{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T03:34:37Z","timestamp":1768793677354,"version":"3.49.0"},"reference-count":58,"publisher":"Impact Journals, LLC","issue":"36","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncotarget"],"published-print":{"date-parts":[[2015,11,17]]},"DOI":"10.18632\/oncotarget.4912","type":"journal-article","created":{"date-parts":[[2015,9,29]],"date-time":"2015-09-29T21:54:23Z","timestamp":1443563663000},"page":"39111-39126","source":"Crossref","is-referenced-by-count":15,"title":["Oncogenic features of the bone morphogenic protein 7 (BMP7) in pheochromocytoma"],"prefix":"10.18632","volume":"6","author":[{"given":"Ines","family":"Leinh\u00e4user","sequence":"first","affiliation":[{"name":"Institute of Pathology, Helmholtz Zentrum M\u00fcnchen, Neuherberg, Germany"},{"name":"Institute of Radiation Biology, Helmholtz Zentrum M\u00fcnchen, Neuherberg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Richter","sequence":"additional","affiliation":[{"name":"Institute of Pathology, Helmholtz Zentrum M\u00fcnchen, Neuherberg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Misu","family":"Lee","sequence":"additional","affiliation":[{"name":"Institute of Pathology, Helmholtz Zentrum M\u00fcnchen, Neuherberg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ines","family":"H\u00f6fig","sequence":"additional","affiliation":[{"name":"Institute of Radiation Biology, Helmholtz Zentrum M\u00fcnchen, Neuherberg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nata\u0161a","family":"Anastasov","sequence":"additional","affiliation":[{"name":"Institute of Radiation Biology, Helmholtz Zentrum M\u00fcnchen, Neuherberg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Falko","family":"Fend","sequence":"additional","affiliation":[{"name":"Institute of Pathology and Neuropathology Comprehensive Cancer Center T\u00fcbingen and University of T\u00fcbingen, T\u00fcbingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tonino","family":"Ercolino","sequence":"additional","affiliation":[{"name":"Azienda Ospedaliero-Universitaria di Careggi, Endocrine Unit, Florence, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Massimo","family":"Mannelli","sequence":"additional","affiliation":[{"name":"Department of Experimental and Clinical Biomedical Sciences, University of Florence, Florence, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne-Paule","family":"Gimenez-Roqueplo","sequence":"additional","affiliation":[{"name":"INSERM, UMR U970, Paris Cardiovascular Research Center-PARCC, Paris, France"},{"name":"Universit\u00e9 Paris Descartes, Sorbonne Paris Cit\u00e9, Facult\u00e9 de M\u00e9decine, Paris, France"},{"name":"Assistance Publique H\u00f4pitaux de Paris, H\u00f4pital europ\u00e9en Georges Pompidou, Department of Genetics, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mercedes","family":"Robledo","sequence":"additional","affiliation":[{"name":"Hereditary Endocrine Cancer Group, Spanish National Cancer Research Centre (CNIO), Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronald","family":"de Krijger","sequence":"additional","affiliation":[{"name":"Department of Pathology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felix","family":"Beuschlein","sequence":"additional","affiliation":[{"name":"Endocrine Research Unit, Medizinische Klinik und Poliklinik IV, Klinikum der Universit\u00e4t M\u00fcnchen, M\u00fcnchen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael J.","family":"Atkinson","sequence":"additional","affiliation":[{"name":"Institute of Radiation Biology, Helmholtz Zentrum M\u00fcnchen, Neuherberg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalia S.","family":"Pellegata","sequence":"additional","affiliation":[{"name":"Institute of Pathology, Helmholtz Zentrum M\u00fcnchen, Neuherberg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7892","published-online":{"date-parts":[[2015,8,18]]},"reference":[{"key":"1","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/nrendo.2014.188","article-title":"Paraganglioma and phaeochromocytoma: from genetics to personalized medicine","volume":"11","author":"Gimenez-Roqueplo","year":"2015","journal-title":"Nat Rev Endocrinol"},{"key":"2","doi-asserted-by":"crossref","first-page":"6044","DOI":"10.1038\/ncomms7044","article-title":"Multi-omics analysis defines core genomic alterations in pheochromocytomas and paragangliomas","volume":"6","author":"Sibony","year":"2015","journal-title":"Nat Commun"},{"key":"3","doi-asserted-by":"crossref","first-page":"6140","DOI":"10.1038\/ncomms7140","article-title":"Whole-exome sequencing identifies somatic ATRX mutations in pheochromocytomas and paragangliomas","volume":"6","author":"Daber","year":"2015","journal-title":"Nat Commun"},{"key":"4","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1677\/erc.1.00838","article-title":"Distinct gene expression profiles in norepinephrine- and epinephrine-producing hereditary and sporadic pheochromocytomas: activation of hypoxia-driven angiogenic pathways in von Hippel-Lindau syndrome","volume":"11","author":"Elkahloun","year":"2004","journal-title":"Endocr Relat Cancer"},{"key":"5","doi-asserted-by":"crossref","first-page":"2382","DOI":"10.1210\/me.2010-0256","article-title":"Research resource: Transcriptional profiling reveals different pseudohypoxic signatures in SDHB and VHL-related pheochromocytomas","volume":"24","author":"de la Vega","year":"2010","journal-title":"Mol Endocrinol"},{"key":"6","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1210\/jc.2010-1946","article-title":"Clinical risk factors for malignancy and overall survival in patients with pheochromocytomas and sympathetic paragangliomas: primary tumor size and primary tumor location as prognostic indicators","volume":"96","author":"Jimenez","year":"2011","journal-title":"J Clin Endocrinol Metab"},{"key":"7","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1677\/erc.1.00829","article-title":"Malignant pheochromocytoma: current status and initiatives for future progress","volume":"11","author":"Neumann","year":"2004","journal-title":"Endocr Relat Cancer"},{"key":"8","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1007\/BF03348026","article-title":"The treatment of malignant pheochromocytoma with iodine-131 metaiodobenzylguanidine (131I-MIBG): a comprehensive review of 116 reported patients","volume":"20","author":"Price","year":"1997","journal-title":"J Endocrinol Inv"},{"key":"9","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1210\/jc.2008-1836","article-title":"Rationale and evidence for sunitinib in the treatment of malignant paraganglioma\/pheochromocytoma","volume":"94","author":"Know","year":"2009","journal-title":"J Clin Endocrinol Metab"},{"key":"10","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1055\/s-0029-1220687","article-title":"Novel and evolving therapies in the treatment of malignant phaeochromocytoma: experience with the mTOR inhibitor everolimus (RAD001)","volume":"41","author":"Grossman","year":"2009","journal-title":"Horm Metab Res"},{"key":"11","doi-asserted-by":"crossref","first-page":"6162","DOI":"10.1002\/cncr.27675","article-title":"Phase 2 study of everolimus monotherapy in patients with nonfunctioning neuroendocrine tumors or pheochromocytomas\/paragangliomas","volume":"118","author":"Bang","year":"2012","journal-title":"Cancer"},{"key":"12","first-page":"3048","article-title":"Recessive transmission of a multiple endocrine neoplasia syndrome in the rat","volume":"62","author":"Atkinson","year":"2002","journal-title":"Cancer Res"},{"key":"13","doi-asserted-by":"crossref","first-page":"2362","DOI":"10.1002\/ijc.24925","article-title":"Allelic loss of chromosomes 8 and 19 in MENX-associated rat pheochromocytoma","volume":"126","author":"Pellegata","year":"2010","journal-title":"Int J Cancer"},{"key":"14","doi-asserted-by":"crossref","first-page":"18493","DOI":"10.1073\/pnas.1003956107","article-title":"Pheochromocytoma in rats with multiple endocrine neoplasia (MENX) shares gene expression patterns with human pheochromocytoma","volume":"107","author":"Beckers","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"15","first-page":"175352","article-title":"Functional Imaging of Pheochromocytoma with 68Ga-DOTATOC and 11C-HED in a Genetically Defined Rat Model of Multiple Endocrine Neoplasia","author":"Pellegata","year":"2011","journal-title":"Int J Mol Imaging"},{"key":"16","doi-asserted-by":"crossref","first-page":"2111","DOI":"10.2967\/jnumed.113.119966","article-title":"Preclinical evaluation of 18F-LMI1195 forimaging of pheochromocytoma in the MENX tumor model","volume":"54","author":"Pellegata","year":"2013","journal-title":"J Nucl Med"},{"key":"17","doi-asserted-by":"crossref","first-page":"15558","DOI":"10.1073\/pnas.0603877103","article-title":"Germline mutations in p27Kip1 cause a multiple endocrine neoplasia syndrome in rats and man","volume":"103","author":"Atkinson","year":"2006","journal-title":"Proc Natl Acad Sci USA"},{"key":"18","doi-asserted-by":"crossref","first-page":"349","DOI":"10.2741\/1090","article-title":"Signal transduction and biological functions of bone morphogenetic proteins","volume":"9","author":"Mi","year":"2004","journal-title":"Front Biosci"},{"key":"19","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.gendis.2014.07.005","article-title":"Bone Morphogenetic Protein (BMP) signaling in development and human diseases","volume":"1","author":"Shen","year":"2014","journal-title":"Genes Dis"},{"key":"20","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1227\/01.NEU.0000363722.42097.C2","article-title":"Bone morphogenetic proteins and cancer: review of the literature","volume":"66","author":"Park","year":"2010","journal-title":"Neurosurgery"},{"key":"21","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.cytogfr.2005.04.002","article-title":"BMP signaling and early embryonic patterning","volume":"16","author":"Mishina","year":"2005","journal-title":"Cytokine Growth Factor Rev"},{"key":"22","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1038\/37284","article-title":"TGF-beta signalling from cell membrane to nucleus through SMAD proteins","volume":"390","author":"ten Dijke","year":"1997","journal-title":"Nature"},{"key":"23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1006\/dbio.2001.0388","article-title":"Intracellular BMP signaling regulation in vertebrates: pathway or network?","volume":"239","author":"Cho","year":"2001","journal-title":"Dev Biol"},{"key":"24","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1007\/S12094-009-0328-8","article-title":"Biology of BMP signalling and cancer","volume":"11","author":"Grande Pulido","year":"2009","journal-title":"Clin Transl Oncol"},{"key":"25","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1093\/annonc\/mdm453","article-title":"Bone morphogenetic protein 7 expression associates with bone metastasis in breast carcinomas","volume":"19","author":"Kallioniemi","year":"2008","journal-title":"Ann Oncol"},{"key":"26","doi-asserted-by":"crossref","first-page":"1722","DOI":"10.1016\/j.cellsig.2007.03.008","article-title":"Proinvasive activity of BMP-7 through SMAD4\/src-independent and ERK\/Rac JNK-dependent signaling pathways in colon cancer cells","volume":"19","author":"Gespach","year":"2007","journal-title":"Cell Signal"},{"key":"27","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1038\/sj.bjc.6606075","article-title":"Expression of BMP-7 in human gastric cancer and its clinical significance","volume":"104","author":"Natsugoe","year":"2011","journal-title":"Br J Cancer"},{"key":"28","doi-asserted-by":"crossref","first-page":"9326","DOI":"10.1038\/sj.onc.1208127","article-title":"BMP signals inhibit proliferation andtumor growth of androgen-insensitive prostate carcinoma cells","volume":"23","author":"Miyazono","year":"2004","journal-title":"Oncogene"},{"key":"29","doi-asserted-by":"crossref","first-page":"2424","DOI":"10.1073\/pnas.73.7.2424","article-title":"Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor","volume":"73","author":"Tischler","year":"1976","journal-title":"Proc Natl Acad Sci U S A"},{"key":"30","doi-asserted-by":"crossref","first-page":"E904","DOI":"10.1152\/ajpendo.90840.2008","article-title":"Enhancement of aldosterone-induced catecholamine production by bone morphogenetic protein-4 through activating Rho and SAPK\/JNK pathway in adrenomedullar cells","volume":"296","author":"Makino","year":"2009","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"31","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/S0092-8674(02)00971-6","article-title":"Integrins: bidirectional, allosteric signaling machines","volume":"110","author":"Hynes","year":"2002","journal-title":"Cell"},{"key":"32","doi-asserted-by":"crossref","first-page":"2861","DOI":"10.1091\/mbc.10.9.2861","article-title":"Stimulation of beta1-integrin function by epidermal growth factor and heregulin-beta has distinct requirements for erbB2 but a similar dependence on phosphoinositide 3-OH kinase","volume":"10","author":"Shimizu","year":"1999","journal-title":"Mol Biol Cell"},{"key":"33","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1002\/jcp.21568","article-title":"BMP-2 increases migration of human chondrosarcoma cells via PI3K\/Akt pathway","volume":"217","author":"Tang","year":"2008","journal-title":"J Cell Physiol"},{"key":"34","doi-asserted-by":"crossref","first-page":"2846","DOI":"10.1038\/onc.2013.259","article-title":"Self-reinforcing loop of amphiregulin and Y-box binding protein-1 contributes to poor outcomes in ovarian cancer","volume":"33","author":"Mills","year":"2014","journal-title":"Oncogene"},{"key":"35","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1021\/cb9002865","article-title":"structure-activity relationship study of dorsomorphin analogues identifies selective VEGF and BMP inhibitors","volume":"5","author":"Hong","year":"2010","journal-title":"ACS Chem Biol"},{"key":"36","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1210\/me.2012-1055","article-title":"Secretin receptor promotes the proliferation of endocrine tumor cells via the PI3K\/AKT pathway","volume":"26","author":"Pellegata","year":"2012","journal-title":"Mol Endocrinol"},{"key":"37","doi-asserted-by":"crossref","first-page":"1871","DOI":"10.1007\/s10620-013-2611-3","article-title":"BMP7 expression in esophageal squamous cell carcinoma and its potential role in modulating metastasis","volume":"58","author":"Gong","year":"2013","journal-title":"Dig Dis Sci"},{"key":"38","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1007\/s10585-007-9118-2","article-title":"TGF-beta and BMP7 interactions in tumour progression and bone metastasis","volume":"24","author":"van der Pluijm","year":"2007","journal-title":"Clin Exp Metastasis"},{"key":"39","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.1007\/s00253-011-3865-3","article-title":"BMP2 promotes migration and invasion of breast cancer cells via cytoskeletal reorganization and adhesion decrease: an AFM investigation","volume":"93","author":"Cai","year":"2012","journal-title":"Appl Microbiol Biotechnol"},{"key":"40","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1007\/s11010-011-1170-1","article-title":"Bone morphogenetic protein 4 (BMP4) is required for migration and invasion of breast cancer","volume":"363","author":"Gong","year":"2012","journal-title":"Mol Cell Biochem"},{"key":"41","first-page":"1016","article-title":"Molecular impact of bone morphogenetic protein 7, on lung cancer cells and its clinical significance","volume":"29","author":"Jiang","year":"2012","journal-title":"Int J Mol Med"},{"key":"42","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1158\/0008-5472.448.65.2","article-title":"Bone morphogenic proteins are overexpressed in malignant melanoma and promote cell invasion and migration","volume":"65","author":"Bosserhoff","year":"2005","journal-title":"Cancer Res"},{"key":"43","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/s13402-011-0058-0","article-title":"BMP-7 inhibits TGF-\u03b2-induced invasion of breast cancer cells through inhibition of integrin \u03b2(3) expression","volume":"35","author":"Ten Dijke","year":"2012","journal-title":"Cell Oncol"},{"key":"44","doi-asserted-by":"crossref","first-page":"4366","DOI":"10.1210\/jc.2004-2198","article-title":"AKT is highly phosphorylated in pheochromocytomas but not in benign adrenocortical tumors","volume":"90","author":"Allolio","year":"2005","journal-title":"J Clin Endocrinol Metab"},{"key":"45","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1038\/bjc.2012.313","article-title":"Resistance to the mTOR-inhibitor RAD001 elevates integrin alpha2- and beta1-triggered motility, migration and invasion of prostate cancer cells","volume":"107","author":"Blaheta","year":"2012","journal-title":"Br J Cancer"},{"key":"46","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1530\/JME-12-0028","article-title":"Combined blockade of signalling pathways shows marked anti-tumour potential in phaeochromocytoma cell lines","volume":"49","author":"Grossman","year":"2012","journal-title":"J Mol Endocrinol"},{"key":"47","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1124\/mol.54.5.815","article-title":"Studies on the mechanism of resistance to rapamycin in human cancer cells","volume":"54","author":"Houghton","year":"1998","journal-title":"Mol Pharmacol"},{"key":"48","doi-asserted-by":"crossref","first-page":"376","DOI":"10.5732\/cjc.012.10287","article-title":"Molecular mechanisms of tumor resistance to PI3K-mTOR-targeted therapy","volume":"32","author":"Yu","year":"2013","journal-title":"Chin J Cancer"},{"key":"49","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.1158\/1535-7163.MCT-08-0017","article-title":"Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase\/mammalian target of rapamycin inhibitor with potentantitumor activity","volume":"7","author":"Simonen","year":"2008","journal-title":"Mol Cancer Ther"},{"key":"50","doi-asserted-by":"crossref","first-page":"2437","DOI":"10.1038\/onc.2014.189","article-title":"Inhibition of BMP signaling suppresses metastasis in mammary cancer","volume":"34","author":"Moses","year":"2015","journal-title":"Oncogene"},{"key":"51","doi-asserted-by":"crossref","first-page":"e90748","DOI":"10.1371\/journal.pone.0090748","article-title":"DMH1, a small molecule inhibitor of BMP type i receptors, suppresses growth and invasion of lung cancer","volume":"9","author":"Huang","year":"2014","journal-title":"PLoS One"},{"key":"52","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1530\/EJE-14-1164","article-title":"Immunohistochemical expression of stem cell markers in pheochromocytomas\/paragangliomas is associated with SDHx mutations","volume":"173","author":"Gimenez-Roqueplo","year":"2015","journal-title":"Eur J Endocrinol"},{"key":"53","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1007\/s004410000290","article-title":"Pheochromocytoma cell lines from heterozygous neurofibromatosis knockout mice","volume":"302","author":"Tischler","year":"2000","journal-title":"Cell Tissue Res"},{"key":"54","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/s10585-009-9236-0","article-title":"Characterization of an animal model of aggressive metastatic pheochromocytoma linked to a specific gene signature","volume":"26","author":"Morris","year":"2009","journal-title":"Clin Exp Metastasis"},{"key":"55","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1002\/jgm.2653","article-title":"Poloxamer synperonic F108 improves cellular transduction with lentiviral vectors","volume":"14","author":"Anastasov","year":"2012","journal-title":"J Gene Med"},{"key":"56","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1186\/1476-4598-9-116","article-title":"Characterization of a naturally-occurring p27 mutation predisposing to multiple endocrine tumors","volume":"9","author":"Pellegata","year":"2010","journal-title":"Mol Cancer"},{"key":"57","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1530\/ERC-14-0472","article-title":"Somatostatin receptor 3 is a putative target for the medical treatment of gonadotroph adenomas of the pituitary","volume":"22","author":"Pellegata","year":"2014","journal-title":"Endocr Relat Cancer"},{"key":"58","article-title":"Targeting PI3K\/mTOR signaling displays potent antitumor efficacy against nonfunctioning pituitary adenomas","author":"Pellegata","year":"2015","journal-title":"Clinical Cancer Research"}],"container-title":["Oncotarget"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.4912","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,11]],"date-time":"2024-06-11T13:08:33Z","timestamp":1718111313000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.4912"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,8,18]]},"references-count":58,"journal-issue":{"issue":"36","published-print":{"date-parts":[[2015,11,17]]}},"alternative-id":["4912","26337467"],"URL":"https:\/\/doi.org\/10.18632\/oncotarget.4912","relation":{},"ISSN":["1949-2553"],"issn-type":[{"value":"1949-2553","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,8,18]]}}}