{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T22:40:52Z","timestamp":1774564852436,"version":"3.50.1"},"reference-count":26,"publisher":"Impact Journals, LLC","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncotarget"],"published-print":{"date-parts":[[2016,3,22]]},"DOI":"10.18632\/oncotarget.7350","type":"journal-article","created":{"date-parts":[[2016,2,12]],"date-time":"2016-02-12T15:19:53Z","timestamp":1455290393000},"page":"14251-14258","source":"Crossref","is-referenced-by-count":47,"title":["Myeloid neoplasms with isolated isochromosome 17q demonstrate a high frequency of mutations in <i>SETBP1, SRSF2, ASXL1<\/i> and <i>NRAS<\/i>"],"prefix":"10.18632","volume":"7","author":[{"given":"Rashmi","family":"Kanagal-Shamanna","sequence":"first","affiliation":[{"name":"Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rajyalakshmi","family":"Luthra","sequence":"additional","affiliation":[{"name":"Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cameron C.","family":"Yin","sequence":"additional","affiliation":[{"name":"Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keyur P.","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koichi","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinyan","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chong","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Stingo","sequence":"additional","affiliation":[{"name":"Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhuang","family":"Zuo","sequence":"additional","affiliation":[{"name":"Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark J.","family":"Routbort","sequence":"additional","affiliation":[{"name":"Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rajesh R.","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia","family":"Fox","sequence":"additional","affiliation":[{"name":"Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Farhad","family":"Ravandi","sequence":"additional","affiliation":[{"name":"Department of Statistics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guillermo","family":"Garcia-Manero","sequence":"additional","affiliation":[{"name":"Department of Statistics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. Jeffrey","family":"Medeiros","sequence":"additional","affiliation":[{"name":"Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos E.","family":"Bueso-Ramos","sequence":"additional","affiliation":[{"name":"Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7892","published-online":{"date-parts":[[2016,2,12]]},"reference":[{"key":"1","doi-asserted-by":"crossref","first-page":"2879","DOI":"10.1002\/cncr.26537","article-title":"Myeloid neoplasms with isolated isochromosome 17q represent a clinicopathologic entity associated with myelodysplastic\/myeloproliferative features, a high risk of leukemic transformation, and wild-type TP53","volume":"118","author":"Yin","year":"2012","journal-title":"Cancer"},{"key":"2","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1046\/j.1365-2141.1999.01537.x","article-title":"Isolated isochromosome 17q: a distinct type of mixed myeloproliferative disorder\/myelodysplastic syndrome with an aggressive clinical course","volume":"106","author":"Hanson","year":"1999","journal-title":"Br J Haematol"},{"key":"3","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1002\/ajh.23755","article-title":"Clinicopathologic and molecular characterization of myeloid neoplasms harboring isochromosome 17(q10)","volume":"89","author":"His","year":"2014","journal-title":"Am J Haematol"},{"key":"4","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1200\/JCO.2011.35.6394","article-title":"New comprehensive cytogenetic scoring system for primary myelodysplastic syndromes (MDS) and oligoblastic acute myeloid leukemia after MDS derived from an international database merge","volume":"30","author":"Pfeilstocker","year":"2012","journal-title":"J Clin Oncol"},{"key":"5","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/j.leukres.2013.04.010","article-title":"Characterization and prognostic implication of 17 chromosome abnormalities in myelodysplastic syndrome","volume":"37","author":"Granada","year":"2013","journal-title":"Leuk Res"},{"key":"6","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1182\/blood-2009-11-254441","article-title":"Refinement of cytogenetic classification in acute myeloid leukemia: determination of prognostic significance of rare recurring chromosomal abnormalities among 5876 younger adult patients treated in the United Kingdom Medical Research Council trials","volume":"116","author":"Burnett","year":"2010","journal-title":"Blood"},{"key":"7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1086\/380648","article-title":"The breakpoint region of the most common isochromosome, i(17q), in human neoplasia is characterized by a complex genomic architecture with large, palindromic, low-copy repeats","volume":"74","author":"Fioretos","year":"2004","journal-title":"Am J Hum Genet"},{"key":"8","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1182\/blood.V94.1.225.413k24_225_232","article-title":"Isochromosome 17q in blast crisis of chronic myeloid leukemia and in other hematologic malignancies is the result of clustered breakpoints in 17p11 and is not associated with coding TP53 mutations","volume":"94","author":"Hoglund","year":"1999","journal-title":"Blood"},{"key":"9","doi-asserted-by":"crossref","first-page":"1852","DOI":"10.1038\/leu.2013.133","article-title":"SETBP1 mutations occur in 9% of MDS\/MPN and in 4% of MPN cases and are strongly associated with atypical CML, monosomy 7, isochromosome i(17)(q10), ASXL1 and CBL mutations","volume":"27","author":"Schnittger","year":"2013","journal-title":"Leukemia"},{"key":"10","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1111\/bjh.13355","article-title":"Correlation of myelodysplastic syndromes with i(17) (q10) and TP53 and SETBP1 mutations","volume":"171","author":"Alvarez","year":"2015","journal-title":"Br J Haematol"},{"key":"11","doi-asserted-by":"crossref","first-page":"2059","DOI":"10.1056\/NEJMoa1301689","article-title":"Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia","volume":"368","author":"Cancer Genome Atlas Research N","year":"2013","journal-title":"New Engl J Med"},{"key":"12","first-page":"126","article-title":"The Landscape of Myeloid Neoplasms with Isochromosome 17q Discloses a Specific Mutation Profile and Is Characterized By an Accumulation of Prognostically Adverse Molecular Markers","author":"Haferlach","year":"2015","journal-title":"Blood"},{"key":"13","first-page":"1367","article-title":"Acute myeloid leukemia ontogeny is defined by distinct somatic mutations","volume":"125","author":"Erba","year":"2014","journal-title":"Blood"},{"key":"14","first-page":"124","article-title":"Molecular Analyses of MDS\/MPN Overlap Entities According to WHO Classification Reveal a Distinct Molecular Pattern for MDS\/MPN, Unclassifiable","author":"Schnittger","year":"2014","journal-title":"Blood"},{"key":"15","doi-asserted-by":"crossref","first-page":"1857","DOI":"10.1182\/blood-2014-10-607341","article-title":"An international consortium proposal of uniform response criteria for myelodysplastic\/myeloproliferative neoplasms (MDS\/MPN) in adults","volume":"125","author":"Mesa","year":"2015","journal-title":"Blood"},{"key":"16","doi-asserted-by":"crossref","first-page":"2428","DOI":"10.1200\/JCO.2012.47.3314","article-title":"Prognostic score including gene mutations in chronic myelomonocytic leukemia","volume":"31","author":"Haferlach","year":"2013","journal-title":"J Clin Oncol"},{"key":"17","doi-asserted-by":"crossref","first-page":"3080","DOI":"10.1182\/blood-2012-01-404863","article-title":"SRSF2 mutations in 275 cases with chronic myelomonocytic leukemia (CMML)","volume":"120","author":"Ogawa","year":"2012","journal-title":"Blood"},{"key":"18","doi-asserted-by":"crossref","first-page":"e244","DOI":"10.3324\/haematol.2014.113159","article-title":"Specific molecular mutation patterns delineate chronic neutrophilic leukemia, atypical chronic myeloid leukemia, and chronic myelomonocytic leukemia","volume":"99","author":"Schnittger","year":"2014","journal-title":"Haematologica"},{"key":"19","doi-asserted-by":"crossref","first-page":"2206","DOI":"10.1038\/leu.2014.125","article-title":"ASXL1 and SETBP1 mutations and their prognostic contribution in chronic myelomonocytic leukemia: a two-center study of 466 patients","volume":"28","author":"Solary","year":"2014","journal-title":"Leukemia"},{"key":"20","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1038\/ng.2696","article-title":"Somatic SETBP1 mutations in myeloid malignancies","volume":"45","author":"Shiraishi","year":"2013","journal-title":"Nat Genet"},{"key":"21","doi-asserted-by":"crossref","first-page":"2100","DOI":"10.1038\/leu.2013.97","article-title":"SETBP1 mutations in 415 patients with primary myelofibrosis or chronic myelomonocytic leukemia: independent prognostic impact in CMML","volume":"27","author":"Tefferi","year":"2013","journal-title":"Leukemia"},{"key":"22","doi-asserted-by":"crossref","first-page":"3858","DOI":"10.1200\/JCO.2009.27.1361","article-title":"Next-generation sequencing technology reveals a characteristic pattern of molecular mutations in 72. 8% of chronic myelomonocytic leukemia by detecting frequent alterations in TET2, CBL, RAS, and RUNX1","volume":"28","author":"Kern","year":"2010","journal-title":"J Clin Oncol"},{"key":"23","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1038\/ng.2495","article-title":"Recurrent SETBP1 mutations in atypical chronic myeloid leukemia","volume":"45","author":"Boultwood","year":"2013","journal-title":"Nat Genet"},{"key":"24","doi-asserted-by":"crossref","first-page":"2645","DOI":"10.1182\/blood-2014-02-553800","article-title":"Atypical chronic myeloid leukemia is clinically distinct from unclassifiable myelodysplastic\/myeloproliferative neoplasms","volume":"123","author":"Mehrotra","year":"2014","journal-title":"Blood"},{"key":"25","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1182\/blood-2013-05-500959","article-title":"The new genetics of chronic neutrophilic leukemia and atypical CML: implications for diagnosis and treatment","volume":"122","author":"Tyner","year":"2013","journal-title":"Blood"},{"key":"26","doi-asserted-by":"crossref","first-page":"E4726","DOI":"10.1073\/pnas.1514105112","article-title":"Disease-associated mutation in SRSF2 misregulates splicing by altering RNA-binding affinities","volume":"112","author":"Manley","year":"2015","journal-title":"Proc Natl Acad Sci USA"}],"container-title":["Oncotarget"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.7350","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,11]],"date-time":"2020-05-11T18:23:12Z","timestamp":1589221392000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.7350"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2,12]]},"references-count":26,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2016,3,22]]}},"alternative-id":["7350","26883102"],"URL":"https:\/\/doi.org\/10.18632\/oncotarget.7350","relation":{},"ISSN":["1949-2553"],"issn-type":[{"value":"1949-2553","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,2,12]]}}}