{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T09:01:38Z","timestamp":1790499698108,"version":"4.1.0"},"reference-count":44,"publisher":"Impact Journals, LLC","issue":"20","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncotarget"],"published-print":{"date-parts":[[2015,7,20]]},"DOI":"10.18632\/oncotarget.3777","type":"journal-article","created":{"date-parts":[[2015,9,15]],"date-time":"2015-09-15T06:29:45Z","timestamp":1442298585000},"page":"18050-18065","source":"Crossref","is-referenced-by-count":15,"title":["XB130 translocation to microfilamentous structures mediates NNK-induced migration of human bronchial epithelial cells"],"prefix":"10.18632","volume":"6","author":[{"given":"Qifei","family":"Wu","sequence":"first","affiliation":[{"name":"Latner Thoracic Surgery Research Laboratories, University Health Network, Toronto General Research Institute, Toronto, Ontario, Canada"},{"name":"Department of Thoracic Surgery, the First Affiliated Hospital, School of Medicine, Xi'an Jiaotong University, Xi'an, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeya","family":"Nadesalingam","sequence":"additional","affiliation":[{"name":"Latner Thoracic Surgery Research Laboratories, University Health Network, Toronto General Research Institute, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serisha","family":"Moodley","sequence":"additional","affiliation":[{"name":"Latner Thoracic Surgery Research Laboratories, University Health Network, Toronto General Research Institute, Toronto, Ontario, Canada"},{"name":"Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohui","family":"Bai","sequence":"additional","affiliation":[{"name":"Latner Thoracic Surgery Research Laboratories, University Health Network, Toronto General Research Institute, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingyao","family":"Liu","sequence":"additional","affiliation":[{"name":"Latner Thoracic Surgery Research Laboratories, University Health Network, Toronto General Research Institute, Toronto, Ontario, Canada"},{"name":"Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada"},{"name":"Department of Surgery, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7892","published-online":{"date-parts":[[2015,4,20]]},"reference":[{"key":"1","doi-asserted-by":"crossref","first-page":"e109710","DOI":"10.1371\/journal.pone.0109710","article-title":"Microbial communities in the upper respiratory tract of patients with asthma and chronic obstructive pulmonary disease","volume":"9","author":"Kim","year":"2014","journal-title":"PLoS One"},{"key":"2","doi-asserted-by":"crossref","first-page":"5","DOI":"10.3322\/canjclin.53.1.5","article-title":"Cancer statistics, 2003","volume":"53","author":"Thun","year":"2003","journal-title":"CA Cancer J Clin"},{"key":"3","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1016\/S0140-6736(11)60968-9","article-title":"Chronic obstructive pulmonary disease","volume":"379","author":"Miravitlles","year":"2012","journal-title":"Lancet"},{"key":"4","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1172\/JCI200316147","article-title":"Rapid Akt activation by nicotine and a tobacco carcinogen modulates the phenotype of normal human airway epithelial cells","volume":"111","author":"Dennis","year":"2003","journal-title":"J Clin Invest"},{"key":"5","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1158\/0008-5472.CAN-03-3241","article-title":"Tobacco carcinogen-induced cellular transformation increases activation of the phosphatidylinositol 3\u2032-kinase\/Akt pathwayand","volume":"64","author":"Dennis","year":"2004","journal-title":"Cancer Res"},{"key":"6","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1038\/onc.2012.39","article-title":"IKBKE is induced by STAT3 and tobacco carcinogen and determines chemosensitivity in non-small cell lung cancer","volume":"32","author":"Cheng","year":"2013","journal-title":"Oncogene"},{"key":"7","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1124\/dmd.109.031492","article-title":"Formation and distribution of NNK metabolites in an isolated perfused rat lung","volume":"38","author":"Zimmerman","year":"2010","journal-title":"Drug Metab Dispos"},{"key":"8","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.3390\/cancers6021138","article-title":"Mechanisms of Cancer Induction by Tobacco-Specific NNK and NNN","volume":"6","author":"Seng","year":"2014","journal-title":"Cancers (Basel)"},{"key":"9","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.canlet.2011.12.008","article-title":"NNK promotes migration and invasion of lung cancer cells through activation of c-Src\/PKCiota\/FAK loop","volume":"318","author":"Deng","year":"2012","journal-title":"Cancer Lett"},{"key":"10","doi-asserted-by":"crossref","first-page":"S580","DOI":"10.1245\/s10434-011-2064-x","article-title":"NNK enhances cell migration through alpha7-nicotinic acetylcholine receptor accompanied by increased of fibronectin expression in gastric cancer","volume":"19","author":"Chang","year":"2012","journal-title":"Ann Surg Oncol"},{"key":"11","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1097\/SLA.0b013e3181a6ce7e","article-title":"Tobacco-specific carcinogen enhances colon cancer cell migration through alpha7-nicotinic acetylcholine receptor","volume":"249","author":"Lin","year":"2009","journal-title":"Ann Surg"},{"key":"12","first-page":"663","article-title":"The adaptor proteins p40CAP and p30CAS as molecular hubs in cell migration and invasion of cancer cells","volume":"1","author":"Defilippi","year":"2011","journal-title":"Am J Cancer Res"},{"key":"13","doi-asserted-by":"crossref","first-page":"6270","DOI":"10.1038\/sj.onc.1204769","article-title":"Adaptor proteins","volume":"20","author":"Flynn","year":"2001","journal-title":"Oncogene"},{"key":"14","doi-asserted-by":"crossref","first-page":"16401","DOI":"10.1074\/jbc.M701684200","article-title":"XB130, a novel adaptor protein for signal transduction","volume":"282","author":"Liu","year":"2007","journal-title":"J Biol Chem"},{"key":"15","first-page":"903014","article-title":"XB130-A Novel Adaptor Protein: Gene, Function, and Roles in Tumorigenesis","volume":"2014","author":"Liu","year":"2014","journal-title":"Scientifica (Cairo)"},{"key":"16","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1038\/onc.2008.447","article-title":"XB130, a tissue-specific adaptor protein that couples the RET\/PTC oncogenic kinase to PI 3-kinase pathway","volume":"28","author":"Liu","year":"2009","journal-title":"Oncogene"},{"key":"17","doi-asserted-by":"crossref","first-page":"e43646","DOI":"10.1371\/journal.pone.0043646","article-title":"XB130 mediates cancer cell proliferation and survival through multiple signaling events downstream of Akt","volume":"7","author":"Liu","year":"2012","journal-title":"PLoS One"},{"key":"18","doi-asserted-by":"crossref","first-page":"e59057","DOI":"10.1371\/journal.pone.0059057","article-title":"XB130, a new adaptor protein, regulates expression of tumor suppressive microRNAs in cancer cells","volume":"8","author":"Liu","year":"2013","journal-title":"PLoS One"},{"key":"19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1479-5876-12-1","article-title":"XB130 promotes proliferation and invasion of gastric cancer cells","volume":"12","author":"Liao","year":"2014","journal-title":"J Transl Med"},{"key":"20","doi-asserted-by":"crossref","first-page":"4149","DOI":"10.1007\/s00018-012-1044-z","article-title":"Knowledge translation: airway epithelial cell migration and respiratory diseases","volume":"69","author":"Liu","year":"2012","journal-title":"Cell Mol Life Sci"},{"key":"21","doi-asserted-by":"crossref","first-page":"4156","DOI":"10.1242\/jcs.071050","article-title":"Adaptor protein XB130 is a Rac-controlled component of lamellipodia that regulates cell motility and invasion","volume":"123","author":"Liu","year":"2010","journal-title":"J Cell Sci"},{"key":"22","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/2043-9113-1-10","article-title":"Roles of XB30, a novel adaptor protein, in cancer","volume":"1","author":"Liu","year":"2011","journal-title":"J Clin Bioinforma"},{"key":"23","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1007\/s00018-011-0812-5","article-title":"The actin-binding domain of actin filament-associated protein (AFAP) is involved in the regulation of cytoskeletal structure","volume":"69","author":"Liu","year":"2012","journal-title":"Cell Mol Life Sci"},{"key":"24","doi-asserted-by":"crossref","first-page":"e13960","DOI":"10.1371\/journal.pone.0013960","article-title":"Characterization of engineered actin binding proteins that control filament assembly and structure","volume":"5","author":"Rock","year":"2010","journal-title":"PLoS One"},{"key":"25","first-page":"352","article-title":"Cortactin: the gray eminence of the cytoskeleton","volume":"21","author":"Kapus","year":"2006","journal-title":"Physiology (Bethesda)"},{"key":"26","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1002\/cm.20296","article-title":"Cortactin branches out: roles in regulating protrusive actin dynamics","volume":"65","author":"Weed","year":"2008","journal-title":"Cell Motil Cytoskeleton"},{"key":"27","doi-asserted-by":"crossref","first-page":"e23653","DOI":"10.1371\/journal.pone.0023653","article-title":"The homolog of the five SH3-domain protein (HOFI\/SH3PXD2B) regulates lamellipodia formation and cell spreading","volume":"6","author":"Geiszt","year":"2011","journal-title":"PLoS One"},{"key":"28","doi-asserted-by":"crossref","first-page":"3221","DOI":"10.1091\/mbc.e08-01-0016","article-title":"Molecular dissection of the structural machinery underlying the tissue-invasive activity of membrane type-1 matrix metalloproteinase","volume":"19","author":"Weiss","year":"2008","journal-title":"Mol Biol Cell"},{"key":"29","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1002\/jcp.21609","article-title":"Phorbol ester-induced podosomes in normal human bronchial epithelial cells","volume":"218","author":"Liu","year":"2009","journal-title":"J Cell Physiol"},{"key":"30","doi-asserted-by":"crossref","first-page":"5545","DOI":"10.1128\/MCB.00382-10","article-title":"The protein kinase C cascade regulates recruitment of matrix metalloprotease 9 to podosomes and its release and activation","volume":"30","author":"Liu","year":"2010","journal-title":"Mol Cell Biol"},{"key":"31","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1016\/j.cmet.2011.03.024","article-title":"Protein phosphorylation and prevention of cytochrome oxidase inhibition by ATP: coupled mechanisms of energy metabolism regulation","volume":"13","author":"Manfredi","year":"2011","journal-title":"Cell Metab"},{"key":"32","doi-asserted-by":"crossref","first-page":"6644","DOI":"10.1021\/bi300722t","article-title":"Arg\/Abl2 modulates the affinity and stoichiometry of binding of cortactin to F-actin","volume":"51","author":"Koleske","year":"2012","journal-title":"Biochemistry"},{"key":"33","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1242\/jcs.093781","article-title":"Cortactin in cell migration and cancer at a glance","volume":"125","author":"Koleske","year":"2012","journal-title":"J Cell Sci"},{"key":"34","doi-asserted-by":"crossref","first-page":"2940","DOI":"10.1242\/jcs.100834","article-title":"Met receptor tyrosine kinase signals through a cortactin-Gab1 scaffold complex, to mediate invadopodia","volume":"125","author":"Park","year":"2012","journal-title":"J Cell Sci"},{"key":"35","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1128\/MCB.00330-09","article-title":"SRC-mediated phosphorylation of dynamin and cortactin regulates the \u201cconstitutive\u201d endocytosis of transferrin","volume":"30","author":"McNiven","year":"2010","journal-title":"Mol Cell Biol"},{"key":"36","doi-asserted-by":"crossref","first-page":"6185","DOI":"10.1242\/jcs.121046","article-title":"Src binds cortactin through an SH2 domain cystine-mediated linkage","volume":"125","author":"Weed","year":"2012","journal-title":"J Cell Sci"},{"key":"37","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1080\/15216540600962818","article-title":"MT1-MMP: a key regulator of cell migration in tissue","volume":"58","author":"Itoh","year":"2006","journal-title":"IUBMB Life"},{"key":"38","doi-asserted-by":"crossref","first-page":"2820","DOI":"10.1242\/jcs.122358","article-title":"A specific subset of RabGTPases controls cell surface exposure of MT1-MMP, extracellular matrix degradation and three-dimensional invasion of macrophages","volume":"126","author":"Linder","year":"2013","journal-title":"J Cell Sci"},{"key":"39","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.semcdb.2007.06.008","article-title":"Membrane type 1-matrix metalloproteinase: substrate diversity in pericellular proteolysis","volume":"19","author":"Stack","year":"2008","journal-title":"Semin Cell Dev Biol"},{"key":"40","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1083\/jcb.153.5.893","article-title":"Membrane-type 1 matrix metalloproteinase cleaves CD44 and promotes cell migration","volume":"153","author":"Seiki","year":"2001","journal-title":"J Cell Biol"},{"key":"41","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.ejcb.2010.04.007","article-title":"Secretory and endo\/exocytic trafficking in invadopodia formation: the MT1-MMP paradigm","volume":"90","author":"Scita","year":"2011","journal-title":"Eur J Cell Biol"},{"key":"42","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1083\/jcb.124.5.743","article-title":"Phosphorylation of the growth arrest-specific protein Gas2 is coupled to actin rearrangements during Go\u2014>G1 transition in NIH 3T3 cells","volume":"124","author":"Schneider","year":"1994","journal-title":"J Cell Biol"},{"key":"43","doi-asserted-by":"crossref","first-page":"e38049","DOI":"10.1371\/journal.pone.0038049","article-title":"Claudin 1 mediates TNFalpha-induced gene expression and cell migration in human lung carcinoma cells","volume":"7","author":"Liu","year":"2012","journal-title":"PLoS One"},{"key":"44","doi-asserted-by":"crossref","first-page":"26555","DOI":"10.1074\/jbc.272.42.26555","article-title":"Role of the cytoskeleton in calcium signaling in NIH 3T3 cells. An intact cytoskeleton is required for agonist-induced [Ca2+]i signaling, but not for capacitative calcium entry","volume":"272","author":"Putney","year":"1997","journal-title":"J Biol Chem"}],"container-title":["Oncotarget"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.3777","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,13]],"date-time":"2020-05-13T12:26:35Z","timestamp":1589372795000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.3777"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,4,20]]},"references-count":44,"journal-issue":{"issue":"20","published-print":{"date-parts":[[2015,7,20]]}},"alternative-id":["3777","25980441"],"URL":"https:\/\/doi.org\/10.18632\/oncotarget.3777","relation":{},"ISSN":["1949-2553"],"issn-type":[{"value":"1949-2553","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,4,20]]}}}