{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T04:27:07Z","timestamp":1789705627194,"version":"4.0.1"},"reference-count":33,"publisher":"Impact Journals, LLC","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncotarget"],"published-print":{"date-parts":[[2015,3,30]]},"DOI":"10.18632\/oncotarget.3165","type":"journal-article","created":{"date-parts":[[2015,9,15]],"date-time":"2015-09-15T03:55:06Z","timestamp":1442289306000},"page":"6931-6943","source":"Crossref","is-referenced-by-count":39,"title":["The miR-491-3p\/mTORC2\/FOXO1 regulatory loop modulates chemo-sensitivity in human tongue cancer"],"prefix":"10.18632","volume":"6","author":[{"given":"Guopei","family":"Zheng","sequence":"first","affiliation":[{"name":"Cancer Hospital and Cancer Research Institute of Guangzhou Medical University, Guangzhou 510095, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoting","family":"Jia","sequence":"additional","affiliation":[{"name":"Cancer Hospital and Cancer Research Institute of Guangzhou Medical University, Guangzhou 510095, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cong","family":"Peng","sequence":"additional","affiliation":[{"name":"Cancer Hospital and Cancer Research Institute of Guangzhou Medical University, Guangzhou 510095, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingen","family":"Deng","sequence":"additional","affiliation":[{"name":"Cancer Hospital and Cancer Research Institute of Guangzhou Medical University, Guangzhou 510095, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiang","family":"Yin","sequence":"additional","affiliation":[{"name":"Cancer Hospital and Cancer Research Institute of Guangzhou Medical University, Guangzhou 510095, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhijie","family":"Zhang","sequence":"additional","affiliation":[{"name":"Cancer Hospital and Cancer Research Institute of Guangzhou Medical University, Guangzhou 510095, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Li","sequence":"additional","affiliation":[{"name":"Cancer Hospital and Cancer Research Institute of Guangzhou Medical University, Guangzhou 510095, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Deng","sequence":"additional","affiliation":[{"name":"Cancer Hospital and Cancer Research Institute of Guangzhou Medical University, Guangzhou 510095, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaorong","family":"Liu","sequence":"additional","affiliation":[{"name":"Cancer Hospital and Cancer Research Institute of Guangzhou Medical University, Guangzhou 510095, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Liu","sequence":"additional","affiliation":[{"name":"Cancer Hospital and Cancer Research Institute of Guangzhou Medical University, Guangzhou 510095, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minying","family":"Lu","sequence":"additional","affiliation":[{"name":"Cancer Hospital and Cancer Research Institute of Guangzhou Medical University, Guangzhou 510095, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengkun","family":"Wang","sequence":"additional","affiliation":[{"name":"Cancer Hospital and Cancer Research Institute of Guangzhou Medical University, Guangzhou 510095, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yixue","family":"Gu","sequence":"additional","affiliation":[{"name":"Cancer Hospital and Cancer Research Institute of Guangzhou Medical University, Guangzhou 510095, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhimin","family":"He","sequence":"additional","affiliation":[{"name":"Cancer Hospital and Cancer Research Institute of Guangzhou Medical University, Guangzhou 510095, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7892","published-online":{"date-parts":[[2015,2,19]]},"reference":[{"key":"1","doi-asserted-by":"crossref","first-page":"212","DOI":"10.3322\/caac.20121","article-title":"Cancer statistics, 2011: the impact of eliminating socioeconomic and racial disparities on premature cancer deaths","volume":"61","author":"Jemal","year":"2011","journal-title":"CA Cancer J Clin"},{"key":"2","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1016\/S0140-6736(00)90011-4","article-title":"Chemotherapy added to locoregional treatment for head and neck squamous-cell carcinoma: three meta-analyses of updated individual data. MACH-NC Collaborative Group. Meta-Analysis of Chemotherapy on Head and Neck Cancer","volume":"355","author":"Design\u00e9","year":"2000","journal-title":"Lancet"},{"key":"3","doi-asserted-by":"crossref","first-page":"5481","DOI":"10.1158\/1078-0432.CCR-05-0285","article-title":"Expression of class III \u03b2-tubulin is predictive of patient outcome in patients with non-small cell lung cancer receiving vinorelbine-based chemotherapy","volume":"11","author":"Dumontet","year":"2005","journal-title":"Clin Cancer Res"},{"key":"4","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1158\/0008-5472.CAN-07-3063","article-title":"Induction of cancer metastasis by cyclophosphamide pretreatment of host mice: an opposite effect of chemotherapy","volume":"68","author":"Hoffman","year":"2008","journal-title":"Cancer Res"},{"key":"5","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.drup.2009.07.001","article-title":"Understanding the causes of multidrug resistance in cancer: a comparison of doxorubicin and sunitinib","volume":"12","author":"Verheul","year":"2009","journal-title":"Drug Resist Update"},{"key":"6","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.drup.2010.02.001","article-title":"Implication of microRNAs in drug resistance for designing novel cancer therapy","volume":"13","author":"Ali","year":"2010","journal-title":"Drug Resist Update"},{"key":"7","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.cell.2005.06.036","article-title":"miRNAs, cancer and stem cell division","volume":"122","author":"Calin","year":"2005","journal-title":"Cell"},{"key":"8","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1038\/nrg2634","article-title":"Causes and consequences of microRNA dysregulation in cancer","volume":"10","author":"Croce","year":"2009","journal-title":"Nat Rev Genet"},{"key":"9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1158\/1535-7163.MCT-07-0573","article-title":"microRNAs modulate the chemosensitivity of tumor cells","volume":"7","author":"Sadee","year":"2008","journal-title":"Mol Cancer Ther"},{"key":"10","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.bbrc.2008.09.086","article-title":"Effects of miR-34a on cell growth and chemoresistance in prostate cancer PC3 cells","volume":"377","author":"Ito","year":"2008","journal-title":"Biochem Biophys Res Commun"},{"key":"11","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1111\/j.1582-4934.2009.00964.x","article-title":"Identification of microRNA profiles in docetaxelresistant human non-small cell lung carcinoma cells (SPC-A1)","volume":"14","author":"Long-Bang","year":"2010","journal-title":"J Cell Mol Med"},{"key":"12","doi-asserted-by":"crossref","first-page":"5060","DOI":"10.1158\/1078-0432.CCR-08-2245","article-title":"miR-200 expression regulates epithelial-to-mesenchymal transition in bladder cancer cells and reverses resistance to epidermal growth factor receptor therapy","volume":"15","author":"Dinney","year":"2009","journal-title":"Clin Cancer Res"},{"key":"13","doi-asserted-by":"crossref","first-page":"6704","DOI":"10.1158\/0008-5472.CAN-09-1298","article-title":"Up-regulation of miR-200 and let-7 by natural agents leads to the reversal of epithelial-to-mesenchymal transition in gemcitabine-resistant pancreatic cancer cells","volume":"69","author":"Sarkar","year":"2009","journal-title":"Cancer Res"},{"key":"14","doi-asserted-by":"crossref","first-page":"2588","DOI":"10.1158\/1078-0432.CCR-07-0666","article-title":"Mature miR-184 as Potential Oncogenic microRNA of Squamous Cell Carcinoma of Tongue","volume":"14","author":"Wei","year":"2008","journal-title":"Clin Cancer Res"},{"key":"15","doi-asserted-by":"crossref","first-page":"3998","DOI":"10.1158\/1078-0432.CCR-08-3053","article-title":"Carcinomas as an Apoptosis Inhibitor miR-21 Indicates Poor Prognosis in Tongue Squamous Cell","volume":"15","author":"Song","year":"2009","journal-title":"Clin Cancer Res"},{"key":"16","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1038\/onc.2011.263","article-title":"MiR-200b and miR-15b regulate chemotherapy-induced epithelial-mesenchymal transition in human tongue cancer cells by targeting BMI1","volume":"31","author":"Li","year":"2012","journal-title":"Oncogene"},{"key":"17","doi-asserted-by":"crossref","first-page":"4506","DOI":"10.1111\/j.1742-4658.2010.07836.x","article-title":"Identification of carbonic anhydrase9 as a contributor to pingyangmycin-induced drug resistance in human tongue cancer cells","volume":"277","author":"He","year":"2010","journal-title":"FEBS J"},{"key":"18","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/1477-7827-7-13","article-title":"Altered microRNA expression in patients with non-obstructive azoospermia","volume":"7","author":"Sun","year":"2009","journal-title":"Reprod Biol Endocrinol"},{"key":"19","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.3892\/ijo.2011.961","article-title":"Microarray-based analysis: identification of hypoxia-regulated microRNAs in retinoblastoma cells","volume":"38","author":"Fan","year":"2011","journal-title":"Int J Oncol"},{"key":"20","article-title":"Two mature products of MIR-491 coordinate to suppress key cancer hallmarks in glioblastoma","author":"Zhang","year":"2014","journal-title":"Oncogene"},{"key":"21","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.cell.2012.03.017","article-title":"mTOR signaling in growth control and disease","volume":"149","author":"Sabatini","year":"2012","journal-title":"Cell"},{"key":"22","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/nrm3025","article-title":"mTOR: from growth signal integration to cancer, diabetes and ageing","volume":"12","author":"Sabatini","year":"2011","journal-title":"Nat Rev Mol Cell Biol"},{"key":"23","doi-asserted-by":"crossref","first-page":"11712","DOI":"10.1158\/0008-5472.CAN-07-2223","article-title":"mTORC2 activity is elevated in gliomas and promotes growth and cell motility via overexpression of rictor","volume":"67","author":"Gera","year":"2007","journal-title":"Cancer Res"},{"key":"24","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1186\/1476-4598-9-57","article-title":"Targeting mTORC2 inhibits colon cancer cell proliferationand tumor formation","volume":"9","author":"Dormond","year":"2010","journal-title":"Mol Cancer"},{"key":"25","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1007\/s10549-012-2036-2","article-title":"Targeting of mTORC2 prevents cell migration and promotes apoptosis in breast cancer","volume":"134","author":"Bai","year":"2012","journal-title":"Breast Cancer Res Treat"},{"key":"26","doi-asserted-by":"crossref","first-page":"1618","DOI":"10.1158\/0008-5472.CAN-07-5869","article-title":"Rictor and integrin-linked kinase interact and regulate Akt phosphorylation and cancer cell survival","volume":"68","author":"Dedhar","year":"2008","journal-title":"Cancer Res"},{"key":"27","doi-asserted-by":"crossref","first-page":"9360","DOI":"10.1158\/0008-5472.CAN-10-0207","article-title":"mTOR complex component Rictor interacts with PKCzeta and regulates cancer cell metastasis","volume":"70","author":"Zhang","year":"2010","journal-title":"Cancer Res"},{"key":"28","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.ccr.2008.12.017","article-title":"mTOR complex 2 is required for the development of prostate cancer induced by Pten loss in mice","volume":"15","author":"Sabatini","year":"2009","journal-title":"Cancer Cell"},{"key":"29","doi-asserted-by":"crossref","first-page":"6450","DOI":"10.1158\/0008-5472.CAN-11-0364","article-title":"miR-152 is a tumor suppressor microRNA that is silenced by DNA hypermethylation in endometrial cancer","volume":"71","author":"Inazawa","year":"2011","journal-title":"Cancer Res"},{"key":"30","doi-asserted-by":"crossref","first-page":"5765","DOI":"10.1158\/0008-5472.CAN-11-0368","article-title":"The tumor suppressive microRNA miR-218 targets the mTOR component Rictor and inhibits AKT phosphorylation in oral cancer","volume":"71","author":"Inazawa","year":"2011","journal-title":"Cancer Res"},{"key":"31","doi-asserted-by":"crossref","first-page":"e80300","DOI":"10.1371\/journal.pone.0080300","article-title":"MiR-424\/503-mediated Rictor upregulation promotes tumor progression","volume":"8","author":"Okada","year":"2013","journal-title":"PLoS One"},{"key":"32","doi-asserted-by":"crossref","first-page":"5392","DOI":"10.18632\/oncotarget.2107","article-title":"FOXO1 downregulation contributes to the oncogenic program of primary mediastinal B-cell lymphoma","volume":"5","author":"Ushmorov","year":"2014","journal-title":"Oncotarget"},{"key":"33","doi-asserted-by":"crossref","first-page":"7617","DOI":"10.1038\/sj.onc.1207137","article-title":"Inhibition of Akt kinase signalling and activation of Forkhead are indispensable for upregulation of FasL expression in apoptosis of glioma cells","volume":"22","author":"Kaminska","year":"2003","journal-title":"Oncogene"}],"container-title":["Oncotarget"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.3165","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,8]],"date-time":"2020-09-08T05:38:58Z","timestamp":1599543538000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.3165"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,2,19]]},"references-count":33,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2015,3,30]]}},"alternative-id":["3165","25749387"],"URL":"https:\/\/doi.org\/10.18632\/oncotarget.3165","relation":{},"ISSN":["1949-2553"],"issn-type":[{"value":"1949-2553","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,2,19]]}}}