{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T07:35:34Z","timestamp":1777620934288,"version":"3.51.4"},"reference-count":51,"publisher":"Impact Journals, LLC","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncotarget"],"published-print":{"date-parts":[[2016,2,2]]},"DOI":"10.18632\/oncotarget.6824","type":"journal-article","created":{"date-parts":[[2016,1,7]],"date-time":"2016-01-07T01:34:51Z","timestamp":1452130491000},"page":"5892-5908","source":"Crossref","is-referenced-by-count":28,"title":["Gastro-duodenal fluid induced nuclear factor-<i>\u03baappa<\/i>B activation and early pre-malignant alterations in murine hypopharyngeal mucosa"],"prefix":"10.18632","volume":"7","author":[{"given":"Dimitra P.","family":"Vageli","sequence":"first","affiliation":[{"name":"Department of Surgery, Yale Larynx Laboratory Section of Otolaryngology, Yale School of Medicine, New Haven, CT, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manju L.","family":"Prasad","sequence":"additional","affiliation":[{"name":"Pathology and of Surgery (Otolaryngology), Yale School of Medicine, New Haven, CT, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clarence T.","family":"Sasaki","sequence":"additional","affiliation":[{"name":"Department of Surgery, Yale Larynx Laboratory Section of Otolaryngology, Yale School of Medicine, New Haven, CT, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7892","published-online":{"date-parts":[[2016,1,6]]},"reference":[{"key":"1","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1097\/01.moo.0000193198.40096.be","article-title":"Biliary laryngopharyngeal reflux: a new pathological entity","volume":"14","author":"Paludetti","year":"2006","journal-title":"Curr Opin Otolaryngol Head Neck Surg"},{"key":"2","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1177\/000348940511400304","article-title":"Bile-induced laryngitis: is there a basis in evidence?","volume":"114","author":"Eisen","year":"2005","journal-title":"Ann Otol Rhinol Laryngol"},{"key":"3","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1159\/000327521","article-title":"ORL J Can bile acids be an etiological factor for laryngeal carcinoma?","volume":"73","author":"Uslu","year":"2011","journal-title":"Otorhinolaryngol Relat Spec"},{"key":"4","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1111\/j.1365-2036.2011.04709.x","article-title":"Systematic review: the role of bile acids in the pathogenesis of gastro-oesophageal reflux disease and related neoplasia","volume":"34","author":"Spechler","year":"2011","journal-title":"Aliment Pharmacol Ther"},{"key":"5","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1097\/00000658-199522240-00010","article-title":"Mixed reflux of gastric and duodenal juices is more harmful to the esophagus than gastric juice alone. The need for surgical therapy re-emphasized","volume":"222","author":"Hagen","year":"1995","journal-title":"Ann Surg"},{"key":"6","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1136\/thx.2007.082719","article-title":"Gastro-oesophageal reflux and aspiration in patients with advanced lung disease","volume":"64","author":"Golden","year":"2009","journal-title":"Thorax"},{"key":"7","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1158\/0008-5472.CAN-08-3703","article-title":"Unlike Esophageal Squamous Cells, Barrett's Epithelial Cells Resist Apoptosis by Activating the Nuclear Factor-\u03baB Pathway","volume":"69","author":"Souza","year":"2009","journal-title":"Cancer Res"},{"key":"8","doi-asserted-by":"crossref","first-page":"G278","DOI":"10.1152\/ajpgi.00092.2011","article-title":"Deoxycholic acid causes DNA damage while inducing apoptotic resistance through NF-\u03baB activation in benign Barrett's epithelial cells","volume":"301","author":"Souza","year":"2011","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"9","doi-asserted-by":"crossref","first-page":"G58","DOI":"10.1152\/ajpgi.00438.2012","article-title":"Gastroesophageal reflux activates the NF-\u03baB pathway and impairs esophageal barrier function in mice","volume":"305","author":"Chen","year":"2013","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1002\/ijc.29029","article-title":"Reflux composition influences the level of NF-\u03baB activation and upstream kinase preference in oesophageal adenocarcinoma cells","volume":"136","author":"Jenkins","year":"2015","journal-title":"Int J Cancer"},{"key":"11","first-page":"149","article-title":"Cell culture models for studying the development of Barrett's esophagus: a systematic review","volume":"35","author":"van Baal","year":"2012","journal-title":"Cell Oncol (Dordr)"},{"key":"12","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1038\/nature04870","article-title":"Nuclear factor-kappaB in cancer development and progression","volume":"441","author":"Karin","year":"2006","journal-title":"(Review) Nature"},{"key":"13","doi-asserted-by":"crossref","first-page":"5680","DOI":"10.1158\/1078-0432.CCR-07-0670","article-title":"A novel nuclear factor-kappaB gene signature is differentially expressed in head and neck squamous cell carcinomas in association with TP53 status","volume":"13","author":"Chen","year":"2007","journal-title":"Clin Cancer Res"},{"key":"14","doi-asserted-by":"crossref","first-page":"593","DOI":"10.2174\/156800910791859425","article-title":"Effect of NF-\u03baB signaling on apoptosis in chronic inflammation-associated carcinogenesis","volume":"10","author":"Cho","year":"2010","journal-title":"Curr Cancer Drug Targets"},{"key":"15","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1111\/j.1442-2050.2010.01148.x","article-title":"and ex vivo models of extended reflux exposure demonstrate that weakly acidic mixed reflux heightens NF-\u03baB -mediated gene expression","volume":"24","author":"Jenkins","year":"2011","journal-title":"Dis Esophagus"},{"key":"16","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1146\/annurev.immunol.14.1.649","article-title":"The NF-kappa B and I kappa B proteins: new discoveries and insights","volume":"14","author":"Baldwin","year":"1996","journal-title":"Annu Rev Immunol"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1002\/hed.24231","article-title":"Anmodel for gastro-duodenal reflux-induced nuclear factor-kappaB activation and its role in hypopharyngeal carcinogenesis","author":"Vageli","year":"2015","journal-title":"Head Neck"},{"key":"18","doi-asserted-by":"crossref","first-page":"8210","DOI":"10.1158\/0008-5472.CAN-06-1213","article-title":"Gene expression profiles identify epithelial-to-mesenchymal transition and activation of nuclear factor-kappaB signaling as characteristics of a high-risk head and neck squamous cell carcinoma","volume":"66","author":"Yarbrough","year":"2006","journal-title":"Cancer Res"},{"key":"19","doi-asserted-by":"crossref","first-page":"6722","DOI":"10.1158\/0008-5472.CAN-05-3758","article-title":"Protein kinase casein kinase 2 mediates inhibitor-kappaB kinase and aberrant nuclear factor-kappaB activation by serum factor(s) in head and neck squamous carcinoma cells","volume":"66","author":"Van Waes","year":"2006","journal-title":"Cancer Res"},{"key":"20","first-page":"394","article-title":"Differential expression of bcl-2 and bax in squamous cell carcinomas of the oral cavity","volume":"32B","author":"Speight","year":"1996","journal-title":"Eur J Cancer B Oral Oncol"},{"key":"21","doi-asserted-by":"crossref","first-page":"3688","DOI":"10.1158\/0008-5472.CAN-10-3445","article-title":"\u0394Np63 versatility regulates a Broad NF-\u03baB gene program and promotes squamous epithelial proliferation, migration, and inflammation","volume":"71","author":"Chen","year":"2011","journal-title":"Cancer Res"},{"key":"22","doi-asserted-by":"crossref","first-page":"6867","DOI":"10.1158\/0008-5472.CAN-11-2460","article-title":"TNF-\u03b1 promotes c-REL\/\u0394Np63\u03b1 interaction and TAp73 dissociation from key genes that mediate growth arrest and apoptosis in head and neck cancer","volume":"71","author":"Van Waes","year":"2011","journal-title":"Cancer Res"},{"key":"23","doi-asserted-by":"crossref","first-page":"6598","DOI":"10.1038\/sj.onc.1205920","article-title":"Wnt and frizzled receptors as potential targets for immunotherapy in head and neck squamous cell carcinomas","volume":"21","author":"Carson","year":"2002","journal-title":"Oncogene"},{"key":"24","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1093\/carcin\/bgt390","article-title":"WNT5A-mediated \u03b2-catenin-independent signalling is a novel regulator of cancer cell metabolism","volume":"35","author":"Jirstr\u00f6m","year":"2014","journal-title":"Carcinogenesis"},{"key":"25","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1038\/onc.2013.49","article-title":"Aberrant IKK\u03b1 and IKK\u03b2 cooperatively activate NF-\u03baB and induce EGFR\/AP1 signaling to promote survival and migration of head and neck cancer","volume":"33","author":"Chen","year":"2014","journal-title":"Oncogene"},{"key":"26","doi-asserted-by":"crossref","first-page":"5135","DOI":"10.1038\/onc.2009.279","article-title":"Epidermal growth factor receptor variant III mediates head and neck cancer cell invasionSTAT3 activation","volume":"29","author":"Grandis","year":"2010","journal-title":"Oncogene"},{"key":"27","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1593\/neo.06274","article-title":"Molecular cross-talk between the NFkappaB and STAT3 signaling pathways in head and neck squamous cell carcinoma","volume":"8","author":"Gutkind","year":"2006","journal-title":"Neoplasia"},{"key":"28","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4161\/cbt.9.1.10905","article-title":"The molecular pathogenesis of head and neck cancer","volume":"9","author":"Grandis","year":"2010","journal-title":"Cancer Biol Ther"},{"key":"29","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1016\/S0039-6060(97)90327-5","article-title":"Composition and concentration of bile acid reflux into the esophagus of patients with gastroesophageal reflux disease","volume":"122","author":"Siewert","year":"1997","journal-title":"Surgery"},{"key":"30","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1053\/j.gastro.2010.03.035","article-title":"Acid and bile salt-induced CDX2 expression differs in esophageal squamous cells from patients with and without Barrett's esophagus","volume":"139","author":"Souza","year":"2010","journal-title":"Gastroenterology"},{"key":"31","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/1758-3284-1-11","article-title":"Grading systems in head and neck dysplasia: their prognostic value, weaknesses and utility (review)","volume":"1","author":"Slootweg","year":"2009","journal-title":"Head Neck Oncol"},{"key":"32","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1111\/his.12427","article-title":"Evaluation of a new grading system for laryngeal squamous intraepithelial lesions-a proposed unified classification","volume":"65","author":"Cardesa","year":"2014","journal-title":"Histopathology"},{"key":"33","unstructured":"Conti, Gimenez-Conti, Benavides, Frijhoff, Conti, Ward (ed.). Atlas of Laboratory Mouse Histology. Gastrointestinal. \u00a9 2004 Texas Histopages, Inc."},{"key":"34","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1007\/s12105-009-0103-8","article-title":"Dysplasia of the upper aerodigestive tract squamous epithelium (review)","volume":"3","author":"Eversole","year":"2009","journal-title":"Head Neck Pathol"},{"key":"35","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/j.1365-2273.1982.tb01557.x","article-title":"Hyperplasia, keratosis, dysplasia and carcinoma in situ of the vocal cords--a follow-up study","volume":"7","author":"Olofsson","year":"1982","journal-title":"Clin Otolaryngol Allied Sci"},{"key":"36","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1038\/labinvest.2013.128","article-title":"Quantitative assessment Ki-67 score for prediction of response to neoadjuvant chemotherapy in breast cancer","volume":"94","author":"Rimm","year":"2014","journal-title":"Lab Invest"},{"key":"37","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1016\/j.febslet.2005.01.053","article-title":"The flexible loop of Bcl-2 is required for molecular interaction with immunosuppressant FK-506 binding protein 38 (FKBP38)","volume":"579","author":"Yoon","year":"2005","journal-title":"FEBS Lett"},{"key":"38","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1111\/j.1600-0714.2007.00584.x","article-title":"Oral epithelial dysplasia classification systems: predictive value, utility, weaknesses and scope for improvement","volume":"37","author":"Dabelsteen","year":"2008","journal-title":"J Oral Pathol Med"},{"key":"39","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1159\/000341498","article-title":"Barrett's to oesophageal cancer sequence: a model of inflammatory-driven upper gastrointestinal cancer","volume":"29","author":"Reynolds","year":"2012","journal-title":"Dig Surg"},{"key":"40","first-page":"49","article-title":"From epithelial dysplasia to squamous carcinoma of the head and neck region: evolutive and prognostic histopathological markers","volume":"527","author":"Bosatra","year":"1997","journal-title":"Acta Otolaryngol Suppl"},{"key":"41","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/j.prp.2012.08.002","article-title":"Impact of the epithelial dysplasia grading and Ki67 proliferation index in the adjacent non-malignant mucosa on recurrence and survival in head and neck squamous cell carcinoma","volume":"208","author":"Guimar\u00e3es","year":"2012","journal-title":"Pathol Res Pract"},{"key":"42","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1016\/j.ijom.2009.06.011","article-title":"Prognostic value of Ki67 from clinically and histologically \u2018normal\u2019 distant mucosa in patients surgically treated for oral squamous cell carcinoma: a prospective study","volume":"38","author":"Foschini","year":"2009","journal-title":"Int J Oral Maxillofac Surg"},{"key":"43","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.5858\/2006-130-1309-UATSDC","article-title":"Upper aerodigestive tract squamous dysplasia: correlation with p16, p53, pRb, and Ki-67 expression","volume":"130","author":"Robinson","year":"2006","journal-title":"Arch Pathol Lab Med"},{"key":"44","first-page":"817","article-title":"Markers for dysplasia of the upper aerodigestive tract. Suprabasal expression of PCNA, p53, and CK19 in alcohol-fixed, embedded tissue","volume":"141","author":"Gown","year":"1992","journal-title":"Am J Pathol"},{"key":"45","doi-asserted-by":"crossref","first-page":"e67361","DOI":"10.1371\/journal.pone.0067361","article-title":"Clinical significance of altered expression of \u03b2-catenin and E-cadherin in oral dysplasia and cancer: potential link with ALCAM expression","volume":"8","author":"Ralhan","year":"2013","journal-title":"PLoS One"},{"key":"46","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1111\/j.1365-2559.2011.03929.x","article-title":"Nuclear translocation of \u03b2-catenin synchronized with loss of E-cadherin in oral epithelial dysplasia with a characteristic two-phase appearance","volume":"59","author":"Saku","year":"2011","journal-title":"Histopathology"},{"key":"47","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1016\/j.oraloncology.2012.05.011","article-title":"Epithelial to mesenchymal transition (EMT) biomarkers-E-cadherin, beta-catenin, APC and Vimentin-in oral squamous cell carcinogenesis and transformation","volume":"48","author":"Farah","year":"2012","journal-title":"Oral Oncol"},{"key":"48","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.lfs.2015.01.038","article-title":"Characterization of the enhanced apoptotic response to azidothymidine by pharmacological inhibition of NF-kB","volume":"127","author":"Macchi","year":"2015","journal-title":"Life Sci"},{"key":"49","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1186\/s12885-015-1356-0","article-title":"Wilms' tumor gene 1 regulates p63 and promotes cell proliferation in squamous cell carcinoma of the head and neck","volume":"15","author":"Li","year":"2015","journal-title":"BMC Cancer"},{"key":"50","doi-asserted-by":"crossref","first-page":"6125","DOI":"10.1038\/sj.onc.1210441","article-title":"p53 and Delta Np63 alpha differentially bind and regulate target genes involved in cell cycle arrest, DNA repair and apoptosis","volume":"26","author":"Pietenpol","year":"2007","journal-title":"Oncogene"},{"key":"51","doi-asserted-by":"crossref","first-page":"763","DOI":"10.3892\/ijmm_00000190","article-title":"Transcriptional mechanisms of WNT5A based on NF-kappaB, Hedgehog, TGFbeta, and Notch signaling cascades","volume":"23","author":"Katoh","year":"2009","journal-title":"Int J Mol Med"}],"container-title":["Oncotarget"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.6824","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,13]],"date-time":"2024-06-13T17:25:49Z","timestamp":1718299549000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.6824"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1,6]]},"references-count":51,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2016,2,2]]}},"alternative-id":["6824","26745676"],"URL":"https:\/\/doi.org\/10.18632\/oncotarget.6824","relation":{},"ISSN":["1949-2553"],"issn-type":[{"value":"1949-2553","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,1,6]]}}}