{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T15:47:13Z","timestamp":1779205633060,"version":"3.51.4"},"reference-count":52,"publisher":"Impact Journals, LLC","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncotarget"],"published-print":{"date-parts":[[2016,3,1]]},"DOI":"10.18632\/oncotarget.7006","type":"journal-article","created":{"date-parts":[[2016,1,25]],"date-time":"2016-01-25T08:02:43Z","timestamp":1453708963000},"page":"10386-10401","source":"Crossref","is-referenced-by-count":7,"title":["Resistance to the nucleotide analogue cidofovir in HPV(+) cells: a multifactorial process involving UMP\/CMP kinase 1"],"prefix":"10.18632","volume":"7","author":[{"given":"Dimitri","family":"Topalis","sequence":"first","affiliation":[{"name":"Rega Institute for Medical Research, KU Leuven, 3000 Leuven, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatiane C.","family":"Nogueira","sequence":"additional","affiliation":[{"name":"Rega Institute for Medical Research, KU Leuven, 3000 Leuven, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tim","family":"De Schutter","sequence":"additional","affiliation":[{"name":"Rega Institute for Medical Research, KU Leuven, 3000 Leuven, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chahrazade","family":"El Amri","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9s, UPMC University Paris 06, UMR 8256, B2A, Biological Adaptation and Ageing, Integrated Cellular Ageing and Inflammation, Molecular and Functional Enzymology, Paris, 75252 Paris Cedex 05, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcela","family":"Kre\u010dmerov\u00e1","sequence":"additional","affiliation":[{"name":"Institute of Organic Chemistry and Biochemistry, Academy of Sciences of The Czech Republic, v.v.i., CZ-166 10 Prague 6, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lieve","family":"Naesens","sequence":"additional","affiliation":[{"name":"Rega Institute for Medical Research, KU Leuven, 3000 Leuven, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Balzarini","sequence":"additional","affiliation":[{"name":"Rega Institute for Medical Research, KU Leuven, 3000 Leuven, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Graciela","family":"Andrei","sequence":"additional","affiliation":[{"name":"Rega Institute for Medical Research, KU Leuven, 3000 Leuven, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Snoeck","sequence":"additional","affiliation":[{"name":"Rega Institute for Medical Research, KU Leuven, 3000 Leuven, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7892","published-online":{"date-parts":[[2016,1,25]]},"reference":[{"key":"1","first-page":"1561","article-title":"Role of cidofovir in the treatment of DNA virus infections, other than CMV infections, in immunocompromised patients","volume":"3","author":"De Clercq","year":"2002","journal-title":"Curr Opin Investig Drugs"},{"key":"2","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/S0161-6420(95)30985-2","article-title":"Intravitreal cidofovir (HPMPC) treatment of cytomegalovirus retinitis in patients with acquired immune deficiency syndrome","volume":"102","author":"Freeman","year":"1995","journal-title":"Ophthalmology"},{"key":"3","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1111\/j.1399-3062.2006.00186.x","article-title":"Dual infection with polyomavirus BK and acyclovir-resistant herpes simplex virus successfully treated with cidofovir in a bone marrow transplant recipient","volume":"9","author":"Snoeck","year":"2007","journal-title":"Transpl Infect Dis"},{"key":"4","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/j.bcp.2011.03.027","article-title":"The clinical potential of the acyclic (and cyclic) nucleoside phosphonates: the magic of the phosphonate bond","volume":"82","author":"De Clercq","year":"2011","journal-title":"Biochem Pharmacol"},{"key":"5","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1093\/clinids\/18.4.570","article-title":"Successful treatment of progressive mucocutaneous infection due to acyclovir- and foscarnet-resistant herpes simplex virus with (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine (HPMPC)","volume":"18","author":"De Clercq","year":"1994","journal-title":"Clin Infect Dis"},{"key":"6","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1097\/00001432-199812000-00014","article-title":"Specific therapies for human papilloma virus infections","volume":"11","author":"De Clercq","year":"1998","journal-title":"Curr Opin Infect Dis"},{"key":"7","doi-asserted-by":"publisher","first-page":"6473","DOI":"10.1158\/1078-0432.CCR-13-1121","article-title":"Cidofovir: a novel antitumor agent for glioblastoma","volume":"19","author":"Cobbs","year":"2013","journal-title":"Clin Cancer Res"},{"key":"8","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1002\/1097-0215(200102)9999:9999<::AID-IJC1183>3.0.CO;2-K","article-title":"Potent inhibition of hemangiosarcoma development in mice by cidofovir","volume":"92","author":"Neyts","year":"2001","journal-title":"Int J Cancer"},{"key":"9","first-page":"384","article-title":"The antiviral agent cidofovir [(S)-1-(3-hydroxy-2-phosphonyl-methoxypropyl)cytosine] has pronounced activity against nasopharyngeal carcinoma grown in nude mice","volume":"58","author":"Pagano","year":"1998","journal-title":"Cancer Res"},{"key":"10","first-page":"519","article-title":"Effects of cidofovir on human papillomavirus-positive cervical cancer cells xenografts in nude mice","volume":"18","author":"Li","year":"2010","journal-title":"Oncol Res"},{"key":"11","first-page":"397","article-title":"Induction of apoptosis by cidofovir in human papillomavirus (HPV)-positive cells","volume":"12","author":"De Clercq","year":"2000","journal-title":"Oncol Res"},{"key":"12","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1186\/1755-8794-6-18","article-title":"Cidofovir selectivity is based on the different response of normal and cancer cells to DNA damage","volume":"6","author":"Snoeck","year":"2013","journal-title":"BMC Med Genomics"},{"key":"13","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.antiviral.2014.10.012","article-title":"Insights into the mechanism of action of cidofovir and other acyclic nucleoside phosphonates against polyoma- and papillomaviruses and non-viral induced neoplasia","volume":"114C","author":"Snoeck","year":"2015","journal-title":"Antiviral Res"},{"key":"14","doi-asserted-by":"publisher","first-page":"4895","DOI":"10.1093\/nar\/gkm479","article-title":"Enantioselectivity of human AMP, dTMP and UMP-CMP kinases","volume":"35","author":"Deville-Bonne","year":"2007","journal-title":"Nucleic Acids Res"},{"key":"15","doi-asserted-by":"crossref","first-page":"1784","DOI":"10.1046\/j.1432-1033.2003.03537.x","article-title":"Reaction of human UMP-CMP kinase with natural and analog substrates","volume":"270","author":"Deville-Bonne","year":"2003","journal-title":"Eur J Biochem"},{"key":"16","doi-asserted-by":"publisher","first-page":"3704","DOI":"10.1111\/j.1742-4658.2007.05902.x","article-title":"Nucleotide binding to human UMP-CMP kinase using fluorescent derivatives- a screening based on affinity for the UMP-CMP binding site","volume":"274","author":"Deville-Bonne","year":"2007","journal-title":"FEBS J"},{"key":"17","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/j.antiviral.2010.02.001","article-title":"Human and viral nucleoside\/nucleotide kinases involved in antiviral drug activation: structural and catalytic properties","volume":"86","author":"Janin","year":"2010","journal-title":"Antiviral Res"},{"key":"18","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1124\/mol.56.3.562","article-title":"Phosphorylation of deoxycytidine analog monophosphates by UMP-CMP kinase: molecular characterization of the human enzyme","volume":"56","author":"Karlsson","year":"1999","journal-title":"Mol Pharmacol"},{"key":"19","doi-asserted-by":"publisher","first-page":"1563","DOI":"10.1074\/jbc.M707997200","article-title":"Human UMP-CMP kinase 2, a novel nucleoside monophosphate kinase localized in mitochondria","volume":"283","author":"Karlsson","year":"2008","journal-title":"J Biol Chem"},{"key":"20","first-page":"1624","article-title":"Characterization of human UMP\/CMP kinase and its phosphorylation of D- and L-form deoxycytidine analogue monophosphates","volume":"62","author":"Cheng","year":"2002","journal-title":"Cancer Res"},{"key":"21","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1038\/nrc3342","article-title":"The effects of deregulated DNA damage signalling on cancer chemotherapy response and resistance","volume":"12","author":"Jonkers","year":"2012","journal-title":"Nat Rev Cancer"},{"key":"22","first-page":"1267","article-title":"The pharmacology of cancer resistance","volume":"27","author":"O'Connor","year":"2007","journal-title":"Anticancer Res"},{"key":"23","doi-asserted-by":"publisher","first-page":"1041","DOI":"10.1016\/j.bcp.2011.12.025","article-title":"Acquired resistance to drugs targeting receptor tyrosine kinases","volume":"83","author":"Rosenzweig","year":"2012","journal-title":"Biochem Pharmacol"},{"key":"24","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1038\/sj.leu.2402114","article-title":"Nucleoside analogues: mechanisms of drug resistance and reversal strategies","volume":"15","author":"Dumontet","year":"2001","journal-title":"Leukemia"},{"key":"25","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/S0145-2126(01)00184-9","article-title":"Potential mechanisms of resistance to cytarabine in AML patients","volume":"26","author":"Dumontet","year":"2002","journal-title":"Leuk Res"},{"key":"26","doi-asserted-by":"publisher","first-page":"2349","DOI":"10.1158\/0008-5472.CAN-07-5528","article-title":"Two distinct molecular mechanisms underlying cytarabine resistance in human leukemic cells","volume":"68","author":"Gros","year":"2008","journal-title":"Cancer Res"},{"key":"27","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1590\/S0100-879X2006001100005","article-title":"Cytosine arabinoside-metabolizing enzyme genes are underexpressed in children with MLL gene-rearranged acute lymphoblastic leukemia","volume":"39","author":"Tone","year":"2006","journal-title":"Braz J Med Biol Res"},{"key":"28","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.3892\/ijo_00000245","article-title":"Defective expression of deoxycytidine kinase in cytarabine-resistant acute myeloid leukemia cells","volume":"34","author":"Kim","year":"2009","journal-title":"Int J Oncol"},{"key":"29","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1016\/0006-2952(93)90670-R","article-title":"Mechanism of uptake of the phosphonate analog (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine (HPMPC) in Vero cells","volume":"46","author":"Fridland","year":"1993","journal-title":"Biochem Pharmacol"},{"key":"30","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1016\/j.ejps.2009.04.001","article-title":"Expression and activity of the efflux transporters ABCB1, ABCC2 and ABCG2 in the human colorectal carcinoma cell line LS513","volume":"37","author":"Li","year":"2009","journal-title":"Eur J Pharm Sci"},{"key":"31","doi-asserted-by":"publisher","first-page":"1343","DOI":"10.1158\/1535-7163.MCT-13-0100","article-title":"Overlapping functions of ABC transporters in topotecan disposition as determined in gene knockout mouse models","volume":"12","author":"Gallo","year":"2013","journal-title":"Mol Cancer Ther"},{"key":"32","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1002\/path.1955","article-title":"Expression of drug pathway proteins is independent of tumour type","volume":"209","author":"McLeod","year":"2006","journal-title":"J Pathol"},{"key":"33","doi-asserted-by":"crossref","first-page":"16617","DOI":"10.1016\/S0021-9258(17)46267-3","article-title":"Termination of DNA synthesis by 9-beta-D-arabinofuranosyl-2-fluoroadenine. A mechanism for cytotoxicity","volume":"265","author":"Plunkett","year":"1990","journal-title":"J Biol Chem"},{"key":"34","doi-asserted-by":"publisher","first-page":"e19490","DOI":"10.1371\/journal.pone.0019490","article-title":"UMP\/CMPK is not the critical enzyme in the metabolism of pyrimidine ribonucleotide and activation of deoxycytidine analogs in human RKO cells","volume":"6","author":"Cheng","year":"2011","journal-title":"PLoS One"},{"key":"35","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1016\/j.bcp.2009.09.010","article-title":"Modulation of human UMP\/CMP kinase affects activation and cellular sensitivity of deoxycytidine analogs","volume":"79","author":"Cheng","year":"2010","journal-title":"Biochem Pharmacol"},{"key":"36","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1093\/oxfordjournals.jbchem.a022120","article-title":"Exchange of nucleoside monophosphate-binding domains in adenylate kinase and UMP\/CMP kinase","volume":"124","author":"Tanizawa","year":"1998","journal-title":"J Biochem"},{"key":"37","doi-asserted-by":"publisher","first-page":"33882","DOI":"10.1074\/jbc.M401989200","article-title":"Substrate-induced conformational changes in human UMP\/CMP kinase","volume":"279","author":"Lavie","year":"2004","journal-title":"J Biol Chem"},{"key":"38","doi-asserted-by":"crossref","first-page":"8075","DOI":"10.1016\/S0021-9258(17)37162-4","article-title":"Mechanism of adenylate kinase. The conserved aspartates 140 and 141 are important for transition state stabilization instead of substrate-induced conformational changes","volume":"269","author":"Tsai","year":"1994","journal-title":"J Biol Chem"},{"key":"39","doi-asserted-by":"publisher","first-page":"1221","DOI":"10.1124\/jpet.103.063966","article-title":"Multidrug resistance protein (MRP) 4- and MRP 5-mediated efflux of 9-(2-phosphonylmethoxyethyl)adenine by microglia","volume":"309","author":"Bendayan","year":"2004","journal-title":"J Pharmacol Exp Ther"},{"key":"40","doi-asserted-by":"publisher","first-page":"29509","DOI":"10.1074\/jbc.M304059200","article-title":"MRP8, ATP-binding cassette C11 (ABCC11), is a cyclic nucleotide efflux pump and a resistance factor for fluoropyrimidines 2\u2032,3\u2032-dideoxycytidine and 9\u2032-(2\u2032-phosphonylmethoxyethyl)adenine","volume":"278","author":"Kruh","year":"2003","journal-title":"J Biol Chem"},{"key":"41","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1023\/A:1012827221844","article-title":"MRP subfamily transporters and resistance to anticancer agents","volume":"33","author":"Belinsky","year":"2001","journal-title":"J Bioenerg Biomembr"},{"key":"42","doi-asserted-by":"crossref","first-page":"1934","DOI":"10.1093\/jnci\/92.23.1934","article-title":"Analysis of the MRP4 drug resistance profile in transfected NIH3T3 cells","volume":"92","author":"Kruh","year":"2000","journal-title":"J Natl Cancer Inst"},{"key":"43","doi-asserted-by":"publisher","first-page":"E14","DOI":"10.1208\/ps040314","article-title":"Role of MRP4 and MRP5 in biology and chemotherapy","volume":"4","author":"Schuetz","year":"2002","journal-title":"AAPS PharmSci"},{"key":"44","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/S0022-3565(24)29264-8","article-title":"Nucleoside phosphonate interactions with multiple organic anion transporters in renal proximal tubule","volume":"299","author":"Miller","year":"2001","journal-title":"J Pharmacol Exp Ther"},{"key":"45","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1016\/0006-2952(93)90670-R","article-title":"Mechanism of uptake of the phosphonate analog (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine (HPMPC) in Vero cells","volume":"46","author":"Fridland","year":"1993","journal-title":"Biochem Pharmacol"},{"key":"46","doi-asserted-by":"publisher","first-page":"1529","DOI":"10.1517\/13543784.2015.1099628","article-title":"An overview of early investigational drugs for the treatment of human papilloma virus infection and associated dysplasia","volume":"24","author":"Hampson","year":"2015","journal-title":"Expert Opin Investig Drugs"},{"key":"47","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1186\/1476-4598-10-71","article-title":"PIK3CA-mediated PI3-kinase signalling is essential for HPV-induced transformation","volume":"10","author":"Steenbergen","year":"2011","journal-title":"Mol Cancer"},{"key":"48","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1186\/1476-4598-12-158","article-title":"Reduced tumorigenicity and pathogenicity of cervical carcinoma SiHa cells selected for resistance to cidofovir","volume":"12","author":"Snoeck","year":"2013","journal-title":"Mol Cancer"},{"key":"49","first-page":"523","article-title":"Antiproliferative effects of acyclic nucleoside phosphonates on human papillomavirus (HPV)-harboring cell lines compared with HPV-negative cell lines","volume":"10","author":"De Clercq","year":"1998","journal-title":"Oncol Res"},{"key":"50","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1006\/abio.1994.1326","article-title":"Improved spectrophotometric assay of nucleoside monophosphate kinase activity using the pyruvate kinase\/lactate dehydrogenase coupling system","volume":"220","author":"Barzu","year":"1994","journal-title":"Anal Biochem"},{"key":"51","doi-asserted-by":"publisher","first-page":"1605","DOI":"10.1002\/cbic.201200199","article-title":"Borononucleotides as substrates\/binders for human NMP kinases: enzymatic and spectroscopic evaluation","volume":"13","author":"Smietana","year":"2012","journal-title":"Chembiochem"},{"key":"52","doi-asserted-by":"crossref","first-page":"4462","DOI":"10.1073\/pnas.89.10.4462","article-title":"Environment affects amino acid preference for secondary structure","volume":"89","author":"Johnson","year":"1992","journal-title":"Proc Natl Acad Sci U S A"}],"container-title":["Oncotarget"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.7006","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T06:45:45Z","timestamp":1748760345000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.7006"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1,25]]},"references-count":52,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2016,3,1]]}},"alternative-id":["7006","26824416"],"URL":"https:\/\/doi.org\/10.18632\/oncotarget.7006","relation":{},"ISSN":["1949-2553"],"issn-type":[{"value":"1949-2553","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,1,25]]}}}