{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T22:00:23Z","timestamp":1792706423720,"version":"4.5.0"},"reference-count":53,"publisher":"Impact Journals, LLC","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncotarget"],"published-print":{"date-parts":[[2016,1,5]]},"DOI":"10.18632\/oncotarget.6412","type":"journal-article","created":{"date-parts":[[2015,11,27]],"date-time":"2015-11-27T15:40:49Z","timestamp":1448638849000},"page":"712-728","source":"Crossref","is-referenced-by-count":12,"title":["Peritoneal and hematogenous metastases of ovarian cancer cells are both controlled by the p90RSK through a self-reinforcing cell autonomous mechanism"],"prefix":"10.18632","volume":"7","author":[{"given":"Erica","family":"Torchiaro","sequence":"first","affiliation":[{"name":"Department of Oncology, University of Torino School of Medicine, Turin, Italy"},{"name":"Candiolo Cancer Institute, Fondazione del Piemonte per l'Oncologia (FPO)-Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Candiolo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annalisa","family":"Lorenzato","sequence":"additional","affiliation":[{"name":"Department of Oncology, University of Torino School of Medicine, Turin, Italy"},{"name":"Candiolo Cancer Institute, Fondazione del Piemonte per l'Oncologia (FPO)-Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Candiolo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Olivero","sequence":"additional","affiliation":[{"name":"Department of Oncology, University of Torino School of Medicine, Turin, Italy"},{"name":"Candiolo Cancer Institute, Fondazione del Piemonte per l'Oncologia (FPO)-Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Candiolo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donatella","family":"Valdembri","sequence":"additional","affiliation":[{"name":"Department of Oncology, University of Torino School of Medicine, Turin, Italy"},{"name":"Candiolo Cancer Institute, Fondazione del Piemonte per l'Oncologia (FPO)-Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Candiolo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo Armando","family":"Gagliardi","sequence":"additional","affiliation":[{"name":"Department of Oncology, University of Torino School of Medicine, Turin, Italy"},{"name":"Candiolo Cancer Institute, Fondazione del Piemonte per l'Oncologia (FPO)-Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Candiolo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Gai","sequence":"additional","affiliation":[{"name":"Department of Molecular Biotechnologies and Health Sciences, University of Turin at the Molecular Biotechnology Center, Torino, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Erriquez","sequence":"additional","affiliation":[{"name":"Candiolo Cancer Institute, Fondazione del Piemonte per l'Oncologia (FPO)-Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Candiolo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guido","family":"Serini","sequence":"additional","affiliation":[{"name":"Department of Oncology, University of Torino School of Medicine, Turin, Italy"},{"name":"Candiolo Cancer Institute, Fondazione del Piemonte per l'Oncologia (FPO)-Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Candiolo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Flavia","family":"Di Renzo","sequence":"additional","affiliation":[{"name":"Department of Oncology, University of Torino School of Medicine, Turin, Italy"},{"name":"Candiolo Cancer Institute, Fondazione del Piemonte per l'Oncologia (FPO)-Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Candiolo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7892","published-online":{"date-parts":[[2015,11,26]]},"reference":[{"key":"1","doi-asserted-by":"crossref","first-page":"2519","DOI":"10.1056\/NEJMra041842","article-title":"Cancer of the ovary","volume":"351","author":"Cannistra","year":"2004","journal-title":"N Engl J Med"},{"key":"2","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.ccr.2014.05.002","article-title":"Hematogenous metastasis of ovarian cancer: rethinking mode of spread","volume":"26","author":"Nick","year":"2014","journal-title":"Cancer Cell"},{"key":"3","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1038\/nm.2492","article-title":"Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth","volume":"17","author":"Lengyel","year":"2011","journal-title":"Nat Med"},{"key":"4","doi-asserted-by":"crossref","first-page":"6099","DOI":"10.1158\/0008-5472.CAN-13-1087","article-title":"RSK isoforms in cancer cell invasion and metastasis","volume":"73","author":"Ramos","year":"2013","journal-title":"Cancer Res"},{"key":"5","doi-asserted-by":"crossref","first-page":"2654","DOI":"10.1101\/gad.1989110","article-title":"A genome-wide RNAi screen identifies multiple RSK-dependent regulators of cell migration","volume":"24","author":"Haber","year":"2010","journal-title":"Genes Dev"},{"key":"6","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1016\/j.ajpath.2014.11.021","article-title":"RSK1 Activation Promotes Invasion in Nodular Melanoma","volume":"185","author":"Osman","year":"2015","journal-title":"Am J Pathol"},{"key":"7","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/j.molcel.2009.08.002","article-title":"RSK is a principal effector of the RAS-ERK pathway for eliciting a coordinate promotile\/invasive gene program and phenotype in epithelial cells","volume":"35","author":"Fr\u00f6din","year":"2009","journal-title":"Mol Cell"},{"key":"8","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1172\/JCI40582","article-title":"p90 ribosomal S6 kinase 2 promotes invasion and metastasis of human head and neck squamous cell carcinoma cells","volume":"120","author":"Chen","year":"2010","journal-title":"J Clin Invest"},{"key":"9","doi-asserted-by":"crossref","first-page":"32528","DOI":"10.1074\/jbc.M113.500561","article-title":"The prometastatic ribosomal S6 kinase 2-cAMP response element-binding protein (RSK2-CREB) signaling pathway up-regulates the actin-binding protein fascin-1 to promote tumor metastasis","volume":"288","author":"Kang","year":"2013","journal-title":"J Biol Chem"},{"key":"10","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1038\/nrm2509","article-title":"The RSK family of kinases: emerging roles in cellular signalling","volume":"9","author":"Blenis","year":"2008","journal-title":"Nat Rev Mol Cell Biol"},{"key":"11","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1042\/BJ20110289","article-title":"Regulation and function of the RSK family of protein kinases","volume":"441","author":"Roux","year":"2012","journal-title":"Biochem J"},{"key":"12","doi-asserted-by":"crossref","first-page":"5301","DOI":"10.1158\/0008-5472.CAN-12-4448","article-title":"The p90 RSK family members: common functions and isoform specificity","volume":"73","author":"Pardo","year":"2013","journal-title":"Cancer Res"},{"key":"13","doi-asserted-by":"crossref","first-page":"3108","DOI":"10.1158\/0008-5472.CAN-04-3151","article-title":"The serine\/threonine protein kinase, p90 ribosomal S6 kinase, is an important regulator of prostate cancer cell proliferation","volume":"65","author":"Lannigan","year":"2005","journal-title":"Cancer Res"},{"key":"14","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1158\/0008-5472.1027.65.3","article-title":"Identification of the first specific inhibitor of p90 ribosomal S6 kinase (RSK) reveals an unexpected role for RSK in cancer cell proliferation","volume":"65","author":"Lannigan","year":"2005","journal-title":"Cancer Res"},{"key":"15","doi-asserted-by":"crossref","first-page":"2846","DOI":"10.1038\/onc.2013.259","article-title":"Self-reinforcing loop of amphiregulin and Y-box binding protein-1 contributes to poor outcomes in ovarian cancer","volume":"33","author":"Mills","year":"2014","journal-title":"Oncogene"},{"key":"16","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1038\/nature11003","article-title":"The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity","volume":"483","author":"Murray","year":"2012","journal-title":"Nature"},{"key":"17","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1038\/nrc779","article-title":"Scatter-factor and semaphorin receptors: cell signalling for invasive growth","volume":"2","author":"Comoglio","year":"2002","journal-title":"Nature Rev Cancer"},{"key":"18","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1038\/nrm1261","article-title":"Met, metastasis, motility and more","volume":"4","author":"Vande Woude","year":"2003","journal-title":"Nat Rev Mol Cell Biol"},{"key":"19","doi-asserted-by":"crossref","first-page":"2329","DOI":"10.1158\/0008-5472.CAN-07-5167","article-title":"Loss of E-cadherin promotes ovarian cancer metastasis via alpha 5-integrin, which is a therapeutic target","volume":"68","author":"Lengyel","year":"2008","journal-title":"Cancer Res"},{"key":"20","doi-asserted-by":"crossref","first-page":"2184","DOI":"10.2353\/ajpath.2009.090028","article-title":"{beta}3-integrin expression on tumor cells inhibits tumor progression, reduces metastasis, and is associated with a favorable prognosis in patients with ovarian cancer","volume":"175","author":"Lengyel","year":"2009","journal-title":"Am J Pathol"},{"key":"21","doi-asserted-by":"crossref","first-page":"6071","DOI":"10.1158\/0008-5472.CAN-09-4442","article-title":"Transiently entrapped circulating tumor cells interact with neutrophils to facilitate lung metastasis development","volume":"70","author":"Robertson","year":"2010","journal-title":"Cancer Res"},{"key":"22","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.ygyno.2010.12.355","article-title":"Increased circulating hepatocyte growth factor (HGF): a marker of epithelial ovarian cancer and an indicator of poor prognosis","volume":"121","author":"Syversen","year":"2011","journal-title":"Gynecol Oncol"},{"key":"23","doi-asserted-by":"crossref","first-page":"4614","DOI":"10.1172\/JCI74778","article-title":"Mesothelial cells promote early ovarian cancer metastasis through fibronectin secretion","volume":"124","author":"Lengyel","year":"2014","journal-title":"J Clin Invest"},{"key":"24","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.ccr.2013.08.012","article-title":"An integrin-linked machinery of cytoskeletal regulation that enables experimental tumor initiation and metastatic colonization","volume":"24","author":"Weinberg","year":"2013","journal-title":"Cancer Cell"},{"key":"25","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/0014-5793(87)80160-6","article-title":"Localization of the cellular-fibronectin-specific epitope recognized by the monoclonal antibody IST-9 using fusion proteins expressed in E. coli","volume":"215","author":"Baralle","year":"1987","journal-title":"FEBS Lett"},{"key":"26","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1242\/jcs.01623","article-title":"A specific alpha5beta1-integrin conformation promotes directional integrin translocation and fibronectin matrix formation","volume":"118","author":"Humphries","year":"2005","journal-title":"J Cell Sci"},{"key":"27","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1083\/jcb.200907174","article-title":"Focal adhesions are sites of integrin extension","volume":"188","author":"Humphries","year":"2010","journal-title":"J Cell Biol"},{"key":"28","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0092-8674(87)90146-2","article-title":"Cell adhesion protein receptors as targets for transforming growth factor-beta action","volume":"51","author":"Massagu\u00e9","year":"1987","journal-title":"Cell"},{"key":"29","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1093\/emboj\/18.5.1345","article-title":"TGF-beta induces fibronectin synthesis through a c-Jun N-terminal kinase-dependent, Smad4-independent pathway","volume":"18","author":"Howe","year":"1999","journal-title":"EMBO J"},{"key":"30","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1242\/jcs.060905","article-title":"Pericellular fibronectin is required for RhoA-dependent responses to cyclic strain in fibroblasts","volume":"123","author":"Chiquet","year":"2010","journal-title":"J Cell Sci"},{"key":"31","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.ccr.2009.03.017","article-title":"Translational activation of snail1 and other developmentally regulated transcription factors by YB-1 promotes an epithelial-mesenchymal transition","volume":"15","author":"Sorensen","year":"2009","journal-title":"Cancer Cell"},{"key":"32","doi-asserted-by":"crossref","first-page":"R99","DOI":"10.1186\/bcr2202","article-title":"Y-box binding protein-1 serine 102 is a downstream target of p90 ribosomal S6 kinase in basal-like breast cancer cells","volume":"10","author":"Dunn","year":"2008","journal-title":"Breast Cancer Res"},{"key":"33","doi-asserted-by":"crossref","first-page":"4434","DOI":"10.1038\/onc.2011.617","article-title":"MKNK1 is a YB-1 target gene responsible for imparting trastuzumab resistance and can be blocked by RSK inhibition","volume":"31","author":"Dunn","year":"2012","journal-title":"Oncogene"},{"key":"34","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1038\/sj.ki.5002719","article-title":"Y-box protein-1 controls transforming growth factor-beta1 translation in proximal tubular cells","volume":"73","author":"Mertens","year":"2008","journal-title":"Kidney Int"},{"key":"35","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/j.ccr.2005.05.014","article-title":"Mutant PIK3CA promotes cell growth and invasion of human cancer cells","volume":"7","author":"Velculescu","year":"2005","journal-title":"Cancer Cell"},{"key":"36","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1007\/978-0-387-98094-2_16","article-title":"Organotypic models of metastasis: A three-dimensional culture mimicking the human peritoneum and omentum for the study of the early steps of ovarian cancer metastasis","volume":"149","author":"Lengyel","year":"2009","journal-title":"Cancer Treat Res"},{"key":"37","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1158\/2159-8274.CD-11-0010","article-title":"Ovarian cancer spheroids use myosin-generated force to clear the mesothelium","volume":"1","author":"Brugge","year":"2011","journal-title":"Cancer Discov"},{"key":"38","doi-asserted-by":"crossref","first-page":"1798","DOI":"10.1096\/fj.05-4134com","article-title":"Fibronectin is required for integrin alphavbeta6-mediated activation of latent TGF-beta complexes containing LTBP-1","volume":"19","author":"Rifkin","year":"2005","journal-title":"FASEB J"},{"key":"39","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1002\/path.4104","article-title":"The myofibroblast matrix: implications for tissue repair and fibrosis","volume":"229","author":"White","year":"2013","journal-title":"J Pathol"},{"key":"40","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1083\/jcb.201402006","article-title":"Prestress in the extracellular matrix sensitizes latent TGF-\u03b21 for activation","volume":"207","author":"Hinz","year":"2014","journal-title":"J Cell Biol"},{"key":"41","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0065-230X(08)60772-1","article-title":"Fibronectin and its integrin receptors in cancer","volume":"76","author":"Ruoslahti","year":"1999","journal-title":"Adv Cancer Res"},{"key":"42","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1006\/excr.1996.0045","article-title":"Fibronectin fibrils and growth factors stimulate anchorage-independent growth of a murine mammary carcinoma","volume":"222","author":"Elliott","year":"1996","journal-title":"Exp Cell Res"},{"key":"43","doi-asserted-by":"crossref","first-page":"4337","DOI":"10.1016\/S0021-9258(17)35666-1","article-title":"Transforming growth factor-beta stimulates the expression of fibronectin and collagen and their incorporation into the extracellular matrix","volume":"261","author":"Massagu\u00e9","year":"1986","journal-title":"J Biol Chem"},{"key":"44","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1016\/j.ccell.2015.04.003","article-title":"Translational Activation of HIF1\u03b1 by YB-1 Promotes Sarcoma Metastasis","volume":"27","author":"LePard","year":"2015","journal-title":"Cancer Cell"},{"key":"45","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1093\/jnci\/djt210","article-title":"Role of focal adhesion kinase in regulating YB-1-mediated paclitaxel resistance in ovarian cancer","volume":"105","author":"Sood","year":"2013","journal-title":"J Natl Cancer Inst"},{"key":"46","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1042\/BJ20070797","article-title":"The selectivity of protein kinase inhibitors: a further update","volume":"408","author":"Cohen","year":"2007","journal-title":"Biochem J"},{"key":"47","doi-asserted-by":"crossref","first-page":"329","DOI":"10.18632\/oncotarget.834","article-title":"Luteolin is a novel p90 ribosomal S6 kinase (RSK) inhibitor that suppresses Notch4 signaling by blocking the activation of Y-box binding protein-1 (YB-1)","volume":"4","author":"Dunn","year":"2013","journal-title":"Oncotarget"},{"key":"48","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1083\/jcb.200501027","article-title":"p90Rsk is not involved in cytostatic factor arrest in mouse oocytes","volume":"169","author":"Verlhac","year":"2005","journal-title":"J Cell Biol"},{"key":"49","doi-asserted-by":"crossref","first-page":"2191","DOI":"10.1158\/1078-0432.CCR-06-1915","article-title":"The therapeutic potential of hepatocyte growth factor to sensitize ovarian cancer cells to cisplatin and paclitaxel","volume":"13","author":"Di Renzo","year":"2007","journal-title":"Clin Cancer Res"},{"key":"50","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1002\/ijc.23209","article-title":"A cancer-predisposing \u201chot spot\u201d mutation of the fumarase gene creates a dominant negative protein","volume":"122","author":"Di Renzo","year":"2008","journal-title":"Int J Cancer"},{"key":"51","doi-asserted-by":"crossref","first-page":"4055","DOI":"10.1096\/fj.13-247924","article-title":"Heat-shock protein 27 (HSP27, HSPB1) is up-regulated by MET kinase inhibitors and confers resistance to MET-targeted therapy","volume":"28","author":"Di Renzo","year":"2014","journal-title":"FASEB J"},{"key":"52","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1042\/BJ20121323","article-title":"YB-1: oncoprotein, prognostic marker and therapeutic target?","volume":"449","author":"Braithwaite","year":"2013","journal-title":"Biochem J"},{"key":"53","first-page":"7025","article-title":"Novel somatic mutations of the MET oncogene in human carcinoma metastases activating cell motility and invasion","volume":"62","author":"Di Renzo","year":"2002","journal-title":"Cancer Res"}],"container-title":["Oncotarget"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.6412","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,16]],"date-time":"2023-08-16T00:21:06Z","timestamp":1692145266000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.6412"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,11,26]]},"references-count":53,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,1,5]]}},"alternative-id":["6412","26625210"],"URL":"https:\/\/doi.org\/10.18632\/oncotarget.6412","relation":{},"ISSN":["1949-2553"],"issn-type":[{"value":"1949-2553","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,11,26]]}}}