{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T03:37:19Z","timestamp":1784605039056,"version":"3.55.0"},"reference-count":53,"publisher":"Impact Journals, LLC","issue":"29","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncotarget"],"published-print":{"date-parts":[[2015,9,29]]},"DOI":"10.18632\/oncotarget.5614","type":"journal-article","created":{"date-parts":[[2015,9,29]],"date-time":"2015-09-29T17:43:03Z","timestamp":1443548583000},"page":"26690-26701","source":"Crossref","is-referenced-by-count":37,"title":["To unite or divide: mitochondrial dynamics in the murine outer retina that preceded age related photoreceptor loss"],"prefix":"10.18632","volume":"6","author":[{"given":"Jaimie Hoh","family":"Kam","sequence":"first","affiliation":[{"name":"Institute of Ophthalmology, University College London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glen","family":"Jeffery","sequence":"additional","affiliation":[{"name":"Institute of Ophthalmology, University College London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7892","published-online":{"date-parts":[[2015,9,10]]},"reference":[{"key":"1","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1111\/j.1532-5415.1972.tb00787.x","article-title":"The biologic clock: the mitochondria?","volume":"20","author":"Harman","year":"1972","journal-title":"Journal of the American Geriatrics Society"},{"key":"2","first-page":"642","article-title":"Mitochondrial DNA mutations as an important contributor to ageing and degenerative diseases","volume":"1","author":"Tanaka","year":"1989","journal-title":"Lancet"},{"key":"3","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.cell.2005.02.001","article-title":"Mitochondria, oxidants, and aging","volume":"120","author":"Finkel","year":"2005","journal-title":"Cell"},{"key":"4","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1016\/j.cell.2013.05.039","article-title":"The hallmarks of aging","volume":"153","author":"Kroemer","year":"2013","journal-title":"Cell"},{"key":"5","volume-title":"The Eye","author":"Graymore","year":"1969"},{"key":"6","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/j.preteyeres.2009.06.001","article-title":"Para-inflammation in the aging retina","volume":"28","author":"Forrester","year":"2009","journal-title":"Progress in retinal and eye research"},{"key":"7","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1017\/S0952523807070204","article-title":"The ageing photoreceptor","volume":"24","author":"Jeffery","year":"2007","journal-title":"Visual neuroscience"},{"key":"8","doi-asserted-by":"crossref","first-page":"2584","DOI":"10.1016\/j.neurobiolaging.2014.05.012","article-title":"Death by color: differential cone loss in the aging mouse retina","volume":"35","author":"Jeffery","year":"2014","journal-title":"Neurobiology of aging"},{"key":"9","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1159\/000316480","article-title":"The importance of mitochondria in age-related and inherited eye disorders","volume":"44","author":"Boulton","year":"2010","journal-title":"Ophthalmic research"},{"key":"10","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1038\/eye.1987.47","article-title":"The ageing retina: physiology or pathology","volume":"1","author":"Marshall","year":"1987","journal-title":"Eye"},{"key":"11","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.preteyeres.2009.11.003","article-title":"The pivotal role of the complement system in aging and age-related macular degeneration: hypothesis re-visited","volume":"29","author":"Bok","year":"2010","journal-title":"Progress in retinal and eye research"},{"key":"12","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1038\/nrm3013","article-title":"Mitochondrial fusion and fission in cell life and death","volume":"11","author":"Westermann","year":"2010","journal-title":"Nature reviews Molecular cell biology"},{"key":"13","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1126\/science.1219855","article-title":"Mitochondrial fission, fusion, and stress","volume":"337","author":"van der Bliek","year":"2012","journal-title":"Science"},{"key":"14","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/j.mad.2005.03.002","article-title":"Morpho-dynamic changes of mitochondria during ageing of human endothelial cells","volume":"126","author":"Bereiter-Hahn","year":"2005","journal-title":"Mechanisms of ageing and development"},{"key":"15","doi-asserted-by":"crossref","first-page":"2533","DOI":"10.1242\/jcs.070490","article-title":"New insights into the role of mitochondria in aging: mitochondrial dynamics and more","volume":"123","author":"Leeuwenburgh","year":"2010","journal-title":"Journal of cell science"},{"key":"16","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.3109\/02713683.2011.607536","article-title":"Mitochondrial dysfunction in retinal diseases","volume":"36","author":"Mitra","year":"2011","journal-title":"Current eye research"},{"key":"17","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1111\/j.1474-9726.2011.00690.x","article-title":"Increase in mitochondrial DNA mutations impairs retinal function and renders the retina vulnerable to injury","volume":"10","author":"Crowston","year":"2011","journal-title":"Aging cell"},{"key":"18","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1016\/j.preteyeres.2008.09.001","article-title":"Mitochondrial DNA damage and its potential role in retinal degeneration","volume":"27","author":"Boulton","year":"2008","journal-title":"Progress in retinal and eye research"},{"key":"19","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.mam.2012.03.009","article-title":"Consequences of oxidative stress in age-related macular degeneration","volume":"33","author":"Boulton","year":"2012","journal-title":"Molecular aspects of medicine"},{"key":"20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1432-1033.1987.tb13572.x","article-title":"Cytochrome-c oxidase. Subunit structure and proton pumping","volume":"169","author":"Wilson","year":"1987","journal-title":"European journal of biochemistry \/ FEBS"},{"key":"21","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.bbrc.2008.01.067","article-title":"Evidence for a pro-apoptotic phenotype in skeletal muscle of hypertensive rats","volume":"368","author":"Rush","year":"2008","journal-title":"Biochem Biophys Res Commun"},{"key":"22","doi-asserted-by":"crossref","first-page":"2840","DOI":"10.1038\/sj.onc.1210096","article-title":"Chemotherapy resistance of mouse WAP-SVT\/t breast cancer cells is mediated by osteopontin, inhibiting apoptosis downstream of caspase-3","volume":"26","author":"Graessmann","year":"2007","journal-title":"Oncogene"},{"key":"23","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1038\/337620a0","article-title":"Mitochondrial heat-shock protein hsp60 is essential for assembly of proteins imported into yeast mitochondria","volume":"337","author":"Horwich","year":"1989","journal-title":"Nature"},{"key":"24","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1111\/j.1582-4934.2005.tb00336.x","article-title":"HSP60, Bax, apoptosis and the heart","volume":"9","author":"Knowlton","year":"2005","journal-title":"Journal of cellular and molecular medicine"},{"key":"25","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1002\/jemt.1070270303","article-title":"Dynamics of mitochondria in living cells: shape changes, dislocations, fusion, and fission of mitochondria","volume":"27","author":"Voth","year":"1994","journal-title":"Microscopy research and technique"},{"key":"26","first-page":"210934","article-title":"New insights into the role of mitochondrial dynamics and autophagy during oxidative stress and aging in the heart","volume":"2014","author":"Sadoshima","year":"2014","journal-title":"Oxidative medicine and cellular longevity"},{"key":"27","doi-asserted-by":"crossref","first-page":"R169","DOI":"10.1093\/hmg\/ddp326","article-title":"Mitochondrial dynamics--fusion, fission, movement, and mitophagy--in neurodegenerative diseases","volume":"18","author":"Chan","year":"2009","journal-title":"Human molecular genetics"},{"key":"28","first-page":"2035","article-title":"Ultrastructural changes in Bruch\u2019s membrane of apolipoprotein E-deficient mice","volume":"41","author":"Grossniklaus","year":"2000","journal-title":"Investigative ophthalmology & visual science"},{"key":"29","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.exer.2014.02.023","article-title":"Recharging mitochondrial batteries in old eyes. Near infra-red increases ATP","volume":"122","author":"Jeffery","year":"2014","journal-title":"Experimental eye research"},{"key":"30","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.brainres.2007.10.083","article-title":"The locations of mitochondria in mammalian photoreceptors: relation to retinal vasculature","volume":"1189","author":"Provis","year":"2008","journal-title":"Brain research"},{"key":"31","doi-asserted-by":"crossref","first-page":"292","DOI":"10.3109\/02713683.2012.756526","article-title":"Quantitative retinal and choroidal blood flow during light, dark adaptation and flicker light stimulation in rats using fluorescent microspheres","volume":"38","author":"Duong","year":"2013","journal-title":"Current eye research"},{"key":"32","doi-asserted-by":"crossref","first-page":"2236","DOI":"10.1056\/NEJMra1215233","article-title":"Mitochondrial dynamics--mitochondrial fission and fusion in human diseases","volume":"369","author":"Archer","year":"2013","journal-title":"The New England journal of medicine"},{"key":"33","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1126\/science.1079368","article-title":"Mitochondrial biogenesis in mammals: the role of endogenous nitric oxide","volume":"299","author":"Carruba","year":"2003","journal-title":"Science"},{"key":"34","doi-asserted-by":"crossref","first-page":"16507","DOI":"10.1073\/pnas.0405432101","article-title":"Mitochondrial biogenesis by NO yields functionally active mitochondria in mammals","volume":"101","author":"Moncada","year":"2004","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"35","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.prostaglandins.2004.01.005","article-title":"Can endogenous gaseous messengers control mitochondrial biogenesis in mammalian cells?","volume":"73","author":"Carruba","year":"2004","journal-title":"Prostaglandins & other lipid mediators"},{"key":"36","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bcp.2003.10.015","article-title":"Mitochondrial biogenesis as a cellular signaling framework","volume":"67","author":"Carruba","year":"2004","journal-title":"Biochemical pharmacology"},{"key":"37","doi-asserted-by":"crossref","first-page":"2869","DOI":"10.1016\/j.neurobiolaging.2015.06.010","article-title":"Mitochondrial decline precedes phenotype development in the complement factor H mouse model of retinal degeneration but can be corrected by near infrared light","volume":"36","author":"Jeffery","year":"2015","journal-title":"Neurobiology of aging"},{"key":"38","doi-asserted-by":"crossref","first-page":"412","DOI":"10.2353\/ajpath.2009.080927","article-title":"Complement factor h is critical in the maintenance of retinal perfusion","volume":"175","author":"Jeffery","year":"2009","journal-title":"The American journal of pathology"},{"key":"39","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1146\/annurev.bi.59.070190.003033","article-title":"Structure and function of cytochrome c oxidase","volume":"59","author":"Capaldi","year":"1990","journal-title":"Annual review of biochemistry"},{"key":"40","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1016\/j.ceb.2003.10.015","article-title":"Mitochondrial fission in apoptosis, neurodegeneration and aging","volume":"15","author":"Lipton","year":"2003","journal-title":"Current opinion in cell biology"},{"key":"41","doi-asserted-by":"crossref","first-page":"6306","DOI":"10.3390\/ijms14036306","article-title":"Mitochondria and reactive oxygen species: physiology and pathophysiology","volume":"14","author":"Jaimes","year":"2013","journal-title":"International journal of molecular sciences"},{"key":"42","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1042\/BJ20141462","article-title":"Alteration of structure and function of ATP synthase and cytochrome c oxidase by lack of Fo-a and Cox3 subunits caused by mitochondrial DNA 9205delTA mutation","volume":"466","author":"Houstek","year":"2015","journal-title":"The Biochemical journal"},{"key":"43","doi-asserted-by":"crossref","first-page":"R812","DOI":"10.1152\/ajpregu.90708.2008","article-title":"Aging augments mitochondrial susceptibility to heat stress","volume":"296","author":"Kregel","year":"2009","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"44","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1152\/jappl.2000.89.2.749","article-title":"Aging reduces adaptive capacity and stress protein expression in the liver after heat stress","volume":"89","author":"Kregel","year":"2000","journal-title":"Journal of applied physiology"},{"key":"45","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/1477-5956-2-8","article-title":"Expressional patterns of chaperones in ten human tumor cell lines","volume":"2","author":"Lubec","year":"2004","journal-title":"Proteome science"},{"key":"46","doi-asserted-by":"crossref","first-page":"2571","DOI":"10.1161\/01.STR.0000189632.98944.ab","article-title":"Association of serum-soluble heat shock protein 60 with carotid atherosclerosis: clinical significance determined in a follow-up study","volume":"36","author":"Xu","year":"2005","journal-title":"Stroke; a journal of cerebral circulation"},{"key":"47","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1161\/01.CIR.103.8.1071","article-title":"Antibodies to human heat-shock protein 60 are associated with the presence and severity of coronary artery disease: evidence for an autoimmune component of atherogenesis","volume":"103","author":"Epstein","year":"2001","journal-title":"Circulation"},{"key":"48","doi-asserted-by":"crossref","first-page":"2040","DOI":"10.1093\/emboj\/18.8.2040","article-title":"Presence of a pre-apoptotic complex of pro-caspase-3, Hsp60 and Hsp10 in the mitochondrial fraction of jurkat cells","volume":"18","author":"Orrenius","year":"1999","journal-title":"The EMBO journal"},{"key":"49","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1097\/00006324-200106000-00015","article-title":"Age-related changes in the mouse outer retina","volume":"78","author":"Naash","year":"2001","journal-title":"Optometry and vision science : official publication of the American Academy of Optometry"},{"key":"50","doi-asserted-by":"crossref","first-page":"2989","DOI":"10.1172\/JCI64427","article-title":"Inflammatory priming predisposes mice to age-related retinal degeneration","volume":"122","author":"Palczewski","year":"2012","journal-title":"The Journal of clinical investigation"},{"key":"51","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1002\/cne.901880204","article-title":"Rods and cones in the mouse retina. I. Structural analysis using light and electron microscopy","volume":"188","author":"LaVail","year":"1979","journal-title":"The Journal of comparative neurology"},{"key":"52","doi-asserted-by":"crossref","first-page":"11222","DOI":"10.1523\/JNEUROSCI.4239-09.2010","article-title":"Age-related deterioration of rod vision in mice","volume":"30","author":"Kefalov","year":"2010","journal-title":"The Journal of neuroscience"},{"key":"53","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1167\/iovs.14-15334","article-title":"Assessment of retinal function and morphology in aging Ccl2 knockout mice","volume":"56","author":"Fletcher","year":"2015","journal-title":"Investigative ophthalmology & visual science"}],"container-title":["Oncotarget"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.5614","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,13]],"date-time":"2020-05-13T16:51:41Z","timestamp":1589388701000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.5614"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9,10]]},"references-count":53,"journal-issue":{"issue":"29","published-print":{"date-parts":[[2015,9,29]]}},"alternative-id":["5614","26393878"],"URL":"https:\/\/doi.org\/10.18632\/oncotarget.5614","relation":{},"ISSN":["1949-2553"],"issn-type":[{"value":"1949-2553","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,9,10]]}}}