{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:06:44Z","timestamp":1791925604238,"version":"4.3.4"},"reference-count":71,"publisher":"Impact Journals, LLC","issue":"31","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncotarget"],"published-print":{"date-parts":[[2015,10,13]]},"DOI":"10.18632\/oncotarget.5156","type":"journal-article","created":{"date-parts":[[2015,9,29]],"date-time":"2015-09-29T21:54:23Z","timestamp":1443563663000},"page":"32089-32103","source":"Crossref","is-referenced-by-count":36,"title":["Co-targeting of Bcl-2 and mTOR pathway triggers synergistic apoptosis in BH3 mimetics resistant acute lymphoblastic leukemia"],"prefix":"10.18632","volume":"6","author":[{"given":"Stefano","family":"Iacovelli","sequence":"first","affiliation":[{"name":"Department of Cellular Biotechnologies and Hematology, Sapienza University of Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Rosaria","family":"Ricciardi","sequence":"additional","affiliation":[{"name":"Hematology, \u201cSant'Andrea\u201d Hospital - Sapienza University of Rome, Department of Clinical and Molecular Medicine, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Allegretti","sequence":"additional","affiliation":[{"name":"Department of Cellular Biotechnologies and Hematology, Sapienza University of Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"Mirabilii","sequence":"additional","affiliation":[{"name":"Department of Cellular Biotechnologies and Hematology, Sapienza University of Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Licchetta","sequence":"additional","affiliation":[{"name":"Hematology, \u201cSant'Andrea\u201d Hospital - Sapienza University of Rome, Department of Clinical and Molecular Medicine, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Bergamo","sequence":"additional","affiliation":[{"name":"Department of Cellular Biotechnologies and Hematology, Sapienza University of Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cinzia","family":"Rinaldo","sequence":"additional","affiliation":[{"name":"Institute of Molecular Biology and Pathology, National Research Council, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann","family":"Zeuner","sequence":"additional","affiliation":[{"name":"Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanit\u00e0, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin","family":"Fo\u00e0","sequence":"additional","affiliation":[{"name":"Department of Cellular Biotechnologies and Hematology, Sapienza University of Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Milella","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Regina Elena National Cancer Institute, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James A.","family":"McCubrey","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Brody School of Medicine at East Carolina University, Greenville, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto M.","family":"Martelli","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Neuromotor Sciences, University of Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agostino","family":"Tafuri","sequence":"additional","affiliation":[{"name":"Hematology, \u201cSant'Andrea\u201d Hospital - Sapienza University of Rome, Department of Clinical and Molecular Medicine, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7892","published-online":{"date-parts":[[2015,9,16]]},"reference":[{"key":"1","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1002\/cncr.24862","article-title":"Adult acute lymphoblastic leukemia: concepts and strategies","volume":"116","author":"Kantarjian","year":"2010","journal-title":"Cancer"},{"key":"2","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1016\/S0140-6736(08)60457-2","article-title":"Acute lymphoblastic leukaemia","volume":"371","author":"Look","year":"2008","journal-title":"Lancet"},{"key":"3","doi-asserted-by":"crossref","first-page":"8548","DOI":"10.1073\/pnas.85.22.8548","article-title":"Evolution of B-cell malignancy: pre-B-cell leukemia resulting from MYC activation in a B-cell neoplasm with a rearranged BCL2 gene","volume":"85","author":"Croce","year":"1988","journal-title":"Proc Natl Acad Sci USA"},{"key":"4","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/0092-8674(89)90174-8","article-title":"Bcl-2-immunoglobulin transgenic mice demonstrate extended B cell survival and follicular lymphoproliferation","volume":"57","author":"Korsmeyer","year":"1989","journal-title":"Cell"},{"key":"5","doi-asserted-by":"crossref","first-page":"1817","DOI":"10.1038\/sj.leu.2401168","article-title":"Expression of Bcl-2 family of proteins in fresh myeloma cells","volume":"12","author":"Mitsuya","year":"1998","journal-title":"Leukemia"},{"key":"6","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.ccr.2004.07.011","article-title":"Antiapoptotic BCL-2 is required for maintenance of a model leukemia","volume":"6","author":"Korsmeyer","year":"2004","journal-title":"Cancer Cell"},{"key":"7","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1182\/blood.V89.2.630","article-title":"Mcl-1, a Bcl-2 family member, delays the death of hematopoietic cells under a variety of apoptosis-inducing conditions","volume":"89","author":"Craig","year":"1997","journal-title":"Blood"},{"key":"8","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.ccr.2006.03.027","article-title":"Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members","volume":"9","author":"Letai","year":"2006","journal-title":"Cancer Cell"},{"key":"9","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1182\/blood.V81.4.1025.1025","article-title":"Prolonged survival of B-lineage acute lymphoblastic leukemia cells is accompanied by overexpression of bcl-2 protein","volume":"81","author":"Pui","year":"1993","journal-title":"Blood"},{"key":"10","doi-asserted-by":"crossref","first-page":"1606","DOI":"10.1038\/sj.leu.2401866","article-title":"Relapse in childhood acute lymphoblastic leukemia is associated with a decrease of the Bax\/Bcl-2 ratio and loss of spontaneous caspase-3 processing","volume":"14","author":"Daniel","year":"2000","journal-title":"Leukemia"},{"key":"11","first-page":"32","article-title":"Prognostic role of Bcl-xL and p53 in childhood acute lymphoblastic leukemia (ALL)","volume":"4","author":"Crisci","year":"2005","journal-title":"Cancer Biol Ther"},{"key":"12","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1182\/blood.V87.3.1140.bloodjournal8731140","article-title":"Clinical relevance of Bcl-2 overexpression in childhood acute lymphoblastic leukemia","volume":"87","author":"Campana","year":"1996","journal-title":"Blood"},{"key":"13","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1038\/sj.leu.2401529","article-title":"Bcl-2 family members in childhood acute lymphoblastic leukemia: relationships with features at presentation,anddrug response and long-term clinical outcome","volume":"13","author":"Kamps","year":"1999","journal-title":"Leukemia"},{"key":"14","doi-asserted-by":"crossref","first-page":"2300","DOI":"10.1182\/blood-2007-06-098012","article-title":"BCL-2 dependence and ABT-737 sensitivity in acute lymphoblastic leukemia","volume":"111","author":"Letai","year":"2008","journal-title":"Blood"},{"key":"15","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1038\/leu.2010.322","article-title":"The novel antisense Bcl-2 inhibitor SPC2996 causes rapid leukemic cell clearance and immune activation in chronic lymphocytic leukemia","volume":"25","author":"Wissenbach","year":"2011","journal-title":"Leukemia"},{"key":"16","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.1158\/1535-7163.MCT-13-0058","article-title":"BH3 mimetics: status of the field and new developments","volume":"12","author":"Billard","year":"2013","journal-title":"Mol Cancer Ther"},{"key":"17","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1038\/nature03579","article-title":"An inhibitor of Bcl-2 family proteins induces regression of solid tumours","volume":"435","author":"Korsmeyer","year":"2005","journal-title":"Nature"},{"key":"18","first-page":"3127","article-title":"Targeting the B-cell lymphoma\/leukemia 2 family in cancer","volume":"130","author":"Letai","year":"2012","journal-title":"J Clin Oncol"},{"key":"19","doi-asserted-by":"crossref","first-page":"S149","DOI":"10.1038\/onc.2009.52","article-title":"Mimicking the BH3 domain to kill cancer cells","volume":"27","author":"Letai","year":"2008","journal-title":"Oncogene"},{"key":"20","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1038\/sj.leu.2404719","article-title":"ABT-737, an inhibitor of Bcl-2 family proteins, is a potent inducer of apoptosis in multiple myeloma cells","volume":"21","author":"Kumar","year":"2007","journal-title":"Leukemia"},{"key":"21","first-page":"1","article-title":"activity of BCL-2 family inhibitors ABT-199 and ABT-737 combined with 5-azacytidine in myeloid malignancies","volume":"17","author":"Tibes","year":"2014","journal-title":"Leuk Lymphoma"},{"key":"22","doi-asserted-by":"crossref","first-page":"2057","DOI":"10.1182\/blood-2007-03-080325","article-title":"Activity of vincristine, L-ASP, and dexamethasone against acute lymphoblastic leukemia is enhanced by the BH3-mimetic ABT-737and","volume":"110","author":"Reynolds","year":"2007","journal-title":"Blood"},{"key":"23","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1124\/mol.109.060780","article-title":"The Bcl-2 homology domain 3 mimetic ABT-737 targets the apoptotic machinery in acute lymphoblastic leukemia resulting in synergisticandinteractions with established drugs","volume":"77","author":"Lock","year":"2010","journal-title":"Mol Pharmacol"},{"key":"24","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/j.ccr.2006.08.027","article-title":"The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak\/Bax if Mcl-1 is neutralized","volume":"10","author":"Huang","year":"2006","journal-title":"Cancer Cell"},{"key":"25","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.ccr.2006.10.006","article-title":"Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia","volume":"10","author":"Ruvolo","year":"2006","journal-title":"Cancer Cell"},{"key":"26","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1172\/JCI28281","article-title":"Chronic lymphocytic leukemia requires BCL2 to sequester prodeath BIM, explaining sensitivity to BCL2 antagonist ABT-737","volume":"117","author":"Letai","year":"2007","journal-title":"J Clin Invest"},{"key":"27","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1158\/0008-5472.CAN-06-2203","article-title":"Influence of Bcl-2 family members on the cellular response of small-cell lung cancer cell lines to ABT-737","volume":"67","author":"Tse","year":"2007","journal-title":"Cancer Res"},{"key":"28","doi-asserted-by":"crossref","first-page":"3069","DOI":"10.1158\/0008-5472.CAN-11-4106","article-title":"Mcl-1 phosphorylation defines ABT-737 resistance that can be overcome by increased NOXA expression in leukemic B-cells","volume":"72","author":"Almasan","year":"2012","journal-title":"Cancer Res"},{"key":"29","doi-asserted-by":"crossref","first-page":"3304","DOI":"10.1182\/blood-2009-07-233304","article-title":"Acquired resistance to ABT-737 in lymphoma cells that up-regulate MCL-1 and BFL-1","volume":"115","author":"Letai","year":"2010","journal-title":"Blood"},{"key":"30","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1158\/0008-5472.CAN-06-3964","article-title":"Mcl-1 down-regulation potentiates ABT-737 lethality by cooperatively inducing Bak activation and Bax translocation","volume":"67","author":"Grant","year":"2007","journal-title":"Cancer Res"},{"key":"31","doi-asserted-by":"crossref","first-page":"35287","DOI":"10.1074\/jbc.M113.495986","article-title":"Pan-mammalian target of rapamycin (mTOR) inhibitor AZD8055 primes rhabdomyosarcoma cells for ABT-737-induced apoptosis by down-regulating Mcl-1 protein","volume":"288","author":"Fulda","year":"2013","journal-title":"J Biol Chem"},{"key":"32","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1038\/sj.leu.2404691","article-title":"High-resolution genomic profiling of childhood ALL reveals novel recurrent genetic lesions affecting pathways involved in lymphocyte differentiation and cell cycle progression","volume":"21","author":"Hoogerbrugge","year":"2007","journal-title":"Leukemia"},{"key":"33","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1038\/nature10725","article-title":"The genetic basis of early T-cell precursor acute lymphoblastic leukaemia","volume":"481","author":"Wei","year":"2012","journal-title":"Nature"},{"key":"34","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1074\/mcp.M112.017483","article-title":"Phosphoproteomic analysis of leukemia cells under basal and drug-treated conditions identifies markers of kinase pathway activation and mechanisms of resistance","volume":"11","author":"Cutillas","year":"2012","journal-title":"Mol Cell Proteomics"},{"key":"35","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1038\/leu.2009.223","article-title":"Targeted therapy in T-cell malignancies: dysregulation of the cellular signaling pathways","volume":"24","author":"Zhao","year":"2010","journal-title":"Leukemia"},{"key":"36","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1038\/leu.2008.26","article-title":"Contributions of the Raf\/MEK\/ERK, PI3K\/PTEN\/Akt\/mTOR and Jak\/STAT pathways to leukemia","volume":"22","author":"Martelli","year":"2008","journal-title":"Leukemia"},{"key":"37","doi-asserted-by":"crossref","first-page":"811","DOI":"10.18632\/oncotarget.579","article-title":"Harnessing the PIK\/Akt\/mTOR pathway in T-cell acute lymphoblastic leukemia: eliminating activity by targeting at different levels","volume":"3","author":"Martelli","year":"2012","journal-title":"Oncotarget"},{"key":"38","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/S0092-8674(02)00833-4","article-title":"Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action","volume":"110","author":"Yonezawa","year":"2002","journal-title":"Cell"},{"key":"39","doi-asserted-by":"crossref","first-page":"40406","DOI":"10.1074\/jbc.M508361200","article-title":"mTOR. RICTOR is the Ser473 kinase for Akt\/protein kinase B in 3T3-L1 adipocytes","volume":"280","author":"Mueckler","year":"2005","journal-title":"J Biol Chem"},{"key":"40","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1126\/science.1106148","article-title":"Phosphorylation and regulation of Akt\/PKB by the rictor-mTOR complex","volume":"307","author":"Sabatini","year":"2005","journal-title":"Science"},{"key":"41","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1016\/j.bbamcr.2010.04.005","article-title":"The emerging role of the phosphatidylinositol 3-kinase\/Akt\/mammalian target of rapamycin signaling network in normal myelopoiesis and leukemogenesis","volume":"1803","author":"McCubrey","year":"2010","journal-title":"Biochim Biophys Acta"},{"key":"42","doi-asserted-by":"crossref","first-page":"2981","DOI":"10.1016\/j.febslet.2010.05.061","article-title":"Mcl-1: the molecular regulation of protein function","volume":"584","author":"Edwards","year":"2010","journal-title":"FEBS Lett"},{"key":"43","doi-asserted-by":"crossref","first-page":"4006","DOI":"10.1128\/MCB.00620-06","article-title":"Degradation of Mcl-1 by beta-TrCP mediates glycogen synthase kinase 3-induced tumor suppression and chemosensitization","volume":"27","author":"Li","year":"2007","journal-title":"Mol Cell Biol"},{"key":"44","doi-asserted-by":"crossref","first-page":"2881","DOI":"10.18632\/oncotarget.2037","article-title":"GSK-3 as potential target for therapeutic intervention in cancer","volume":"5","author":"Rakus","year":"2014","journal-title":"Oncotarget"},{"key":"45","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1016\/j.molcel.2006.02.009","article-title":"Glycogen synthase kinase-3 regulates mitochondrial outer membrane permeabilization and apoptosis by destabilization of MCL-1","volume":"21","author":"Green","year":"2006","journal-title":"Mol Cell"},{"key":"46","doi-asserted-by":"crossref","first-page":"3509","DOI":"10.1182\/blood-2006-06-030833","article-title":"Rapamycin derivatives reduce mTORC2 signaling and inhibit AKT activation in AML","volume":"109","author":"Konopleva","year":"2007","journal-title":"Blood"},{"key":"47","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1038\/sj.leu.2404471","article-title":"Antiproliferative activity of RAD001 (everolimus) as a single agent and combined with other agents in mantle cell lymphoma","volume":"21","author":"Koeffler","year":"2007","journal-title":"Leukemia"},{"key":"48","doi-asserted-by":"crossref","first-page":"2159","DOI":"10.1038\/leu.2008.243","article-title":"Blockade of mTOR signaling potentiates the ability of histone deacetylase inhibitor to induce growth arrest and differentiation of acute myelogenous leukemia cells","volume":"22","author":"Yokoyama","year":"2008","journal-title":"Leukemia"},{"key":"49","doi-asserted-by":"crossref","first-page":"1686","DOI":"10.1038\/leu.2010.170","article-title":"Perspectives on inhibiting mTOR as a future treatment strategy for hematological malignancies","volume":"24","author":"Bouscary","year":"2010","journal-title":"Leukemia"},{"key":"50","doi-asserted-by":"crossref","first-page":"e80070","DOI":"10.1371\/journal.pone.0080070","article-title":"Differential Effects of Selective Inhibitors Targeting the PI3K\/AKT\/mTOR Pathway in Acute Lymphoblastic Leukemia","volume":"8","author":"Ottmann","year":"2013","journal-title":"PLoS One"},{"key":"51","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1182\/blood-2005-05-1935","article-title":"The mTOR inhibitor CCI-779 induces apoptosis and inhibits growth in preclinical models of primary adult human ALL","volume":"107","author":"Grupp","year":"2006","journal-title":"Blood"},{"key":"52","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1038\/leu.2012.276","article-title":"Efficacy of the investigational mTOR kinase inhibitor MLN0128\/INK128 in models of B-cell acute lymphoblastic leukemia","volume":"27","author":"Liu","year":"2013","journal-title":"Leukemia"},{"key":"53","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.18632\/oncotarget.802","article-title":"Advances in targeting signal transduction pathways","volume":"3","author":"Candido","year":"2012","journal-title":"Oncotarget"},{"key":"54","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1186\/1471-2407-10-377","article-title":"Expression profile and specific network features of the apoptotic machinery explain relapse of acute myeloid leukemia after chemotherapy","volume":"10","author":"Milone","year":"2010","journal-title":"BMC Cancer"},{"key":"55","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1056\/NEJMoa033513","article-title":"Gene-expression patterns in drug-resistant acute lymphoblastic leukemia cells and response to treatment","volume":"351","author":"Evans","year":"2004","journal-title":"N Engl J Med"},{"key":"56","doi-asserted-by":"crossref","first-page":"3972","DOI":"10.1038\/sj.onc.1210166","article-title":"\u2018Seed\u2019 analysis of off-target siRNAs reveals an essential role of Mcl-1 in resistance to the small-molecule Bcl-2\/Bcl-xL inhibitor ABT-737","volume":"26","author":"Shen","year":"2007","journal-title":"Oncogene"},{"key":"57","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1093\/jnci\/djn076","article-title":"Mechanism of synergy of N-(4-hydroxyphenyl)retinamide and ABT-737 in acute lymphoblastic leukemia cell lines: Mcl-1 inactivation","volume":"100","author":"Reynolds","year":"2008","journal-title":"J Natl Cancer Inst"},{"key":"58","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1177\/1535370214538745","article-title":"Caspase-dependent Mcl-1 cleavage and effect of Mcl-1 phosphorylation in ABT-737-induced apoptosis in human acute lymphoblastic leukemia cell lines","volume":"239","author":"Kang","year":"2014","journal-title":"Exp Bio Med (Maywood)"},{"key":"59","doi-asserted-by":"crossref","first-page":"371","DOI":"10.18632\/oncotarget.477","article-title":"Two hits are better than one: targeting both phosphatidylinositol 3-kinase and mammalian target of rapamycin as a therapeutic strategy for acute leukemia treatment","volume":"3","author":"McCubrey","year":"2012","journal-title":"Oncotarget"},{"key":"60","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1158\/0008-5472.CAN-12-1365","article-title":"Dual inhibition of Bcl-2 and Bcl-xL strikingly enhances PI3K inhibition-induced apoptosis in human myeloid leukemia cells through a GSK3- and Bim-dependent mechanism","volume":"73","author":"Grant","year":"2013","journal-title":"Cancer Res"},{"key":"61","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1007\/s00109-013-1076-3","article-title":"PI3K inhibitor GDC-0941 enhances apoptotic effects of BH-3 mimetic ABT-737 in AML cells in the hypoxic bone marrow microenvironment","volume":"91","author":"Konopleva","year":"2013","journal-title":"J Mol Med (Berl)"},{"key":"62","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1158\/1541-7786.MCR-11-0394","article-title":"Phosphoinositide-3-kinase\/AKT\/mTORC1\/2 signaling determines sensitivity of Burkitt's Lymphoma cells to BH3-mimetics","volume":"10","author":"Inman","year":"2012","journal-title":"Mol Cancer Res"},{"key":"63","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.canlet.2014.03.001","article-title":"PI3K\/mTOR dual inhibitor NVP-BEZ235 decreases Mcl-1 expression and sensitizes ovarian carcinoma cells to Bcl-xL-targeting strategies, provided that Bim expression is induced","volume":"348","author":"Poulain","year":"2014","journal-title":"Cancer Lett"},{"key":"64","doi-asserted-by":"crossref","first-page":"2846","DOI":"10.1158\/0008-5472.CAN-13-3460","article-title":"Rapamycin rescues ABT-737 efficacy in small cell lung cancer","volume":"74","author":"Hann","year":"2014","journal-title":"Cancer Res"},{"key":"65","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1038\/leu.2008.79","article-title":"The novel Akt inhibitor, perifosine, induces caspase dependent apoptosis and downregulates P-glycoprotein expression in multidrug-resistant human T-acute leukemia cells by a JNK-dependent mechanism","volume":"22","author":"Martelli","year":"2008","journal-title":"Leukemia"},{"key":"66","doi-asserted-by":"crossref","first-page":"2922","DOI":"10.1101\/gad.1156903","article-title":"DNA damage response and MCL-1 destruction initiate apoptosis in adenovirus-infected cells","volume":"17","author":"White","year":"2003","journal-title":"Genes Dev"},{"key":"67","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1101\/gad.1093903","article-title":"Elimination of Mcl-1 is required for the initiation of apoptosis following ultraviolet irradiation","volume":"17","author":"Wang","year":"2003","journal-title":"Genes Dev"},{"key":"68","doi-asserted-by":"crossref","first-page":"5807","DOI":"10.1182\/blood-2011-12-400929","article-title":"Bcl-2, Bcl-x(L), and Bcl-w are not equivalent targets of ABT-737 and navitoclax (ABT-263) in lymphoid and leukemic cells","volume":"119","author":"Vandenberg","year":"2012","journal-title":"Blood"},{"key":"69","first-page":"826","article-title":"Kinetic rationale for cytokine-induced recruitment of myeloblastic leukemia followed by cycle-specific chemotherapy","volume":"4","author":"Andreef","year":"1990","journal-title":"Leukemia"},{"key":"70","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1038\/sj.leu.2403859","article-title":"Quantitative single cell determination of ERK phosphorylation and regulation in relapsed and refractory primary acute myeloid leukemia","volume":"19","author":"Andreeff","year":"2005","journal-title":"Leukemia"},{"key":"71","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1002\/cyto.990130802","article-title":"Features of apoptotic cells measured by flow cytometry","volume":"13","author":"Traganos","year":"1992","journal-title":"Cytometry"}],"container-title":["Oncotarget"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.5156","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,9]],"date-time":"2020-09-09T00:21:38Z","timestamp":1599610898000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.5156"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9,16]]},"references-count":71,"journal-issue":{"issue":"31","published-print":{"date-parts":[[2015,10,13]]}},"alternative-id":["5156","26392332"],"URL":"https:\/\/doi.org\/10.18632\/oncotarget.5156","relation":{},"ISSN":["1949-2553"],"issn-type":[{"value":"1949-2553","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,9,16]]}}}