{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T21:20:04Z","timestamp":1790112004274,"version":"4.0.1"},"reference-count":43,"publisher":"Impact Journals, LLC","issue":"38","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncotarget"],"published-print":{"date-parts":[[2015,12,1]]},"DOI":"10.18632\/oncotarget.5885","type":"journal-article","created":{"date-parts":[[2015,10,27]],"date-time":"2015-10-27T18:39:46Z","timestamp":1445971186000},"page":"40866-40879","source":"Crossref","is-referenced-by-count":17,"title":["Bis-cyclopropane analog of disorazole C1 is a microtubule-destabilizing agent active in abcb1-overexpressing human colon cancer cells"],"prefix":"10.18632","volume":"6","author":[{"given":"Shaoyu","family":"Wu","sequence":"first","affiliation":[{"name":"Division of Hematology-Oncology, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15232, USA"},{"name":"Cancer Therapeutics Program, University of Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, PA 15213, USA"},{"name":"Department of Chemistry, School of Pharmaceutical Science, Southern Medical University, Guangzhou 510515, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhijian","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Nephrology, NanFang Hospital, Southern Medical University, Guangzhou 510515, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chad D.","family":"Hopkins","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of Pittsburgh, Pittsburgh, PA 15260, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Wei","sequence":"additional","affiliation":[{"name":"Division of Hematology-Oncology, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15232, USA"},{"name":"Cancer Therapeutics Program, University of Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, PA 15213, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward","family":"Chu","sequence":"additional","affiliation":[{"name":"Division of Hematology-Oncology, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15232, USA"},{"name":"Cancer Therapeutics Program, University of Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, PA 15213, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Wipf","sequence":"additional","affiliation":[{"name":"Cancer Therapeutics Program, University of Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, PA 15213, USA"},{"name":"Department of Chemistry, University of Pittsburgh, Pittsburgh, PA 15260, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John C.","family":"Schmitz","sequence":"additional","affiliation":[{"name":"Division of Hematology-Oncology, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15232, USA"},{"name":"Cancer Therapeutics Program, University of Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, PA 15213, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7892","published-online":{"date-parts":[[2015,10,19]]},"reference":[{"key":"1","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1039\/B515619J","article-title":"Anticancer drugs from nature\u2014natural products as a unique source of new microtubule-stabilizing agents","volume":"24","author":"Gertsch","year":"2007","journal-title":"Nat Prod Rep"},{"key":"2","first-page":"20","article-title":"Cancer wars: natural products strike back","volume":"2","author":"Desaubry","year":"2014","journal-title":"Front Chem"},{"key":"3","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1021\/np5000796","article-title":"New horizons for old drugs and drug leads","volume":"77","author":"Newman","year":"2014","journal-title":"J Nat Prod"},{"key":"4","doi-asserted-by":"crossref","first-page":"3670","DOI":"10.1016\/j.bbagen.2013.02.008","article-title":"Natural products: a continuing source of novel drug leads","volume":"1830","author":"Newman","year":"2013","journal-title":"Biochim Biophys Acta"},{"key":"5","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1039\/C0NP90032J","article-title":"A sea of biosynthesis: marine natural products meet the molecular age","volume":"28","author":"Moore","year":"2011","journal-title":"Nat Prod Rep"},{"key":"6","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1039\/b822528a","article-title":"Antitumor compounds from actinomycetes: from gene clusters to new derivatives by combinatorial biosynthesis","volume":"26","author":"Salas","year":"2009","journal-title":"Nat Prod Rep"},{"key":"7","doi-asserted-by":"crossref","first-page":"1999","DOI":"10.1021\/cr800188v","article-title":"Advances in solution- and solid-phase synthesis toward the generation of natural product-like libraries","volume":"109","author":"Arya","year":"2009","journal-title":"Chem Rev"},{"key":"8","doi-asserted-by":"crossref","first-page":"7296","DOI":"10.1021\/ja401184g","article-title":"Stochastic voyages into uncharted chemical space produce a representative library of all possible drug-like compounds","volume":"135","author":"Beratan","year":"2013","journal-title":"J Am Chem Soc"},{"key":"9","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1351\/pac200779040753","article-title":"From natural products to biological tools","volume":"79","author":"Xiao","year":"2007","journal-title":"Pur Appl Chem"},{"key":"10","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/S0079-6468(08)70308-4","article-title":"Squalene synthase inhibitors: their potential as hypocholesterolaemic agents","volume":"33","author":"Procopiou","year":"1996","journal-title":"Prog Med Chem"},{"key":"11","doi-asserted-by":"crossref","first-page":"2053","DOI":"10.1039\/b504418a","article-title":"Chemistry and biology of wortmannin","volume":"3","author":"Halter","year":"2005","journal-title":"Org Biomol Chem"},{"key":"12","doi-asserted-by":"crossref","first-page":"1901","DOI":"10.1021\/jm0105171","article-title":"Synthesis and biological evaluation of structurally highly modified analogues of the antimitotic natural product curacin A","volume":"45","author":"Day","year":"2002","journal-title":"J Med Chem"},{"key":"13","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1039\/b813799b","article-title":"Isolation, biology and chemistry of the disorazoles: new anti-cancer macrodiolides","volume":"26","author":"Wipf","year":"2009","journal-title":"Nat Prod Rep"},{"key":"14","doi-asserted-by":"crossref","first-page":"31","DOI":"10.7164\/antibiotics.48.31","article-title":"Disorazol A, an efficient inhibitor of eukaryotic organisms isolated from myxobacteria","volume":"48","author":"Reichenbach","year":"1995","journal-title":"J Antibiot (Tokyo)"},{"key":"15","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1002\/jlac.199419940802","article-title":"Disorazoles, highly cytotoxic metabolites from the sorangicin-producing bacterium, strain so ce12","volume":"1994","author":"Hofle","year":"1994","journal-title":"Leibigs Ann Chem"},{"key":"16","doi-asserted-by":"crossref","first-page":"15346","DOI":"10.1021\/ja0443068","article-title":"Total synthesis of (\u2212)-disorazole C1","volume":"126","author":"Graham","year":"2004","journal-title":"J Am Chem Soc"},{"key":"17","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1124\/jpet.109.162842","article-title":"Identifying a resistance determinant for the antimitotic natural products disorazole C1 and A1","volume":"332","author":"Wipf","year":"2010","journal-title":"J Pharmacol Exp Ther"},{"key":"18","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1124\/jpet.108.147330","article-title":"Microtubule binding and disruption and induction of premature senescence by disorazole C","volume":"328","author":"Ducruet","year":"2009","journal-title":"J Pharmacol Exp Ther"},{"key":"19","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1111\/j.1747-0285.2005.00313.x","article-title":"Cellular analysis of disorazole C and structure-activity relationship of analogs of the natural product","volume":"67","author":"Lazo","year":"2006","journal-title":"Chem Biol Drug Des"},{"key":"20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1472-6769-10-1","article-title":"Mitotic slippage in non-cancer cells induced by a microtubule disruptor, disorazole C1","volume":"10","author":"Saunders","year":"2010","journal-title":"BMC Chem Biol"},{"key":"21","doi-asserted-by":"crossref","first-page":"4088","DOI":"10.1021\/ol2015994","article-title":"Total synthesis of (\u2212)-CP2-disorazole C1","volume":"13","author":"Wipf","year":"2011","journal-title":"Org Lett"},{"key":"22","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1080\/14756360409162441","article-title":"Synthesis of cyclopropane isosteres of the antiepilepsy drug vigabatrin and evaluation of their inhibition of GABA aminotransferase","volume":"19","author":"Silverman","year":"2004","journal-title":"J Enzyme Inhib Med Chem"},{"key":"23","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1007\/s12272-013-0134-2","article-title":"Design, synthesis, and biological evaluation of cyclopropyl analogues of stilbene with raloxifene side chain as subtype-selective ligands for estrogen receptor","volume":"36","author":"Kim","year":"2013","journal-title":"Arch Pharm Res"},{"key":"24","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1172\/JCI8625","article-title":"Pretreatment with DNA-damaging agents permits selective killing of checkpoint-deficient cells by microtubule-active drugs","volume":"105","author":"Fojo","year":"2000","journal-title":"J Clin Invest"},{"key":"25","first-page":"1047","article-title":"Disruption of p53 function in immortalized human cells does not affect survival or apoptosis after taxol or vincristine treatment","volume":"4","author":"O'Connor","year":"1998","journal-title":"Clin Cancer Res"},{"key":"26","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1124\/jpet.110.175604","article-title":"Ixabepilone, a novel microtubule-targeting agent for breast cancer, is a substrate for P-glycoprotein (P-gp\/MDR1\/ABCB1) but not breast cancer resistance protein (BCRP\/ABCG2)","volume":"337","author":"Gan","year":"2011","journal-title":"J Pharmacol Exp Ther"},{"key":"27","doi-asserted-by":"crossref","first-page":"2205","DOI":"10.1172\/JCI117910","article-title":"Generation of a drug resistance profile by quantitation of mdr-1\/P-glycoprotein in the cell lines of the National Cancer Institute Anticancer Drug Screen","volume":"95","author":"Fojo","year":"1995","journal-title":"J Clin Invest"},{"key":"28","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/S0093-7754(03)00125-8","article-title":"EPO906 (epothilone B): a promising novel microtubule stabilizer","volume":"30","author":"Hohneker","year":"2003","journal-title":"Semin Oncol"},{"key":"29","first-page":"153","article-title":"Microtubules and their role in cellular stress in cancer","volume":"4","author":"McCarroll","year":"2014","journal-title":"Front Oncol"},{"key":"30","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1002\/cm.20109","article-title":"Comparison of beta-tubulin mRNA and protein levels in 12 human cancer cell lines","volume":"63","author":"Lobert","year":"2006","journal-title":"Cell Motil Cytoskeleton"},{"key":"31","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1002\/cm.20436","article-title":"Tumoral and tissue-specific expression of the major human beta-tubulin isotypes","volume":"67","author":"Rodriguez-Antona","year":"2010","journal-title":"Cytoskeleton (Hoboken)"},{"key":"32","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1038\/nrclinonc.2010.228","article-title":"Mitosis is not a key target of microtubule agents in patient tumors","volume":"8","author":"Fojo","year":"2011","journal-title":"Nat Rev Clin Oncol"},{"key":"33","doi-asserted-by":"crossref","first-page":"5188","DOI":"10.1128\/MCB.15.9.5188","article-title":"The N-terminal domain of c-Myc associates with alpha-tubulin and microtubulesand","volume":"15","author":"Zajac-Kaye","year":"1995","journal-title":"Mol Cell Biol"},{"key":"34","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1002\/iub.25","article-title":"Microtubules: a dynamic target in cancer therapy","volume":"60","author":"Kavallaris","year":"2008","journal-title":"IUBMB Life"},{"key":"35","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1055\/s-0030-1250073","article-title":"Microtubule-binding natural products for cancer therapy","volume":"76","author":"Guo","year":"2010","journal-title":"Planta Med"},{"key":"36","doi-asserted-by":"crossref","first-page":"2778","DOI":"10.2174\/138161212800626193","article-title":"Tubulins as therapeutic targets in cancer: from bench to bedside","volume":"18","author":"Draber","year":"2012","journal-title":"Curr Pharm Des"},{"key":"37","doi-asserted-by":"crossref","first-page":"1618","DOI":"10.1158\/1078-0432.CCR-07-2201","article-title":"The epothilones: translating from the laboratory to the clinic","volume":"14","author":"Swain","year":"2008","journal-title":"Clin Cancer Res"},{"key":"38","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1016\/S0959-8049(00)00042-3","article-title":"Opposite effects of antimicrotubule agents on c-myc oncogene expression depending on the cell lines used","volume":"36","author":"Briand","year":"2000","journal-title":"Eur J Cancer"},{"key":"39","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/j.cell.2014.05.042","article-title":"APC is an RNA-binding protein, and its interactome provides a link to neural development and microtubule assembly","volume":"158","author":"Flanagan","year":"2014","journal-title":"Cell"},{"key":"40","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1038\/35036335","article-title":"p53 is associated with cellular microtubules and is transported to the nucleus by dynein","volume":"2","author":"Fojo","year":"2000","journal-title":"Nat Cell Biol"},{"key":"41","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1073\/pnas.1416418112","article-title":"Microtubule-targeting agents augment the toxicity of DNA-damaging agents by disrupting intracellular trafficking of DNA repair proteins","volume":"112","author":"Fojo","year":"2015","journal-title":"Proc Natl Acad Sci U S A"},{"key":"42","first-page":"6710","article-title":"Characteristics of cell lines established from human colorectal carcinoma","volume":"47","author":"Gazdar","year":"1987","journal-title":"Cancer Res"},{"key":"43","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1083\/jcb.143.5.1341","article-title":"Integration of endothelial cells in multicellular spheroids prevents apoptosis and induces differentiation","volume":"143","author":"Augustin","year":"1998","journal-title":"J Cell Biol"}],"container-title":["Oncotarget"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.5885","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,13]],"date-time":"2020-05-13T18:02:26Z","timestamp":1589392946000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.5885"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10,19]]},"references-count":43,"journal-issue":{"issue":"38","published-print":{"date-parts":[[2015,12,1]]}},"alternative-id":["5885","26506423"],"URL":"https:\/\/doi.org\/10.18632\/oncotarget.5885","relation":{},"ISSN":["1949-2553"],"issn-type":[{"value":"1949-2553","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,10,19]]}}}