{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T13:36:06Z","timestamp":1790516166192,"version":"4.1.0"},"reference-count":44,"publisher":"Impact Journals, LLC","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncotarget"],"published-print":{"date-parts":[[2016,1,19]]},"DOI":"10.18632\/oncotarget.6465","type":"journal-article","created":{"date-parts":[[2015,12,5]],"date-time":"2015-12-05T02:54:09Z","timestamp":1449284049000},"page":"2809-2822","source":"Crossref","is-referenced-by-count":86,"title":["Ulocuplumab (BMS-936564 \/ MDX1338): a fully human anti-CXCR4 antibody induces cell death in chronic lymphocytic leukemia mediated through a reactive oxygen species-dependent pathway"],"prefix":"10.18632","volume":"7","author":[{"given":"Manoj K.","family":"Kashyap","sequence":"first","affiliation":[{"name":"UCSD-Moores Cancer Center, La Jolla, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepak","family":"Kumar","sequence":"additional","affiliation":[{"name":"UCSD-Moores Cancer Center, La Jolla, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harrison","family":"Jones","sequence":"additional","affiliation":[{"name":"UCSD-Moores Cancer Center, La Jolla, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos I.","family":"Amaya-Chanaga","sequence":"additional","affiliation":[{"name":"UCSD-Moores Cancer Center, La Jolla, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael Y.","family":"Choi","sequence":"additional","affiliation":[{"name":"UCSD-Moores Cancer Center, La Jolla, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanna","family":"Melo-Cardenas","sequence":"additional","affiliation":[{"name":"UCSD-Moores Cancer Center, La Jolla, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amine","family":"Ale-Ali","sequence":"additional","affiliation":[{"name":"UCSD-Moores Cancer Center, La Jolla, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle R.","family":"Kuhne","sequence":"additional","affiliation":[{"name":"Bristol-Myers Squibb, Department of Cell Biology and Physiology, Redwood City, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Sabbatini","sequence":"additional","affiliation":[{"name":"Department of Early Clinical and Translational Research, Bristol-Myers Squibb, Princeton, NJ, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lewis J.","family":"Cohen","sequence":"additional","affiliation":[{"name":"Department of Early Clinical and Translational Research, Bristol-Myers Squibb, Princeton, NJ, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suresh G.","family":"Shelat","sequence":"additional","affiliation":[{"name":"Department of Early Clinical and Translational Research, Bristol-Myers Squibb, Princeton, NJ, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura Z.","family":"Rassenti","sequence":"additional","affiliation":[{"name":"CLL Research Consortium, La Jolla, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas J.","family":"Kipps","sequence":"additional","affiliation":[{"name":"UCSD-Moores Cancer Center, La Jolla, CA, USA"},{"name":"CLL Research Consortium, La Jolla, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pina M.","family":"Cardarelli","sequence":"additional","affiliation":[{"name":"Bristol-Myers Squibb, Department of Cell Biology and Physiology, Redwood City, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Januario E.","family":"Castro","sequence":"additional","affiliation":[{"name":"UCSD-Moores Cancer Center, La Jolla, CA, USA"},{"name":"CLL Research Consortium, La Jolla, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7892","published-online":{"date-parts":[[2015,12,4]]},"reference":[{"key":"1","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1056\/NEJMra041720","article-title":"Chronic lymphocytic leukemia","volume":"352","author":"Ferrarini","year":"2005","journal-title":"N Engl J Med"},{"key":"2","doi-asserted-by":"crossref","first-page":"D767","DOI":"10.1093\/nar\/gkn892","article-title":"Human Protein Reference Database--2009 update","volume":"37","author":"Pandey","year":"2009","journal-title":"Nucleic acids research"},{"key":"3","doi-asserted-by":"crossref","first-page":"5215","DOI":"10.1073\/pnas.96.9.5215","article-title":"Quantification of CD4, CCR5, and CXCR4 levels on lymphocyte subsets, dendritic cells, and differentially conditioned monocyte-derived macrophages","volume":"96","author":"Doms","year":"1999","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"4","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1034\/j.1600-065X.2000.17715.x","article-title":"CXCR4: chemokine receptor extraordinaire","volume":"177","author":"Murdoch","year":"2000","journal-title":"Immunological reviews"},{"key":"5","doi-asserted-by":"crossref","first-page":"2927","DOI":"10.1158\/1078-0432.CCR-09-2329","article-title":"CXCL12 (SDF-1)\/CXCR4 pathway in cancer","volume":"16","author":"Fricker","year":"2010","journal-title":"Clinical cancer research"},{"key":"6","doi-asserted-by":"crossref","first-page":"1824","DOI":"10.1182\/blood-2004-12-4918","article-title":"Small peptide inhibitors of the CXCR4 chemokine receptor (CD184) antagonize the activation, migration, and antiapoptotic responses of CXCL12 in chronic lymphocytic leukemia B cells","volume":"106","author":"Burger","year":"2005","journal-title":"Blood"},{"key":"7","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.semcancer.2003.10.003","article-title":"The significance of cancer cell expression of the chemokine receptor CXCR4","volume":"14","author":"Balkwill","year":"2004","journal-title":"Seminars in cancer biology"},{"key":"8","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1111\/j.1365-2141.2007.06590.x","article-title":"The CXCR4 chemokine receptor in acute and chronic leukaemia: a marrow homing receptor and potential therapeutic target","volume":"137","author":"Burkle","year":"2007","journal-title":"British journal of haematology"},{"key":"9","doi-asserted-by":"crossref","first-page":"2655","DOI":"10.1182\/blood.V96.8.2655","article-title":"Blood-derived nurse-like cells protect chronic lymphocytic leukemia B cells from spontaneous apoptosis through stromal cell-derived factor-1","volume":"96","author":"Kipps","year":"2000","journal-title":"Blood"},{"key":"10","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1182\/blood-2004-03-0889","article-title":"Nurselike cells express BAFF and APRIL, which can promote survival of chronic lymphocytic leukemia cells via a paracrine pathway distinct from that of SDF-1alpha","volume":"106","author":"Kipps","year":"2005","journal-title":"Blood"},{"key":"11","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1046\/j.1365-2141.1996.00305.x","article-title":"Human bone marrow stromal cells prevent apoptosis and support the survival of chronic lymphocytic leukaemia cells in vitro","volume":"92","author":"Hoffbrand","year":"1996","journal-title":"Br J Haematol"},{"key":"12","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.3324\/haematol.12553","article-title":"Factors that influence short-term homing of human bone marrow-derived mesenchymal stem cells in a xenogeneic animal model","volume":"93","author":"Yong","year":"2008","journal-title":"Haematologica"},{"key":"13","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1038\/ncb1838","article-title":"Intercellular transfer to signalling endosomes regulates an ex vivo bone marrow niche","volume":"11","author":"Lippincott-Schwartz","year":"2009","journal-title":"Nature cell biology"},{"key":"14","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.3324\/haematol.2009.017178","article-title":"Bone marrow mesenchymal stromal cells non-selectively protect chronic myeloid leukemia cells from imatinib-induced apoptosis via the CXCR4\/CXCL12 axis","volume":"95","author":"Dazzi","year":"2010","journal-title":"Haematologica"},{"key":"15","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1089\/hyb.2008.0069","article-title":"Characterization and application of two novel monoclonal antibodies against human CXCR4: cell proliferation and migration regulation for glioma cell line in vitro by CXCR4\/SDF-1alpha signal","volume":"28","author":"Zhang","year":"2009","journal-title":"Hybridoma"},{"key":"16","doi-asserted-by":"crossref","first-page":"8957","DOI":"10.1128\/JVI.75.19.8957-8967.2001","article-title":"Antigenically distinct conformations of CXCR4","volume":"75","author":"Doms","year":"2001","journal-title":"J Virol"},{"key":"17","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1158\/1078-0432.CCR-12-2333","article-title":"BMS-936564\/MDX-1338: a fully human anti-CXCR4 antibody induces apoptosis in vitro and shows antitumor activity in vivo in hematologic malignancies","volume":"19","author":"Cardarelli","year":"2013","journal-title":"Clin Cancer Res"},{"key":"18","doi-asserted-by":"crossref","first-page":"2322","DOI":"10.1038\/leu.2013.266","article-title":"The novel CXCR4 antagonist POL5551 mobilizes hematopoietic stem and progenitor cells with greater efficiency than Plerixafor","volume":"27","author":"Bonig","year":"2013","journal-title":"Leukemia"},{"key":"19","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.4049\/jimmunol.160.3.1522","article-title":"Intracellular and surface expression of the HIV-1 coreceptor CXCR4\/fusin on various leukocyte subsets: rapid internalization and recycling upon activation","volume":"160","author":"Lipp","year":"1998","journal-title":"J Immunol"},{"key":"20","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0076-6879(09)05203-3","article-title":"CXCR4 and mobilization of hematopoietic precursors","volume":"460","author":"DiPersio","year":"2009","journal-title":"Methods Enzymol"},{"key":"21","doi-asserted-by":"crossref","first-page":"3917","DOI":"10.1182\/blood-2011-10-383406","article-title":"A phase 1\/2 study of chemosensitization with the CXCR4 antagonist plerixafor in relapsed or refractory acute myeloid leukemia","volume":"119","author":"DiPersio","year":"2012","journal-title":"Blood"},{"key":"22","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1182\/blood-2003-09-3236","article-title":"Fludarabine treatment of patients with chronic lymphocytic leukemia induces a p53-dependent gene expression response","volume":"104","author":"Staudt","year":"2004","journal-title":"Blood"},{"key":"23","doi-asserted-by":"crossref","first-page":"3523","DOI":"10.1182\/blood-2011-12-395541","article-title":"Antibody-induced nonapoptotic cell death in human lymphoma and leukemia cells is mediated through a novel reactive oxygen species-dependent pathway","volume":"119","author":"Illidge","year":"2012","journal-title":"Blood"},{"key":"24","first-page":"253","article-title":"Tiron, a ROS scavenger, protects human lung cancer Calu-6 cells against antimycin A-induced cell death","volume":"21","author":"Park","year":"2009","journal-title":"Oncol Rep"},{"key":"25","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.taap.2009.05.020","article-title":"N,N-dimethyl phytosphingosine induces caspase-8-dependent cytochrome c release and apoptosis through ROS generation in human leukemia cells","volume":"239","author":"Hong","year":"2009","journal-title":"Toxicol Appl Pharmacol"},{"key":"26","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/j.pharmthera.2014.07.003","article-title":"Microenvironment dependency in Chronic Lymphocytic Leukemia: The basis for new targeted therapies","volume":"144","author":"Burger","year":"2014","journal-title":"Pharmacol Ther"},{"key":"27","doi-asserted-by":"crossref","first-page":"594","DOI":"10.4161\/mabs.2.6.13420","article-title":"Therapeutic antibodies directed at G protein-coupled receptors","volume":"2","author":"Marshall","year":"2010","journal-title":"mAbs"},{"key":"28","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1182\/asheducation-2011.1.96","article-title":"Nurture versus nature: the microenvironment in chronic lymphocytic leukemia","volume":"2011","author":"Burger","year":"2011","journal-title":"Hematology Am Soc Hematol Educ Program"},{"key":"29","first-page":"4190","article-title":"BMS-936564 (Anti-CXCR4 Antibody) Induces Specific Leukemia Cell Mobilization and Objective Clinical Responses In CLL Patients Treated Under a Phase I Clinical Trial","volume":"21","author":"Castro","year":"2013","journal-title":"Blood"},{"key":"30","doi-asserted-by":"crossref","first-page":"318","DOI":"10.4065\/79.3.318","article-title":"Expression of the chemokine receptors CXCR4 and CCR7 and disease progression in B-cell chronic lymphocytic leukemia\/ small lymphocytic lymphoma","volume":"79","author":"Ansell","year":"2004","journal-title":"Mayo Clin Proc"},{"key":"31","doi-asserted-by":"crossref","first-page":"3658","DOI":"10.1182\/blood.V94.11.3658","article-title":"Chronic lymphocytic leukemia B cells express functional CXCR4 chemokine receptors that mediate spontaneous migration beneath bone marrow stromal cells","volume":"94","author":"Kipps","year":"1999","journal-title":"Blood"},{"key":"32","doi-asserted-by":"crossref","first-page":"1954","DOI":"10.1038\/sj.leu.2401602","article-title":"Overexpression of the chemokine receptor CXCR4 in B cell chronic lymphocytic leukemia is associated with increased functional response to stromal cell-derived factor-1 (SDF-1)","volume":"13","author":"Kanz","year":"1999","journal-title":"Leukemia"},{"key":"33","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1177\/107327481201900105","article-title":"Treatment of relapsed or refractory chronic lymphocytic leukemia","volume":"19","author":"Pinilla-Ibarz","year":"2012","journal-title":"Cancer Control"},{"key":"34","first-page":"122","article-title":"Extended exposure to the CXCR4 inhibitor plerixafor may lead to enhanced microenvironment interactions in acute lymphoblastic leukemia (ALL)","author":"Brown","year":"2013","journal-title":"Blood"},{"key":"35","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/S0092-8674(00)81393-8","article-title":"CD4-independent infection by HIV-2 is mediated by fusin\/CXCR4","volume":"87","author":"Hoxie","year":"1996","journal-title":"Cell"},{"key":"36","doi-asserted-by":"crossref","first-page":"608","DOI":"10.3324\/haematol.2011.052779","article-title":"AMD3100 disrupts the cross-talk between chronic lymphocytic leukemia cells and a mesenchymal stromal or nurse-like cell-based microenvironment: pre-clinical evidence for its association with chronic lymphocytic leukemia treatments","volume":"97","author":"Lagneaux","year":"2012","journal-title":"Haematologica"},{"key":"37","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1038\/nm1263","article-title":"Caspase-independent cell death","volume":"11","author":"Martin","year":"2005","journal-title":"Nat Med"},{"key":"38","doi-asserted-by":"crossref","first-page":"6452","DOI":"10.1038\/onc.2008.311","article-title":"Caspase-independent cell death: leaving the set without the final cut","volume":"27","author":"Green","year":"2008","journal-title":"Oncogene"},{"key":"39","first-page":"1640","article-title":"The immunological profile of B-cell disorders and proposal of a scoring system for the diagnosis of CLL","volume":"8","author":"Catovsky","year":"1994","journal-title":"Leukemia"},{"key":"40","doi-asserted-by":"crossref","unstructured":"World Medical Association Declaration of Helsinki: ethical principles for medical research involving human subjects. JAMA. 2000; 284:3043\u20133045.","DOI":"10.1001\/jama.284.23.3043"},{"key":"41","doi-asserted-by":"crossref","first-page":"945","DOI":"10.3324\/haematol.2014.122069","article-title":"Targeting the spliceosome in chronic lymphocytic leukemia with the macrolides FD-895 and pladienolide-B","volume":"100","author":"Castro","year":"2015","journal-title":"Haematologica"},{"key":"42","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.beha.2010.01.001","article-title":"Diagnostic issues in chronic lymphocytic leukaemia (CLL)","volume":"23","author":"Catovsky","year":"2010","journal-title":"Best Pract Res Clin Haematol"},{"key":"43","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1172\/JCI1472","article-title":"Gene transfer of CD40-ligand induces autologous immune recognition of chronic lymphocytic leukemia B cells","volume":"101","author":"Kipps","year":"1998","journal-title":"J Clin Invest"},{"key":"44","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1038\/sj.leu.2404144","article-title":"Thymidine-phosphorothioate oligonucleotides induce activation and apoptosis of CLL cells independently of CpG motifs or BCL-2 gene interference","volume":"20","author":"Kipps","year":"2006","journal-title":"Leukemia"}],"container-title":["Oncotarget"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.6465","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,16]],"date-time":"2023-08-16T02:10:07Z","timestamp":1692151807000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.6465"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12,4]]},"references-count":44,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016,1,19]]}},"alternative-id":["6465","26646452"],"URL":"https:\/\/doi.org\/10.18632\/oncotarget.6465","relation":{},"ISSN":["1949-2553"],"issn-type":[{"value":"1949-2553","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,12,4]]}}}