{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T11:43:11Z","timestamp":1792669391547,"version":"4.5.0"},"reference-count":37,"publisher":"Impact Journals, LLC","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncotarget"],"published-print":{"date-parts":[[2016,3,8]]},"DOI":"10.18632\/oncotarget.7516","type":"journal-article","created":{"date-parts":[[2016,2,20]],"date-time":"2016-02-20T04:21:03Z","timestamp":1455942063000},"page":"10857-10869","source":"Crossref","is-referenced-by-count":8,"title":["An efficient model of human endometriosis by induced unopposed estrogenicity in baboons"],"prefix":"10.18632","volume":"7","author":[{"given":"Hareesh B.","family":"Nair","sequence":"first","affiliation":[{"name":"Evestra, Inc., San Antonio, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Baker","sequence":"additional","affiliation":[{"name":"Southwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael A.","family":"Owston","sequence":"additional","affiliation":[{"name":"Southwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renee","family":"Escalona","sequence":"additional","affiliation":[{"name":"Southwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward J.","family":"Dick","sequence":"additional","affiliation":[{"name":"Southwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John L.","family":"VandeBerg","sequence":"additional","affiliation":[{"name":"Southwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus J.","family":"Nickisch","sequence":"additional","affiliation":[{"name":"Evestra, Inc., San Antonio, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7892","published-online":{"date-parts":[[2016,2,19]]},"reference":[{"key":"1","doi-asserted-by":"crossref","first-page":"453","DOI":"10.4065\/70.5.453","article-title":"Endometriosis: current management","volume":"70","author":"Ory","year":"1995","journal-title":"Mayo Clin Proc"},{"key":"2","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1097\/GCO.0b013e3283630d56","article-title":"The genetics and biochemistry of endometriosis","volume":"25","author":"Burney","year":"2013","journal-title":"Curr Opin Obstet Gynecol"},{"issue":"Suppl 4","key":"3","first-page":"1487","article-title":"Modeling the early endometriotic lesion: mesothelium-endometrial cell co-culture increases endometrial invasion and alters mesothelial and endometrial gene transcription","volume":"90","author":"Witz","year":"2008","journal-title":"Fertil Steril"},{"key":"4","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1093\/molehr\/gap043","article-title":"Induction of endometrial epithelial cell invasion and c-fms expression by transforming growth factor beta","volume":"15","author":"Kirma","year":"2009","journal-title":"Mol Hum Reprod"},{"key":"5","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1016\/j.fertnstert.2012.02.007","article-title":"Increased expression of macrophage colony-stimulating factor and its receptor in patients with endometriosis","volume":"97","author":"Tekmal","year":"2012","journal-title":"Fertil Steril"},{"key":"6","doi-asserted-by":"crossref","first-page":"g1752","DOI":"10.1136\/bmj.g1752","article-title":"Endometriosis","volume":"348","author":"Farquhar","year":"2014","journal-title":"BMJ"},{"key":"7","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1016\/j.fertnstert.2014.02.012","article-title":"Treatment of pelvic pain associated with endometriosis: a committee opinion","volume":"101","author":"Practice Committee of the American Society for Reproductive Medicine","year":"2014","journal-title":"Fertil Steril"},{"key":"8","doi-asserted-by":"crossref","first-page":"4982","DOI":"10.1210\/en.2010-0275","article-title":"The endometrial response to chorionic gonadotropin is blunted in a baboon model of endometriosis","volume":"151","author":"Fazleabas","year":"2010","journal-title":"Endocrinology"},{"key":"9","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.1093\/humrep\/13.7.1825","article-title":"The contribution of subtle oocyte or sperm dysfunction affecting fertilization in endometriosis-associated or unexplained infertility: a controlled comparison with tubal infertility and use of donor spermatozoa","volume":"13","author":"Ford","year":"1998","journal-title":"Hum Reprod"},{"key":"10","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1056\/NEJM198802253180805","article-title":"Administration of nasal nafarelin as compared with oral danazol for endometriosis. A multicenter double-blind comparative clinical trial","volume":"318","author":"Jacobson","year":"1988","journal-title":"N Engl J Med"},{"key":"11","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1016\/0002-9378(90)90432-7","article-title":"Efficacy and safety of nafarelin in the treatment of endometriosis","volume":"162","author":"Long","year":"1990","journal-title":"Am J Obstet Gynecol"},{"key":"12","first-page":"1499","article-title":"Managing adverse effects of hormonal contraceptives","volume":"82","author":"Grossman Barr","year":"2010","journal-title":"Am Fam Physician"},{"key":"13","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1016\/S0889-8545(05)70161-3","article-title":"Update on the medical treatment of endometriosis","volume":"27","author":"Schlaff","year":"2000","journal-title":"Obstet Gynecol Clin North Am"},{"key":"14","first-page":"145","article-title":"Evidence that the loss of bone mass induced by GnRH agonists is not totally recovered","volume":"22","author":"Rico","year":"1995","journal-title":"Mauritas"},{"key":"15","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1095\/biolreprod.113.107722","article-title":"Induced endometriosis in nonhuman primates","volume":"88","author":"Slayden","year":"2013","journal-title":"Biol Reprod"},{"key":"16","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1016\/j.fertnstert.2011.06.037","article-title":"Is the baboon model appropriate for endometriosis studies?","volume":"96","author":"Donnez","year":"2011","journal-title":"Fertil Steril"},{"key":"17","doi-asserted-by":"crossref","first-page":"5105","DOI":"10.1210\/en.2007-0716","article-title":"Estrogen is not essential for full endometrial restoration after breakdown: lessons from a mouse model","volume":"148","author":"Salamonsen","year":"2007","journal-title":"Endocrinology"},{"key":"18","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1177\/1933719108322430","article-title":"Nonhuman primate models for translational research in endometriosis","volume":"16","author":"Mwenda","year":"2009","journal-title":"Reprod Sci"},{"key":"19","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1095\/biolreprod45.3.411","article-title":"Prevalence and laparoscopic appearance of spontaneous endometriosis in the baboon (Papio anubis, Papio cynocephalus)","volume":"45","author":"Koninckx","year":"1991","journal-title":"Biol Reprod"},{"key":"20","first-page":"44","article-title":"Changes in eutopic endometrial gene expression during the progression of experimental endometriosis in the baboon, Papio anubis","volume":"88","author":"Fazleabas","year":"2013","journal-title":"Biol Reprod"},{"key":"21","doi-asserted-by":"crossref","first-page":"2341","DOI":"10.1093\/humrep\/des196","article-title":"Lesion kinetics in a non-human primate model of endometriosis","volume":"27","author":"Fazleabas","year":"2012","journal-title":"Hum Reprod"},{"key":"22","doi-asserted-by":"crossref","first-page":"637","DOI":"10.2217\/17455057.3.5.637","article-title":"Baboon model for the study of endometriosis","volume":"3","author":"D'Hooghe","year":"2007","journal-title":"Womens Health (Lond Engl)"},{"key":"23","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.placenta.2015.01.003","article-title":"The perinatal origins of major reproductive disorders in the adolescent: Research avenues","volume":"36","author":"Benagiano","year":"2015","journal-title":"Placenta"},{"key":"24","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1056\/NEJMoa1103182","article-title":"Ulipristal acetate versus placebo for fibroid treatment before surgery","volume":"366","author":"Loumaye","year":"2012","journal-title":"N Engl J Med"},{"key":"25","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1111\/j.1749-6632.2002.tb02798.x","article-title":"Selective progesterone receptor modulators (SPRMs): a novel therapeutic concept in endometriosis","volume":"955","author":"Elger","year":"2002","journal-title":"Ann N Y Acad Sci"},{"key":"26","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1016\/j.steroids.2011.02.038","article-title":"Estrogen receptor-\u03b2 activation in combination with letrozole blocks the growth of breast cancer tumors resistant to letrozole therapy","volume":"76","author":"Tekmal","year":"2011","journal-title":"Steroids"},{"key":"27","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1677\/joe.0.0710077","article-title":"Concentration of oestrogens and androgens in human ovarian venous plasma and follicular fluid throughout the menstrual cycle","volume":"71","author":"McLean","year":"1976","journal-title":"J Endocrinol"},{"key":"28","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1016\/j.steroids.2013.04.003","article-title":"Synthesis and antiprogestational properties of novel17-fluorinated steroids","volume":"78","author":"Edwards","year":"2013","journal-title":"Steroids"},{"key":"29","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1055\/s-0029-1242997","article-title":"Progesterone resistance in a baboon model of endometriosis","volume":"28","author":"Fazleabas","year":"2010","journal-title":"Semin Reprod Med"},{"key":"30","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1007\/s10549-014-2911-0","article-title":"Fatal breast cancer risk in relation to use of unopposed estrogen and combined hormone therapy","volume":"145","author":"Weiss","year":"2014","journal-title":"Breast Cancer Res Treat"},{"key":"31","doi-asserted-by":"crossref","first-page":"215","DOI":"10.3109\/13697137.2014.905529","article-title":"Risks and benefits of hormone therapy: has medical dogma now been overturned?","volume":"17","author":"Burger","year":"2014","journal-title":"Climacteric"},{"key":"32","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1097\/IGC.0000000000000075","article-title":"Reproductive factors and the risk of endometrial cancer","volume":"24","author":"Ali","year":"2014","journal-title":"Int J Gynecol Cancer"},{"key":"33","first-page":"10","article-title":"Treatment of vaginal bleeding irregularities induced by progestin only contraceptives","author":"G\u00fclmezoglu","year":"2013","journal-title":"Cochrane Database Syst Rev"},{"key":"34","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/S0039-128X(00)00175-6","article-title":"L\u00e4hteenm\u00e4ki P. Progestin-only contraceptive rings","volume":"65","author":"Mishell","year":"2000","journal-title":"Steroids"},{"key":"35","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.jsbmb.2013.05.008","article-title":"Effects of menopausal hormonal therapy on occult breast tumors","volume":"137","author":"Heitjan","year":"2013","journal-title":"J Steroid Biochem Mol Biol"},{"key":"36","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/s12672-013-0145-y","article-title":"Occult breast tumor reservoir: biological properties and clinical significance","volume":"4","author":"Heitjan","year":"2013","journal-title":"Horm Cancer"},{"key":"37","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1002\/path.4657","article-title":"Models of endometriosis and their utility in studying progression to ovarian clear cell carcinoma","volume":"238","author":"Charnock-Jones","year":"2016","journal-title":"J Pathol"}],"container-title":["Oncotarget"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.7516","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,11]],"date-time":"2020-05-11T18:15:28Z","timestamp":1589220928000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.7516"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2,19]]},"references-count":37,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2016,3,8]]}},"alternative-id":["7516","26908459"],"URL":"https:\/\/doi.org\/10.18632\/oncotarget.7516","relation":{},"ISSN":["1949-2553"],"issn-type":[{"value":"1949-2553","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,2,19]]}}}