{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T20:53:15Z","timestamp":1782247995523,"version":"3.54.5"},"reference-count":48,"publisher":"Impact Journals, LLC","issue":"28","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncotarget"],"published-print":{"date-parts":[[2015,9,22]]},"DOI":"10.18632\/oncotarget.4486","type":"journal-article","created":{"date-parts":[[2015,9,28]],"date-time":"2015-09-28T16:51:29Z","timestamp":1443459089000},"page":"25121-25134","source":"Crossref","is-referenced-by-count":17,"title":["Intracellular lactate-mediated induction of estrogen receptor beta (ER\u03b2) in biphasic malignant pleural mesothelioma cells"],"prefix":"10.18632","volume":"6","author":[{"given":"Arcangela G.","family":"Manente","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Sciences, University of Piemonte Orientale \u201cA. Avogadro\u201d, 28100, Novara, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Pinton","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, University of Piemonte Orientale \u201cA. Avogadro\u201d, 28100, Novara, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Zonca","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, University of Piemonte Orientale \u201cA. Avogadro\u201d, 28100, Novara, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Cilli","sequence":"additional","affiliation":[{"name":"IRCCS San Martino-IST, 16132, Genova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"Rinaldi","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, University of Piemonte Orientale \u201cA. Avogadro\u201d, 28100, Novara, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Daga","sequence":"additional","affiliation":[{"name":"IRCCS San Martino-IST, 16132, Genova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Nilsson","sequence":"additional","affiliation":[{"name":"Karo Bio AB, Novum, S-141 57, Huddinge, Sweden"},{"name":"Department of Biosciences and Nutrition, Karolinska Institutet, Novum, S-141 57, Huddinge, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Moro","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, University of Piemonte Orientale \u201cA. Avogadro\u201d, 28100, Novara, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7892","published-online":{"date-parts":[[2015,7,9]]},"reference":[{"key":"1","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1097\/MCP.0b013e328354acfe","article-title":"Asbestos-related pleural disease","volume":"18","author":"Myers","year":"2012","journal-title":"Curr Opin Pulm Med"},{"key":"2","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1056\/NEJMra050152","article-title":"Advances in malignant mesothelioma","volume":"353","author":"Lake","year":"2005","journal-title":"N Engl J Med"},{"key":"3","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1053\/sonc.2002.30227","article-title":"The pathogenesis of mesothelioma","volume":"29","author":"Testa","year":"2002","journal-title":"Semin Oncol"},{"key":"4","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1146\/annurev-publhealth-031811-124704","article-title":"The worldwide pandemic of asbests-related diseases","volume":"34","author":"Lemen","year":"2013","journal-title":"Annu Rev Public Health"},{"key":"5","first-page":"1","article-title":"Asbestos and the lung in the 21st century: an update","volume":"8","author":"Yates","year":"2013","journal-title":"Clin Respir J"},{"key":"6","first-page":"491","article-title":"Malignant pleural mesothelioma: an epidemiological perspective","volume":"1","author":"Robinson","year":"2012","journal-title":"Ann Cardiothorac Surg"},{"key":"7","article-title":"Pathology and genetics of tumours of the lung pleura thymus and heart","author":"Harris","year":"2004","journal-title":"IARC Press Lyon"},{"key":"8","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1097\/JTO.0b013e318211127a","article-title":"Pleomorphic epithelioid diffuse malignant pleural mesothelioma: a clinicopathological review and conceptual proposal to reclassify as biphasic or sarcomatoid mesothelioma","volume":"6","author":"Travis","year":"2011","journal-title":"J Thorac Oncol"},{"key":"9","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1136\/jclinpath-2013-201609","article-title":"Challenges and controversies in the diagnosis of malignant mesothelioma: part 2. Malignant mesothelioma subtypes, pleural synovial sarcoma, molecular and prognostic aspects of mesothelioma, BAP1, aquaporin-1 and microRNA","volume":"66","author":"Klebe","year":"2013","journal-title":"J Clin Pathol"},{"key":"10","first-page":"428","article-title":"Systematic review of trimodality therapy for patients with malignant pleural mesothelioma","volume":"1","author":"Yan","year":"2012","journal-title":"Ann Cardiothorac Surg"},{"key":"11","doi-asserted-by":"crossref","first-page":"2636","DOI":"10.1200\/JCO.2003.11.136","article-title":"Phase III study of pemetrexed in combination with cisplatin versus cisplatin alone in patients with malignant pleural mesothelioma","volume":"21","author":"Paoletti","year":"2003","journal-title":"J Clin Oncol"},{"key":"12","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.ctrv.2014.10.007","article-title":"Malignant pleural mesothelioma: new hope in the horizon with novel therapeutic strategies","volume":"41","author":"Lianes","year":"2015","journal-title":"Cancer Treat Rev"},{"key":"13","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.ccm.2012.12.005","article-title":"Malignant pleural mesothelioma: update on treatment options with a focus on novel therapies","volume":"34","author":"Sterman","year":"2013","journal-title":"Clin Chest Med"},{"key":"14","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.lungcan.2012.02.022","article-title":"Exploratory analysis of activation of PTEN-PI3K pathway and downstream proteins in malignant pleural mesothelioma (MPM)","volume":"77","author":"Felip","year":"2012","journal-title":"Lung Cancer"},{"key":"15","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1158\/1078-0432.CCR-11-2259","article-title":"Molecular Pathways: Targeting Mechanisms of Asbestos and Erionite Carcinogenesis in Mesothelioma","volume":"18","author":"Yang","year":"2012","journal-title":"Clin Cancer Res"},{"key":"16","doi-asserted-by":"crossref","first-page":"6080","DOI":"10.1038\/sj.onc.1208744","article-title":"Human and mouse mesotheliomas exhibit elevated AKT\/PKB activity, which can be targeted pharmacologically to inhibit tumor cell growth","volume":"24","author":"Testa","year":"2005","journal-title":"Oncogene"},{"key":"17","doi-asserted-by":"crossref","first-page":"e36856","DOI":"10.1371\/journal.pone.0036856","article-title":"Perifosine as a potential novel anti-cancer agent inhibits EGFR\/MET-AKT axis in malignant pleural mesothelioma","volume":"7","author":"Moro","year":"2012","journal-title":"PlosOne"},{"key":"18","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1038\/nrc2981","article-title":"Regulation of cancer cell metabolism","volume":"11","author":"Mak","year":"2011","journal-title":"Nat Rev Cancer"},{"key":"19","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1007\/s10555-007-9055-1","article-title":"Hypoxia in cancer: significance and impact on clinical outcome","volume":"26","author":"Mayer","year":"2007","journal-title":"Cancer Metastasis Rev"},{"key":"20","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1002\/iub.572","article-title":"The monocarboxylate transporter family - role and regulation","volume":"64","author":"Wilson","year":"2012","journal-title":"IUBMB Life"},{"key":"21","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1007\/s00424-009-0750-3","article-title":"Hypoxia stimulates lactate release and modulates monocarboxylate transporter (MCT1, MCT2, and MCT4) expression in human adipocytes","volume":"459","author":"Trayhurn","year":"2010","journal-title":"Pflugers Arch"},{"key":"22","doi-asserted-by":"crossref","first-page":"9030","DOI":"10.1074\/jbc.M511397200","article-title":"The plasma membrane lactate transporter MCT4, but not MCT1, is up-regulated by hypoxia through a HIF-1alpha-dependent mechanism","volume":"281","author":"Halestrap","year":"2006","journal-title":"J Biol Chem"},{"key":"23","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.humpath.2014.09.013","article-title":"Expression of lactate\/Hsymporters MCT1 and MCT4 and their chaperone CD147 predicts tumor progression in clear cell renal cell carcinoma: immunohistochemical and The Cancer Genome Atlas data analyses","volume":"46","author":"Kim","year":"2015","journal-title":"Hum Pathol"},{"key":"24","doi-asserted-by":"crossref","first-page":"e105038","DOI":"10.1371\/journal.pone.0105038","article-title":"Monocarboxylate transporters 1-4 in NSCLC: MCT1 is an independent prognostic marker for survival","volume":"9","author":"Bremnes","year":"2014","journal-title":"PLoS One"},{"key":"25","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.bbrc.2014.07.050","article-title":"Expression of the hypoxia-inducible monocarboxylate transporter MCT4 is increased in triple negative breast cancer and correlates independently with clinical outcome","volume":"451","author":"Pouyss\u00e9gur","year":"2014","journal-title":"Biochem Biophys Res Commun"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1002\/mc.22222","article-title":"CD147 and MCT1-potential partners in bladder cancer aggressiveness and cisplatin resistance","author":"Baltazar","year":"2014","journal-title":"Mol Carcinog"},{"key":"27","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1210\/me.2007-0128","article-title":"The transcription factor aryl hydrocarbon receptor nuclear translocator functions as an estrogen receptor beta-selective coactivator and its recruitment to alternative pathways mediates antiestrogenic effects of dioxin","volume":"22","author":"Pongratz","year":"2008","journal-title":"Mol Endocrinol"},{"key":"28","doi-asserted-by":"crossref","first-page":"6517","DOI":"10.1073\/pnas.1136688100","article-title":"The basic helix-loop-helix-PAS protein ARNT functions as a potent coactivator of estrogen receptor-dependent transcription","volume":"100","author":"Pongratz","year":"2003","journal-title":"Proc Natl Acad Sci USA"},{"key":"29","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.bbrc.2014.05.107","article-title":"Overexpression of ER\u03b2 is sufficient to inhibit hypoxia-inducible factor-1 transactivation","volume":"450","author":"Lee","year":"2014","journal-title":"Biochem Biophys Res Commun"},{"key":"30","doi-asserted-by":"crossref","first-page":"R32","DOI":"10.1186\/bcr2854","article-title":"Estrogen receptor beta inhibits transcriptional activity of hypoxia inducible factor-1 through the downregulation of arylhydrocarbon receptor nuclear translocator","volume":"13","author":"Lee","year":"2011","journal-title":"Breast Cancer Res"},{"key":"31","doi-asserted-by":"crossref","first-page":"4598","DOI":"10.1158\/0008-5472.CAN-08-4523","article-title":"Estrogen receptor-beta affects the prognosis of human malignant mesothelioma","volume":"69","author":"Moro","year":"2009","journal-title":"Cancer Res"},{"key":"32","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1186\/1476-4598-13-227","article-title":"Agonist activation of estrogen receptor beta (ER\u03b2 sensitizes malignant pleural mesothelioma cells to cisplatin cytotoxicity","volume":"13","author":"Moro","year":"2014","journal-title":"Molecular Cancer"},{"key":"33","doi-asserted-by":"crossref","first-page":"e14110","DOI":"10.1371\/journal.pone.0014110","article-title":"Estrogen receptor \u03b2 exerts tumor repressive functions in human malignant pleural mesothelioma via EGFR inactivation and affects response to gefitinib","volume":"5","author":"Moro","year":"2010","journal-title":"PlosOne"},{"key":"34","doi-asserted-by":"crossref","first-page":"e72","DOI":"10.1038\/oncsis.2013.32","article-title":"Estrogen receptor \u03b2 activation impairs mesothelioma cell metabolism and growthand","volume":"2","author":"Moro","year":"2013","journal-title":"Oncogenesis"},{"key":"35","first-page":"ra46","article-title":"The deacetylase SIRT1 promotes membrane localization and activation of Akt and PDK1 during tumorigenesis and cardiac hypertrophy","volume":"4","author":"Gupta","year":"2011","journal-title":"Sci Signal"},{"key":"36","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.bbapap.2003.11.009","article-title":"Structure, regulation and function of PKB\/AKT: a major therapeutic target","volume":"1697","author":"Hemmings","year":"2004","journal-title":"Biochim Biophys Acta"},{"key":"37","doi-asserted-by":"crossref","first-page":"2502","DOI":"10.4161\/cc.8.16.9335","article-title":"The Akt kinases: isoform specificity in metabolism and cancer","volume":"8","author":"McGraw","year":"2009","journal-title":"Cell Cycle"},{"key":"38","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1158\/0008-5472.CAN-13-2961","article-title":"Akt1 and Akt3 exert opposing roles in the regulation of vascular tumor growth","volume":"75","author":"Benjamin","year":"2015","journal-title":"Cancer Res"},{"key":"39","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.radonc.2009.06.025","article-title":"Pyruvate into lactate and back: from the Warburg effect to symbiotic energy fuel exchange in cancer cells","volume":"92","author":"Feron","year":"2009","journal-title":"Radiother Oncol"},{"key":"40","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/s10863-012-9428-1","article-title":"Role of monocarboxylate transporters in human cancers: state of the art","volume":"44","author":"Baltazar","year":"2012","journal-title":"J Bioenerg Biomembr"},{"key":"41","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1158\/0008-5472.CAN-14-2260","article-title":"Genetic Disruption of Lactate\/H+ Symporters (MCTs) and Their Subunit CD147\/BASIGIN Sensitizes Glycolytic Tumor Cells to Phenformin","volume":"75","author":"Pouyssegur","year":"2015","journal-title":"Cancer Res"},{"key":"42","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1186\/1476-4598-12-152","article-title":"Tumor glycolysis as a target for cancer therapy: progress and prospects","volume":"12","author":"Geschwind","year":"2013","journal-title":"Mol Cancer"},{"key":"43","doi-asserted-by":"crossref","first-page":"4794","DOI":"10.1093\/nar\/gks066","article-title":"Lactate, a product of glycolytic metabolism, inhibits histone deacetylase activity and promotes changes in gene expression","volume":"40","author":"Ramsahoye","year":"2012","journal-title":"Nucleic Acids Res"},{"key":"44","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.drudis.2012.10.003","article-title":"Three-dimensional cell culture: the missing link in drug discovery","volume":"18","author":"O'Driscoll","year":"2013","journal-title":"Drug Discov Today"},{"key":"45","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1038\/leu.2011.68","article-title":"Effect of ligand-activated estrogen receptor \u03b2 on lymphoma growthand","volume":"25","author":"Okret","year":"2011","journal-title":"Leukemia"},{"key":"46","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.dld.2011.06.014","article-title":"An oestrogen receptor \u03b2-selective agonist exerts anti-neoplastic effects in experimental intrahepatic cholangiocarcinoma","volume":"44","author":"Semeraro","year":"2012","journal-title":"Dig Liver Dis"},{"key":"47","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1177\/1087057106292763","article-title":"Rapid generation of single-tumor spheroids for high-throughput cell function and toxicity analysis","volume":"11","author":"Kubbies","year":"2006","journal-title":"J Biomol Screen"},{"key":"48","unstructured":"R Core Team: R: A Language and Environment for Statistical Computing. Vienna, Austria: R Foundation for Statistical Computing. 2012. ISBN 3-900051-07-0, URL http:\/\/www.R-project.org\/."}],"container-title":["Oncotarget"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.4486","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,13]],"date-time":"2020-05-13T13:51:31Z","timestamp":1589377891000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.4486"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7,9]]},"references-count":48,"journal-issue":{"issue":"28","published-print":{"date-parts":[[2015,9,22]]}},"alternative-id":["4486","26208479"],"URL":"https:\/\/doi.org\/10.18632\/oncotarget.4486","relation":{},"ISSN":["1949-2553"],"issn-type":[{"value":"1949-2553","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,7,9]]}}}