{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T19:24:55Z","timestamp":1780687495492,"version":"3.54.1"},"reference-count":32,"publisher":"Impact Journals, LLC","issue":"17","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncotarget"],"published-print":{"date-parts":[[2015,6,20]]},"DOI":"10.18632\/oncotarget.3802","type":"journal-article","created":{"date-parts":[[2015,9,15]],"date-time":"2015-09-15T06:31:06Z","timestamp":1442298666000},"page":"14993-15007","source":"Crossref","is-referenced-by-count":86,"title":["MicroRNA-451 regulates stemness of side population cells via PI3K\/Akt\/mTOR signaling pathway in multiple myeloma"],"prefix":"10.18632","volume":"6","author":[{"given":"Juan","family":"Du","sequence":"first","affiliation":[{"name":"Department of Hematology, The Myeloma and Lymphoma Center, Changzheng Hospital, The Second Military Medical University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuyan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Hematology, The Myeloma and Lymphoma Center, Changzheng Hospital, The Second Military Medical University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"He","sequence":"additional","affiliation":[{"name":"Department of Hematology, The Myeloma and Lymphoma Center, Changzheng Hospital, The Second Military Medical University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Hematology, The Myeloma and Lymphoma Center, Changzheng Hospital, The Second Military Medical University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Qu","sequence":"additional","affiliation":[{"name":"Department of Hematology, The Myeloma and Lymphoma Center, Changzheng Hospital, The Second Military Medical University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenqing","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Hematology, The Myeloma and Lymphoma Center, Changzheng Hospital, The Second Military Medical University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianling","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Hematology, The Myeloma and Lymphoma Center, Changzheng Hospital, The Second Military Medical University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Hematology, The Myeloma and Lymphoma Center, Changzheng Hospital, The Second Military Medical University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Xi","sequence":"additional","affiliation":[{"name":"Department of Hematology, The Myeloma and Lymphoma Center, Changzheng Hospital, The Second Military Medical University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weijun","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Hematology, The Myeloma and Lymphoma Center, Changzheng Hospital, The Second Military Medical University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunyang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Hematology, The Myeloma and Lymphoma Center, Changzheng Hospital, The Second Military Medical University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Lymphoma\/Myeloma, Division of Cancer Medicine and Center for Cancer Immunology Research, The University of Texas, MD Anderson Cancer Center, Houston, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Hou","sequence":"additional","affiliation":[{"name":"Department of Hematology, The Myeloma and Lymphoma Center, Changzheng Hospital, The Second Military Medical University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7892","published-online":{"date-parts":[[2015,4,12]]},"reference":[{"issue":"Suppl 1","key":"1","first-page":"S5","article-title":"Multiple myeloma: biology of the disease","volume":"24","author":"Anderson","year":"2010","journal-title":"Blood Rev"},{"key":"2","doi-asserted-by":"crossref","first-page":"e571","DOI":"10.1016\/S1470-2045(13)70404-2","article-title":"Management of multiple myeloma in Asia: resource-stratified guidelines","volume":"14","author":"Chim","year":"2013","journal-title":"Lancet Oncol"},{"key":"3","doi-asserted-by":"crossref","first-page":"S43","DOI":"10.1038\/480S43a","article-title":"Tumorigenesis: Testing ground for cancer stem cells","volume":"480","author":"Delude","year":"2011","journal-title":"Nature"},{"key":"4","doi-asserted-by":"crossref","first-page":"2332","DOI":"10.1182\/blood-2003-09-3064","article-title":"Characterization of clonogenic multiple myeloma cells","volume":"103","author":"Tanhehco","year":"2004","journal-title":"Blood"},{"key":"5","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1158\/0008-5472.CAN-07-3096","article-title":"Clonogenic multiple myeloma progenitors, stem cell properties, and drug resistance","volume":"68","author":"Borrello","year":"2008","journal-title":"Cancer Res"},{"key":"6","doi-asserted-by":"crossref","first-page":"6155","DOI":"10.1158\/1078-0432.CCR-12-0531","article-title":"Stemness of B-cell progenitors in multiple myeloma bone marrow","volume":"18","author":"Alsina","year":"2012","journal-title":"Clin Cancer Res"},{"key":"7","doi-asserted-by":"crossref","first-page":"2530","DOI":"10.1038\/leu.2012.140","article-title":"CD19-CD45 low\/\u2212 CD38 high\/CD138+ plasma cells enrich for human tumorigenic myeloma cells","volume":"26","author":"Weissman","year":"2012","journal-title":"Leukemia"},{"key":"8","doi-asserted-by":"crossref","first-page":"e56954","DOI":"10.1371\/journal.pone.0056954","article-title":"Bortezomib reduces the tumorigenicity of multiple myeloma via downregulation of upregulated targets in clonogenic side population cells","volume":"8","author":"Kitabayashi","year":"2013","journal-title":"PLoS One"},{"key":"9","doi-asserted-by":"crossref","first-page":"1797","DOI":"10.1084\/jem.183.4.1797","article-title":"Isolation and functional properties of murine hematopoietic stem cells that are replicating","volume":"183","author":"Mulligan","year":"1996","journal-title":"J Exp Med"},{"key":"10","doi-asserted-by":"crossref","first-page":"4048","DOI":"10.1073\/pnas.0611682104","article-title":"Hedgehog signaling maintains a tumor stem cell compartment in multiple myeloma","volume":"104","author":"Kim","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"key":"11","doi-asserted-by":"crossref","first-page":"2895","DOI":"10.1200\/JCO.2007.15.8428","article-title":"Multiple myeloma cancer stem cells","volume":"26","author":"Matsui","year":"2008","journal-title":"J Clin Oncol"},{"key":"12","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1080\/10428190802272676","article-title":"Presence of Hoechst low side populations in multiple myeloma","volume":"49","author":"Joshua","year":"2008","journal-title":"Leuk Lymphoma"},{"key":"13","doi-asserted-by":"crossref","first-page":"4409","DOI":"10.1182\/blood-2010-02-267344","article-title":"Lenalidomide targets clonogenic side population in multiple myeloma: pathophysiologic and clinical implications","volume":"117","author":"Daley","year":"2011","journal-title":"Blood"},{"key":"14","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.cell.2009.01.002","article-title":"MicroRNAs: target recognition and regulatory functions","volume":"136","author":"Bartel","year":"2009","journal-title":"Cell"},{"key":"15","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1038\/nrg3471","article-title":"Adult-specific functions of animal microRNAs","volume":"14","author":"Lai","year":"2013","journal-title":"Nat Rev Genet"},{"key":"16","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.2174\/13894501113149990190","article-title":"Cancer \u201cStemness\u201d- Regulating MicroRNAs: Role, Mechanisms and Therapeutic Potential","volume":"14","author":"Singh","year":"2013","journal-title":"Curr Drug Targets"},{"key":"17","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1038\/nrm2868","article-title":"MicroRNA control of signal transduction","volume":"11","author":"Piccolo","year":"2010","journal-title":"Nat Rev Mol Cell Biol"},{"key":"18","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1038\/nm0901-1028","article-title":"The ABC transporter Bcrp1\/ABCG2 is expressed in a wide variety of stem cells and is a molecular determinant of the side-population phenotype","volume":"7","author":"Morris","year":"2001","journal-title":"Nat Med"},{"key":"19","doi-asserted-by":"crossref","first-page":"3571","DOI":"10.1182\/blood-2011-06-364182","article-title":"A clinically relevant population of leukemic CD34(+)CD38(\u2212) cells in acute myeloid leukemia","volume":"119","author":"Morsberger","year":"2012","journal-title":"Blood"},{"key":"20","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1002\/stem.1448","article-title":"MicroRNA-200C and \u2212150 Play an Important Role in Endothelial Cell Differentiation and Vasculogenesis by Targeting Transcription Repressor ZEB1","volume":"31","author":"Xu","year":"2013","journal-title":"Stem Cells"},{"key":"21","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.1002\/stem.741","article-title":"MicroRNA-451 is involved in the self-renewal, tumorigenicity, and chemoresistance of colorectal cancer stem cells","volume":"29","author":"Gonzalez-Huarriz","year":"2011","journal-title":"Stem Cells"},{"key":"22","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1038\/nature08454","article-title":"Molecular networks as sensors and drivers of common human diseases","volume":"461","author":"Schadt","year":"2009","journal-title":"Nature"},{"key":"23","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1038\/nrg2884","article-title":"Analysing biological pathways in genome-wide association studies","volume":"11","author":"Hakonarson","year":"2010","journal-title":"Nat Rev Genet"},{"key":"24","doi-asserted-by":"crossref","first-page":"e50005","DOI":"10.1371\/journal.pone.0050005","article-title":"Anti-myeloma activity of Akt inhibition is linked to the activation status of PI3K\/Akt and MEK\/ERK pathway","volume":"7","author":"Halling","year":"2012","journal-title":"PLoS One"},{"key":"25","doi-asserted-by":"crossref","first-page":"125","DOI":"10.2174\/13816128113199990638","article-title":"The mTOR Signaling Pathway is an Emerging Therapeutic Target in Multiple Myeloma","volume":"20","author":"Mao","year":"2014","journal-title":"Curr Pharm Des"},{"key":"26","doi-asserted-by":"crossref","first-page":"1986","DOI":"10.1182\/blood-2010-05-284810","article-title":"A small-molecule inhibitor of D-cyclin transactivation displays preclinical efficacy in myeloma and leukemia via phosphoinositide 3-kinase pathway","volume":"117","author":"Wang","year":"2011","journal-title":"Blood"},{"key":"27","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1186\/1756-8722-6-91","article-title":"Fact or fiction--identifying the elusive multiple myeloma stem cell","volume":"6","author":"Li","year":"2013","journal-title":"J Hematol Oncol"},{"key":"28","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1182\/blood-2013-02-482919","article-title":"RARalpha2 expression confers myeloma stem cell features","volume":"122","author":"Wang","year":"2013","journal-title":"Blood"},{"key":"29","doi-asserted-by":"crossref","first-page":"2281","DOI":"10.1158\/1078-0432.CCR-08-1818","article-title":"microRNA-451 regulates macrophage migration inhibitory factor production and proliferation of gastrointestinal cancer cells","volume":"15","author":"Agirre","year":"2009","journal-title":"Clin Cancer Res"},{"key":"30","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1016\/j.bcp.2008.06.007","article-title":"Role of MicroRNA miR-27a and miR-451 in the regulation of MDR1\/P-glycoprotein expression in human cancer cells","volume":"76","author":"Liu","year":"2008","journal-title":"Biochem Pharmacol"},{"key":"31","first-page":"395","article-title":"Targeting the PI3K\/AKT\/mTOR Pathway","volume":"2013","author":"Khuri","year":"2013","journal-title":"Am Soc Clin Oncol Educ Book"},{"key":"32","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1182\/blood-2005-01-0034","article-title":"Cyclin D dysregulation: an early and unifying pathogenic event in multiple myeloma","volume":"106","author":"Shaughnessy","year":"2005","journal-title":"Blood"}],"container-title":["Oncotarget"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.3802","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,13]],"date-time":"2020-05-13T11:53:28Z","timestamp":1589370808000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.3802"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,4,12]]},"references-count":32,"journal-issue":{"issue":"17","published-print":{"date-parts":[[2015,6,20]]}},"alternative-id":["3802","25915427"],"URL":"https:\/\/doi.org\/10.18632\/oncotarget.3802","relation":{},"ISSN":["1949-2553"],"issn-type":[{"value":"1949-2553","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,4,12]]}}}