{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T13:29:58Z","timestamp":1791379798574,"version":"4.3.3"},"reference-count":54,"publisher":"Impact Journals, LLC","issue":"38","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncotarget"],"published-print":{"date-parts":[[2015,12,1]]},"DOI":"10.18632\/oncotarget.5843","type":"journal-article","created":{"date-parts":[[2015,10,27]],"date-time":"2015-10-27T13:53:33Z","timestamp":1445954013000},"page":"41146-41161","source":"Crossref","is-referenced-by-count":81,"title":["Silibinin-mediated metabolic reprogramming attenuates pancreatic cancer-induced cachexia and tumor growth"],"prefix":"10.18632","volume":"6","author":[{"given":"Surendra K.","family":"Shukla","sequence":"first","affiliation":[{"name":"The Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aneesha","family":"Dasgupta","sequence":"additional","affiliation":[{"name":"The Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA"},{"name":"Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamiya","family":"Mehla","sequence":"additional","affiliation":[{"name":"The Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Venugopal","family":"Gunda","sequence":"additional","affiliation":[{"name":"The Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enza","family":"Vernucci","sequence":"additional","affiliation":[{"name":"The Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua","family":"Souchek","sequence":"additional","affiliation":[{"name":"The Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gennifer","family":"Goode","sequence":"additional","affiliation":[{"name":"The Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan","family":"King","sequence":"additional","affiliation":[{"name":"The Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anusha","family":"Mishra","sequence":"additional","affiliation":[{"name":"The Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ibha","family":"Rai","sequence":"additional","affiliation":[{"name":"The Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sangeetha","family":"Nagarajan","sequence":"additional","affiliation":[{"name":"The Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina V.","family":"Chaika","sequence":"additional","affiliation":[{"name":"The Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pankaj K.","family":"Singh","sequence":"additional","affiliation":[{"name":"The Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA"},{"name":"Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA"},{"name":"Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA"},{"name":"Department of Genetics Cell Biology and Anatomy, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7892","published-online":{"date-parts":[[2015,10,16]]},"reference":[{"key":"1","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1007\/s00535-013-0787-0","article-title":"Cancer cachexia\u2014pathophysiology and management","volume":"48","author":"Inui","year":"2013","journal-title":"J Gastroenterol"},{"key":"2","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1177\/0115426506021002168","article-title":"Clinical anticachexia treatments","volume":"21","author":"Tisdale","year":"2006","journal-title":"Nutrition in clinical practice: official publication of the American Society for Parenteral and Enteral Nutrition"},{"key":"3","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1097\/01.mco.0000165004.93707.88","article-title":"Systemic inflammation, cachexia and prognosis in patients with cancer","volume":"8","author":"Wigmore","year":"2005","journal-title":"Current opinion in clinical nutrition and metabolic care"},{"key":"4","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1038\/nrc3829","article-title":"Cancer cachexia: understanding the molecular basis","volume":"14","author":"Lopez-Soriano","year":"2014","journal-title":"Nature reviews Cancer"},{"key":"5","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1146\/annurev-med-061509-131248","article-title":"Muscle wasting in cancer cachexia: clinical implications, diagnosis, and emerging treatment strategies","volume":"62","author":"Steiner","year":"2011","journal-title":"Annual review of medicine"},{"key":"6","doi-asserted-by":"crossref","first-page":"2913","DOI":"10.1158\/0008-5472.CAN-14-0155","article-title":"Projecting cancer incidence and deaths to 2030: the unexpected burden of thyroid, liver, and pancreas cancers in the United States","volume":"74","author":"Matrisian","year":"2014","journal-title":"Cancer research"},{"key":"7","first-page":"5","article-title":"Cancer statistics, 2015","volume":"65","author":"Jemal","year":"2015","journal-title":"CA: a cancer journal for clinicians"},{"key":"8","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1038\/nrclinonc.2015.53","article-title":"Pancreatic cancer: from state-of-the-art treatments to promising novel therapies","volume":"12","author":"Hidalgo","year":"2015","journal-title":"Nature reviews Clinical oncology"},{"key":"9","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1634\/theoncologist.3-3-178","article-title":"Pancreatic Cancer: Local Success and Distant Failure","volume":"3","author":"Grossbard","year":"1998","journal-title":"Oncologist"},{"key":"10","doi-asserted-by":"crossref","first-page":"S81","DOI":"10.1016\/j.surg.2012.05.028","article-title":"Cachexia but not obesity worsens the postoperative outcome after pancreatoduodenectomy in pancreatic cancer","volume":"152","author":"Werner","year":"2012","journal-title":"Surgery"},{"key":"11","doi-asserted-by":"crossref","first-page":"2867","DOI":"10.3748\/wjg.v18.i22.2867","article-title":"Intervention of mirtazapine on gemcitabine-induced mild cachexia in nude mice with pancreatic carcinoma xenografts","volume":"18","author":"Jia","year":"2012","journal-title":"World journal of gastroenterology: WJG"},{"key":"12","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1586\/14737140.2.1.121","article-title":"Anticancer drugs that induce cancer-associated cachectic syndromes","volume":"2","author":"Inui","year":"2002","journal-title":"Expert review of anticancer therapy"},{"key":"13","first-page":"639401","article-title":"Natural compounds as regulators of the cancer cell metabolism","volume":"2013","author":"Diederich","year":"2013","journal-title":"International journal of cell biology"},{"key":"14","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.canlet.2011.02.023","article-title":"Epigallocatechin-3-gallate effectively attenuates skeletal muscle atrophy caused by cancer cachexia","volume":"305","author":"Wu","year":"2011","journal-title":"Cancer letters"},{"key":"15","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/j.canlet.2008.03.053","article-title":"Multitargeted therapy of cancer by silymarin","volume":"269","author":"Agarwal","year":"2008","journal-title":"Cancer letters"},{"key":"16","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1007\/s00011-013-0640-1","article-title":"Silibinin inhibits the production of pro-inflammatory cytokines through inhibition of NF-kappaB signaling pathway in HMC-1 human mast cells","volume":"62","author":"Ko","year":"2013","journal-title":"Inflammation research: official journal of the European Histamine Research Society [et al]"},{"key":"17","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1038\/onc.2008.398","article-title":"Silibinin inhibits hypoxia-inducible factor-1alpha and mTOR\/p70S6K\/4E-BP1 signalling pathway in human cervical and hepatoma cancer cells: implications for anticancer therapy","volume":"28","author":"Mateo","year":"2009","journal-title":"Oncogene"},{"key":"18","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1038\/nrgastro.2012.63","article-title":"MicroRNAs in pancreatic cancer metabolism","volume":"9","author":"Mehla","year":"2012","journal-title":"Nature reviews Gastroenterology & hepatology"},{"key":"19","doi-asserted-by":"crossref","first-page":"3685","DOI":"10.1172\/JCI69741","article-title":"Targeting lactate metabolism for cancer therapeutics","volume":"123","author":"Cleveland","year":"2013","journal-title":"The Journal of clinical investigation"},{"key":"20","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.tibs.2014.06.005","article-title":"The pentose phosphate pathway and cancer","volume":"39","author":"Hay","year":"2014","journal-title":"Trends in biochemical sciences"},{"key":"21","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a014217","article-title":"MYC, metabolism, cell growth, and tumorigenesis","volume":"3","author":"Dang","year":"2013","journal-title":"Cold Spring Harbor perspectives in medicine"},{"key":"22","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1208\/s12248-013-9486-2","article-title":"Molecular mechanisms of silibinin-mediated cancer chemoprevention with major emphasis on prostate cancer","volume":"15","author":"Agarwal","year":"2013","journal-title":"The AAPS journal"},{"key":"23","doi-asserted-by":"crossref","first-page":"7319","DOI":"10.1073\/pnas.131568898","article-title":"Stat3-mediated Myc expression is required for Src transformation and PDGF-induced mitogenesis","volume":"98","author":"Jove","year":"2001","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"24","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/2049-3002-2-18","article-title":"Metabolic reprogramming induced by ketone bodies diminishes pancreatic cancer cachexia","volume":"2","author":"Singh","year":"2014","journal-title":"Cancer & metabolism"},{"key":"25","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.cell.2011.02.013","article-title":"Hallmarks of cancer: the next generation","volume":"144","author":"Weinberg","year":"2011","journal-title":"Cell"},{"key":"26","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1038\/nrc2817","article-title":"Targeting metabolic transformation for cancer therapy","volume":"10","author":"Gottlieb","year":"2010","journal-title":"Nature reviews Cancer"},{"key":"27","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1038\/nrc2981","article-title":"Regulation of cancer cell metabolism","volume":"11","author":"Mak","year":"2011","journal-title":"Nature reviews Cancer"},{"key":"28","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1126\/science.1160809","article-title":"Understanding the Warburg effect: the metabolic requirements of cell proliferation","volume":"324","author":"Thompson","year":"2009","journal-title":"Science"},{"key":"29","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.tibs.2010.05.003","article-title":"Glutamine addiction: a new therapeutic target in cancer","volume":"35","author":"Thompson","year":"2010","journal-title":"Trends in biochemical sciences"},{"key":"30","doi-asserted-by":"crossref","first-page":"4633","DOI":"10.1038\/sj.onc.1209597","article-title":"Glycolysis inhibition for anticancer treatment","volume":"25","author":"Huang","year":"2006","journal-title":"Oncogene"},{"key":"31","doi-asserted-by":"crossref","first-page":"e1065","DOI":"10.1038\/cddis.2014.38","article-title":"Metabolism addiction in pancreatic cancer","volume":"5","author":"Kloog","year":"2014","journal-title":"Cell death & disease"},{"key":"32","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1038\/nrc3009","article-title":"Metabolism: choose your carbon source","volume":"11","author":"Burgess","year":"2011","journal-title":"Nature reviews Cancer"},{"key":"33","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1016\/j.surg.2004.05.032","article-title":"Glucose transporter-1 gene expression is associated with pancreatic cancer invasiveness and MMP-2 activity","volume":"136","author":"Whang","year":"2004","journal-title":"Surgery"},{"key":"34","doi-asserted-by":"crossref","first-page":"13787","DOI":"10.1073\/pnas.1203339109","article-title":"MUC1 mucin stabilizes and activates hypoxia-inducible factor 1 alpha to regulate metabolism in pancreatic cancer","volume":"109","author":"Singh","year":"2012","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"35","doi-asserted-by":"crossref","first-page":"e32996","DOI":"10.1371\/journal.pone.0032996","article-title":"Differential expression of metabolic genes in tumor and stromal components of primary and metastatic loci in pancreatic adenocarcinoma","volume":"7","author":"Singh","year":"2012","journal-title":"PLoS One"},{"key":"36","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.ccr.2013.06.014","article-title":"Hexokinase 2 is required for tumor initiation and maintenance and its systemic deletion is therapeutic in mouse models of cancer","volume":"24","author":"Hay","year":"2013","journal-title":"Cancer cell"},{"key":"37","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1158\/2159-8290.CD-12-0345","article-title":"Cancer cell metabolism: one hallmark, many faces","volume":"2","author":"Sabatini","year":"2012","journal-title":"Cancer discovery"},{"key":"38","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1006\/bbrc.1999.0890","article-title":"Flavonoids are potential inhibitors of glucose uptake in U937 cells","volume":"260","author":"Park","year":"1999","journal-title":"Biochemical and biophysical research communications"},{"key":"39","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1146\/annurev-cellbio-092910-154237","article-title":"Aerobic glycolysis: meeting the metabolic requirements of cell proliferation","volume":"27","author":"Vander Heiden","year":"2011","journal-title":"Annual review of cell and developmental biology"},{"key":"40","doi-asserted-by":"crossref","first-page":"5546","DOI":"10.1158\/1078-0432.CCR-12-0977","article-title":"c-Myc and cancer metabolism","volume":"18","author":"Sedoris","year":"2012","journal-title":"Clinical cancer research: an official journal of the American Association for Cancer Research"},{"key":"41","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1016\/j.ctrv.2015.04.008","article-title":"Silibinin and STAT3: A natural way of targeting transcription factors for cancer therapy","volume":"41","author":"Menendez","year":"2015","journal-title":"Cancer treatment reviews"},{"key":"42","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.3390\/cancers6031579","article-title":"STAT3 Activities and Energy Metabolism: Dangerous Liaisons","volume":"6","author":"Poli","year":"2014","journal-title":"Cancers"},{"key":"43","first-page":"487","article-title":"Glucose tolerance and insulin secretion in pancreatic cancer","volume":"25","author":"Campione","year":"1993","journal-title":"The Italian journal of gastroenterology"},{"key":"44","first-page":"154","article-title":"Cancer anorexia - cachexia syndrome","volume":"44","author":"Rotty","year":"2012","journal-title":"Acta medica Indonesiana"},{"key":"45","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1177\/0115426505020004369","article-title":"The cancer cachexia syndrome: a review of metabolic and clinical manifestations","volume":"20","author":"Harb","year":"2005","journal-title":"Nutrition in clinical practice: official publication of the American Society for Parenteral and Enteral Nutrition"},{"key":"46","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1080\/01635581.2014.863365","article-title":"Silibinin inhibits tumor promotional triggers and tumorigenesis against chemically induced two-stage skin carcinogenesis in Swiss albino mice: possible role of oxidative stress and inflammation","volume":"66","author":"Sultana","year":"2014","journal-title":"Nutrition and cancer"},{"key":"47","doi-asserted-by":"crossref","first-page":"268","DOI":"10.3109\/10715762.2013.765951","article-title":"Silibinin attenuates oxidative metabolism and cytokine production by monocytes from preeclamptic women","volume":"47","author":"Peracoli","year":"2013","journal-title":"Free radical research"},{"key":"48","doi-asserted-by":"crossref","first-page":"5201","DOI":"10.1158\/0008-5472.CAN-06-4647","article-title":"Platelet-derived growth factor receptor beta-mediated phosphorylation of MUC1 enhances invasiveness in pancreatic adenocarcinoma cells","volume":"67","author":"Hollingsworth","year":"2007","journal-title":"Cancer Res"},{"key":"49","doi-asserted-by":"crossref","first-page":"26985","DOI":"10.1074\/jbc.M805036200","article-title":"Phosphorylation of MUC1 by Met modulates interaction with p53 and MMP1 expression","volume":"283","author":"Hollingsworth","year":"2008","journal-title":"J Biol Chem"},{"key":"50","doi-asserted-by":"crossref","first-page":"3859","DOI":"10.1111\/j.1742-4658.2012.08745.x","article-title":"Hepatitis B virus X protein and c-Myc cooperate in the upregulation of ribosome biogenesis and in cellular transformation","volume":"279","author":"Kumar","year":"2012","journal-title":"The FEBS journal"},{"key":"51","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1186\/s12985-015-0293-5","article-title":"The HBx oncoprotein of hepatitis B virus potentiates cell transformation by inducing c-Myc-dependent expression of the RNA polymerase I transcription factor UBF","volume":"12","author":"Kumar","year":"2015","journal-title":"Virology journal"},{"key":"52","doi-asserted-by":"crossref","first-page":"19118","DOI":"10.18632\/oncotarget.4078","article-title":"MUC16-mediated activation of mTOR and c-Myc reprograms pancreatic cancer metabolism","volume":"6","author":"Singh","year":"2015","journal-title":"Oncotarget"},{"key":"53","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1007\/978-1-61737-985-7_13","article-title":"LC-MS-based metabolomics","volume":"708","author":"Shulaev","year":"2011","journal-title":"Methods in molecular biology"},{"key":"54","doi-asserted-by":"crossref","first-page":"W127","DOI":"10.1093\/nar\/gks374","article-title":"MetaboAnalyst 2.0\u2014a comprehensive server for metabolomic data analysis","volume":"40","author":"Wishart","year":"2012","journal-title":"Nucleic acids research"}],"container-title":["Oncotarget"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.5843","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,13]],"date-time":"2020-05-13T18:00:00Z","timestamp":1589392800000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.5843"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10,16]]},"references-count":54,"journal-issue":{"issue":"38","published-print":{"date-parts":[[2015,12,1]]}},"alternative-id":["5843","26510913"],"URL":"https:\/\/doi.org\/10.18632\/oncotarget.5843","relation":{},"ISSN":["1949-2553"],"issn-type":[{"value":"1949-2553","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,10,16]]}}}