{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T20:48:31Z","timestamp":1787863711701,"version":"build-2784847793"},"reference-count":64,"publisher":"Impact Journals, LLC","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncotarget"],"published-print":{"date-parts":[[2015,2,20]]},"DOI":"10.18632\/oncotarget.2850","type":"journal-article","created":{"date-parts":[[2015,9,15]],"date-time":"2015-09-15T08:00:44Z","timestamp":1442304044000},"page":"3443-3451","source":"Crossref","is-referenced-by-count":23,"title":["Oncogenes and tumor suppressor genes in squamous cell carcinoma of the tongue in young patients"],"prefix":"10.18632","volume":"6","author":[{"given":"Andreas","family":"Knopf","sequence":"first","affiliation":[{"name":"Technische Universit\u00e4t M\u00fcnchen, Hals-Nasen-Ohrenklinik und Poliklinik, 81675 M\u00fcnchen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justine","family":"Lempart","sequence":"additional","affiliation":[{"name":"Technische Universit\u00e4t M\u00fcnchen, Hals-Nasen-Ohrenklinik und Poliklinik, 81675 M\u00fcnchen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murat","family":"Bas","sequence":"additional","affiliation":[{"name":"Technische Universit\u00e4t M\u00fcnchen, Hals-Nasen-Ohrenklinik und Poliklinik, 81675 M\u00fcnchen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Slotta-Huspenina","sequence":"additional","affiliation":[{"name":"Technische Universit\u00e4t M\u00fcnchen, Institut f\u00fcr Allgemeine Pathologie und Pathologische Anatomie, 81675 M\u00fcnchen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naglaa","family":"Mansour","sequence":"additional","affiliation":[{"name":"Technische Universit\u00e4t M\u00fcnchen, Hals-Nasen-Ohrenklinik und Poliklinik, 81675 M\u00fcnchen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie Kristin","family":"Fritsche","sequence":"additional","affiliation":[{"name":"Technische Universit\u00e4t M\u00fcnchen, Hals-Nasen-Ohrenklinik und Poliklinik, 81675 M\u00fcnchen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7892","published-online":{"date-parts":[[2015,1,30]]},"reference":[{"key":"1","doi-asserted-by":"crossref","first-page":"74","DOI":"10.3322\/canjclin.55.2.74","article-title":"Global cancer statistics, 2002","volume":"55","author":"Pisani","year":"2005","journal-title":"CA Cancer J Clin"},{"key":"2","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1002\/cncr.22563","article-title":"Conditional survival in head and neck squamous cell carcinoma: results from the SEER dataset 1973-1998","volume":"109","author":"Rosenthal","year":"2007","journal-title":"Cancer"},{"key":"3","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1002\/hed.21220","article-title":"Never-smokers, never-drinkers: unique clinical subgroup of young patients with head and neck squamous cell cancers","volume":"32","author":"Rosenman","year":"2010","journal-title":"Head Neck"},{"key":"4","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1200\/JCO.2007.14.1713","article-title":"Incidence trends for human papillomavirus-related and -unrelated oral squamous cell carcinomas in the United States","volume":"26","author":"Gillison","year":"2008","journal-title":"J Clin Oncol"},{"key":"5","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1111\/j.1600-0528.2007.00299.x","article-title":"Trends in palatine tonsillar cancer incidence and mortality rates in the United States","volume":"35","author":"Golas","year":"2007","journal-title":"Community Dent Oral Epidemiol"},{"key":"6","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1002\/ijc.10577","article-title":"Incidence and survival of squamous cell carcinoma of the tongue in Scandinavia, with special reference to young adults","volume":"101","author":"Wennerberg","year":"2002","journal-title":"Int J Cancer"},{"key":"7","first-page":"Doc09","article-title":"Basics of tumor development and importance of human papilloma virus (HPV) for head and neck cancer","volume":"11","author":"Klussmann","year":"2012","journal-title":"GMS Curr Top Otorhinolaryngol Head Neck Surg"},{"key":"8","doi-asserted-by":"crossref","first-page":"1843","DOI":"10.1002\/cncr.20998","article-title":"Tongue and tonsil carcinoma: increasing trends in the U.S. population ages 20-44 years","volume":"103","author":"Jordan","year":"2005","journal-title":"Cancer"},{"key":"9","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1207\/s15324796abm2902_2","article-title":"Commentary on Schroder, et al (2003a, 2003b)","volume":"29","author":"Shiboski","year":"2005","journal-title":"Ann Behav Med"},{"key":"10","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.1200\/JCO.2010.31.7883","article-title":"Increasing incidence of oral tongue squamous cell carcinoma in young white women, age 18 to 44 years","volume":"29","author":"Chera","year":"2011","journal-title":"J Clin Oncol"},{"key":"11","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/S0194-5998(00)70142-2","article-title":"Squamous cell carcinoma of the tongue in young adults: increasing incidence and factors that predict treatment outcomes","volume":"122","author":"Byers","year":"2000","journal-title":"Otolaryngol Head Neck Surg"},{"key":"12","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1054\/ijom.2002.0271","article-title":"Survival in patients under 45 years with squamous cell carcinoma of the oral tongue","volume":"32","author":"Sebastian","year":"2003","journal-title":"Int J Oral Maxillofac Surg"},{"key":"13","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/S1368-8375(02)00026-X","article-title":"Squamous cell carcinoma of the oral cavity in patients aged 45 years and under: a descriptive analysis of 116 cases diagnosed in the South East of England from 1990 to 1997","volume":"39","author":"Warnakulasuriya","year":"2003","journal-title":"Oral Oncol"},{"key":"14","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1002\/ijc.28152","article-title":"Mechanisms of oral carcinogenesis induced by dibenzo[a,l]pyrene: an environmental pollutant and a tobacco smoke constituent","volume":"133","author":"Jiang","year":"2013","journal-title":"Int J Cancer"},{"key":"15","doi-asserted-by":"crossref","first-page":"2005","DOI":"10.1002\/cncr.28015","article-title":"Prognostic value of p16 expression and alcohol consumption in Japanese patients with oropharyngeal squamous cell carcinoma","volume":"119","author":"Asakage","year":"2013","journal-title":"Cancer"},{"key":"16","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1053\/j.seminoncol.2004.09.013","article-title":"Descriptive epidemiology and risk factors for head and neck cancer","volume":"31","author":"Spitz","year":"2004","journal-title":"Semin Oncol"},{"key":"17","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1002\/hed.22935","article-title":"Oral and oropharyngeal squamous cell carcinoma in young patients: the Netherlands Cancer Institute experience","volume":"35","author":"Wreesmann","year":"2013","journal-title":"Head Neck"},{"key":"18","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1126\/science.1208130","article-title":"The mutational landscape of head and neck squamous cell carcinoma","volume":"333","author":"McKenna","year":"2011","journal-title":"Science"},{"key":"19","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.surneu.2006.02.043","article-title":"Extracranial meningioma in the vicinity of the temporal bone: a difficult preoperative diagnosis","volume":"67","author":"Patel","year":"2007","journal-title":"Surg Neurol"},{"key":"20","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/S1368-8375(02)00064-7","article-title":"Specific p53 mutations predict poor prognosis in oral squamous cell carcinoma","volume":"39","author":"Fukuda","year":"2003","journal-title":"Oral Oncol"},{"key":"21","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1126\/science.1206923","article-title":"Exome sequencing of head and neck squamous cell carcinoma reveals inactivating mutations in NOTCH1","volume":"333","author":"Wang","year":"2011","journal-title":"Science"},{"key":"22","doi-asserted-by":"crossref","first-page":"1951","DOI":"10.1172\/JCI59889","article-title":"The molecular pathogenesis of head and neck squamous cell carcinoma","volume":"122","author":"Ellisen","year":"2012","journal-title":"J Clin Invest"},{"key":"23","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1136\/jcp.2003.007641","article-title":"Molecular biology of squamous cell carcinoma of the head and neck","volume":"59","author":"Jordan","year":"2006","journal-title":"J Clin Pathol"},{"key":"24","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1002\/ijc.2910520606","article-title":"The p53 tumor-suppressor gene and ras oncogene mutations in oral squamous-cell carcinoma","volume":"52","author":"Tsuchida","year":"1992","journal-title":"Int J Cancer"},{"key":"25","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/0092-8674(92)90593-2","article-title":"A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia","volume":"71","author":"Fornace","year":"1992","journal-title":"Cell"},{"key":"26","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1002\/j.1460-2075.1993.tb05678.x","article-title":"mdm2 expression is induced by wild type p53 activity","volume":"12","author":"Oren","year":"1993","journal-title":"EMBO J"},{"key":"27","first-page":"3630","article-title":"High frequency of p16 (CDKN2\/MTS-1\/INK4A) inactivation in head and neck squamous cell carcinoma","volume":"56","author":"Nawroz","year":"1996","journal-title":"Cancer Res"},{"key":"28","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1016\/S0092-8674(00)81519-6","article-title":"Cdk phosphorylation triggers sequential intramolecular interactions that progressively block Rb functions as cells move through G1","volume":"98","author":"Dean","year":"1999","journal-title":"Cell"},{"key":"29","first-page":"910","article-title":"Increasing incidence of cancer of the tongue in the United States among young adults","volume":"2","author":"Severson","year":"1987","journal-title":"Lancet"},{"key":"30","doi-asserted-by":"crossref","first-page":"1943","DOI":"10.1001\/jama.1988.03720130021012","article-title":"Tobacco and cancer of the tongue in young adults","volume":"259","author":"Goepfert","year":"1988","journal-title":"JAMA"},{"key":"31","first-page":"649498","article-title":"Oral cavity and pharynx cancer incidence trends by subsite in the United States: changing gender patterns","volume":"2012","author":"Devesa","year":"2012","journal-title":"J Oncol"},{"key":"32","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1056\/NEJM198609043151013","article-title":"Rising mortality from cancer of the tongue in young white males","volume":"315","author":"Depue","year":"1986","journal-title":"N Engl J Med"},{"key":"33","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1002\/hed.2880160202","article-title":"Oral tongue cancer in young adults less than 40 years of age: rationale for aggressive therapy","volume":"16","author":"Harari","year":"1994","journal-title":"Head Neck"},{"key":"34","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1001\/archotol.1996.01890240021006","article-title":"Cancer of the tongue in patients younger than 40 years. A distinct entity?","volume":"122","author":"Syrjanen","year":"1996","journal-title":"Arch Otolaryngol Head Neck Surg"},{"key":"35","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1002\/(SICI)1097-0347(199808)20:5<363::AID-HED1>3.0.CO;2-W","article-title":"Squamous cell carcinoma of the tongue in young patients: a matched-pair analysis","volume":"20","author":"Shah","year":"1998","journal-title":"Head Neck"},{"key":"36","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1017\/S002221510011312X","article-title":"Head and neck cancer in the young: a prognostic conundrum?","volume":"104","author":"Howard","year":"1990","journal-title":"J Laryngol Otol"},{"key":"37","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1017\/S0022215100101008","article-title":"Malignant tumours of the tongue in young adults. Experience of a secondary referral centre","volume":"100","author":"Shaw","year":"1986","journal-title":"J Laryngol Otol"},{"key":"38","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1200\/JCO.1998.16.2.745","article-title":"Oral tongue cancer in patients less than 45 years old: institutional experience and comparison with older patients","volume":"16","author":"Langer","year":"1998","journal-title":"J Clin Oncol"},{"key":"39","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1097\/00005537-199902000-00015","article-title":"A matched control study of treatment outcome in young patients with squamous cell carcinoma of the head and neck","volume":"109","author":"Pintilie","year":"1999","journal-title":"Laryngoscope"},{"key":"40","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1111\/j.1365-2273.1992.tb01691.x","article-title":"Squamous carcinoma of the head and neck in the young adult","volume":"17","author":"Stell","year":"1992","journal-title":"Clin Otolaryngol Allied Sci"},{"key":"41","doi-asserted-by":"crossref","first-page":"334","DOI":"10.3892\/or.2013.2455","article-title":"Search for mutations in signaling pathways in head and neck squamous cell carcinoma","volume":"30","author":"Vettore","year":"2013","journal-title":"Oncol Rep"},{"key":"42","first-page":"4579","article-title":"EGF-dependent induction of BCL-xL and p21CIP1\/WAF1 is highly variable in HNSCC cells--implications for EGFR-targeted therapies","volume":"30","author":"Mandic","year":"2010","journal-title":"Anticancer Res"},{"key":"43","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.bjoms.2012.03.018","article-title":"E-cadherin and beta-catenin expression in well-differentiated and moderately-differentiated oral squamous cell carcinoma: relations with clinical variables","volume":"51","author":"de Vicente","year":"2013","journal-title":"Br J Oral Maxillofac Surg"},{"key":"44","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1038\/ncb2082","article-title":"Autophagy negatively regulates Wnt signalling by promoting Dishevelled degradation","volume":"12","author":"Zhang","year":"2010","journal-title":"Nat Cell Biol"},{"key":"45","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/j.cellsig.2012.12.020","article-title":"Knockdown of beta-catenin controls both apoptotic and autophagic cell death through LKB1\/AMPK signaling in head and neck squamous cell carcinoma cell lines","volume":"25","author":"Chang","year":"2013","journal-title":"Cell Signal"},{"key":"46","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1186\/1471-2407-14-679","article-title":"Tongue carcinoma infrequently harbor common actionable genetic alterations","volume":"14","author":"Iyer","year":"2014","journal-title":"BMC Cancer"},{"key":"47","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1097\/00000478-200311000-00010","article-title":"Prevalence of human papillomavirus type 16 DNA in squamous cell carcinoma of the palatine tonsil, and not the oral cavity, in young patients: a distinct clinicopathologic and molecular disease entity","volume":"27","author":"Lu","year":"2003","journal-title":"Am J Surg Pathol"},{"key":"48","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1111\/j.1600-0714.1993.tb01038.x","article-title":"Analysis of human papillomavirus DNA in oral squamous cell carcinomas","volume":"22","author":"Adler-Storthz","year":"1993","journal-title":"J Oral Pathol Med"},{"key":"49","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1046\/j.1525-1438.2003.13330.x","article-title":"Alterations of the P16 gene in uterine cervical carcinoma from Indian patients","volume":"13","author":"Panda","year":"2003","journal-title":"Int J Gynecol Cancer"},{"key":"50","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1034\/j.1600-0714.2000.290403.x","article-title":"Alterations of p16\/MTS1 gene in oral squamous cell carcinomas from Taiwanese","volume":"29","author":"Wong","year":"2000","journal-title":"J Oral Pathol Med"},{"key":"51","first-page":"5050","article-title":"Higher frequency of alterations in the p16\/CDKN2 gene in squamous cell carcinoma cell lines than in primary tumors of the head and neck","volume":"54","author":"Goodrow","year":"1994","journal-title":"Cancer Res"},{"key":"52","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1002\/(SICI)1098-2264(199905)25:1<16::AID-GCC3>3.0.CO;2-2","article-title":"DNA studies underestimate the major role of CDKN2A inactivation in oral and oropharyngeal squamous cell carcinomas","volume":"25","author":"Tavassoli","year":"1999","journal-title":"Genes Chromosomes Cancer"},{"key":"53","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1016\/S0046-8177(99)90217-4","article-title":"Expression of p16, Rb, and cyclin D1 gene products in oral and laryngeal squamous carcinoma: biological and clinical implications","volume":"30","author":"Benedict","year":"1999","journal-title":"Hum Pathol"},{"key":"54","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1590\/S0100-879X1999000700015","article-title":"Genetic alterations in head and neck squamous cell carcinomas","volume":"32","author":"Nagai","year":"1999","journal-title":"Braz J Med Biol Res"},{"key":"55","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1111\/j.1755-148X.2009.00576.x","article-title":"Met amplification and tumor progression in Cdkn2a-deficient melanocytes","volume":"22","author":"Holmen","year":"2009","journal-title":"Pigment Cell Melanoma Res"},{"key":"56","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1097\/CAD.0b013e328341879d","article-title":"Novel therapeutic target for head and neck squamous cell carcinoma: HGF-MET signaling pathway","volume":"22","author":"Chan","year":"2011","journal-title":"Anticancer Drugs"},{"key":"57","doi-asserted-by":"crossref","unstructured":"Polager, Ginsberg. Trends Cell Biol. 2008; 18:528\u2013535.","DOI":"10.1016\/j.tcb.2008.08.003"},{"key":"58","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1002\/mc.20584","article-title":"E2F2 suppresses Myc-induced proliferation and tumorigenesis","volume":"49","author":"Johnson","year":"2010","journal-title":"Mol Carcinog"},{"key":"59","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1101\/gad.14.8.927","article-title":"BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures","volume":"14","author":"Qin","year":"2000","journal-title":"Genes Dev"},{"key":"60","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1002\/gcc.22125","article-title":"Targeted inhibition of ATR or CHEK1 reverses radioresistance in oral squamous cell carcinoma cells with distal chromosome arm 11q loss","volume":"53","author":"Gollin","year":"2014","journal-title":"Genes Chromosomes Cancer"},{"key":"61","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.radonc.2012.10.020","article-title":"Aberrant overexpression of miR-421 downregulates ATM and leads to a pronounced DSB repair defect and clinical hypersensitivity in SKX squamous cell carcinoma","volume":"106","author":"Hu","year":"2013","journal-title":"Radiother Oncol"},{"key":"62","doi-asserted-by":"crossref","first-page":"992","DOI":"10.3109\/00016489.2013.795289","article-title":"Recurrent loss of the FHIT gene and its impact on lymphatic metastasis in early oral squamous cell carcinoma","volume":"133","author":"Kim","year":"2013","journal-title":"Acta Otolaryngol"},{"key":"63","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1002\/path.4383","article-title":"Wnt\/beta-catenin signalling maintains self-renewal and tumourigenicity of head and neck squamous cell carcinoma stem-like cells by activating Oct4","volume":"234","author":"Lim","year":"2014","journal-title":"J Pathol"},{"key":"64","doi-asserted-by":"crossref","first-page":"8613","DOI":"10.1158\/0008-5472.CAN-05-1966","article-title":"Fhit and CHK1 have opposing effects on homologous recombination repair","volume":"65","author":"Wang","year":"2005","journal-title":"Cancer Res"}],"container-title":["Oncotarget"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.2850","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,11]],"date-time":"2024-06-11T04:06:09Z","timestamp":1718078769000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.2850"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1,30]]},"references-count":64,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2015,2,20]]}},"alternative-id":["2850","25633809"],"URL":"https:\/\/doi.org\/10.18632\/oncotarget.2850","relation":{},"ISSN":["1949-2553"],"issn-type":[{"value":"1949-2553","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,1,30]]}}}