{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T14:46:22Z","timestamp":1791297982011,"version":"4.1.0"},"reference-count":30,"publisher":"Impact Journals, LLC","issue":"32","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncotarget"],"published-print":{"date-parts":[[2015,10,20]]},"DOI":"10.18632\/oncotarget.5106","type":"journal-article","created":{"date-parts":[[2015,10,24]],"date-time":"2015-10-24T23:08:04Z","timestamp":1445728084000},"page":"32955-32965","source":"Crossref","is-referenced-by-count":72,"title":["Deciphering the molecular basis of invasiveness in\n                    <i>Sdhb<\/i>\n                    -deficient cells"],"prefix":"10.18632","volume":"6","author":[{"given":"C\u00e9line","family":"Loriot","sequence":"first","affiliation":[{"name":"INSERM, UMR970, Paris Cardiovascular Research Centre, F-75015 Paris, France"},{"name":"Universit\u00e9 Paris Descartes, Sorbonne Paris Cit\u00e9, Facult\u00e9 de M\u00e9decine, F-75006 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e9lanie","family":"Domingues","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Descartes, Sorbonne Paris Cit\u00e9, Facult\u00e9 de M\u00e9decine, F-75006 Paris, France"},{"name":"INSERM, U1021, CNRS UMR3347, Institut Curie, F-91405 Orsay, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adeline","family":"Berger","sequence":"additional","affiliation":[{"name":"INSERM, U968, Institut de la vision, F-75012 Paris, France"},{"name":"Universit\u00e9 Pierre et Marie Curie Paris 06, F-75005 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e9lanie","family":"Menara","sequence":"additional","affiliation":[{"name":"INSERM, UMR970, Paris Cardiovascular Research Centre, F-75015 Paris, France"},{"name":"Universit\u00e9 Paris Descartes, Sorbonne Paris Cit\u00e9, Facult\u00e9 de M\u00e9decine, F-75006 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ma\u00ebva","family":"Ruel","sequence":"additional","affiliation":[{"name":"INSERM, UMR970, Paris Cardiovascular Research Centre, F-75015 Paris, France"},{"name":"Universit\u00e9 Paris Descartes, Sorbonne Paris Cit\u00e9, Facult\u00e9 de M\u00e9decine, F-75006 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aur\u00e9lie","family":"Morin","sequence":"additional","affiliation":[{"name":"INSERM, UMR970, Paris Cardiovascular Research Centre, F-75015 Paris, France"},{"name":"Universit\u00e9 Paris Descartes, Sorbonne Paris Cit\u00e9, Facult\u00e9 de M\u00e9decine, F-75006 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis-Jaime","family":"Castro-Vega","sequence":"additional","affiliation":[{"name":"INSERM, UMR970, Paris Cardiovascular Research Centre, F-75015 Paris, France"},{"name":"Universit\u00e9 Paris Descartes, Sorbonne Paris Cit\u00e9, Facult\u00e9 de M\u00e9decine, F-75006 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c9ric","family":"Letouz\u00e9","sequence":"additional","affiliation":[{"name":"Programme Cartes d'Identit\u00e9 des Tumeurs, Ligue Nationale Contre Le Cancer, F-75013 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cosimo","family":"Martinelli","sequence":"additional","affiliation":[{"name":"INSERM, UMR970, Paris Cardiovascular Research Centre, F-75015 Paris, France"},{"name":"Universit\u00e9 Paris Descartes, Sorbonne Paris Cit\u00e9, Facult\u00e9 de M\u00e9decine, F-75006 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexis-Pierre","family":"Bemelmans","sequence":"additional","affiliation":[{"name":"BM, Molecular Imaging Research Center (MIRCen), F-92265 Fontenay-aux-Roses, France"},{"name":"CNRS, CEA URA 2210, F-92265 Fontenay-aux-Roses, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lionel","family":"Larue","sequence":"additional","affiliation":[{"name":"INSERM, U1021, CNRS UMR3347, Institut Curie, F-91405 Orsay, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne-Paule","family":"Gimenez-Roqueplo","sequence":"additional","affiliation":[{"name":"INSERM, UMR970, Paris Cardiovascular Research Centre, F-75015 Paris, France"},{"name":"Universit\u00e9 Paris Descartes, Sorbonne Paris Cit\u00e9, Facult\u00e9 de M\u00e9decine, F-75006 Paris, France"},{"name":"Assistance Publique-H\u00f4pitaux de Paris, H\u00f4pital Europ\u00e9en Georges Pompidou, Service de G\u00e9n\u00e9tique, F-75015 Paris, France"},{"name":"Rare Adrenal Cancer Network-Cortico M\u00e9dullosurr\u00e9nale Tumeurs Endocrines, Institut National du Cancer, F-75014 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith","family":"Favier","sequence":"additional","affiliation":[{"name":"INSERM, UMR970, Paris Cardiovascular Research Centre, F-75015 Paris, France"},{"name":"Universit\u00e9 Paris Descartes, Sorbonne Paris Cit\u00e9, Facult\u00e9 de M\u00e9decine, F-75006 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7892","published-online":{"date-parts":[[2015,10,8]]},"reference":[{"key":"1","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1038\/nrc3648","article-title":"Pheochromocytoma and paraganglioma pathogenesis: learning from genetic heterogeneity","volume":"14","author":"Dahia","year":"2014","journal-title":"Nat Rev Cancer"},{"key":"2","article-title":"Whole-exome sequencing identifies MDH2 as a new familial paraganglioma gene","volume":"107","author":"Moran","year":"2015","journal-title":"Journal of the National Cancer Institute"},{"key":"3","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/nrendo.2014.188","article-title":"Paraganglioma and phaeochromocytoma: from genetics to personalized medicine","volume":"11","author":"Gimenez-Roqueplo","year":"2015","journal-title":"Nature reviews Endocrinology"},{"key":"4","doi-asserted-by":"crossref","first-page":"3822","DOI":"10.1210\/jc.2007-0709","article-title":"Succinate dehydrogenase B gene mutations predict survival in patients with malignant pheochromocytomas or paragangliomas","volume":"92","author":"Plouin","year":"2007","journal-title":"The Journal of clinical endocrinology and metabolism"},{"key":"5","doi-asserted-by":"crossref","first-page":"6044","DOI":"10.1038\/ncomms7044","article-title":"Multi-omics analysis defines core genomic alterations in pheochromocytomas and paragangliomas","volume":"6","author":"Zinzindohoue","year":"2015","journal-title":"Nature communications"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2015.172","article-title":"Rethinking pheochromocytomas and paragangliomas from a genomic perspective","author":"Favier","year":"2015","journal-title":"Oncogene"},{"key":"7","doi-asserted-by":"crossref","first-page":"E954","DOI":"10.1210\/jc.2011-3437","article-title":"Epithelial to mesenchymal transition is activated in metastatic pheochromocytomas and paragangliomas caused by SDHB gene mutations","volume":"97","author":"Favier","year":"2012","journal-title":"The Journal of clinical endocrinology and metabolism"},{"key":"8","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1172\/JCI0215518","article-title":"Evidence that fibroblasts derive from epithelium during tissue fibrosis","volume":"110","author":"Neilson","year":"2002","journal-title":"The Journal of clinical investigation"},{"key":"9","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1038\/nrc822","article-title":"Epithelial-mesenchymal transitions in tumour progression","volume":"2","author":"Thiery","year":"2002","journal-title":"Nat Rev Cancer"},{"key":"10","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1172\/JCI39104","article-title":"The basics of epithelial-mesenchymal transition","volume":"119","author":"Weinberg","year":"2009","journal-title":"The Journal of clinical investigation"},{"key":"11","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1038\/jid.2012.256","article-title":"Keratins mediate localization of hemidesmosomes and repress cell motility","volume":"133","author":"Magin","year":"2013","journal-title":"The Journal of investigative dermatology"},{"key":"12","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1083\/jcb.200603161","article-title":"New consensus nomenclature for mammalian keratins","volume":"174","author":"Wright","year":"2006","journal-title":"The Journal of cell biology"},{"key":"13","doi-asserted-by":"crossref","first-page":"1917","DOI":"10.1038\/bjc.2012.202","article-title":"Clinical relevance of circulating CK-19mRNA-positive tumour cells before front-line treatment in patients with metastatic breast cancer","volume":"106","author":"Georgoulias","year":"2012","journal-title":"British journal of cancer"},{"key":"14","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1177\/00220345990780061001","article-title":"Keratin 19 downregulation by oral squamous cell carcinoma lines increases invasive potential","volume":"78","author":"Shuler","year":"1999","journal-title":"Journal of dental research"},{"key":"15","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1186\/1471-2407-11-66","article-title":"Identification of epigenetically regulated genes that predict patient outcome in neuroblastoma","volume":"11","author":"Martinsson","year":"2011","journal-title":"BMC cancer"},{"key":"16","doi-asserted-by":"crossref","first-page":"134","DOI":"10.3892\/ijo.2012.1684","article-title":"Epithelial-mesenchymal transition-related gene expression as a new prognostic marker for neuroblastoma","volume":"42","author":"Komuro","year":"2013","journal-title":"International journal of oncology"},{"key":"17","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1038\/sj.bjc.6604180","article-title":"Functional epigenomics approach to identify methylated candidate tumour suppressor genes in renal cell carcinoma","volume":"98","author":"Maher","year":"2008","journal-title":"British journal of cancer"},{"key":"18","doi-asserted-by":"crossref","first-page":"4335","DOI":"10.1158\/1078-0432.CCR-12-3295","article-title":"Regulation of cell proliferation and migration by keratin-induced nuclear import of early growth response-1 in breast cancer cells","volume":"19","author":"Shin","year":"2013","journal-title":"Clin Cancer Res"},{"key":"19","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1016\/j.bbrc.2005.02.006","article-title":"Negative regulation of the expressions of cytokeratins 8 and 19 by SLUG repressor protein in human breast cells","volume":"329","author":"Chaudhuri","year":"2005","journal-title":"Biochemical and biophysical research communications"},{"key":"20","doi-asserted-by":"crossref","first-page":"e33284","DOI":"10.1371\/journal.pone.0033284","article-title":"Genome-wide DNA methylation indicates silencing of tumor suppressor genes in uterine leiomyoma","volume":"7","author":"Bulun","year":"2012","journal-title":"PloS one"},{"key":"21","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1089\/dna.2010.1108","article-title":"Functional and epigenetic characterization of the KRT19 gene in renal cell neoplasms","volume":"30","author":"Henrique","year":"2011","journal-title":"DNA and cell biology"},{"key":"22","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1101\/gad.191056.112","article-title":"Inhibition of alpha-KG-dependent histone and DNA demethylases by fumarate and succinate that are accumulated in mutations of FH and SDH tumor suppressors","volume":"26","author":"Guan","year":"2012","journal-title":"Genes & development"},{"key":"23","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1158\/2159-8290.CD-13-0092","article-title":"Succinate dehydrogenase mutation underlies global epigenomic divergence in gastrointestinal stromal tumor","volume":"3","author":"Wang","year":"2013","journal-title":"Cancer discovery"},{"key":"24","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/j.ccr.2013.04.018","article-title":"SDH mutations establish a hypermethylator phenotype in paraganglioma","volume":"23","author":"De Reynies","year":"2013","journal-title":"Cancer cell"},{"key":"25","doi-asserted-by":"crossref","first-page":"2237","DOI":"10.1002\/ijc.29080","article-title":"Oncometabolites-driven tumorigenesis: From genetics to targeted therapy","volume":"135","author":"Favier","year":"2014","journal-title":"International journal of cancer"},{"key":"26","first-page":"858","article-title":"Crossing the endothelial barrier during metastasis","volume":"13","author":"Ridley","year":"2013","journal-title":"Nature reviews"},{"key":"27","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1002\/(SICI)1097-0185(20000201)258:2<119::AID-AR1>3.0.CO;2-U","article-title":"Mechanisms involved in valvuloseptal endocardial cushion formation in early cardiogenesis: roles of transforming growth factor (TGF)-beta and bone morphogenetic protein (BMP)","volume":"258","author":"Nakamura","year":"2000","journal-title":"The Anatomical record"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2015.06.027","article-title":"From Nf1 to Sdhb knockout: Successes and failures in the quest for animal models of pheochromocytoma","author":"Favier","year":"2015","journal-title":"Mol Cell Endocrinol"},{"key":"29","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/j.ccr.2011.12.029","article-title":"Transient low doses of DNA-demethylating agents exert durable antitumor effects on hematological and epithelial tumor cells","volume":"21","author":"Feller-Kopman","year":"2012","journal-title":"Cancer cell"},{"key":"30","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1002\/jgm.788","article-title":"Retinal cell type expression specificity of HIV-1-derived gene transfer vectors upon subretinal injection in the adult rat: influence of pseudotyping and promoter","volume":"7","author":"Mallet","year":"2005","journal-title":"The journal of gene medicine"}],"container-title":["Oncotarget"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.5106","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,13]],"date-time":"2020-05-13T12:38:04Z","timestamp":1589373484000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.5106"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10,8]]},"references-count":30,"journal-issue":{"issue":"32","published-print":{"date-parts":[[2015,10,20]]}},"alternative-id":["5106","26460615"],"URL":"https:\/\/doi.org\/10.18632\/oncotarget.5106","relation":{},"ISSN":["1949-2553"],"issn-type":[{"value":"1949-2553","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,10,8]]}}}