{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T05:27:42Z","timestamp":1789882062412,"version":"4.0.1"},"reference-count":33,"publisher":"Impact Journals, LLC","issue":"32","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncotarget"],"published-print":{"date-parts":[[2015,10,20]]},"DOI":"10.18632\/oncotarget.5615","type":"journal-article","created":{"date-parts":[[2015,9,29]],"date-time":"2015-09-29T21:54:23Z","timestamp":1443563663000},"page":"33769-33780","source":"Crossref","is-referenced-by-count":52,"title":["Pyrvinium selectively targets blast phase-chronic myeloid leukemia through inhibition of mitochondrial respiration"],"prefix":"10.18632","volume":"6","author":[{"given":"Wei","family":"Xiang","sequence":"first","affiliation":[{"name":"Department of Haematology, Singapore General Hospital, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jit Kong","family":"Cheong","sequence":"additional","affiliation":[{"name":"Program in Cancer and Stem Cell Biology, Duke-NUS Graduate Medical School, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi Hui","family":"Ang","sequence":"additional","affiliation":[{"name":"Program in Cancer and Stem Cell Biology, Duke-NUS Graduate Medical School, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bryan","family":"Teo","sequence":"additional","affiliation":[{"name":"Department of Haematology, Singapore General Hospital, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Xu","sequence":"additional","affiliation":[{"name":"Program in Cancer and Stem Cell Biology, Duke-NUS Graduate Medical School, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kartini","family":"Asari","sequence":"additional","affiliation":[{"name":"Department of Haematology, Singapore General Hospital, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen Tian","family":"Sun","sequence":"additional","affiliation":[{"name":"Program in Cancer and Stem Cell Biology, Duke-NUS Graduate Medical School, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hein","family":"Than","sequence":"additional","affiliation":[{"name":"Department of Haematology, Singapore General Hospital, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralph M.","family":"Bunte","sequence":"additional","affiliation":[{"name":"Office of Research, Duke-NUS Graduate Medical School, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David M.","family":"Virshup","sequence":"additional","affiliation":[{"name":"Program in Cancer and Stem Cell Biology, Duke-NUS Graduate Medical School, Singapore"},{"name":"Department of Pediatrics, Duke University School of Medicine, Durham, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Chuah","sequence":"additional","affiliation":[{"name":"Department of Haematology, Singapore General Hospital, Singapore"},{"name":"Program in Cancer and Stem Cell Biology, Duke-NUS Graduate Medical School, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7892","published-online":{"date-parts":[[2015,9,10]]},"reference":[{"key":"1","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1182\/blood-2012-03-380147","article-title":"How I treat CML blast crisis","volume":"120","author":"Hehlmann","year":"2012","journal-title":"Blood"},{"key":"2","doi-asserted-by":"crossref","first-page":"2254","DOI":"10.1172\/JCI41246","article-title":"Chronic myeloid leukemia: mechanisms of blastic transformation","volume":"120","author":"Skorski","year":"2010","journal-title":"J Clin Invest"},{"key":"3","doi-asserted-by":"crossref","first-page":"E2298","DOI":"10.1073\/pnas.1301838110","article-title":"Targeting of the MNK-eIF4E axis in blast crisis chronic myeloid leukemia inhibits leukemia stem cell function","volume":"110","author":"Chuah","year":"2013","journal-title":"Proc Natl Acad Sci U S A"},{"key":"4","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1038\/nrc3317","article-title":"Pushing the limits of targeted therapy in chronic myeloid leukaemia","volume":"12","author":"Deininger","year":"2012","journal-title":"Nat Rev Cancer"},{"key":"5","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.ccr.2011.10.028","article-title":"Power cut: inhibiting mitochondrial translation to target leukemia","volume":"20","author":"Ebert","year":"2011","journal-title":"Cancer Cell"},{"key":"6","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.stem.2012.12.013","article-title":"BCL-2 inhibition targets oxidative phosphorylation and selectively eradicates quiescent human leukemia stem cells","volume":"12","author":"Becker","year":"2013","journal-title":"Cell Stem Cell"},{"key":"7","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1016\/j.ccr.2011.10.015","article-title":"Inhibition of mitochondrial translation as a therapeutic strategy for human acute myeloid leukemia","volume":"20","author":"Bartoszko","year":"2011","journal-title":"Cancer Cell"},{"key":"8","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1097\/00007611-197606000-00041","article-title":"Treatment of intestinal parasitic disease","volume":"69","author":"Jung","year":"1976","journal-title":"South Med J"},{"key":"9","doi-asserted-by":"crossref","first-page":"4569","DOI":"10.18632\/oncotarget.3174","article-title":"Antibiotics that target mitochondria effectively eradicate cancer stem cells, across multiple tumor types: Treating cancer like an infectious disease","volume":"6","author":"Lisanti","year":"2015","journal-title":"Oncotarget"},{"key":"10","doi-asserted-by":"crossref","first-page":"e71508","DOI":"10.1371\/journal.pone.0071508","article-title":"The antihelmintic drug pyrvinium pamoate targets aggressive breast cancer","volume":"8","author":"Reuben","year":"2013","journal-title":"PLoS One"},{"key":"11","doi-asserted-by":"crossref","first-page":"e614","DOI":"10.1038\/cddis.2013.142","article-title":"Pyrvinium targets autophagy addiction to promote cancer cell death","volume":"4","author":"Wei","year":"2013","journal-title":"Cell Death Dis"},{"key":"12","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.canlet.2011.12.034","article-title":"Pyrvinium pamoate inhibits proliferation of myeloma\/erythroleukemia cells by suppressing mitochondrial respiratory complex I and STAT3","volume":"319","author":"Kasahara","year":"2012","journal-title":"Cancer Lett"},{"key":"13","doi-asserted-by":"crossref","first-page":"e3951","DOI":"10.1371\/journal.pone.0003951","article-title":"Pyrvinium targets the unfolded protein response to hypoglycemia and its anti-tumor activity is enhanced by combination therapy","volume":"3","author":"Li","year":"2008","journal-title":"PLoS One"},{"key":"14","first-page":"137","article-title":"Reprofiling a classical anthelmintic, pyrvinium pamoate, as an anti-cancer drug targeting mitochondrial respiration","volume":"2","author":"Kasahara","year":"2012","journal-title":"Front Oncol"},{"key":"15","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1038\/nchembio.453","article-title":"Small-molecule inhibition of Wnt signaling through activation of casein kinase 1alpha","volume":"6","author":"Ghidu","year":"2010","journal-title":"Nat Chem Biol"},{"key":"16","doi-asserted-by":"crossref","first-page":"4811","DOI":"10.1158\/0008-5472.CAN-14-0317","article-title":"Pyrvinium attenuates Hedgehog signaling downstream of Smoothened","volume":"74","author":"Wang","year":"2014","journal-title":"Cancer Res"},{"key":"17","doi-asserted-by":"crossref","first-page":"e101969","DOI":"10.1371\/journal.pone.0101969","article-title":"Repurposing the FDA-Approved Pinworm Drug Pyrvinium as a Novel Chemotherapeutic Agent for Intestinal Polyposis","volume":"9","author":"Lee","year":"2014","journal-title":"PLoS One"},{"key":"18","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1111\/j.1349-7006.2004.tb03330.x","article-title":"Antitumor activity of pyrvinium pamoate, 6-(dimethylamino)-2-[2-(2,5-dimethyl-1-phenyl-1H-pyrrol-3-yl)ethenyl]-1-methyl-qu inolinium pamoate salt, showing preferential cytotoxicity during glucose starvation","volume":"95","author":"Hanaoka","year":"2004","journal-title":"Cancer Sci"},{"key":"19","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1158\/0008-5472.CAN-09-1947","article-title":"Drug combination studies and their synergy quantification using the Chou-Talalay method","volume":"70","author":"Chou","year":"2010","journal-title":"Cancer Res"},{"key":"20","doi-asserted-by":"crossref","first-page":"7180","DOI":"10.1158\/1078-0432.CCR-06-1112","article-title":"Dasatinib (BMS-354825) pharmacokinetics and pharmacodynamic biomarkers in animal models predict optimal clinical exposure","volume":"12","author":"Blackwood-Chirchir","year":"2006","journal-title":"Clin Cancer Res"},{"key":"21","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1038\/bjc.2014.259","article-title":"Role of Fbxw7 in the maintenance of normal stem cells and cancer-initiating cells","volume":"111","author":"Nakayama","year":"2014","journal-title":"Br J Cancer"},{"key":"22","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1056\/NEJMoa040258","article-title":"Granulocyte-macrophage progenitors as candidate leukemic stem cells in blast-crisis CML","volume":"351","author":"Weissman","year":"2004","journal-title":"N Engl J Med"},{"key":"23","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/S0014-5793(99)00783-8","article-title":"Cells depleted of mitochondrial DNA (rho0) yield insight into physiological mechanisms","volume":"454","author":"Schumacker","year":"1999","journal-title":"FEBS Lett"},{"key":"24","doi-asserted-by":"crossref","first-page":"713","DOI":"10.18632\/oncotarget.333","article-title":"Chronic myeloid leukemia stem cells in the era of targeted therapies: resistance, persistence and long-term dormancy","volume":"2","author":"Turhan","year":"2011","journal-title":"Oncotarget"},{"key":"25","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/nrd3504","article-title":"Targeting cancer metabolism: a therapeutic window opens","volume":"10","author":"Vander Heiden","year":"2011","journal-title":"Nat Rev Drug Discov"},{"key":"26","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1007\/s10555-012-9405-5","article-title":"Animal models of leukemia: any closer to the real thing?","volume":"32","author":"Pardee","year":"2013","journal-title":"Cancer and Metastasis Reviews"},{"key":"27","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1042\/BJ20121140","article-title":"Pyrvinium pamoate does not activate protein kinase CK1, but promotes Akt\/PKB down-regulation and GSK3 activation","volume":"452","author":"Pinna","year":"2013","journal-title":"Biochem J"},{"key":"28","doi-asserted-by":"crossref","first-page":"6223","DOI":"10.1073\/pnas.0700690104","article-title":"Transformation of human mesenchymal stem cells increases their dependency on oxidative phosphorylation for energy production","volume":"104","author":"Boshoff","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"key":"29","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1111\/j.1742-4658.2007.05686.x","article-title":"Energy metabolism in tumor cells","volume":"274","author":"Saavedra","year":"2007","journal-title":"FEBS J"},{"key":"30","doi-asserted-by":"crossref","first-page":"3167","DOI":"10.1182\/blood-2003-04-1271","article-title":"BCR\/ABL kinase inhibition by imatinib mesylate enhances MAP kinase activity in chronic myelogenous leukemia CD34+ cells","volume":"103","author":"Bhatia","year":"2004","journal-title":"Blood"},{"key":"31","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1007\/978-1-59745-521-3_23","article-title":"Establishment of human cell lines lacking mitochondrial DNA","volume":"554","author":"Zhang-Akiyama","year":"2009","journal-title":"Methods Mol Biol"},{"key":"32","doi-asserted-by":"crossref","first-page":"2558","DOI":"10.1038\/onc.2010.627","article-title":"IC261 induces cell cycle arrest and apoptosis of human cancer cells via CK1delta\/varepsilon and Wnt\/beta-catenin independent inhibition of mitotic spindle formation","volume":"30","author":"Virshup","year":"2011","journal-title":"Oncogene"},{"key":"33","doi-asserted-by":"crossref","first-page":"e20914","DOI":"10.1371\/journal.pone.0020914","article-title":"Energy metabolism in human pluripotent stem cells and their differentiated counterparts","volume":"6","author":"Schatten","year":"2011","journal-title":"PLoS One"}],"container-title":["Oncotarget"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.5615","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,9]],"date-time":"2020-09-09T00:21:40Z","timestamp":1599610900000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.5615"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9,10]]},"references-count":33,"journal-issue":{"issue":"32","published-print":{"date-parts":[[2015,10,20]]}},"alternative-id":["5615","26378050"],"URL":"https:\/\/doi.org\/10.18632\/oncotarget.5615","relation":{},"ISSN":["1949-2553"],"issn-type":[{"value":"1949-2553","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,9,10]]}}}