{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T06:11:56Z","timestamp":1790230316112,"version":"4.1.0"},"reference-count":31,"publisher":"Impact Journals, LLC","issue":"18","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncotarget"],"published-print":{"date-parts":[[2016,5,3]]},"DOI":"10.18632\/oncotarget.8224","type":"journal-article","created":{"date-parts":[[2016,3,21]],"date-time":"2016-03-21T23:31:02Z","timestamp":1458603062000},"page":"25549-25557","source":"Crossref","is-referenced-by-count":18,"title":["Phase I trial evaluating the antiviral agent Cidofovir in combination with chemoradiation in cervical cancer patients"],"prefix":"10.18632","volume":"7","author":[{"given":"Eric","family":"Deutsch","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology, Gustave Roussy Cancer Campus, Paris-Sud University, Villejuif, France"},{"name":"Drug Development Department (DITEP), Gustave Roussy Cancer Campus, Paris-Sud University, Villejuif, France"},{"name":"Paris-Sud University, Kremlin-Bic\u00eatre Medical University, DHU TORINO, SIRIC SOCRATES, LABEX LERMIT, Le Kremlin-Bic\u00eatre, France"},{"name":"I NSERM U1030 Molecular Radiotherapy, Gustave Roussy Cancer Campus, Villejuif, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Haie-Meder","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Gustave Roussy Cancer Campus, Paris-Sud University, Villejuif, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed Amine","family":"Bayar","sequence":"additional","affiliation":[{"name":"Biostatistics and Epidemiology Unit, Gustave Roussy Cancer Campus, Villejuif, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Mondini","sequence":"additional","affiliation":[{"name":"I NSERM U1030 Molecular Radiotherapy, Gustave Roussy Cancer Campus, Villejuif, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e9lanie","family":"Laporte","sequence":"additional","affiliation":[{"name":"Department of Medical Biology and Pathology, Translational Research Laboratory and Biobank (UMS3655 CNRS\/US23 INSERM), INSERM Unit U981, Villejuif, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renaud","family":"Mazeron","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Gustave Roussy Cancer Campus, Paris-Sud University, Villejuif, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julien","family":"Adam","sequence":"additional","affiliation":[{"name":"Department of Medical Biology and Pathology, Translational Research Laboratory and Biobank (UMS3655 CNRS\/US23 INSERM), INSERM Unit U981, Villejuif, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Varga","sequence":"additional","affiliation":[{"name":"Drug Development Department (DITEP), Gustave Roussy Cancer Campus, Paris-Sud University, Villejuif, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilles","family":"Vassal","sequence":"additional","affiliation":[{"name":"Department of Clinical Research, Gustave Roussy Cancer Campus, Paris-Sud University, Villejuif, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Magn\u00e9","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Institut de Canc\u00e9rologie de la Loire-Lucien Neuwirth, Saint-Priest en Jarez, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cyrus","family":"Chargari","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Gustave Roussy Cancer Campus, Paris-Sud University, Villejuif, France"},{"name":"I NSERM U1030 Molecular Radiotherapy, Gustave Roussy Cancer Campus, Villejuif, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilie","family":"Lanoy","sequence":"additional","affiliation":[{"name":"Biostatistics and Epidemiology Unit, Gustave Roussy Cancer Campus, Villejuif, France"},{"name":"Inserm U1018 Centre for Research in Epidemiology and Population Health, Paris-Sud University, Villejuif, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Pautier","sequence":"additional","affiliation":[{"name":"Drug Development Department (DITEP), Gustave Roussy Cancer Campus, Paris-Sud University, Villejuif, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonin","family":"Levy","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Gustave Roussy Cancer Campus, Paris-Sud University, Villejuif, France"},{"name":"Drug Development Department (DITEP), Gustave Roussy Cancer Campus, Paris-Sud University, Villejuif, France"},{"name":"I NSERM U1030 Molecular Radiotherapy, Gustave Roussy Cancer Campus, Villejuif, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Charles","family":"Soria","sequence":"additional","affiliation":[{"name":"Drug Development Department (DITEP), Gustave Roussy Cancer Campus, Paris-Sud University, Villejuif, France"},{"name":"Paris-Sud University, Kremlin-Bic\u00eatre Medical University, DHU TORINO, SIRIC SOCRATES, LABEX LERMIT, Le Kremlin-Bic\u00eatre, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7892","published-online":{"date-parts":[[2016,3,21]]},"reference":[{"key":"1","doi-asserted-by":"crossref","first-page":"5802","DOI":"10.1200\/JCO.2008.16.4368","article-title":"Reducing uncertainties about the effects of chemoradiotherapy for cervical cancer: a systematic review and meta-analysis of individual patient data from 18 randomized trials","volume":"26","author":"Chemoradiotherapy for Cervical Cancer Meta-Analysis Collaboration","year":"2008","journal-title":"J Clin Oncol"},{"key":"2","doi-asserted-by":"crossref","first-page":"2334","DOI":"10.1038\/sj.onc.1205006","article-title":"Antiviral agent cidofovir restores p53 function and enhances the radiosensitivity in HPV-associated cancers","volume":"21","author":"Bourhis","year":"2002","journal-title":"Oncogene"},{"key":"3","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.oraloncology.2004.11.003","article-title":"Antiviral activity of cidofovir on a naturally human papillomavirus-16 infected squamous cell carcinoma of the head and neck (SCCHN) cell line improves radiation sensitivity","volume":"41","author":"Ferris","year":"2005","journal-title":"Oral Oncol"},{"key":"4","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1667\/RR0423.1","article-title":"Cidofovir administered with radiation displays an antiangiogenic effect mediated by E6 inhibition and subsequent TP53-dependent VEGF repression in HPV18 + cell lines","volume":"166","author":"Bourhis","year":"2006","journal-title":"Radiat Res"},{"key":"5","doi-asserted-by":"crossref","first-page":"e5018","DOI":"10.1371\/journal.pone.0005018","article-title":"Novel anti-metastatic action of cidofovir mediated by inhibition of E6\/E7, CXCR4 and Rho\/ROCK signaling in HPV tumor cells","volume":"4","author":"Vozenin-Brotons","year":"2009","journal-title":"PLoS One"},{"key":"6","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1002\/(SICI)1096-9896(199909)189:1<12::AID-PATH431>3.0.CO;2-F","article-title":"Human papillomavirus is a necessary cause of invasive cervical cancer worldwide","volume":"189","author":"Mu\u00f1oz","year":"1999","journal-title":"J Pathol"},{"key":"7","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1056\/NEJMoa021641","article-title":"Epidemiologic classification of human papillomavirus types associated with cervical cancer","volume":"348","author":"Meijer","year":"2003","journal-title":"N Engl J Med"},{"key":"8","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1016\/0092-8674(90)90409-8","article-title":"The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53","volume":"63","author":"Howley","year":"1990","journal-title":"Cell"},{"key":"9","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1126\/science.2537532","article-title":"The human papilloma virus-16 E7 oncoprotein is able to bind to the retinoblastoma gene product","volume":"243","author":"Harlow","year":"1989","journal-title":"Science"},{"key":"10","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1128\/AAC.43.5.1198","article-title":"Selective inhibition of human papillomavirusinduced cell proliferation by (S)-1-[3-hydroxy-2-(phosphonylmethoxy)propyl]-cytosine","volume":"43","author":"Gangemi","year":"1999","journal-title":"Antimicrob Agents Chemother"},{"key":"11","doi-asserted-by":"crossref","first-page":"7094","DOI":"10.1038\/sj.onc.1208854","article-title":"Identification of a proliferation gene cluster associated with HPV E6\/E7 expression level and viral DNA load in invasive cervical carcinoma","volume":"24","author":"Radvanyi","year":"2005","journal-title":"Oncogene"},{"key":"12","first-page":"RESEARCH0034","article-title":"Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes","volume":"3","author":"Speleman","year":"2002","journal-title":"Genome biology"},{"key":"13","doi-asserted-by":"crossref","first-page":"4080","DOI":"10.1210\/jc.2013-2165","article-title":"Molecular screening for a personalized treatment approach in advanced adrenocortical cancer","volume":"98","author":"Hescot","year":"2013","journal-title":"J Clin Endocrinol Metab"},{"key":"14","doi-asserted-by":"crossref","first-page":"225","DOI":"10.2165\/00003495-199652020-00006","article-title":"Cidofovir","volume":"52","author":"Bryson","year":"1996","journal-title":"Drugs"},{"key":"15","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1093\/ndt\/17.1.148","article-title":"Cidofovir-induced end-stage renal failure","volume":"17","author":"Rossert","year":"2002","journal-title":"Nephrol Dial Transplant"},{"key":"16","doi-asserted-by":"crossref","first-page":"257","DOI":"10.7326\/0003-4819-126-4-199702150-00001","article-title":"Intravenous cidofovir for peripheral cytomegalovirus retinitis in patients with AIDS. A randomized, controlled trial","volume":"126","author":"Jaffe","year":"1997","journal-title":"Ann Intern Med"},{"key":"17","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1016\/S1470-2045(14)70456-5","article-title":"Activity, safety, and feasibility of cidofovir and imiquimod for treatment of vulval intraepithelial neoplasia (RTVIN): a multicentre, open-label, randomised, phase 2 trial","volume":"15","author":"Griffiths","year":"2014","journal-title":"Lancet Oncol"},{"key":"18","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.ygyno.2011.06.009","article-title":"Accuracy of diffusion-weighted echoplanar MR imaging and ADC mapping in the evaluation of residual cervical carcinoma after radiation therapy","volume":"123","author":"Balleyguier","year":"2011","journal-title":"Gynecol Oncol"},{"key":"19","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1002\/jmri.22546","article-title":"Interest of diffusion-weighted echoplanar MR imaging and apparent diffusion coefficient mapping in gynecological malignancies: a review","volume":"33","author":"Balleyguier","year":"2011","journal-title":"J Magn Reson Imaging"},{"key":"20","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1097\/PGP.0b013e31826f5cf6","article-title":"Immunohistochemical expression of cyclin D1, p16Ink4a, p21WAF1, and Ki-67 correlates with the severity ofcervical neoplasia","volume":"32","author":"Brito Macedo","year":"2013","journal-title":"Int J Gynecol Pathol"},{"key":"21","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/j.ygyno.2011.05.040","article-title":"Phase II trial of cetuximab in the treatment of persistent or recurrent squamous or non-squamous cell carcinoma of the cervix: a Gynecologic Oncology Group study","volume":"122","author":"Boardman","year":"2011","journal-title":"Gynecol Oncol"},{"key":"22","doi-asserted-by":"crossref","first-page":"2530","DOI":"10.1158\/1078-0432.CCR-14-2368","article-title":"PIK3CA pathway mutations predictive of poor response following standard radio chemotherapy +\/\u2212 Cetuximab in cervical cancer patients","volume":"21","author":"Cur\u00e9","year":"2015","journal-title":"Clin Cancer Res"},{"key":"23","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1038\/nature12881","article-title":"Landscape of genomic alterations in cervical carcinomas","volume":"506","author":"Freeman","year":"2014","journal-title":"Nature"},{"key":"24","doi-asserted-by":"crossref","first-page":"5360","DOI":"10.1158\/1078-0432.CCR-14-1837","article-title":"Genome Analysis of Latin American Cervical Cancer: Frequent Activation of the PIK3CA Pathway","volume":"21","author":"Sawitzke","year":"2015","journal-title":"Clin Cancer Res"},{"key":"25","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.ygyno.2012.12.019","article-title":"PIK3CA mutational status and overall survival in patients with cervical cancer treated with radical chemoradiotherapy","volume":"128","author":"Doll","year":"2013","journal-title":"Gynecol Oncol"},{"key":"26","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.critrevonc.2012.09.001","article-title":"Radiation therapy and immunotherapy: implications for a combined cancer treatment","volume":"85","author":"Deutsch","year":"2013","journal-title":"Crit Rev Oncol Hematol"},{"key":"27","first-page":"515","article-title":"Radiation therapy and immunomodulation: Focus on experimental data","volume":"19","author":"Chargari","year":"2015","journal-title":"Cancer Radiother"},{"key":"28","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1158\/1535-7163.MCT-14-1015","article-title":"Synergy of Radiotherapy and a Cancer Vaccine for the Treatment of HPV-Associated Head and Neck Cancer","volume":"14","author":"Dransart","year":"2015","journal-title":"Mol Cancer Ther"},{"key":"29","doi-asserted-by":"crossref","first-page":"6473","DOI":"10.1158\/1078-0432.CCR-13-1121","article-title":"Cidofovir: a novel antitumor agent for glioblastoma","volume":"19","author":"Cobbs","year":"2013","journal-title":"Clin Cancer Res"},{"key":"30","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1021\/bm301832v","article-title":"Drug-induced nanocarrier assembly as a strategy for the cellular delivery of nucleotides and nucleotideanalogues","volume":"14","author":"Hillaireau","year":"2013","journal-title":"Biomacromolecules"},{"key":"31","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1021\/mp300663j","article-title":"Evolution of an amino acid based prodrug approach: stay tuned","volume":"10","author":"McKenna","year":"2013","journal-title":"Mol Pharm"}],"container-title":["Oncotarget"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.8224","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,11]],"date-time":"2020-05-11T19:45:26Z","timestamp":1589226326000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.8224"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3,21]]},"references-count":31,"journal-issue":{"issue":"18","published-print":{"date-parts":[[2016,5,3]]}},"alternative-id":["8224","27016411"],"URL":"https:\/\/doi.org\/10.18632\/oncotarget.8224","relation":{},"ISSN":["1949-2553"],"issn-type":[{"value":"1949-2553","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,3,21]]}}}