-c-MET Nanobody - a new potential drug in multiple myeloma treatment","volume":"9","author":"R\u00f8","year":"2013","journal-title":"Eur J Haematol"}],"container-title":["Oncotarget"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.28300","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,20]],"date-time":"2022-10-20T14:16:39Z","timestamp":1666275399000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.28300"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,20]]},"references-count":48,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,10,20]]}},"alternative-id":["28300"],"URL":"https:\/\/doi.org\/10.18632\/oncotarget.28300","relation":{},"ISSN":["1949-2553"],"issn-type":[{"value":"1949-2553","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10,20]]}}}