{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T20:44:14Z","timestamp":1791146654372,"version":"4.1.0"},"reference-count":64,"publisher":"Impact Journals, LLC","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncotarget"],"published-print":{"date-parts":[[2015,2,28]]},"DOI":"10.18632\/oncotarget.3006","type":"journal-article","created":{"date-parts":[[2015,9,15]],"date-time":"2015-09-15T07:56:59Z","timestamp":1442303819000},"page":"4286-4298","source":"Crossref","is-referenced-by-count":23,"title":["Rapamycin inhibits mSin1 phosphorylation independently of mTORC1 and mTORC2"],"prefix":"10.18632","volume":"6","author":[{"given":"Yan","family":"Luo","sequence":"first","affiliation":[{"name":"State Key Laboratory of Biotherapy\/Collaborative Innovation Center of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, People's Republic of China"},{"name":"Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, Shreveport, LA 71130-3932, USA"},{"name":"Feist-Weiller Cancer Center, Louisiana State University Health Sciences Center, Shreveport, LA 71130-3932, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, Shreveport, LA 71130-3932, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Wu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Biotherapy\/Collaborative Innovation Center of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, People's Republic of China"},{"name":"Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, Shreveport, LA 71130-3932, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karnika","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, Shreveport, LA 71130-3932, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Biotherapy\/Collaborative Innovation Center of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaowei","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Biotherapy\/Collaborative Innovation Center of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangmei","family":"Shen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Biotherapy\/Collaborative Innovation Center of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shile","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, Shreveport, LA 71130-3932, USA"},{"name":"Feist-Weiller Cancer Center, Louisiana State University Health Sciences Center, Shreveport, LA 71130-3932, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7892","published-online":{"date-parts":[[2015,1,30]]},"reference":[{"key":"1","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1042\/BST0390446","article-title":"Differing effects of rapamycin and mTOR kinase inhibitors on protein synthesis","volume":"39","author":"Proud","year":"2011","journal-title":"Biochem Soc Trans"},{"key":"2","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.cell.2012.03.017","article-title":"mTOR Signaling in Growth Control and Disease","volume":"149","author":"Sabatini","year":"2012","journal-title":"Cell"},{"key":"3","doi-asserted-by":"crossref","first-page":"24514","DOI":"10.1074\/jbc.M704406200","article-title":"PRAS40 is a target for mammalian target of rapamycin complex 1 and is required for signaling downstream of this complex","volume":"282","author":"Proud","year":"2007","journal-title":"J Biol Chem"},{"key":"4","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/S0092-8674(02)00833-4","article-title":"Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action","volume":"110","author":"Yonezawa","year":"2002","journal-title":"Cell"},{"key":"5","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/S0092-8674(02)00808-5","article-title":"mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery","volume":"110","author":"Sabatini","year":"2002","journal-title":"Cell"},{"key":"6","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1016\/S1097-2765(03)00114-X","article-title":"GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR","volume":"11","author":"Sabatini","year":"2003","journal-title":"Mol Cell"},{"key":"7","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/S1097-2765(02)00636-6","article-title":"Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control","volume":"10","author":"Hall","year":"2002","journal-title":"Mol Cell"},{"key":"8","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1016\/j.molcel.2007.03.003","article-title":"PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase","volume":"25","author":"Sabatini","year":"2007","journal-title":"Mol Cell"},{"key":"9","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1038\/ncb1547","article-title":"Insulin signalling to mTOR mediated by the Akt\/PKB substrate PRAS40","volume":"9","author":"Kim","year":"2007","journal-title":"Nat Cell Biol"},{"key":"10","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1038\/ncb1183","article-title":"Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive","volume":"6","author":"Hall","year":"2004","journal-title":"Nat Cell Biol"},{"key":"11","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1016\/j.cub.2004.06.054","article-title":"Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton","volume":"14","author":"Sabatini","year":"2004","journal-title":"Curr Biol"},{"key":"12","doi-asserted-by":"crossref","first-page":"1865","DOI":"10.1016\/j.cub.2006.08.001","article-title":"mSin1 is necessary for Akt\/PKB phosphorylation, and its isoforms define three distinct mTORC2s","volume":"16","author":"Sabatini","year":"2006","journal-title":"Curr Biol"},{"key":"13","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.cell.2006.08.033","article-title":"SIN1\/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity","volume":"127","author":"Su","year":"2006","journal-title":"Cell"},{"key":"14","doi-asserted-by":"crossref","first-page":"2820","DOI":"10.1101\/gad.1461206","article-title":"Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity","volume":"20","author":"Guan","year":"2006","journal-title":"Genes Dev"},{"key":"15","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1042\/BJ20070540","article-title":"Identification of Protor as a novel Rictor-binding component of mTOR complex-2","volume":"405","author":"Alessi","year":"2007","journal-title":"Biochem J"},{"key":"16","doi-asserted-by":"crossref","first-page":"25604","DOI":"10.1074\/jbc.M704343200","article-title":"PRR5, a novel component of mTOR complex 2, regulates platelet-derived growth factor receptor beta expression and signaling","volume":"282","author":"Kim","year":"2007","journal-title":"J Biol Chem"},{"key":"17","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1126\/science.1106148","article-title":"Phosphorylation and regulation of Akt\/PKB by the rictor-mTOR complex","volume":"307","author":"Sabatini","year":"2005","journal-title":"Science"},{"key":"18","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.molcel.2006.03.029","article-title":"Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt\/PKB","volume":"22","author":"Sabatini","year":"2006","journal-title":"Mol Cell"},{"key":"19","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1042\/BJ20081668","article-title":"mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1)","volume":"416","author":"Alessi","year":"2008","journal-title":"Biochem J"},{"key":"20","doi-asserted-by":"crossref","first-page":"4998","DOI":"10.1038\/onc.2008.137","article-title":"Rapamycin inhibits F-actin reorganization and phosphorylation of focal adhesion proteins","volume":"27","author":"Huang","year":"2008","journal-title":"Oncogene"},{"key":"21","doi-asserted-by":"crossref","first-page":"38362","DOI":"10.1074\/jbc.M110.141168","article-title":"Rapamycin inhibits cytoskeleton reorganization and cell motility by suppressing RhoA expression and activity","volume":"285","author":"Huang","year":"2010","journal-title":"J Biol Chem"},{"key":"22","doi-asserted-by":"crossref","first-page":"3246","DOI":"10.1158\/0008-5472.CAN-10-4058","article-title":"mTORC1 and mTORC2 regulate EMT, motility, and metastasis of colorectal cancer via RhoA and Rac1 signaling pathways","volume":"71","author":"Evers","year":"2011","journal-title":"Cancer Res"},{"key":"23","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1016\/j.cell.2009.03.046","article-title":"DEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survival","volume":"137","author":"Sabatini","year":"2009","journal-title":"Cell"},{"key":"24","doi-asserted-by":"crossref","first-page":"20109","DOI":"10.1074\/jbc.M110.121699","article-title":"Tti1 and Tel2 are critical factors in mammalian target of rapamycin complex assembly","volume":"285","author":"Mizushima","year":"2010","journal-title":"J Biol Chem"},{"key":"25","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1593\/neo.111570","article-title":"Rapamycin inhibits lymphatic endothelial cell tube formation by downregulating vascular endothelial growth factor receptor 3 protein expression","volume":"14","author":"Huang","year":"2012","journal-title":"Neoplasia"},{"key":"26","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1056\/NEJMoa1113205","article-title":"Intratumor heterogeneity and branched evolution revealed by multiregion sequencing","volume":"366","author":"Gronroos","year":"2012","journal-title":"N Engl J Med"},{"key":"27","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1158\/2159-8290.CD-13-0929","article-title":"A diverse array of cancer-associated MTOR mutations are hyperactivating and can predict rapamycin sensitivity","volume":"4","author":"Sabatini","year":"2014","journal-title":"Cancer Discov"},{"key":"28","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1158\/2159-8290.CD-13-0353","article-title":"Activating mTOR mutations in a patient with an extraordinary response on a phase I trial of everolimus and pazopanib","volume":"4","author":"Rosenberg","year":"2014","journal-title":"Cancer Discov"},{"key":"29","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1016\/j.ceb.2011.09.003","article-title":"mTOR signaling in disease","volume":"23","author":"Hall","year":"2011","journal-title":"Curr Opin Cell Biol"},{"key":"30","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1146\/annurev-pharmtox-010611-134537","article-title":"AMPK and mTOR in cellular energy homeostasis and drug targets","volume":"52","author":"Guan","year":"2012","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"31","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.drudis.2011.02.008","article-title":"Targeting the mTOR kinase domain: the second generation of mTOR inhibitors","volume":"16","author":"Zheng","year":"2011","journal-title":"Drug Discov Today"},{"key":"32","doi-asserted-by":"crossref","first-page":"7052","DOI":"10.1158\/0008-5472.CAN-05-0917","article-title":"Activation of Akt and eIF4E survival pathways by rapamycin-mediated mammalian target of rapamycin inhibition","volume":"65","author":"Fu","year":"2005","journal-title":"Cancer Res"},{"key":"33","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1158\/0008-5472.CAN-05-2925","article-title":"mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt","volume":"66","author":"Rosen","year":"2006","journal-title":"Cancer Res"},{"key":"34","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1126\/science.1199498","article-title":"The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling","volume":"332","author":"Sabatini","year":"2011","journal-title":"Science"},{"key":"35","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1126\/science.1199484","article-title":"Phosphoproteomic analysis identifies Grb10 as an mTORC1 substrate that negatively regulates insulin signaling","volume":"332","author":"Blenis","year":"2011","journal-title":"Science"},{"key":"36","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/j.bbrc.2007.07.151","article-title":"Rapamycin regulates the phosphorylation of rictor","volume":"362","author":"Meric-Bernstam","year":"2007","journal-title":"Biochem Biophys Res Commun"},{"key":"37","doi-asserted-by":"crossref","first-page":"5657","DOI":"10.1128\/MCB.00735-09","article-title":"Characterization of Rictor phosphorylation sites reveals direct regulation of mTOR complex 2 by S6K1","volume":"29","author":"Manning","year":"2009","journal-title":"Mol Cell Biol"},{"key":"38","doi-asserted-by":"crossref","first-page":"2934","DOI":"10.1093\/hmg\/ddn192","article-title":"Cytoplasmic and nuclear distribution of the protein complexes mTORC1 and mTORC2: rapamycin triggers dephosphorylation and delocalization of the mTORC2 components rictor and sin1","volume":"17","author":"Hengstschl\u00e4ger","year":"2008","journal-title":"Hum Mol Genet"},{"key":"39","doi-asserted-by":"crossref","first-page":"40386","DOI":"10.1074\/jbc.M111.282590","article-title":"The mTOR (mammalian target of rapamycin) kinase maintains integrity of mTOR complex 2","volume":"286","author":"Sarbassov dos","year":"2011","journal-title":"J Biol Chem"},{"key":"40","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1002\/pbc.21099","article-title":"SK-NEP-1 and Rh1 are Ewing family tumor lines","volume":"50","author":"Houghton","year":"2008","journal-title":"Pediatr Blood Cancer"},{"key":"41","first-page":"886","article-title":"Rapamycin causes poorly reversible inhibition of mTOR and induces p53-independent apoptosis in human rhabdomyosarcoma cells","volume":"59","author":"Houghton","year":"1999","journal-title":"Cancer Res"},{"key":"42","doi-asserted-by":"crossref","first-page":"36079","DOI":"10.1074\/jbc.C100406200","article-title":"The mammalian target of rapamycin regulates C2C12 myogenesis via a kinase-independent mechanism","volume":"276","author":"Chen","year":"2001","journal-title":"J Biol Chem"},{"key":"43","doi-asserted-by":"crossref","first-page":"C1434","DOI":"10.1152\/ajpcell.00248.2009","article-title":"mTOR regulates skeletal muscle regenerationthrough kinase-dependent and kinase-independent mechanisms","volume":"297","author":"Chen","year":"2009","journal-title":"Am J Physiol Cell Physiol"},{"key":"44","first-page":"16726","article-title":"Myogenic differentiation is dependent on both the kinase function and the N-terminal sequence of mammalian target of rapamycin","volume":"277","author":"Houghton","year":"2000","journal-title":"J Biol Chem"},{"key":"45","doi-asserted-by":"crossref","first-page":"4691","DOI":"10.1128\/MCB.00764-09","article-title":"The mTORC2 complex regulates terminal differentiation of C2C12 myoblasts","volume":"29","author":"Houghton","year":"2009","journal-title":"Mol Cell Biol"},{"key":"46","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1128\/MCB.00601-09","article-title":"mTORC1-activated S6K1 phosphorylates Rictor on threonine 1135 and regulates mTORC2 signaling","volume":"30","author":"Roux","year":"2010","journal-title":"Mol Cell Biol"},{"key":"47","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1038\/onc.2009.401","article-title":"Rictor is a novel target of p70 S6 kinase-1","volume":"29","author":"Downward","year":"2010","journal-title":"Oncogene"},{"key":"48","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1038\/ncb2860","article-title":"Sin1 phosphorylation impairs mTORC2 complex integrity and inhibits downstream Akt signalling to suppress tumorigenesis","volume":"15","author":"Wei","year":"2013","journal-title":"Nat Cell Biol"},{"key":"49","doi-asserted-by":"crossref","first-page":"7029","DOI":"10.1038\/sj.onc.1209691","article-title":"Rapamycin inhibits cell motility by suppression of mTOR-mediated S6K1 and 4E-BP1 pathways","volume":"25","author":"Huang","year":"2006","journal-title":"Oncogene"},{"key":"50","doi-asserted-by":"crossref","first-page":"4438","DOI":"10.1073\/pnas.96.8.4438","article-title":"Protein phosphatase 2A interacts with the 70-kDa S6 kinase and is activated by inhibition of FKBP12-rapamycinassociated protein","volume":"96","author":"Schreiber","year":"1999","journal-title":"Proc Natl Acad Sci USA"},{"key":"51","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1016\/j.cmet.2013.04.010","article-title":"Dynamic adipocyte phosphoproteome reveals that Akt directly regulates mTORC2","volume":"17","author":"James","year":"2013","journal-title":"Cell Metab"},{"key":"52","doi-asserted-by":"crossref","first-page":"14399","DOI":"10.1073\/pnas.1210465109","article-title":"Third target of rapamycin complex negatively regulates development of quiescence in Trypanosoma brucei","volume":"109","author":"Calvo","year":"2012","journal-title":"Proc Natl Acad Sci USA"},{"key":"53","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1016\/j.cub.2005.02.053","article-title":"Rheb binds and regulates the mTOR kinase","volume":"15","author":"Avruch","year":"2005","journal-title":"Curr Biol"},{"key":"54","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1016\/S1097-2765(03)00220-X","article-title":"Insulin activation of Rheb, a mediator of mTOR\/S6K\/4E-BP signaling, is inhibited by TSC1 and 2","volume":"11","author":"Thomas","year":"2003","journal-title":"Mol Cell"},{"key":"55","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1101\/gad.1110003","article-title":"Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling","volume":"17","author":"Guan","year":"2003","journal-title":"Genes Dev"},{"key":"56","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1016\/S0960-9822(03)00506-2","article-title":"Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb","volume":"13","author":"Blenis","year":"2003","journal-title":"Curr Biol"},{"key":"57","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1038\/ncb999","article-title":"Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins","volume":"5","author":"Pan","year":"2003","journal-title":"Nat Cell Biol"},{"key":"58","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1038\/nrm2249","article-title":"AMP-activated\/SNF1 protein kinases: conserved guardians of cellular energy","volume":"8","author":"Hardie","year":"2007","journal-title":"Nat Rev Mol Cell Biol"},{"key":"59","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1101\/gad.1199104","article-title":"Regulation of the TSC pathway by LKB1: evidence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndrome","volume":"18","author":"Guan","year":"2004","journal-title":"Genes Dev"},{"key":"60","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.molcel.2008.03.003","article-title":"AMPK phosphorylation of raptor mediates a metabolic checkpoint","volume":"30","author":"Shaw","year":"2008","journal-title":"Mol Cell"},{"key":"61","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1126\/science.1157535","article-title":"The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1","volume":"320","author":"Sabatini","year":"2008","journal-title":"Science"},{"key":"62","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1038\/ncb1753","article-title":"Regulation of TORC1 by Rag GTPases in nutrient response","volume":"10","author":"Guan","year":"2008","journal-title":"Nat Cell Biol"},{"key":"63","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.cell.2010.02.024","article-title":"Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids","volume":"141","author":"Sabatini","year":"2010","journal-title":"Cell"},{"key":"64","doi-asserted-by":"crossref","first-page":"27019","DOI":"10.1074\/jbc.M113.498055","article-title":"Autoregulation of the mechanistic target of rapamycin (mTOR) complex 2 integrity is controlled by an ATP-dependent mechanism","volume":"288","author":"Sarbassov dos","year":"2013","journal-title":"J Biol Chem"}],"container-title":["Oncotarget"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.3006","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,13]],"date-time":"2020-05-13T10:08:41Z","timestamp":1589364521000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.3006"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1,30]]},"references-count":64,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2015,2,28]]}},"alternative-id":["3006","25738366"],"URL":"https:\/\/doi.org\/10.18632\/oncotarget.3006","relation":{},"ISSN":["1949-2553"],"issn-type":[{"value":"1949-2553","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,1,30]]}}}