{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T05:06:57Z","timestamp":1785215217342,"version":"3.55.0"},"reference-count":63,"publisher":"Impact Journals, LLC","issue":"14","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncotarget"],"published-print":{"date-parts":[[2016,4,5]]},"DOI":"10.18632\/oncotarget.7268","type":"journal-article","created":{"date-parts":[[2016,2,9]],"date-time":"2016-02-09T04:17:48Z","timestamp":1454991468000},"page":"17631-17640","source":"Crossref","is-referenced-by-count":41,"title":["DARPP-32: from neurotransmission to cancer"],"prefix":"10.18632","volume":"7","author":[{"given":"Abbes","family":"Belkhiri","sequence":"first","affiliation":[{"name":"Department of Surgery, Cancer Biology, and Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shoumin","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Surgery, Cancer Biology, and Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wael","family":"El-Rifai","sequence":"additional","affiliation":[{"name":"Department of Surgery, Cancer Biology, and Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, USA"},{"name":"Department of Veterans Affairs, Tennessee Valley Healthcare System, Nashville, TN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7892","published-online":{"date-parts":[[2016,2,8]]},"reference":[{"key":"1","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1523\/JNEUROSCI.03-02-00291.1983","article-title":"Regional distribution of calcium- and cyclic adenosine 3\u2032:5\u2032-monophosphate-regulated protein phosphorylation systems in mammalian brain. I. Particulate systems","volume":"3","author":"Greengard","year":"1983","journal-title":"J Neurosci"},{"key":"2","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1038\/301069a0","article-title":"A dopamine- and cyclic AMP-regulated phosphoprotein enriched in dopamine-innervated brain regions","volume":"301","author":"Greengard","year":"1983","journal-title":"Nature"},{"key":"3","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1523\/JNEUROSCI.04-01-00111.1984","article-title":"DARPP-32, a dopamine- and adenosine 3\u2032:5\u2032-monophosphate-regulated phosphoprotein enriched in dopamine-innervated brain regions. III. Immunocytochemical localization","volume":"4","author":"Greengard","year":"1984","journal-title":"J Neurosci"},{"key":"4","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1523\/JNEUROSCI.06-05-01469.1986","article-title":"DARPP-32, a dopamine- and adenosine 3\u2032:5\u2032-monophosphate-regulated phosphoprotein: regional, tissue, and phylogenetic distribution","volume":"6","author":"Greengard","year":"1986","journal-title":"J Neurosci"},{"key":"5","doi-asserted-by":"crossref","first-page":"8068","DOI":"10.1073\/pnas.86.20.8068","article-title":"Dopamine- and cAMP-regulated phosphoprotein (DARPP-32) and dopamine DA1 agonist-sensitive Na+,K+-ATPase in renal tubule cells","volume":"86","author":"Greengard","year":"1989","journal-title":"Proc Natl Acad Sci U S A"},{"key":"6","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1038\/310503a0","article-title":"DARPP-32, a dopamine-regulated neuronal phosphoprotein, is a potent inhibitor of protein phosphatase-1","volume":"310","author":"Cohen","year":"1984","journal-title":"Nature"},{"key":"7","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/S0896-6273(00)80798-9","article-title":"Beyond the dopamine receptor: the DARPP-32\/protein phosphatase-1 cascade","volume":"23","author":"Nairn","year":"1999","journal-title":"Neuron"},{"key":"8","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1126\/science.294.5544.1024","article-title":"The neurobiology of slow synaptic transmission","volume":"294","author":"Greengard","year":"2001","journal-title":"Science"},{"key":"9","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1146\/annurev.pharmtox.44.101802.121415","article-title":"DARPP-32: an integrator of neurotransmission","volume":"44","author":"Greengard","year":"2004","journal-title":"Annu Rev Pharmacol Toxicol"},{"issue":"Suppl 1","key":"10","first-page":"14","article-title":"The role of DARPP-32 in the actions of drugs of abuse","volume":"47","author":"Greengard","year":"2004","journal-title":"Neuropharmacology"},{"key":"11","doi-asserted-by":"crossref","first-page":"E353","DOI":"10.1208\/aapsj070235","article-title":"DARPP-32 mediates the actions of multiple drugs of abuse","volume":"7","author":"Greengard","year":"2005","journal-title":"The AAPS journal"},{"key":"12","first-page":"34","article-title":"Consistent genetic alterations in xenografts of proximal stomach and gastro-esophageal junction adenocarcinomas","volume":"58","author":"Powell","year":"1998","journal-title":"Cancer Res"},{"key":"13","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1053\/gast.2001.27215","article-title":"Genetic differences between adenocarcinomas arising in Barrett's esophagus and gastric mucosa","volume":"121","author":"Powell","year":"2001","journal-title":"Gastroenterology"},{"key":"14","first-page":"4061","article-title":"Gastric cancers overexpress DARPP-32 and a novel isoform, t-DARPP","volume":"62","author":"Powell","year":"2002","journal-title":"Cancer Res"},{"key":"15","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1073\/pnas.0408305102","article-title":"Regulation of a protein phosphatase cascade allows convergent dopamine and glutamate signals to activate ERK in the striatum","volume":"102","author":"Girault","year":"2005","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"16","doi-asserted-by":"crossref","first-page":"11444","DOI":"10.1523\/JNEUROSCI.1711-05.2005","article-title":"Parsing molecular and behavioral effects of cocaine in mitogen- and stress-activated protein kinase-1-deficient mice","volume":"25","author":"Caboche","year":"2005","journal-title":"J Neurosci"},{"key":"17","doi-asserted-by":"crossref","first-page":"1856","DOI":"10.1073\/pnas.97.4.1856","article-title":"Regulation of the phosphorylation of the dopamine- and cAMP-regulated phosphoprotein of 32 kDa in vivo by dopamine D1, dopamine D2, and adenosine A2A receptors","volume":"97","author":"Fisone","year":"2000","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"18","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/S0166-2236(97)01096-5","article-title":"Adenosine-dopamine receptor-receptor interactions as an integrative mechanism in the basal ganglia","volume":"20","author":"Fuxe","year":"1997","journal-title":"Trends Neurosci"},{"key":"19","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1523\/JNEUROSCI.13-03-01080.1993","article-title":"Adenosine A2 receptors regulate the gene expression of striatopallidal and striatonigral neurons","volume":"13","author":"Vanderhaeghen","year":"1993","journal-title":"J Neurosci"},{"key":"20","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/S0306-4522(97)00510-1","article-title":"Activation of adenosine A2A and dopamine D1 receptors stimulates cyclic AMP-dependent phosphorylation of DARPP-32 in distinct populations of striatal projection neurons","volume":"84","author":"Fisone","year":"1998","journal-title":"Neuroscience"},{"key":"21","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/0014-5793(91)80125-M","article-title":"Differential expression of the mouse D2 dopamine receptor isoforms","volume":"278","author":"Borrelli","year":"1991","journal-title":"FEBS Lett"},{"key":"22","doi-asserted-by":"crossref","first-page":"4305","DOI":"10.1073\/pnas.0730708100","article-title":"Distinct roles of dopamine D2L and D2S receptor isoforms in the regulation of protein phosphorylation at presynaptic and postsynaptic sites","volume":"100","author":"Fisone","year":"2003","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"23","doi-asserted-by":"crossref","first-page":"2589","DOI":"10.1046\/j.1460-9568.1999.00724.x","article-title":"Requirement for DARPP-32 in mediating effect of dopamine D2 receptor activation","volume":"11","author":"Greengard","year":"1999","journal-title":"Eur J Neurosci"},{"key":"24","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/S0006-8993(98)00724-0","article-title":"Quantitative immunocytochemistry of DARPP-32-expressing neurons in the rat caudatoputamen","volume":"808","author":"Greengard","year":"1998","journal-title":"Brain Res"},{"key":"25","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1038\/4516","article-title":"Protein phosphatase 1 modulation of neostriatal AMPA channels: regulation by DARPP-32 and spinophilin","volume":"2","author":"Greengard","year":"1999","journal-title":"Nat Neurosci"},{"key":"26","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1126\/science.281.5378.838","article-title":"DARPP-32: regulator of the efficacy of dopaminergic neurotransmission","volume":"281","author":"Ouimet","year":"1998","journal-title":"Science"},{"key":"27","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1038\/45251","article-title":"Phosphorylation of DARPP-32 by Cdk5 modulates dopamine signalling in neurons","volume":"402","author":"Greengard","year":"1999","journal-title":"Nature"},{"key":"28","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1016\/S0896-6273(00)80482-1","article-title":"Primary structure and function of an A kinase anchoring protein associated with calcium channels","volume":"20","author":"Murphy","year":"1998","journal-title":"Neuron"},{"key":"29","first-page":"56","article-title":"DARPP-32, Jack of All Trades\u2026 Master of Which?","volume":"5","author":"Girault","year":"2011","journal-title":"Front Behav Neurosci"},{"key":"30","doi-asserted-by":"crossref","first-page":"8772","DOI":"10.1074\/jbc.270.15.8772","article-title":"Phosphorylation of DARPP-32, a dopamine- and cAMP-regulated phosphoprotein, by casein kinase I in vitro and in vivo","volume":"270","author":"Girault","year":"1995","journal-title":"The Journal of biological chemistry"},{"key":"31","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1042\/bj3300211","article-title":"Dephosphorylation of Ser-137 in DARPP-32 by protein phosphatases 2A and 2C: different roles in vitro and in striatonigral neurons","volume":"330","author":"Girault","year":"1998","journal-title":"The Biochemical journal"},{"key":"32","doi-asserted-by":"crossref","first-page":"21748","DOI":"10.1016\/S0021-9258(20)88248-9","article-title":"Phosphorylation of DARPP-32, a dopamine- and cAMP-regulated phosphoprotein, by casein kinase II","volume":"264","author":"Greengard","year":"1989","journal-title":"The Journal of biological chemistry"},{"key":"33","doi-asserted-by":"crossref","first-page":"24022","DOI":"10.1016\/S0021-9258(20)80487-6","article-title":"Study of the conformation of DARPP-32, a dopamine- and cAMP-regulated phosphoprotein, by fluorescence spectroscopy","volume":"268","author":"Girault","year":"1993","journal-title":"The Journal of biological chemistry"},{"key":"34","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1038\/mp.2012.174","article-title":"Revisiting DARPP-32 in postmortem human brain: changes in schizophrenia and bipolar disorder and genetic associations with t-DARPP-32 expression","volume":"19","author":"Lipska","year":"2014","journal-title":"Mol Psychiatry"},{"key":"35","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1001\/archpsyc.59.8.705","article-title":"Evidence for decreased DARPP-32 in the prefrontal cortex of patients with schizophrenia","volume":"59","author":"Greengard","year":"2002","journal-title":"Archives of general psychiatry"},{"key":"36","article-title":"Calpain-mediated cleavage of DARPP-32 in Alzheimer's disease","author":"Kim","year":"2015","journal-title":"Aging cell"},{"key":"37","first-page":"1107","article-title":"DNA copy number amplifications in human neoplasms: review of comparative genomic hybridization studies","volume":"152","author":"Zhu","year":"1998","journal-title":"Am J Pathol"},{"key":"38","first-page":"2625","article-title":"Targets of gene amplification and overexpression at 17q in gastric cancer","volume":"62","author":"El-Rifai","year":"2002","journal-title":"Cancer research"},{"key":"39","doi-asserted-by":"crossref","first-page":"6583","DOI":"10.1158\/0008-5472.CAN-05-1433","article-title":"Darpp-32: a novel antiapoptotic gene in upper gastrointestinal carcinomas","volume":"65","author":"El-Rifai","year":"2005","journal-title":"Cancer research"},{"key":"40","doi-asserted-by":"publisher","first-page":"33134","DOI":"10.18632\/oncotarget.5311","article-title":"t-Darpp overexpression in HER2-positive breast cancer confers a survival advantage in lapatinib","volume":"6","author":"Kane","year":"2015","journal-title":"Oncotarget"},{"key":"41","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1186\/1476-4598-9-240","article-title":"t-DARPP regulates phosphatidylinositol-3-kinase-dependent cell growth in breast cancer","volume":"9","author":"Belkhiri","year":"2010","journal-title":"Mol Cancer"},{"key":"42","doi-asserted-by":"crossref","first-page":"e6220","DOI":"10.1371\/journal.pone.0006220","article-title":"Darpp-32 and its truncated variant t-Darpp have antagonistic effects on breast cancer cell growth and herceptin resistance","volume":"4","author":"Kane","year":"2009","journal-title":"PLoS One"},{"key":"43","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1111\/j.1742-1241.2004.00305.x","article-title":"Overexpression of DARPP-32 in colorectal adenocarcinoma","volume":"59","author":"Fan","year":"2005","journal-title":"International journal of clinical practice"},{"key":"44","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.surg.2010.05.011","article-title":"Dopamine and cAMP regulated phosphoprotein MW 32 kDa is overexpressed in early stages of gastric tumorigenesis","volume":"148","author":"El-Rifai","year":"2010","journal-title":"Surgery"},{"key":"45","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.gde.2008.11.008","article-title":"Oncogenic gene fusions in epithelial carcinomas","volume":"19","author":"Chinnaiyan","year":"2009","journal-title":"Current opinion in genetics & development"},{"key":"46","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1038\/nrc2091","article-title":"The impact of translocations and gene fusions on cancer causation","volume":"7","author":"Mertens","year":"2007","journal-title":"Nat Rev Cancer"},{"key":"47","doi-asserted-by":"crossref","first-page":"5341","DOI":"10.1038\/onc.2013.472","article-title":"PPP1R1B-STARD3 chimeric fusion transcript in human gastric cancer promotes tumorigenesis through activation of PI3K\/AKT signaling","volume":"33","author":"Kim","year":"2014","journal-title":"Oncogene"},{"key":"48","article-title":"Regulation of CD44E by DARPP-32-dependent activation of SRp20 splicing factor in gastric tumorigenesis","author":"El-Rifai","year":"2015","journal-title":"Oncogene"},{"key":"49","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1186\/1476-4598-13-192","article-title":"Darpp-32 and t-Darpp are differentially expressed in normal and malignant mouse mammary tissue","volume":"13","author":"Kane","year":"2014","journal-title":"Mol Cancer"},{"key":"50","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1158\/0008-5472.CAN-07-1580","article-title":"t-Darpp promotes cancer cell survival by up-regulation of Bcl2 through Akt-dependent mechanism","volume":"68","author":"El-Rifai","year":"2008","journal-title":"Cancer research"},{"key":"51","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1073\/pnas.1323098111","article-title":"Feedback regulation mediated by Bcl-2 and DARPP-32 regulates inositol 1,4,5-trisphosphate receptor phosphorylation and promotes cell survival","volume":"111","author":"Distelhorst","year":"2014","journal-title":"Proc Natl Acad Sci U S A"},{"key":"52","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1007\/s10620-007-9829-x","article-title":"Reversal of multidrug resistance of adriamycin-resistant gastric adenocarcinoma cells through the up-regulation of DARPP-32","volume":"53","author":"Fan","year":"2008","journal-title":"Dig Dis Sci"},{"key":"53","doi-asserted-by":"crossref","first-page":"1738","DOI":"10.1053\/j.gastro.2011.06.070","article-title":"DARPP-32 increases interactions between epidermal growth factor receptor and ERBB3 to promote tumor resistance to gefitinib","volume":"141","author":"El-Rifai","year":"2011","journal-title":"Gastroenterology"},{"key":"54","doi-asserted-by":"crossref","first-page":"3889","DOI":"10.1158\/1078-0432.CCR-11-3182","article-title":"Resistance to TRAIL is mediated by DARPP-32 in gastric cancer","volume":"18","author":"El-Rifai","year":"2012","journal-title":"Clin Cancer Res"},{"key":"55","doi-asserted-by":"crossref","first-page":"4564","DOI":"10.1158\/1078-0432.CCR-08-0121","article-title":"Expression of t-DARPP mediates trastuzumab resistance in breast cancer cells","volume":"14","author":"El-Rifai","year":"2008","journal-title":"Clin Cancer Res"},{"key":"56","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/s10549-009-0364-7","article-title":"Both t-Darpp and DARPP-32 can cause resistance to trastuzumab in breast cancer cells and are frequently expressed in primary breast cancers","volume":"120","author":"Basik","year":"2010","journal-title":"Breast cancer research and treatment"},{"key":"57","doi-asserted-by":"crossref","first-page":"4504","DOI":"10.1158\/0008-5472.CAN-12-1119","article-title":"Regulation of ERBB2 receptor by t-DARPP mediates trastuzumab resistance in human esophageal adenocarcinoma","volume":"72","author":"El-Rifai","year":"2012","journal-title":"Cancer research"},{"key":"58","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/1476-4598-10-32","article-title":"Regulation of beta-catenin by t-DARPP in upper gastrointestinal cancer cells","volume":"10","author":"El-Rifai","year":"2011","journal-title":"Mol Cancer"},{"key":"59","doi-asserted-by":"crossref","first-page":"4011","DOI":"10.1016\/j.yexcr.2006.09.003","article-title":"Phosphorylation of DARPP-32 regulates breast cancer cell migration downstream of the receptor tyrosine kinase DDR1","volume":"312","author":"Vogel","year":"2006","journal-title":"Exp Cell Res"},{"key":"60","doi-asserted-by":"crossref","first-page":"27533","DOI":"10.1074\/jbc.M109.048884","article-title":"Wnt-5a-induced phosphorylation of DARPP-32 inhibits breast cancer cell migration in a CREB-dependent manner","volume":"284","author":"Andersson","year":"2009","journal-title":"J Biol Chem"},{"key":"61","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1158\/1541-7786.MCR-12-0243-T","article-title":"Regulation of CXCR4-Mediated Invasion by DARPP-32 in Gastric Cancer Cells","volume":"11","author":"El-Rifai","year":"2013","journal-title":"Mol Cancer Res"},{"key":"62","doi-asserted-by":"crossref","first-page":"213","DOI":"10.9738\/INTSURG-D-14-00022.1","article-title":"High Expression of DARPP-32 in Colorectal Cancer Is Associated With Liver Metastases and Predicts Survival for Dukes A and B Patients: Results of a Pilot Study","volume":"100","author":"Bakota","year":"2015","journal-title":"International surgery"},{"key":"63","article-title":"Gastric tumour-derived ANGPT2 regulation by DARPP-32 promotes angiogenesis","author":"El-Rifai","year":"2015","journal-title":"Gut"}],"container-title":["Oncotarget"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.7268","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,3]],"date-time":"2022-06-03T17:58:45Z","timestamp":1654279125000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.7268"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2,8]]},"references-count":63,"journal-issue":{"issue":"14","published-print":{"date-parts":[[2016,4,5]]}},"alternative-id":["7268","26872373"],"URL":"https:\/\/doi.org\/10.18632\/oncotarget.7268","relation":{},"ISSN":["1949-2553"],"issn-type":[{"value":"1949-2553","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,2,8]]}}}