{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T20:30:12Z","timestamp":1789590612620,"version":"build-2803163510"},"reference-count":37,"publisher":"Impact Journals, LLC","issue":"28","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncotarget"],"published-print":{"date-parts":[[2015,9,22]]},"DOI":"10.18632\/oncotarget.4665","type":"journal-article","created":{"date-parts":[[2015,9,28]],"date-time":"2015-09-28T16:51:29Z","timestamp":1443459089000},"page":"25868-25882","source":"Crossref","is-referenced-by-count":9,"title":["Analysis of <i>SDHD<\/i> promoter mutations in various types of melanoma"],"prefix":"10.18632","volume":"6","author":[{"given":"Simone L.","family":"Scholz","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, University Hospital Essen, University Duisburg-Essen, West German Cancer Center and the German Cancer Consortium (DKTK), Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne","family":"Horn","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University Hospital Essen, University Duisburg-Essen, West German Cancer Center and the German Cancer Consortium (DKTK), Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajmohan","family":"Murali","sequence":"additional","affiliation":[{"name":"Department of Pathology, Memorial Sloan Kettering Cancer Center, New York NY, USA"},{"name":"Marie-Jos\u00e9e and Henry R. Kravis Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center, New York NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inga","family":"M\u00f6ller","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University Hospital Essen, University Duisburg-Essen, West German Cancer Center and the German Cancer Consortium (DKTK), Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antje","family":"Sucker","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University Hospital Essen, University Duisburg-Essen, West German Cancer Center and the German Cancer Consortium (DKTK), Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wiebke","family":"Sondermann","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University Hospital Essen, University Duisburg-Essen, West German Cancer Center and the German Cancer Consortium (DKTK), Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathias","family":"Stiller","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University Hospital Essen, University Duisburg-Essen, West German Cancer Center and the German Cancer Consortium (DKTK), Essen Germany"},{"name":"University Duisburg-Essen and the German Cancer Consortium (DKTK), Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bastian","family":"Schilling","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University Hospital Essen, University Duisburg-Essen, West German Cancer Center and the German Cancer Consortium (DKTK), Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth","family":"Livingstone","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University Hospital Essen, University Duisburg-Essen, West German Cancer Center and the German Cancer Consortium (DKTK), Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Zimmer","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University Hospital Essen, University Duisburg-Essen, West German Cancer Center and the German Cancer Consortium (DKTK), Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henning","family":"Reis","sequence":"additional","affiliation":[{"name":"Institute of Pathology, University Hospital Essen, University Duisburg-Essen, West German Cancer Center and the German Cancer Consortium (DKTK), Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia H.","family":"Metz","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University Hospital Essen, University Duisburg-Essen, West German Cancer Center and the German Cancer Consortium (DKTK), Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Zeschnigk","sequence":"additional","affiliation":[{"name":"Department of Human Genetics, University Hospital Essen, University Duisburg-Essen, West German Cancer Center and the German Cancer Consortium (DKTK), Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annette","family":"Paschen","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University Hospital Essen, University Duisburg-Essen, West German Cancer Center and the German Cancer Consortium (DKTK), Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus-Peter","family":"Steuhl","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University Hospital Essen, University Duisburg-Essen, West German Cancer Center and the German Cancer Consortium (DKTK), Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk","family":"Schadendorf","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University Hospital Essen, University Duisburg-Essen, West German Cancer Center and the German Cancer Consortium (DKTK), Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrike","family":"Westekemper","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University Hospital Essen, University Duisburg-Essen, West German Cancer Center and the German Cancer Consortium (DKTK), Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus G.","family":"Griewank","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University Hospital Essen, University Duisburg-Essen, West German Cancer Center and the German Cancer Consortium (DKTK), Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7892","published-online":{"date-parts":[[2015,7,27]]},"reference":[{"key":"1","first-page":"9","article-title":"Cancer statistics, 2014","volume":"64","author":"Jemal","year":"2014","journal-title":"CA: a cancer journal for clinicians"},{"key":"2","first-page":"2095","article-title":"Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010","volume":"380","author":"Baddour","year":"2013","journal-title":"Lancet"},{"key":"3","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1056\/NEJMoa1305133","article-title":"Safety and tumor responses with lambrolizumab (anti-PD-1) in melanoma","volume":"369","author":"Gergich","year":"2013","journal-title":"The New England journal of medicine"},{"key":"4","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1056\/NEJMoa1302369","article-title":"Nivolumab plus ipilimumab in advanced melanoma","volume":"369","author":"Lowy","year":"2013","journal-title":"The New England journal of medicine"},{"key":"5","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1158\/1078-0432.CCR-12-2625","article-title":"Durable cancer regression off-treatment and effective reinduction therapy with an anti-PD-1 antibody","volume":"19","author":"Topalian","year":"2013","journal-title":"Clinical cancer research : an official journal of the American Association for Cancer Research"},{"key":"6","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1200\/JCO.2013.53.0105","article-title":"Survival, durable tumor remission, and long-term safety in patients with advanced melanoma receiving nivolumab","volume":"32","author":"Wigginton","year":"2014","journal-title":"Journal of clinical oncology : official journal of the American Society of Clinical Oncology"},{"key":"7","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/S1470-2045(13)70024-X","article-title":"MEK162 for patients with advanced melanoma harbouring NRAS or Val600 BRAF mutations: a non-randomised, open-label phase 2 study","volume":"14","author":"Dummer","year":"2013","journal-title":"The lancet oncology"},{"key":"8","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.1056\/NEJMoa1406037","article-title":"Combined BRAF and MEK inhibition versus BRAF inhibition alone in melanoma","volume":"371","author":"Bondarenko","year":"2014","journal-title":"The New England journal of medicine"},{"key":"9","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1056\/NEJMoa1412690","article-title":"Improved overall survival in melanoma with combined dabrafenib and trametinib","volume":"372","author":"Wolter","year":"2015","journal-title":"The New England journal of medicine"},{"key":"10","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.cell.2012.06.024","article-title":"A landscape of driver mutations in melanoma","volume":"150","author":"Voet","year":"2012","journal-title":"Cell"},{"key":"11","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1038\/ng.2359","article-title":"Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma","volume":"44","author":"Bosenberg","year":"2012","journal-title":"Nature genetics"},{"key":"12","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1126\/science.1230062","article-title":"TERT promoter mutations in familial and sporadic melanoma","volume":"339","author":"Kumar","year":"2013","journal-title":"Science"},{"key":"13","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1126\/science.1229259","article-title":"Highly recurrent TERT promoter mutations in human melanoma","volume":"339","author":"Garraway","year":"2013","journal-title":"Science"},{"key":"14","article-title":"TERT promoter mutation status as an independent prognostic factor in cutaneous melanoma","volume":"106","author":"Scherag","year":"2014","journal-title":"Journal of the National Cancer Institute"},{"key":"15","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1038\/ng.3101","article-title":"Genome-wide analysis of noncoding regulatory mutations in cancer","volume":"46","author":"Lee","year":"2014","journal-title":"Nature genetics"},{"key":"16","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.ccr.2004.11.022","article-title":"Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-alpha prolyl hydroxylase","volume":"7","author":"Gottlieb","year":"2005","journal-title":"Cancer cell"},{"key":"17","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1086\/324413","article-title":"The R22X mutation of the SDHD gene in hereditary paraganglioma abolishes the enzymatic activity of complex II in the mitochondrial respiratory chain and activates the hypoxia pathway","volume":"69","author":"Jeunemaitre","year":"2001","journal-title":"American journal of human genetics"},{"key":"18","doi-asserted-by":"crossref","first-page":"2231","DOI":"10.1093\/hmg\/ddi227","article-title":"Accumulation of Krebs cycle intermediates and over-expression of HIF1alpha in tumours which result from germline FH and SDH mutations","volume":"14","author":"McGrath","year":"2005","journal-title":"Human molecular genetics"},{"key":"19","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1038\/sj.ejhg.5201904","article-title":"Clinical and molecular genetics of patients with the Carney-Stratakis syndrome and germline mutations of the genes coding for the succinate dehydrogenase subunits SDHB, SDHC, and SDHD","volume":"16","author":"Gimenez-Roqueplo","year":"2008","journal-title":"European journal of human genetics : EJHG"},{"key":"20","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1136\/jmg.39.3.178","article-title":"Prevalence of SDHB, SDHC, and SDHD germline mutations in clinic patients with head and neck paragangliomas","volume":"39","author":"Rubinstein","year":"2002","journal-title":"Journal of medical genetics"},{"key":"21","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1126\/science.287.5454.848","article-title":"Mutations in SDHD, a mitochondrial complex II gene, in hereditary paraganglioma","volume":"287","author":"Devlin","year":"2000","journal-title":"Science"},{"key":"22","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1086\/321282","article-title":"Gene mutations in the succinate dehydrogenase subunit SDHB cause susceptibility to familial pheochromocytoma and to familial paraganglioma","volume":"69","author":"Maher","year":"2001","journal-title":"American journal of human genetics"},{"key":"23","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1016\/S0140-6736(00)04378-6","article-title":"Germline SDHD mutation in familial phaeochromocytoma","volume":"357","author":"Maher","year":"2001","journal-title":"Lancet"},{"key":"24","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1158\/2159-8290.CD-13-0617","article-title":"The genetic landscape of clinical resistance to RAF inhibition in metastatic melanoma","volume":"4","author":"Zimmer","year":"2014","journal-title":"Cancer discovery"},{"key":"25","doi-asserted-by":"crossref","first-page":"10124","DOI":"10.1073\/pnas.88.22.10124","article-title":"A role for sunlight in skin cancer: UV-induced p53 mutations in squamous cell carcinoma","volume":"88","author":"Ponten","year":"1991","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"26","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1038\/nature08658","article-title":"A comprehensive catalogue of somatic mutations from a human cancer genome","volume":"463","author":"Carter","year":"2010","journal-title":"Nature"},{"key":"27","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1158\/2159-8290.CD-13-0330","article-title":"SF3B1 mutations are associated with alternative splicing in uveal melanoma","volume":"3","author":"Marais","year":"2013","journal-title":"Cancer discovery"},{"key":"28","article-title":"Conjunctival Melanomas harbor BRAF and NRAS Mutations and Copy Number Changes Similar to Cutaneous and Mucosal Melanomas","author":"Steuhl","year":"2013","journal-title":"Clinical cancer research: an official journal of the American Association for Cancer Research"},{"key":"29","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1038\/bjc.2013.312","article-title":"TERT promoter mutations in ocular melanoma distinguish between conjunctival and uveal tumours","volume":"109","author":"Zeschnigk","year":"2013","journal-title":"British journal of cancer"},{"key":"30","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1097\/00008390-200412000-00003","article-title":"BRAF mutations are detectable in conjunctival but not uveal melanomas","volume":"14","author":"Houlston","year":"2004","journal-title":"Melanoma research"},{"key":"31","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1038\/nature12213","article-title":"Mutational heterogeneity in cancer and the search for new cancer-associated genes","volume":"499","author":"Ramos","year":"2013","journal-title":"Nature"},{"key":"32","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/1477-3163-3-6","article-title":"Constitutive activation of the Ras-Raf signaling pathway in metastatic melanoma is associated with poor prognosis","volume":"3","author":"Rapp","year":"2004","journal-title":"Journal of carcinogenesis"},{"key":"33","doi-asserted-by":"crossref","first-page":"3143","DOI":"10.1158\/1078-0432.CCR-13-0163","article-title":"Conjunctival melanomas harbor BRAF and NRAS mutations and copy number changes similar to cutaneous and mucosal melanomas","volume":"19","author":"Steuhl","year":"2013","journal-title":"Clinical cancer research : an official journal of the American Association for Cancer Research"},{"key":"34","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1093\/nar\/16.3.1215","article-title":"A simple salting out procedure for extracting DNA from human nucleated cells","volume":"16","author":"Polesky","year":"1988","journal-title":"Nucleic acids research"},{"key":"35","doi-asserted-by":"crossref","first-page":"2078","DOI":"10.1093\/bioinformatics\/btp352","article-title":"The Sequence Alignment\/Map format and SAMtools","volume":"25","author":"Durbin","year":"2009","journal-title":"Bioinformatics"},{"key":"36","first-page":"267","article-title":"Awk \u2014 a pattern scanning and processing language","volume":"9","author":"Weinberger","year":"2006","journal-title":"Software: Practice and Experience"},{"key":"37","doi-asserted-by":"crossref","first-page":"6199","DOI":"10.1200\/JCO.2009.23.4799","article-title":"Final version of 2009 AJCC melanoma staging and classification","volume":"27","author":"Mihm","year":"2009","journal-title":"Journal of clinical oncology : official journal of the American Society of Clinical Oncology"}],"container-title":["Oncotarget"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.4665","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,13]],"date-time":"2020-05-13T14:19:54Z","timestamp":1589379594000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.4665"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7,27]]},"references-count":37,"journal-issue":{"issue":"28","published-print":{"date-parts":[[2015,9,22]]}},"alternative-id":["4665","26327518"],"URL":"https:\/\/doi.org\/10.18632\/oncotarget.4665","relation":{},"ISSN":["1949-2553"],"issn-type":[{"value":"1949-2553","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,7,27]]}}}