{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T06:35:02Z","timestamp":1791182102542,"version":"4.1.0"},"reference-count":36,"publisher":"Impact Journals, LLC","issue":"13","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncotarget"],"published-print":{"date-parts":[[2015,5,10]]},"DOI":"10.18632\/oncotarget.3450","type":"journal-article","created":{"date-parts":[[2015,9,15]],"date-time":"2015-09-15T06:34:56Z","timestamp":1442298896000},"page":"10840-10852","source":"Crossref","is-referenced-by-count":132,"title":["The long non-coding RNA HOTTIP enhances pancreatic cancer cell proliferation, survival and migration"],"prefix":"10.18632","volume":"6","author":[{"given":"Yating","family":"Cheng","sequence":"first","affiliation":[{"name":"Department of Veterinary Physiology and Pharmacology, Texas A&M University, 4466 TAMU, College Station, TX 77843-4466, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Indira","family":"Jutooru","sequence":"additional","affiliation":[{"name":"Department of Veterinary Physiology and Pharmacology, Texas A&M University, 4466 TAMU, College Station, TX 77843-4466, USA"},{"name":"Covance, Inc., Madison, WI 53704, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gayathri","family":"Chadalapaka","sequence":"additional","affiliation":[{"name":"Department of Veterinary Physiology and Pharmacology, Texas A&M University, 4466 TAMU, College Station, TX 77843-4466, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Christopher","family":"Corton","sequence":"additional","affiliation":[{"name":"Integrated Systems Toxicology Division, US-EPA, MD B143-06, Research Triangle Park, NC 27711, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Safe","sequence":"additional","affiliation":[{"name":"Department of Veterinary Physiology and Pharmacology, Texas A&M University, 4466 TAMU, College Station, TX 77843-4466, USA"},{"name":"Institute of Biosciences and Technology, Texas A&M Health Science Center, Houston, TX 77030-3303, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7892","published-online":{"date-parts":[[2015,3,25]]},"reference":[{"key":"1","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1016\/j.stem.2014.05.014","article-title":"Long noncoding RNAs in cell-fate programming and reprogramming","volume":"14","author":"Chang","year":"2014","journal-title":"Cell stem cell"},{"key":"2","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1146\/annurev-biochem-051410-092902","article-title":"Genome regulation by long noncoding RNAs","volume":"81","author":"Chang","year":"2012","journal-title":"Annual review of biochemistry"},{"key":"3","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1016\/j.molcel.2011.08.018","article-title":"Molecular mechanisms of long noncoding RNAs","volume":"43","author":"Chang","year":"2011","journal-title":"Molecular cell"},{"key":"4","doi-asserted-by":"crossref","first-page":"R152","DOI":"10.1093\/hmg\/ddq353","article-title":"Large non-coding RNAs: missing links in cancer?","volume":"19","author":"Rinn","year":"2010","journal-title":"Human molecular genetics"},{"key":"5","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1126\/science.1231776","article-title":"Epigenetic regulation by long noncoding RNAs","volume":"338","author":"Lee","year":"2012","journal-title":"Science"},{"key":"6","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1016\/j.cell.2013.02.012","article-title":"Long noncoding RNAs: cellular address codes in development and disease","volume":"152","author":"Chang","year":"2013","journal-title":"Cell"},{"key":"7","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1016\/j.cell.2007.05.022","article-title":"Functional demarcation of active and silent chromatin domains in human HOX loci by noncoding RNAs","volume":"129","author":"Chang","year":"2007","journal-title":"Cell"},{"key":"8","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1038\/nature08975","article-title":"Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis","volume":"464","author":"van de Vijver","year":"2010","journal-title":"Nature"},{"key":"9","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1126\/science.1192002","article-title":"Long noncoding RNA as modular scaffold of histone modification complexes","volume":"329","author":"Chang","year":"2010","journal-title":"Science"},{"key":"10","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1245\/s10434-011-1581-y","article-title":"Overexpression of long non-coding RNA HOTAIR predicts tumor recurrence in hepatocellular carcinoma patients following liver transplantation","volume":"18","author":"Zheng","year":"2011","journal-title":"Annals of surgical oncology"},{"key":"11","doi-asserted-by":"crossref","first-page":"6320","DOI":"10.1158\/0008-5472.CAN-11-1021","article-title":"Long noncoding RNA HOTAIR regulates polycomb-dependent chromatin modification and is associated with poor prognosis in colorectal cancers","volume":"71","author":"Mori","year":"2011","journal-title":"Cancer research"},{"key":"12","doi-asserted-by":"crossref","first-page":"1616","DOI":"10.1038\/onc.2012.193","article-title":"HOTAIR is a negative prognostic factor and exhibits pro-oncogenic activity in pancreatic cancer","volume":"32","author":"Safe","year":"2013","journal-title":"Oncogene"},{"key":"13","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.1093\/carcin\/bgu055","article-title":"HOTAIR long non-coding RNA is a negative prognostic factor not only in primary tumors, but also in the blood of colorectal cancer patients","volume":"35","author":"Vodicka","year":"2014","journal-title":"Carcinogenesis"},{"key":"14","doi-asserted-by":"crossref","first-page":"2266","DOI":"10.1038\/bjc.2013.548","article-title":"Long non-coding RNA HOTAIR, a driver of malignancy, predicts negative prognosis and exhibits oncogenic activity in oesophageal squamous cell carcinoma","volume":"109","author":"Han","year":"2013","journal-title":"British journal of cancer"},{"key":"15","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1038\/nature09819","article-title":"A long noncoding RNA maintains active chromatin to coordinate homeotic gene expression","volume":"472","author":"Chang","year":"2011","journal-title":"Nature"},{"key":"16","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1002\/hep.26740","article-title":"Long noncoding RNA HOTTIP\/HOXA13 expression is associated with disease progression and predicts outcome in hepatocellular carcinoma patients","volume":"59","author":"Cillo","year":"2014","journal-title":"Hepatology"},{"key":"17","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1038\/nrc3023","article-title":"CD44: can a cancer-initiating cell profit from an abundantly expressed molecule?","volume":"11","author":"Zoller","year":"2011","journal-title":"Nature reviews Cancer"},{"key":"18","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1016\/j.ejca.2010.02.024","article-title":"CD44, a therapeutic target for metastasising tumours","volume":"46","author":"Orian-Rousseau","year":"2010","journal-title":"Eur J Cancer"},{"key":"19","doi-asserted-by":"crossref","first-page":"2899","DOI":"10.1158\/0008-5472.CAN-04-3981","article-title":"RNA interference targeting aurora kinase a suppresses tumor growth and enhances the taxane chemosensitivity in human pancreatic cancer cells","volume":"65","author":"Horii","year":"2005","journal-title":"Cancer research"},{"key":"20","doi-asserted-by":"crossref","first-page":"4831","DOI":"10.1038\/sj.onc.1209494","article-title":"AURKA is one of the downstream targets of MAPK1\/ERK2 in pancreatic cancer","volume":"25","author":"Horii","year":"2006","journal-title":"Oncogene"},{"key":"21","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.cancergencyto.2004.09.008","article-title":"AURKA amplification, chromosome instability, and centrosome abnormality in human pancreatic carcinoma cells","volume":"159","author":"Li","year":"2005","journal-title":"Cancer genetics and cytogenetics"},{"key":"22","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1042\/BJ20130342","article-title":"Elevated SGK1 predicts resistance of breast cancer cells to Akt inhibitors","volume":"452","author":"Alessi","year":"2013","journal-title":"The Biochemical journal"},{"key":"23","first-page":"216","article-title":"HOX genes in pancreatic development and cancer","volume":"12","author":"Morgan","year":"2011","journal-title":"JOP: Journal of the pancreas"},{"key":"24","article-title":"The prostate cancer-up-regulated long noncoding RNA PlncRNA-1 modulates apoptosis and proliferation through reciprocal regulation of androgen receptor","author":"Mao","year":"2012","journal-title":"Urologic oncology"},{"key":"25","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1186\/1471-2407-13-451","article-title":"HOXB7 mRNA is overexpressed in pancreatic ductal adenocarcinomas and its knockdown induces cell cycle arrest and apoptosis","volume":"13","author":"Giorgi","year":"2013","journal-title":"BMC cancer"},{"key":"26","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1002\/cncr.27725","article-title":"HOXB7 promotes invasion and predicts survival in pancreatic adenocarcinoma","volume":"119","author":"Dawson","year":"2013","journal-title":"Cancer"},{"key":"27","doi-asserted-by":"crossref","first-page":"3587","DOI":"10.1158\/1078-0432.CCR-04-1813","article-title":"Expression of HOXB2, a retinoic acid signaling target in pancreatic cancer and pancreatic intraepithelial neoplasia","volume":"11","author":"Henshall","year":"2005","journal-title":"Clinical cancer research: an official journal of the American Association for Cancer Research"},{"key":"28","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1038\/labinvest.2014.53","article-title":"Upregulated SMAD3 promotes epithelial-mesenchymal transition and predicts poor prognosis in pancreatic ductal adenocarcinoma","volume":"94","author":"Sakamoto","year":"2014","journal-title":"Laboratory investigation; a journal of technical methods and pathology"},{"key":"29","doi-asserted-by":"crossref","first-page":"104","DOI":"10.5152\/jtgga.2014.0088","article-title":"HOXA11 and MMP2 gene expression in uterosacral ligaments of women with pelvic organ prolapse","volume":"15","author":"Sahin","year":"2014","journal-title":"Journal of the Turkish German Gynecological Association"},{"key":"30","doi-asserted-by":"crossref","first-page":"2526","DOI":"10.1182\/blood-2008-06-162164","article-title":"A myelopoiesis-associated regulatory intergenic noncoding RNA transcript within the human HOXA cluster","volume":"113","author":"Newburger","year":"2009","journal-title":"Blood"},{"key":"31","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1016\/j.molcel.2011.08.019","article-title":"The noncoding RNA Mistral activates Hoxa6 and Hoxa7 expression and stem cell differentiation by recruiting MLL1 to chromatin","volume":"43","author":"Sauer","year":"2011","journal-title":"Molecular cell"},{"key":"32","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1101\/gad.217018.113","article-title":"linc-HOXA1 is a noncoding RNA that represses Hoxa1 transcription in cis","volume":"27","author":"Raj","year":"2013","journal-title":"Genes & development"},{"key":"33","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.3748\/wjg.15.1072","article-title":"Suppression of matrix metalloproteinase-2 via RNA interference inhibits pancreatic carcinoma cell invasiveness and adhesion","volume":"15","author":"Yin","year":"2009","journal-title":"World journal of gastroenterology: WJG"},{"key":"34","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1002\/ijc.10329","article-title":"Matrix metalloproteinases in cancer: prognostic markers and therapeutic targets","volume":"99","author":"Kahari","year":"2002","journal-title":"International journal of cancer Journal international du cancer"},{"key":"35","doi-asserted-by":"crossref","first-page":"5287","DOI":"10.1200\/JCO.2009.23.5556","article-title":"Matrix metalloproteinases as novel biomarkers and potential therapeutic targets in human cancer","volume":"27","author":"Moses","year":"2009","journal-title":"Journal of clinical oncology: official journal of the American Society of Clinical Oncology"},{"key":"36","first-page":"5","article-title":"Ontology-based meta-analysis of global collections of high-throughput public data","author":"Ronaghi","year":"2010","journal-title":"PloS one"}],"container-title":["Oncotarget"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.3450","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,15]],"date-time":"2020-07-15T15:09:23Z","timestamp":1594825763000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.3450"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,3,25]]},"references-count":36,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2015,5,10]]}},"alternative-id":["3450","25912306"],"URL":"https:\/\/doi.org\/10.18632\/oncotarget.3450","relation":{},"ISSN":["1949-2553"],"issn-type":[{"value":"1949-2553","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,3,25]]}}}