{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T00:18:51Z","timestamp":1779236331471,"version":"3.51.4"},"reference-count":59,"publisher":"Impact Journals, LLC","issue":"36","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncotarget"],"published-print":{"date-parts":[[2015,11,17]]},"DOI":"10.18632\/oncotarget.5904","type":"journal-article","created":{"date-parts":[[2015,10,5]],"date-time":"2015-10-05T03:46:00Z","timestamp":1444016760000},"page":"38504-38516","source":"Crossref","is-referenced-by-count":37,"title":["Recombinant rabies virus expressing dog GM-CSF is an efficacious oral rabies vaccine for dogs"],"prefix":"10.18632","volume":"6","author":[{"given":"Ming","family":"Zhou","sequence":"first","affiliation":[{"name":"State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Songqin","family":"Zhou","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhao","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juncheng","family":"Ruan","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lijun","family":"Tang","sequence":"additional","affiliation":[{"name":"Hubei Provincial Key Laboratory for Applied Toxicology, Hubei Provincial Academy of Preventive Medicine, Wuhan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ziming","family":"Jia","sequence":"additional","affiliation":[{"name":"Hubei Provincial Key Laboratory for Applied Toxicology, Hubei Provincial Academy of Preventive Medicine, Wuhan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Cui","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling","family":"Zhao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhen F.","family":"Fu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China"},{"name":"Department of Pathology, University of Georgia, Athens, GA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7892","published-online":{"date-parts":[[2015,9,30]]},"reference":[{"key":"1","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1016\/S0140-6736(13)62707-5","article-title":"Current status of rabies and prospects for elimination","volume":"384","author":"Jackson","year":"2014","journal-title":"Lancet"},{"key":"2","first-page":"1","article-title":"WHO Expert Consultation on Rabies. Second report","author":"World Health O","year":"2013","journal-title":"World Health Organization technical report series"},{"key":"3","first-page":"309","article-title":"Rabies vaccines: WHO position paper","volume":"85","author":"World Health O","year":"2010","journal-title":"Weekly Epidemiological Record"},{"key":"4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1089\/vbz.2008.0046","article-title":"Rabies in China: an update","volume":"9","author":"Fooks","year":"2009","journal-title":"Vector borne and zoonotic diseases"},{"key":"5","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/0264-410X(95)00197-9","article-title":"Immunization coverage required to prevent outbreaks of dog rabies","volume":"14","author":"Dye","year":"1996","journal-title":"Vaccine"},{"key":"6","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1016\/j.theriogenology.2013.07.016","article-title":"Nonsurgical fertility control for managing free-roaming dog populations: a review of products and criteria for field applications","volume":"80","author":"Miller","year":"2013","journal-title":"Theriogenology"},{"key":"7","doi-asserted-by":"crossref","first-page":"3492","DOI":"10.1016\/j.vaccine.2012.03.069","article-title":"Canine rabies vaccination and domestic dog population characteristics in the developing world: a systematic review","volume":"30","author":"Vonville","year":"2012","journal-title":"Vaccine"},{"key":"8","first-page":"245","article-title":"A community survey of dog bites, anti-rabies treatment, rabies and dog population management in Bangalore city","volume":"33","author":"Narayan","year":"2001","journal-title":"The Journal of communicable diseases"},{"key":"9","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.ijid.2005.10.007","article-title":"Assessing the burden of human rabies in India: results of a national multi-center epidemiological survey","volume":"11","author":"Gangaboraiah","year":"2007","journal-title":"International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases"},{"key":"10","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1186\/1471-2334-14-212","article-title":"Human rabies surveillance and control in China, 2005-2012","volume":"14","author":"Liang","year":"2014","journal-title":"BMC Infect Dis"},{"key":"11","first-page":"602","article-title":"Current status of canine rabies in China","volume":"25","author":"Liang","year":"2012","journal-title":"Biomedical and environmental sciences : BES"},{"key":"12","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.prevetmed.2006.11.003","article-title":"Prevalence of rabies virus infection and rabies antibody in stray dogs: a survey in Bangkok, Thailand","volume":"78","author":"Sitprija","year":"2007","journal-title":"Preventive veterinary medicine"},{"key":"13","doi-asserted-by":"crossref","first-page":"119","DOI":"10.7589\/0090-3558-37.1.119","article-title":"Elimination of rabies from red foxes in eastern Ontario","volume":"37","author":"Pond","year":"2001","journal-title":"Journal of wildlife diseases"},{"key":"14","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.2460\/javma.1998.213.10.1407","article-title":"Prevention of the spread of rabies to wildlife by oral vaccination of raccoons in Massachusetts","volume":"213","author":"Rowell","year":"1998","journal-title":"Journal of the American Veterinary Medical Association"},{"key":"15","doi-asserted-by":"crossref","first-page":"498","DOI":"10.2460\/javma.1998.212.04.498","article-title":"Results of an oral rabies vaccination program for coyotes","volume":"212","author":"Moore","year":"1998","journal-title":"Journal of the American Veterinary Medical Association"},{"key":"16","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1136\/vr.139.2.32","article-title":"Progress and setbacks in the oral immunisation of foxes against rabies in Europe","volume":"139","author":"Meslin","year":"1996","journal-title":"The Veterinary record"},{"key":"17","first-page":"219","article-title":"Oral wildlife rabies vaccination field trials in Europe, with recent emphasis on France","volume":"187","author":"Barrat","year":"1994","journal-title":"Current topics in microbiology and immunology"},{"key":"18","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1038\/312163a0","article-title":"Expression of rabies virus glycoprotein from a recombinant vaccinia virus","volume":"312","author":"Lecocq","year":"1984","journal-title":"Nature"},{"key":"19","doi-asserted-by":"crossref","first-page":"752","DOI":"10.7589\/0090-3558-34.4.752","article-title":"Efficacy of an oral vaccinia-rabies glycoprotein recombinant vaccine in controlling epidemic raccoon rabies in New Jersey","volume":"34","author":"Rupprecht","year":"1998","journal-title":"Journal of wildlife diseases"},{"key":"20","doi-asserted-by":"crossref","first-page":"228","DOI":"10.7589\/0090-3558-34.2.228","article-title":"First North American field release of a vaccinia-rabies glycoprotein recombinant virus","volume":"34","author":"Rupprecht","year":"1998","journal-title":"Journal of wildlife diseases"},{"key":"21","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1038\/354520a0","article-title":"Large-scale eradication of rabies using recombinant vaccinia-rabies vaccine","volume":"354","author":"Afiademanyo","year":"1991","journal-title":"Nature"},{"key":"22","first-page":"1204","article-title":"Human vaccinia infection after contact with a raccoon rabies vaccine bait - Pennsylvania, 2009","volume":"58","author":"Centers for Disease C and Prevention","year":"2009","journal-title":"MMWR Morbidity and mortality weekly report"},{"key":"23","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1056\/NEJMoa010560","article-title":"Human infection due to recombinant vaccinia-rabies glycoprotein virus","volume":"345","author":"Hanlon","year":"2001","journal-title":"The New England journal of medicine"},{"key":"24","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1128\/JVI.53.3.926-934.1985","article-title":"Rabies virulence: effect on pathogenicity and sequence characterization of rabies virus mutations affecting antigenic site III of the glycoprotein","volume":"53","author":"Flamand","year":"1985","journal-title":"Journal of virology"},{"key":"25","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1073\/pnas.80.1.70","article-title":"Characterization of an antigenic determinant of the glycoprotein that correlates with pathogenicity of rabies virus","volume":"80","author":"Koprowski","year":"1983","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"26","doi-asserted-by":"crossref","first-page":"4511","DOI":"10.1016\/S0264-410X(01)00186-4","article-title":"Rapid clearance of SAG-2 rabies virus from dogs after oral vaccination","volume":"19","author":"Rupprecht","year":"2001","journal-title":"Vaccine"},{"key":"27","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/S0264-410X(98)00233-3","article-title":"Efficacy of SAG-2 oral rabies vaccine in two species of jackal (Canis adustus and Canis mesomelas)","volume":"17","author":"Aubert","year":"1999","journal-title":"Vaccine"},{"key":"28","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1016\/S0264-410X(97)00009-1","article-title":"Innocuity studies of SAG-2 oral rabies vaccine in various Zimbabwean wild non-target species","volume":"15","author":"Aubert","year":"1997","journal-title":"Vaccine"},{"key":"29","first-page":"459","article-title":"SAG-2 oral rabies vaccine","volume":"60","author":"Flamand","year":"1993","journal-title":"The Onderstepoort journal of veterinary research"},{"key":"30","doi-asserted-by":"crossref","first-page":"3409","DOI":"10.1016\/j.vaccine.2006.12.054","article-title":"The safety and efficacy of the oral rabies vaccine SAG2 in Indian stray dogs","volume":"25","author":"Barrat","year":"2007","journal-title":"Vaccine"},{"key":"31","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/0264-410X(95)00244-U","article-title":"Immunogenicity, efficacy and safety of an oral rabies vaccine (SAG-2) in dogs","volume":"14","author":"Sanderlin","year":"1996","journal-title":"Vaccine"},{"key":"32","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.virusres.2005.03.017","article-title":"Oral vaccination of dogs with recombinant rabies virus vaccines","volume":"111","author":"Dietzschold","year":"2005","journal-title":"Virus research"},{"key":"33","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.virol.2006.07.037","article-title":"A single immunization with a recombinant canine adenovirus expressing the rabies virus G protein confers protective immunity against rabies in mice","volume":"356","author":"Dietzschold","year":"2006","journal-title":"Virology"},{"key":"34","doi-asserted-by":"crossref","first-page":"2191","DOI":"10.1099\/0022-1317-82-9-2191","article-title":"Immunogenicity of an E1-deleted recombinant human adenovirus against rabies by different routes of administration","volume":"82","author":"Hughes","year":"2001","journal-title":"The Journal of general virology"},{"key":"35","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.vaccine.2007.11.029","article-title":"Oral vaccination of dogs (Canis familiaris) with baits containing the recombinant rabies-canine adenovirus type-2 vaccine confers long-lasting immunity against rabies","volume":"26","author":"Hu","year":"2008","journal-title":"Vaccine"},{"key":"36","doi-asserted-by":"crossref","first-page":"1618","DOI":"10.1128\/JVI.02470-12","article-title":"A new rabies vaccine based on a recombinant ORF virus (parapoxvirus) expressing the rabies virus glycoprotein","volume":"87","author":"Rziha","year":"2013","journal-title":"Journal of virology"},{"key":"37","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1016\/j.vaccine.2007.12.050","article-title":"A recombinant pseudorabies virus expressing rabies virus glycoprotein: safety and immunogenicity in dogs","volume":"26","author":"Hu","year":"2008","journal-title":"Vaccine"},{"key":"38","doi-asserted-by":"crossref","first-page":"e63384","DOI":"10.1371\/journal.pone.0063384","article-title":"Recombinant rabies viruses expressing GM-CSF or flagellin are effective vaccines for both intramuscular and oral immunizations","volume":"8","author":"Fu","year":"2013","journal-title":"PloS one"},{"key":"39","doi-asserted-by":"crossref","first-page":"1634","DOI":"10.1128\/JVI.01552-10","article-title":"Rabies virus expressing dendritic cell-activating molecules enhances the innate and adaptive immune response to vaccination","volume":"85","author":"Fu","year":"2011","journal-title":"Journal of virology"},{"key":"40","doi-asserted-by":"crossref","first-page":"9642","DOI":"10.1128\/JVI.00326-10","article-title":"Expression of MIP-1alpha (CCL3) by a recombinant rabies virus enhances its immunogenicity by inducing innate immunity and recruiting dendritic cells and B cells","volume":"84","author":"Fu","year":"2010","journal-title":"Journal of virology"},{"key":"41","doi-asserted-by":"crossref","first-page":"11808","DOI":"10.1128\/JVI.01346-09","article-title":"The roles of chemokines in rabies virus infection: overexpression may not always be beneficial","volume":"83","author":"Fu","year":"2009","journal-title":"Journal of virology"},{"key":"42","doi-asserted-by":"crossref","first-page":"14141","DOI":"10.1128\/JVI.79.22.14141-14148.2005","article-title":"A single amino acid change in rabies virus glycoprotein increases virus spread and enhances virus pathogenicity","volume":"79","author":"Schnell","year":"2005","journal-title":"Journal of virology"},{"key":"43","doi-asserted-by":"crossref","first-page":"4872","DOI":"10.1073\/pnas.86.13.4872","article-title":"Identification of critical regions in mouse granulocyte-macrophage colony-stimulating factor by scanning-deletion analysis","volume":"86","author":"Kastelein","year":"1989","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"44","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.molimm.2012.04.009","article-title":"The regulation of the development and function of dendritic cell subsets by GM-CSF: more than a hematopoietic growth factor","volume":"52","author":"Lew","year":"2012","journal-title":"Molecular immunology"},{"key":"45","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.virol.2012.01.025","article-title":"A role for granulocyte-macrophage colony-stimulating factor in the regulation of CD8(+) T cell responses to rabies virus","volume":"426","author":"Schnell","year":"2012","journal-title":"Virology"},{"key":"46","doi-asserted-by":"crossref","first-page":"15043","DOI":"10.1128\/JVI.79.24.15043-15053.2005","article-title":"A vesicular stomatitis virus recombinant expressing granulocyte-macrophage colony-stimulating factor induces enhanced T-cell responses and is highly attenuated for replication in animals","volume":"79","author":"Rose","year":"2005","journal-title":"Journal of virology"},{"key":"47","doi-asserted-by":"crossref","first-page":"8978","DOI":"10.1200\/JCO.2005.01.6816","article-title":"Immunogenicity, including vitiligo, and feasibility of vaccination with autologous GM-CSF-transduced tumor cells in metastatic melanoma patients","volume":"23","author":"de Gast","year":"2005","journal-title":"Journal of clinical oncology : official journal of the American Society of Clinical Oncology"},{"key":"48","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1200\/JCO.2001.19.1.145","article-title":"Novel allogeneic granulocyte-macrophage colony-stimulating factor-secreting tumor vaccine for pancreatic cancer: a phase I trial of safety and immune activation","volume":"19","author":"Yeo","year":"2001","journal-title":"Journal of clinical oncology : official journal of the American Society of Clinical Oncology"},{"key":"49","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1006\/cyto.2000.0684","article-title":"Comparative studies of the effects of recombinant GM-CSF and GM-CSF administered via a poxvirus to enhance the concentration of antigen-presenting cells in regional lymph nodes","volume":"12","author":"Greiner","year":"2000","journal-title":"Cytokine"},{"key":"50","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1038\/sj.cgt.7700066","article-title":"Intratumoral recombinant GM-CSF-encoding virus as gene therapy in patients with cutaneous melanoma","volume":"6","author":"Lattime","year":"1999","journal-title":"Cancer gene therapy"},{"key":"51","doi-asserted-by":"crossref","first-page":"3539","DOI":"10.1073\/pnas.90.8.3539","article-title":"Vaccination with irradiated tumor cells engineered to secrete murine granulocyte-macrophage colony-stimulating factor stimulates potent, specific, and long-lasting anti-tumor immunity","volume":"90","author":"Mulligan","year":"1993","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"52","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1186\/s12985-014-0201-4","article-title":"Construction andevaluation of a recombinant live attenuated PRRSV expressing GM-CSF","volume":"11","author":"Tong","year":"2014","journal-title":"Virology journal"},{"key":"53","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1023\/A:1023427228024","article-title":"Immunological and regulatory functions of uninfected and virus infected immature and mature subtypes of dendritic cells--a review","volume":"26","author":"Becker","year":"2003","journal-title":"Virus genes"},{"key":"54","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1038\/32588","article-title":"Dendritic cells and the control of immunity","volume":"392","author":"Steinman","year":"1998","journal-title":"Nature"},{"key":"55","first-page":"233","article-title":"Studies on an inactivated vaccine against rabies virus in domestic animals","volume":"125","author":"Lelli","year":"2006","journal-title":"Developments in biologicals"},{"key":"56","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1038\/322373a0","article-title":"Oral vaccination of the fox against rabies using a live recombinant vaccinia virus","volume":"322","author":"Desmettre","year":"1986","journal-title":"Nature"},{"key":"57","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.cyto.2012.04.016","article-title":"Tonsil-derived mesenchymal progenitor cells acquire a follicular dendritic cell phenotype under cytokine stimulation","volume":"59","author":"Woo","year":"2012","journal-title":"Cytokine"},{"key":"58","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1017\/S0950268811001348","article-title":"An outbreak of sheep rabies in Shanxi province, China","volume":"139","author":"Tu","year":"2011","journal-title":"Epidemiology and infection"},{"key":"59","first-page":"493","article-title":"A simple method of estimating fifty percent end points","volume":"27","author":"Muench","year":"1938","journal-title":"Am J Hyg"}],"container-title":["Oncotarget"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.5904","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,11]],"date-time":"2024-06-11T15:14:48Z","timestamp":1718118888000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.5904"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9,30]]},"references-count":59,"journal-issue":{"issue":"36","published-print":{"date-parts":[[2015,11,17]]}},"alternative-id":["5904","26436700"],"URL":"https:\/\/doi.org\/10.18632\/oncotarget.5904","relation":{},"ISSN":["1949-2553"],"issn-type":[{"value":"1949-2553","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,9,30]]}}}